Heart, lung and vessels最新文献_第2页

Innovative cold storage of donor organs using the Paragonix Sherpa Pak ™ devices. 使用Paragonix Sherpa Pak™设备的供体器官创新冷藏。

Heart, lung and vessels Pub Date : 2015-01-01

S G Michel, G M LaMuraglia Ii, M L L Madariaga, Lisa M Anderson

{"title":"Innovative cold storage of donor organs using the Paragonix Sherpa Pak ™ devices.","authors":"S G Michel, G M LaMuraglia Ii, M L L Madariaga, Lisa M Anderson","doi":"","DOIUrl":"","url":null,"abstract":"Introduction: Currently, the gold standard for donor organ preservation in clinical organ transplantation consists of 3 plastic bags and an ice box. The first plastic bag includes the organ itself immersed in preservation solution (e.g. Celsior). This bag is put in a second bag filled with saline, and then these two are put in a third bag filled with saline which is then put in the ice box. The disadvantage of this method is that the organ usually gets too cold. It has been shown that the theoretical perfect temperature for organ preservation is 4°C - 8°C. While higher temperatures lead to hypoxic injury of the organ because the metabolism is not decreased efficiently, lower temperatures than 4°C increase the risk of cold injury with protein denaturation. In the current study, we investigated a device that keeps the organ temperature consistently in the desired range of 4°C - 8°C and can potentially decrease cold injury to donor organs.Methods: Three different ex vivo studies were performed with the Paragonix Sherpa Pak™ devices: 1) the temperature of the fluid-filled device was measured for up to 30 hours at an outside temperature set at 22°C, 2) the temperature of the fluid-filled device was measured for up to 30 hours at extreme outside temperatures set at -8°C and 31°C, 3) the temperature of a pig heart attached to the device was measured up to 12 hours.Results: All studies showed that the Paragonix Sherpa Pak™ can keep the temperature of the heart consistently between 4° and 8°C.Conclusions: The Paragonix Sherpa Pak™ device may decrease cold injury of donor organs by maintaining the temperature consistently between 4°C and 8°C and therefore may decrease primary graft failure after organ transplantation.","PeriodicalId":89932,"journal":{"name":"Heart, lung and vessels","volume":"7 3","pages":"246-55"},"PeriodicalIF":0.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/be/29/hlv-07-246.PMC4593023.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34281757","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Oral direct thrombin inhibition: a double-edged sword? 口服凝血酶直接抑制:双刃剑?

Heart, lung and vessels Pub Date : 2015-01-01

Gabriele Fragasso, Angelo Corti, Ferdinando Loiacono, Alberto Margonato, Armando D'Angelo

引用次数: 0

Impact of different dosage of protamine on heparin reversal during off-pump coronary artery bypass: a clinical study. 不同剂量鱼精蛋白对非体外循环冠状动脉搭桥术中肝素逆转影响的临床研究。

Heart, lung and vessels Pub Date : 2015-01-01

Salvatore Suelzu, Andrea Cossu, Giovanni Pala, Michele Portoghese, Valeria Columbanu, Gabriele Sales, Luigi Solinas, Luca Brazzi

{"title":"Impact of different dosage of protamine on heparin reversal during off-pump coronary artery bypass: a clinical study.","authors":"Salvatore Suelzu, Andrea Cossu, Giovanni Pala, Michele Portoghese, Valeria Columbanu, Gabriele Sales, Luigi Solinas, Luca Brazzi","doi":"","DOIUrl":"","url":null,"abstract":"Introduction: Currently, a dose of protamine equal to 1 mg for each 100 units of heparin given is used to reverse the residual heparin activity following off-pump coronary artery bypass. We hypothesized that a 1:1 ratio (ratio of protamine to heparin) could be higher than necessary inducing post-operative disturbance of hemostasis.Methods: Between January and March 2014 in 9 patients undergoing off-pump coronary artery bypass, we evaluated the effect of a dose of protamine equal to 1 mg per 100 units of heparin (Total Calculated Dose) on hemostasis as evaluated by means of thromboelastomery. Two data analyses were performed: the first after the administration of 2/3 of the Total Calculated Dose of protamine and the second after the administration of the Total Calculated Dose of protamine.Results: We found that the administration of 2/3 of Total Calculated Dose of protamine was always able to reverse the anticoagulant effect of heparin and that a significant clotting time elongation was induced by the infusion of the second part of the Total Calculated Dose of protamine. No modification in clot firmness was observed.Conclusions: The present study seems to suggest that the commonly applied ratio equal to 1:1 (ratio of protamine to heparin) could be higher than needed with potential and hazardous impacts on the efficacy of the coagulation system.","PeriodicalId":89932,"journal":{"name":"Heart, lung and vessels","volume":"7 3","pages":"238-45"},"PeriodicalIF":0.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/01/ef/hlv-07-238.PMC4593022.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34281756","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Aortic to right atrial fistula secondary to chronic ruptured sinus of Valsalva aneurysm. 主动脉至右心房瘘继发于慢性Valsalva动脉瘤窦破裂。

Heart, lung and vessels Pub Date : 2015-01-01

Nisal K Perera, Sean D Galvin, Omar Farouque, George Matalanis

引用次数: 0

Biomarkers, diagnosis and management of sepsis-induced acute kidney injury: a narrative review. 生物标志物，败血症引起的急性肾损伤的诊断和管理:叙述回顾。

Heart, lung and vessels Pub Date : 2015-01-01

Zhongheng Zhang

引用次数: 0

Ventilator strategies for VV ECMO management with concomitant tracheal injury and H1N1 influenza. 合并气管损伤和H1N1流感的VV ECMO管理的呼吸机策略

Heart, lung and vessels Pub Date : 2015-01-01

Adam P Johnson, Nicholas C Cavarocchi, Hitoshi Hirose

引用次数: 0

Lung protective ventilation in Cardiac Surgery. 心脏外科肺保护性通气。

Heart, lung and vessels Pub Date : 2015-01-01

Stefano Romagnoli, Zaccaria Ricci

引用次数: 0

List of guest reviewers. 嘉宾评审名单。

Heart, lung and vessels Pub Date : 2015-01-01

引用次数: 0

Haemodynamic response at double lumen bronchial tube placement - Airtraq vs. MacIntosh laryngoscope, a randomised controlled trial. 双腔支气管插管时的血流动力学反应- Airtraq与MacIntosh喉镜，一项随机对照试验。

Heart, lung and vessels Pub Date : 2015-01-01

Thomas Hamp, Thomas Stumpner, Georg Grubhofer, Kurt Ruetzler, Rainer Thell, Helmut Hager

{"title":"Haemodynamic response at double lumen bronchial tube placement - Airtraq vs. MacIntosh laryngoscope, a randomised controlled trial.","authors":"Thomas Hamp, Thomas Stumpner, Georg Grubhofer, Kurt Ruetzler, Rainer Thell, Helmut Hager","doi":"","DOIUrl":"","url":null,"abstract":"Introduction: Tracheal intubation causes a haemodynamic response that might be harmful for patients. The Airtraq® laryngoscope has been shown to decrease the haemodynamic response to single-lumen tube intubation. We hypothesised that double-lumen bronchial tube placement with the Double-lumen Airtraq® laryngoscope would cause a reduced haemodynamic response and decreased catecholamine release compared with the MacIntosh laryngoscope.Methods: Forty adult patients were randomly assigned to the Airtraq® group or to the MacIntosh group. Intubation with either the Airtraq® or the MacIntosh laryngoscope was performed two minutes after standardised induction of anaesthesia. Arterial blood pressure, heart rate, catecholamine levels, bispectral index and duration of the intubation procedure were measured.Results: Mean (standard deviation [95% confidence interval]) systolic arterial blood pressure at laryngoscopy with the Airtraq® laryngoscope was 124 (34 [106 to 141]) mmHg and, with the MacIntosh laryngoscope, it was 110 (25 [99 to 122]) mmHg (p=1.0). Heart rate at laryngoscopy with the Airtraq® laryngoscope was 75 beats·min-1 (16 [67 to 83]) and, with the MacIntosh laryngoscope, it was 64 beats·min-1 (14 [58 to 71]) (p=0.71). Adrenaline levels post-intubation were 54.3 ng·l-1 (41.5) [29.3 to 79.4] in the Airtraq® group and 30.5 ng·l-1 (25.6) [15.1 to 46.0] in the MacIntosh group (p=0.016). The duration of intubation with the Airtraq® laryngoscope was 88 s (31 [72-104]) while, with the MacIntosh laryngoscope, the duration was 75 s (35 [59-92]) (p=0.26).Conclusions: The use of the Double-lumen Airtraq® laryngoscope provides no benefit regarding stress response compared to the MacIntosh laryngoscope.","PeriodicalId":89932,"journal":{"name":"Heart, lung and vessels","volume":"7 1","pages":"54-63"},"PeriodicalIF":0.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/58/40/hlv-07-054.PMC4381823.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33205767","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The attractiveness of network meta-analysis: a comprehensive systematic and narrative review. 网络元分析的吸引力:一个全面、系统和叙事的回顾。

Heart, lung and vessels Pub Date : 2015-01-01

Teresa Greco, Giuseppe Biondi-Zoccai, Omar Saleh, Laura Pasin, Luca Cabrini, Alberto Zangrillo, Giovanni Landoni

{"title":"The attractiveness of network meta-analysis: a comprehensive systematic and narrative review.","authors":"Teresa Greco, Giuseppe Biondi-Zoccai, Omar Saleh, Laura Pasin, Luca Cabrini, Alberto Zangrillo, Giovanni Landoni","doi":"","DOIUrl":"","url":null,"abstract":"Network meta-analysis provides a global estimate of comparative treatment effectiveness combining both direct and indirect evidence. In the past decade, the medical literature has witnessed a rapid increase in the possibility to combine evidence from different treatment comparisons. This opportunity is attractive for clinicians since their major concern is to identify the single best available treatment. In addition, despite the sudden increase of publications concerning network meta-analysis, only a limited number focus on methodological and statistical aspects, and many issues remain unclear. The aim of our work was to explore and emphasize the potential attractiveness of network meta-analyses. We performed a systematic and narrative review (last updated on April 15, 2014) in order to assess the scholarly diffusion of network meta-analyses. The following data were collected: author identification, year and journal of publication, PubMed index, number of treatments and studies included, characteristics of network configuration, nature of primary outcome, clinical indication, type of intervention investigated and medical area. Since 2003 there has been an exponential increase in the number of published network meta-analyses. Out of 340 articles included according to our selection criteria, encompassing 248 treatment networks, cardiovascular and pulmonary diseases were the most prevalent topics, with an average of 5 treatments being compared stemming from an average of 10 controlled trials. In conclusion, network meta-analyses are becoming increasingly attractive as they offer a comprehensive framework for decision-making. Whether they will also contribute to improvements in patient outlook remains to be proven. ","PeriodicalId":89932,"journal":{"name":"Heart, lung and vessels","volume":"7 2","pages":"133-42"},"PeriodicalIF":0.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/99/d0/hlv-07-133.PMC4476767.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33890017","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0