Blood Coagulation & Fibrinolysis最新文献

The impact of intrauterine growth on coagulation and factor XII function in preterm infants. 宫内生长对早产儿凝血及因子XII功能的影响。

IF 1.2 4区医学

Blood Coagulation & Fibrinolysis Pub Date : 2025-07-01 Epub Date: 2025-04-23 DOI: 10.1097/MBC.0000000000001361

Şükran Yildirim, Asuman Çoban, Ayşegül Ünüvar, Zeynep İnce

{"title":"The impact of intrauterine growth on coagulation and factor XII function in preterm infants.","authors":"Şükran Yildirim, Asuman Çoban, Ayşegül Ünüvar, Zeynep İnce","doi":"10.1097/MBC.0000000000001361","DOIUrl":"10.1097/MBC.0000000000001361","url":null,"abstract":"This study aims to examine the impact of intrauterine growth restriction (IUGR) on coagulation in preterm newborns and assess the administration of fresh frozen plasma. The study involved 30 preterm infants with IUGR and 32 preterm infants without it. Blood samples were collected within 4 h after birth to analyze blood gases, complete blood counts, renal and liver function tests, and coagulation factors. Differences between the two groups were assessed using SPSS version 15. IUGR significantly impacts coagulation in infants born before the 32nd week of gestation. Preterm infants with IUGR, specifically those born before 32 weeks, show notably lower levels of coagulation factors V, VII, XIII, and antithrombin III. Additionally, they have higher levels of factor VIII and longer thromboplastin times. The coagulation effects are less pronounced in infants born at or after 32 weeks of gestation than those born before 32 weeks. Moreover, factor XII levels are significantly higher in all preterm infants with IUGR. Preterm infants with intraventricular hemorrhage have prolonged prothrombin time and activated partial thromboplastin time, and their coagulation factor levels differ significantly. Conventional coagulation tests may not reliably predict bleeding tendencies in preterm infants with IUGR. However, these tests help assess the risk of intraventricular hemorrhage in preterm babies. Infants born before 32 weeks of gestation often have lower levels of coagulation factors because of growth restriction, which makes the administration of fresh frozen plasma a reasonable option in cases of bleeding for this population. Additionally, factor XII levels may provide insight into conditions related to hypoxia and inflammation, including IUGR.","PeriodicalId":8992,"journal":{"name":"Blood Coagulation & Fibrinolysis","volume":" ","pages":"164-170"},"PeriodicalIF":1.2,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143969493","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Platelet secretion defects and increased CD63 expression in Hermansky-Pudlak syndrome: a case report. Hermansky-Pudlak综合征中血小板分泌缺陷和CD63表达升高1例报告。

IF 1.2 4区医学

Blood Coagulation & Fibrinolysis Pub Date : 2025-07-01 Epub Date: 2025-05-02 DOI: 10.1097/MBC.0000000000001366

Massoumeh Shahbazi, Minoo Ahmadinejad

引用次数: 0

The factor V H1327R (rs1800595) polymorphism is associated with venous thromboembolic events: a case-control study in southern Iran. 因子H1327R （rs1800595）多态性与静脉血栓栓塞事件相关：伊朗南部的一项病例对照研究

IF 1.2 4区医学

Blood Coagulation & Fibrinolysis Pub Date : 2025-07-01 Epub Date: 2025-06-04 DOI: 10.1097/MBC.0000000000001336

Ahmadreza Fahandej Sadi, Jamileh Saberzadeh, Ardeshir Bahmanimehr, Mohammad Ali Takhshid, Hadis Soleimanzadeh, Parisa Tandel, Hamed Javanmardi, Nahid Nasiri

{"title":"The factor V H1327R (rs1800595) polymorphism is associated with venous thromboembolic events: a case-control study in southern Iran.","authors":"Ahmadreza Fahandej Sadi, Jamileh Saberzadeh, Ardeshir Bahmanimehr, Mohammad Ali Takhshid, Hadis Soleimanzadeh, Parisa Tandel, Hamed Javanmardi, Nahid Nasiri","doi":"10.1097/MBC.0000000000001336","DOIUrl":"10.1097/MBC.0000000000001336","url":null,"abstract":"Venous thromboembolism (VTE) is a complex condition influenced by genetic and acquired factors. While genetic variations in proteins like S, C, and antithrombin are known to play a role in VTE, some cases remain unexplained. This study aims to investigate other genetic variations, including Protein Z (rs3024731), FV (rs1800595), and FGA (rs6050), to understand their potential association with VTE risk. The study included 118 VTE patients and 118 healthy individuals with no history of thromboembolic disorders. Blood samples were collected from the patients for DNA extraction, and genotyping was carried out using the amplification refractory mutation system-PCR (ARMS-PCR) technique. The results were validated through DNA sequencing. Data analysis was done using SPSS 27 software. Analysis has revealed significant differences in the genotypic and allelic frequencies of the rs1800595 polymorphism between the control and case groups. It was found that individuals with the AG genotype had a 2.22 times higher likelihood of experiencing thrombophilia events [odds ratio (OR) = 2.229, P = 0.039, confidence interval (CI) = 95%], while the G allele increased the risk by 2.103 times (OR = 2.103, P = 0.047, CI = 95%). No significant correlation was observed between VTE and the rs3024731 and rs6050 polymorphisms. The rs1800595 polymorphism in the FV gene may be associated with an increased risk of thrombophilia in VTE patients.","PeriodicalId":8992,"journal":{"name":"Blood Coagulation & Fibrinolysis","volume":" ","pages":"137-141"},"PeriodicalIF":1.2,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144214800","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Recessively inherited protein C deficiency in two sisters: intracerebral hemorrhage and coagulopathy complications. 隐性遗传蛋白C缺乏症姐妹二例：脑出血和凝血病并发症。

IF 1.2 4区医学

Blood Coagulation & Fibrinolysis Pub Date : 2025-07-01 Epub Date: 2025-04-23 DOI: 10.1097/MBC.0000000000001365

Goran G B Banjac, Boban B B Banjac, Lidija L B Banjac

{"title":"Recessively inherited protein C deficiency in two sisters: intracerebral hemorrhage and coagulopathy complications.","authors":"Goran G B Banjac, Boban B B Banjac, Lidija L B Banjac","doi":"10.1097/MBC.0000000000001365","DOIUrl":"10.1097/MBC.0000000000001365","url":null,"abstract":"Background: Protein C (PROC) deficiency is a rare hematological disorder caused by mutations in the PROC gene, leading to severe coagulopathy in homozygous cases. This report highlights the hematological challenges in managing homozygous protein C deficiency, particularly its association with intracerebral hemorrhage and thrombosis.Case report: We describe two sisters with a homozygous PROC gene mutation (c.797A>G, p.Tyr266Cys), presenting with protein C activity <10%. The older sister (born 2020) developed neonatal intracerebral hemorrhage, followed by recurrent hemorrhage and deep vein thrombosis by 2025, managed with heparin, warfarin, and rivaroxaban. The younger sister (born 2022) also experienced neonatal hemorrhage and required anticoagulant therapy with heparin and warfarin. Both developed neurological complications, including epilepsy.Conclusion: Homozygous protein C deficiency can lead to severe neonatal coagulopathy, necessitating early diagnosis and aggressive anticoagulant therapy. This case underscores the importance of multidisciplinary management and genetic screening in affected families.","PeriodicalId":8992,"journal":{"name":"Blood Coagulation & Fibrinolysis","volume":" ","pages":"212-214"},"PeriodicalIF":1.2,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143963939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A novel pathogenic variant in the fibrinogen gamma chain gene p.Glu275Lys causes congenital hypofibrinogenemia. 纤维蛋白原γ链基因p.g ul275lys的一种新的致病变异导致先天性低纤维蛋白原血症。

IF 1.2 4区医学

Blood Coagulation & Fibrinolysis Pub Date : 2025-07-01 Epub Date: 2025-04-25 DOI: 10.1097/MBC.0000000000001362

Miroslava Drotarova, Rosanna Asselta, Sonia Caccia, Ingrid Skornova, Jana Zolkova, Zuzana Kolkova, Dusan Loderer, Vladimir Podusel, Jan Stasko, Tomas Simurda

{"title":"A novel pathogenic variant in the fibrinogen gamma chain gene p.Glu275Lys causes congenital hypofibrinogenemia.","authors":"Miroslava Drotarova, Rosanna Asselta, Sonia Caccia, Ingrid Skornova, Jana Zolkova, Zuzana Kolkova, Dusan Loderer, Vladimir Podusel, Jan Stasko, Tomas Simurda","doi":"10.1097/MBC.0000000000001362","DOIUrl":"10.1097/MBC.0000000000001362","url":null,"abstract":"Congenital hypofibrinogenemia presents not only with bleeding, but also paradoxically with thrombosis. This heterogeneity of clinical phenotype complicates both diagnosis and management. The thrombotic phenotype is thought to arise from alterations in fibrin structure and stability, leading to abnormal clot formation and an increased risk of thrombosis. Coagulation assays, gene analysis, and protein modeling were utilized to elucidate the pathogenic variant. We highlight the pathophysiology of the novel missense variant in the FGG gene (c.823G/A, p.Glu275Lys ), which causes mild hypofibrinogenemia and clinically manifests as an ischemic stroke. Protein modeling displays that the amino-acid substitution of glutamine with lysine at position 275 in mentioned missense variant causes local changes in the fibrinogen structure. The structural changes are mainly minor surface alterations and changes in physicochemical properties, which could potentially affect the recruitment of other proteins or lead to abnormal fibrin polymerization. This study provides novel insights into the pathophysiological mechanism, emphasizing the importance of molecular and structural analyses in understanding and managing atypical presentations of fibrinogen disorders.","PeriodicalId":8992,"journal":{"name":"Blood Coagulation & Fibrinolysis","volume":" ","pages":"215-220"},"PeriodicalIF":1.2,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12240145/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143967373","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The association between the polymorphism of FXI c.539A>G and venous thromboembolism in the population of central China. 中国中部人群FXI c.539A>G多态性与静脉血栓栓塞的关系

IF 1.2 4区医学

Blood Coagulation & Fibrinolysis Pub Date : 2025-07-01 Epub Date: 2025-05-14 DOI: 10.1097/MBC.0000000000001368

Na Liu, Yanyan You, Jingdi Liu, Liang Tang, Wei Zeng

{"title":"The association between the polymorphism of FXI c.539A>G and venous thromboembolism in the population of central China.","authors":"Na Liu, Yanyan You, Jingdi Liu, Liang Tang, Wei Zeng","doi":"10.1097/MBC.0000000000001368","DOIUrl":"10.1097/MBC.0000000000001368","url":null,"abstract":"Background: Venous thromboembolism (VTE) has a genetic component that can differ significantly among populations. The genetic landscape of VTE in China, where incidence is rising, may harbor unique susceptibilities. This study aimed to examine the factor XI (FXI) c.539A>G polymorphism's role in VTE risk and its correlation with FXI levels among central Chinese VTE patients.Methods: We included 1748 VTE patients and 1819 matched controls, and extracted genomic DNA. Direct sequencing identified the FXI c.539A>G mutation in 50 patient samples. FXI antigen levels were quantified using ELISA, and bioinformatics evaluated the mutation's biological significance.Results: The FXI c.539A>G mutation occurred in three heterozygous individuals. It was more prevalent in VTE patients (2.26%) than controls (1.37%), with a significant odds ratio of 1.66 (95% CI: 1.16-2.37, P = 5.03 × 10 -3 ). Patients with the mutation showed increased FXI antigen levels (16.76 ± 5.78 ng/ml) versus the wild-type (10.77 ± 4.98 ng/ml, P = 1.20 × 10 -3 ), without affecting FXI activity ( P = 0.57).Conclusion: The FXI c.539A>G variant is associated with VTE in central China, marked by elevated FXI antigen levels but not altered activity. This finding suggests that FXI c.539A>G may serve as a genetic marker for VTE risk. Further studies are needed to explore its role in early screening of VTE and gene-environment interactions.","PeriodicalId":8992,"journal":{"name":"Blood Coagulation & Fibrinolysis","volume":" ","pages":"171-179"},"PeriodicalIF":1.2,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143962366","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hemostatic effects of combined Thymus vulgaris and Medicago sativa extracts: in-silico and in-vivo study. 寻常胸腺和紫花苜蓿联合提取物的止血作用：体外和体内研究。

IF 1.2 4区医学

Blood Coagulation & Fibrinolysis Pub Date : 2025-07-01 Epub Date: 2025-05-02 DOI: 10.1097/MBC.0000000000001356

Zahra Sadat Mashkani, Jafar Vatandoost, Toktam Hajjar, Mitra Kheirabadi

{"title":"Hemostatic effects of combined Thymus vulgaris and Medicago sativa extracts: in-silico and in-vivo study.","authors":"Zahra Sadat Mashkani, Jafar Vatandoost, Toktam Hajjar, Mitra Kheirabadi","doi":"10.1097/MBC.0000000000001356","DOIUrl":"10.1097/MBC.0000000000001356","url":null,"abstract":"Objective: This study aims to evaluate the hemostatic effects of combined extracts from Thymus vulgaris and Medicago sativa in an animal model, focusing on their impact on coagulation indices. We hypothesize that the combined extracts will modulate the extrinsic and intrinsic coagulation pathways, improving hemostasis.Methods: Thirty-two male NMRI mice were randomly assigned to four groups ( n = 8): negative control (distilled water), 300 mg/kg/day M. sativa (MS300), 100 mg/kg/day T. vulgaris extract (TV100), and combined extracts (TV100 + MS300). After 14 days of treatment, blood samples were collected to measure prothrombin time (PT) and activated partial thromboplastin time (aPTT). Chemical analysis identified active compounds, and molecular docking studies were performed to assess their interaction with coagulation factor VIIa (FVIIa).Results: The treated groups showed significant changes in coagulation indices compared to the control. PT was significantly decreased ( P < 0.05), and aPTT was significantly increased ( P < 0.05) in the M. sativa , T. vulgaris , and combined extract groups. The combined extract showed the most significant effect. Computational analyses revealed that compounds like Scandenon and Vitamin E interacted with FVIIa, suggesting their role in modulating the extrinsic coagulation pathway. These compounds showed strong binding affinity to FVIIa.Conclusion: Combined extracts of T. vulgaris and M. sativa significantly influence coagulation, especially the extrinsic pathway. The presence of aromatic, hydroxyl, alcoholic, and phenolic groups in these compounds likely contributes to their interaction with coagulation factors. These findings support the potential development of plant-based hemostatic agents for clinical use.","PeriodicalId":8992,"journal":{"name":"Blood Coagulation & Fibrinolysis","volume":" ","pages":"156-163"},"PeriodicalIF":1.2,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143974847","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Haploidentical stem cell transplantation in DOCK8 deficiency: a case report of successful outcomes. DOCK8缺乏症患者单倍体干细胞移植：一例成功结果报告。

IF 1.2 4区医学

Blood Coagulation & Fibrinolysis Pub Date : 2025-07-01 Epub Date: 2025-05-12 DOI: 10.1097/MBC.0000000000001351

Sondus Alsharidah, Ahmed Elhussein, Waleed Al-Herz

引用次数: 0

Enhancing prediction of thrombosis associated with breast cancer using prechemotherapy hematologic and coagulation characteristics. 利用化疗前血液学和凝血学特征加强对乳腺癌血栓形成的预测。

IF 1.2 4区医学

Blood Coagulation & Fibrinolysis Pub Date : 2025-07-01 Epub Date: 2025-05-05 DOI: 10.1097/MBC.0000000000001367

Regan Bucciol, Hannah Parente, Yousra Tera, E Claire Bunker, Aditi Kini, Brooke E Wilson, Mihaela Mates, Maha Othman

{"title":"Enhancing prediction of thrombosis associated with breast cancer using prechemotherapy hematologic and coagulation characteristics.","authors":"Regan Bucciol, Hannah Parente, Yousra Tera, E Claire Bunker, Aditi Kini, Brooke E Wilson, Mihaela Mates, Maha Othman","doi":"10.1097/MBC.0000000000001367","DOIUrl":"10.1097/MBC.0000000000001367","url":null,"abstract":"Introduction: The applicability of venous thromboembolism (VTE) risk assessment models (RAMs), to breast cancer (BC) populations remains unclear. We aimed to compare the efficacy of current RAMs and examine the potential of additional hematologic parameters and thromboelastography (TEG); a point of care test, in improving VTE prediction in breast cancer (BC) patients.Methods: In this pilot study, female BC patients were recruited before chemotherapy and followed for 6-12 months for VTE. VTE risk was assessed using Khorana score, Vienna CATS, PROTECHT, COMPASS-CAT, New Vienna CATSCORE, MDACC CAT, and hypercoagulability status. TEG and hematologic parameters were analyzed, and a modified RAM was developed.Results: Among 47 patients, 5 (10.6%) developed VTE. PROTECHT was the strongest predictor [area under the curve (AUC) = 0.844], followed by Vienna CATS (AUC = 0.781). Adding immature granulocytes and red blood cell count to PROTECHT optimized prediction (AUC = 0.856).Conclusion: Incorporating hematologic parameters into PROTECHT may improve VTE risk prediction in BC patients, warranting further evaluation in larger studies.","PeriodicalId":8992,"journal":{"name":"Blood Coagulation & Fibrinolysis","volume":" ","pages":"221-227"},"PeriodicalIF":1.2,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143962495","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Serum levels of inflammatory markers, sP-selectin, IL-1β, IL-6, and hsCRP are positively correlated with tissue factor transcript level of peripheral blood mononuclear cells in stroke. 脑卒中患者血清炎症标志物、sp -选择素、IL-1β、IL-6、hsCRP水平与外周血单个核细胞组织因子转录物水平呈正相关。

IF 1.2 4区医学

Blood Coagulation & Fibrinolysis Pub Date : 2025-07-01 Epub Date: 2025-05-21 DOI: 10.1097/MBC.0000000000001370

Rasoul Ebrahimi, Tahereh Kalantari, Fatemeh Sarkari, Mahdieh Nematzadeh, Mohammad Jafar Sharifi, Kiana Mohammadian, Parisa Alipour, Fatemeh Safari, Sepide Namdari, Afshin Borhani-Haghighi

{"title":"Serum levels of inflammatory markers, sP-selectin, IL-1β, IL-6, and hsCRP are positively correlated with tissue factor transcript level of peripheral blood mononuclear cells in stroke.","authors":"Rasoul Ebrahimi, Tahereh Kalantari, Fatemeh Sarkari, Mahdieh Nematzadeh, Mohammad Jafar Sharifi, Kiana Mohammadian, Parisa Alipour, Fatemeh Safari, Sepide Namdari, Afshin Borhani-Haghighi","doi":"10.1097/MBC.0000000000001370","DOIUrl":"10.1097/MBC.0000000000001370","url":null,"abstract":"Objectives: Stroke is an injury occurring due to a sudden interruption of blood supply to the brain. It is the leading cause of disability worldwide and the second most prevalent cause of mortality. The objective of this study is whether momentous inflammatory and coagulation markers may have a correlation with each other in stroke patients.Material and methods: Sixty stroke patients and twenty sex-age matched normal controls were sampled. Interleukin (IL)-6, IL-1β, sP-selectin, and high-sensitivity C-reactive protein (hsCRP), key inflammatory markers, were selected and measured by ELISA, and tissue factor gene expression level was evaluated by real-time PCR in peripheral blood mononuclear cells.Results: The serum levels of sP-selectin, IL-1β, IL-6, and hsCRP increased significantly in patients ( P -value < 0.05). In the patient group, a significant correlation was observed between these inflammatory markers and coagulant tissue factor gene expression in peripheral blood mononuclear cells ( P -values < 0.05), while it was not significant in the control group.Conclusion: This study proposed that the main inflammatory markers in connection with tissue factor may play a role in the occurrence of thrombosis in stroke patients. Therefore, targeting and inhibiting the key inflammatory factors along with existing anticoagulants may greatly reduce the complications associated with stroke.","PeriodicalId":8992,"journal":{"name":"Blood Coagulation & Fibrinolysis","volume":" ","pages":"180-190"},"PeriodicalIF":1.2,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144109685","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0