Clinical medicine insights. Ear, nose and throat最新文献_第2页

Depression, Hematologic Parameters, and Blood Levels of Vitamin B₁₂ in Patients With Laryngopharyngeal Reflux Under Use of Proton Pump Inhibitors. 使用质子泵抑制剂后咽喉反流患者的抑郁、血液学参数和血液维生素B12水平

Clinical medicine insights. Ear, nose and throat Pub Date : 2019-02-13 eCollection Date: 2019-01-01 DOI: 10.1177/1179550619828683

Rebecca Heidrich Thoen Ribeiro, Fernando Ambros Ribeiro, Romeu Paulo Martins Silva, Miguel Júnior Sordi Bortolini, Mario da Silva Garrote-Filho, Nilson Penha-Silva

{"title":"Depression, Hematologic Parameters, and Blood Levels of Vitamin B12 in Patients With Laryngopharyngeal Reflux Under Use of Proton Pump Inhibitors.","authors":"Rebecca Heidrich Thoen Ribeiro, Fernando Ambros Ribeiro, Romeu Paulo Martins Silva, Miguel Júnior Sordi Bortolini, Mario da Silva Garrote-Filho, Nilson Penha-Silva","doi":"10.1177/1179550619828683","DOIUrl":"https://doi.org/10.1177/1179550619828683","url":null,"abstract":"Objective: The objective of this study was to evaluate and correlate hematologic indices, vitamin B12 levels, and depression in patients with suspected laryngopharyngeal reflux (LPR) treated with proton pump inhibitor (PPI).Methods: This was a prospective study with a population (n = 23) consisted of patients with suspected LPR and treated with 2 daily doses of Omeprazole 40 mg (80 mg or full dose). The study volunteers performed a complete blood count and vitamin B12 dosage before and after 3 and 6 months of treatment, as well as depression screening using the Center of Epidemiologic Studies-Depression (CES-D) questionnaire before and after 6 months of treatment. Scores greater than 16 were considered as suggestive of depression.Results: The mean score on the CES-D scale of study participants at baseline significantly decreased after 6 months of treatment. A significant decrease was observed in the red blood cells count (RBC) after 6 months in relation to 3 months. Significant increases in mean corpuscular volume (MCV) and mean corpuscular hemoglobin (MCH) were observed from 3 months to 6 months in this study. Vitamin B12 levels increased significantly between baseline and after 6 months of treatment.Conclusion: Decreased scores on the CES-D scale were associated with increased MCV values, with no association with vitamin B12 levels. However, vitamin B12 levels also increased significantly after 6 months of treatment with PPI.","PeriodicalId":89906,"journal":{"name":"Clinical medicine insights. Ear, nose and throat","volume":"12 ","pages":"1179550619828683"},"PeriodicalIF":0.0,"publicationDate":"2019-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/1179550619828683","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36988301","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Maxillary Pneumosinus Dilatans Presenting With Proptosis: A Case Report and Review of the Literature. 上颌肺窦扩张并突出:1例报告及文献复习。

Clinical medicine insights. Ear, nose and throat Pub Date : 2019-02-03 eCollection Date: 2019-01-01 DOI: 10.1177/1179550618825149

Abdullah A Alatar, Yazeed A AlSuliman, Maha S Alrajhi, Fahad S Alfawwaz

{"title":"Maxillary Pneumosinus Dilatans Presenting With Proptosis: A Case Report and Review of the Literature.","authors":"Abdullah A Alatar, Yazeed A AlSuliman, Maha S Alrajhi, Fahad S Alfawwaz","doi":"10.1177/1179550618825149","DOIUrl":"https://doi.org/10.1177/1179550618825149","url":null,"abstract":"Background: Pneumosinus dilatans (PSD) is a rare pathological paranasal sinus expansion. This condition is usually symptomatic or cosmetically apparent, requiring surgical intervention. Multiple hypotheses have been postulated as to the cause of this condition; however, the precise cause and pathogenesis remain obscure.Case report and methods: An 11-year-old boy presented with right eye bulging and was subsequently found to have PSD of the maxillary sinus. A search was conducted of the PubMed electronic database, using the keywords \"pneumosinus dilatans,\" \"pneum(oco)ele,\" \"pneum(oc)ele,\" \"pneum(atoco)ele,\" and \"air cyst.\" Articles published in English were reviewed.Results: The literature review identified 29 cases of PSD involving the maxillary sinus. The mean age of presentation was 25 years old. Only the right maxillary sinus was affected in 16 cases, followed by the bilateral sinuses in 7 cases and the left sinus in 6 cases. In 5 cases, all paranasal sinuses, along with the maxillary sinus, were expanded. The most common presenting symptom was facial swelling, which was found in 55% of the cases, followed by proptosis and pain. Computed tomography is the gold standard radiological method for diagnosing PSD.Conclusions: Pneumosinus dilatans is a rare condition that is usually symptomatic and requires surgical intervention. The etiology of the disease is attributed to multiple hypotheses, but more studies are needed to explore this condition further.","PeriodicalId":89906,"journal":{"name":"Clinical medicine insights. Ear, nose and throat","volume":"12 ","pages":"1179550618825149"},"PeriodicalIF":0.0,"publicationDate":"2019-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/1179550618825149","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36975575","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 8

Computer-Aided Facial Reconstruction of "Mary-Magdalene" Relics Following Hair and Skull Analyses. 基于头发和头骨分析的“抹大拉玛利亚”遗迹的计算机辅助面部重建。

Clinical medicine insights. Ear, nose and throat Pub Date : 2019-01-14 eCollection Date: 2019-01-01 DOI: 10.1177/1179550618821933

Philippe Charlier, Philippe Froesch, Nadia Benmoussa, Stéphane Morin, Anaïs Augias, Yves Ubelmann, Raphaël Weil, Soizic Morin, François Straub, Saudamini Deo

引用次数: 6

Mucoactive Agents in the Therapy of Upper Respiratory Airways Infections: Fair to Describe Them Just as Mucoactive? 黏液活性药物治疗上呼吸道感染:仅仅用黏液活性来描述它们公平吗?

Clinical medicine insights. Ear, nose and throat Pub Date : 2019-01-09 eCollection Date: 2019-01-01 DOI: 10.1177/1179550618821930

Francesco Scaglione, Orlando Petrini

{"title":"Mucoactive Agents in the Therapy of Upper Respiratory Airways Infections: Fair to Describe Them Just as Mucoactive?","authors":"Francesco Scaglione, Orlando Petrini","doi":"10.1177/1179550618821930","DOIUrl":"https://doi.org/10.1177/1179550618821930","url":null,"abstract":"Background: Upper and lower respiratory tract infections are common conditions for which medical advice is sought, and their management relies on the use of prescription and over-the-counter (OTC) medicines. Ambroxol, bromhexine, carbocysteine, erdosteine, N-acetyl cysteine (NAC), and sobrerol are mucoactive agents for which clinical trials have been conducted, have been awarded well-established status by regulatory authorities, and are available as OTC or prescription products.Objective: To briefly review the evidence-based efficacy and safety of these substances in the therapy of upper respiratory airways infections.Methods: We conducted searches in MEDLINE and other databases for clinical trials and reviews done on the efficacy and safety of ambroxol, bromhexine, carbocysteine, erdosteine, NAC, and sobrerol.Results: Clinical trials have shown that these mucolytics have an important place in the relief of cough symptoms by easing the elimination of mucus. All drugs have shown comparable efficacy in the symptomatic treatment of productive cough, with some shared characteristics and some specific features.Conclusions and relevance: All mucolytics reviewed have a good safety profile, although some precautions should be taken when using ambroxol and bromhexine, and the use of NAC and carbocysteine should be monitored in special patient groups. Overall, however, the available evidence from randomised, controlled, and observational trials, as well as pragmatic, real-life experience, suggests that these products are useful in the therapy of upper respiratory airways infections, including bronchitis, sinusitis, and rhinosinusitis.","PeriodicalId":89906,"journal":{"name":"Clinical medicine insights. Ear, nose and throat","volume":"12 ","pages":"1179550618821930"},"PeriodicalIF":0.0,"publicationDate":"2019-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/1179550618821930","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36877457","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 27

The Relationship Between the Width of the Frontal Recess and the Frontal Recess Cells in Japanese Patients 日本患者额隐窝宽度与额隐窝细胞的关系

Clinical medicine insights. Ear, nose and throat Pub Date : 2019-01-01 DOI: 10.1177/1179550619884946

S. Makihara, S. Kariya, M. Okano, T. Naito, K. Uraguchi, Junya Matsumoto, Yohei Noda, K. Nishizaki

{"title":"The Relationship Between the Width of the Frontal Recess and the Frontal Recess Cells in Japanese Patients","authors":"S. Makihara, S. Kariya, M. Okano, T. Naito, K. Uraguchi, Junya Matsumoto, Yohei Noda, K. Nishizaki","doi":"10.1177/1179550619884946","DOIUrl":"https://doi.org/10.1177/1179550619884946","url":null,"abstract":"Objective: The agger nasi cell (ANC) is an easily identifiable landmark when approaching the frontal sinus. The success of endoscopic frontal sinus surgery may be influenced by the width of the frontal recess (FR). The aim of this study is to examine the relationship between the FR width and the ANC size in Japanese patients. In addition, the effect of various frontal recess cells (FRCs) on the development of frontal sinusitis has been examined. Materials and methods: Multiplanar computed tomography (CT) scans of the nasal cavities and paranasal sinuses in 95 patients (190 sides) before endoscopic sinus surgery were reviewed. The presence of FRCs, the thickness of the frontal beak (FB), the ANC size, and the anterior-to-posterior (A-P) length of the frontal isthmus (FI) and FR were evaluated in patients with and without frontal sinusitis. Results: The prevalence of the ANC, frontal cell types 1, 2, 3, and 4, frontal bullar cell (FBC), suprabullar cell, supraorbital ethmoid cell, and interfrontal sinus septal cell was 85.3%, 11.6%, 0%, 7.9%, 0%, 25.3%, 45.8%, 16.8%, and 15.3%, respectively. The ANC volume showed a significant positive correlation with the A-P length of the FI and FR. The incidence of frontal sinusitis in the patients with FBCs was significantly higher than that without FBCs. Conclusion: A large ANC offers a greater potential to facilitating the approach to the frontal sinus because of the extensiveness of the FR in Japanese patients. The presence of FBCs may be related to a higher incidence of frontal sinusitis.","PeriodicalId":89906,"journal":{"name":"Clinical medicine insights. Ear, nose and throat","volume":"37 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73004366","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Reviewers for Clinical Medicine Insights: Ear, Nose and Throat: 2018 临床医学见解:耳，鼻和喉:2018

Clinical medicine insights. Ear, nose and throat Pub Date : 2019-01-01 DOI: 10.1177/1179550619829344

引用次数: 0

Epstein-Barr Virus–Associated With Lymphoepithelial Carcinoma: A Rare Tumor of the Larynx eb病毒与淋巴上皮癌相关:一种罕见的喉部肿瘤

Clinical medicine insights. Ear, nose and throat Pub Date : 2019-01-01 DOI: 10.1177/1179550619865551

Francisco Monteiro, H. Baldaia, Leandro Ribeiro, M. Sousa, P. Oliveira, E. Ferreira, M. Almeida, A. Condé

{"title":"Epstein-Barr Virus–Associated With Lymphoepithelial Carcinoma: A Rare Tumor of the Larynx","authors":"Francisco Monteiro, H. Baldaia, Leandro Ribeiro, M. Sousa, P. Oliveira, E. Ferreira, M. Almeida, A. Condé","doi":"10.1177/1179550619865551","DOIUrl":"https://doi.org/10.1177/1179550619865551","url":null,"abstract":"Lymphoepithelial carcinoma of the larynx is a rare tumor, as this histological entity is mostly diagnosed in nasopharynx. However, it may be present in other non-nasopharyngeal sites and it is extremely rare in the larynx. The authors present a case of a 59-year-old man who presented to the Otorhinolaryngology–Head and Neck Surgery Department complaining of a long-standing dysphonia, odynophagia, and dysphagia. The clinical examination revealed a laryngeal tumor involving the right epiglottis, right aryepiglottic fold, and ipsilateral false vocal fold. It presented with ispilateral neck lymph node extension. Multiple biopsies of the laryngeal lesion were performed under local anesthesia and the histological examination showed a poorly differentiated squamous cell carcinoma. After discussing the case in a multidisciplinary tumor board, a total laryngectomy with a bilateral neck dissection was performed and the histological specimen showed a lymphoepithelial carcinoma. Although immunostaining with LMP-1 antibody was negative, in situ hybridization for Epstein-Barr virus was positive. He underwent adjuvant chemoradiation. He is now at 9-months follow-up period, with no evidence of disease. Lymphoepithelial carcinoma of the larynx is an extremely rare disease, with an aggressive pattern. Epstein-Barr virus–associated lymphoepithelial carcinoma has been exceptionally reported. A correct diagnosis and close collaboration with pathologist is crucial to achieve the best treatment strategy. We present this case to discuss the clinical and histology findings and the different therapeutic aspects of this uncommon histological subtype carcinoma.","PeriodicalId":89906,"journal":{"name":"Clinical medicine insights. Ear, nose and throat","volume":"8 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78695321","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 9

The Correlation Between Preoperative Findings of High-Resolution Computed Tomography (HRCT) and Intraoperative Findings of Chronic Otitis Media (COM) 慢性中耳炎术前高分辨率计算机断层扫描(HRCT)与术中表现的相关性

Clinical medicine insights. Ear, nose and throat Pub Date : 2019-01-01 DOI: 10.1177/1179550619870471

Mariam Aljehani, Rayan Alhussini

{"title":"The Correlation Between Preoperative Findings of High-Resolution Computed Tomography (HRCT) and Intraoperative Findings of Chronic Otitis Media (COM)","authors":"Mariam Aljehani, Rayan Alhussini","doi":"10.1177/1179550619870471","DOIUrl":"https://doi.org/10.1177/1179550619870471","url":null,"abstract":"Objectives: The aim of this study was to investigate the correlation between the preoperative findings of high-resolution computed tomography (HRCT) of temporal bone in chronic otitis media (COM) and the intraoperative findings. Methods: This retrospective study was conducted in the ORL-HNS Unit at Ohud Hospital, Medina, Saudi Arabia, during the period from January to September 2018. We included all patients with COM, and an informed consent was obtained from all participants. The HRCT images were studied in comparison with the intraoperative findings. The parameters of comparison were tympanic membrane, middle ear structures, and the status of cholesteatoma. Results: A total of 39 patients were included in the analysis: 14 male and 25 female patients. The age range was 9 to 50 years. As a result of the comparison between HRCT findings and intraoperative observations, we found that incus erosion through computed tomography (CT) was the same as during surgical observation in 12 cases (30.8%). Malleus appeared eroded on CT in 1 case (2.6%); however, 5 cases were seen with that observation during operation (12.8%). Cholesteatoma was similarly seen in the CT scan and during surgery with a significant relation between intraoperative cholesteatoma extending and HRCT findings of the disease (95% confidence level, P-value = 0.001). The sensitivity, specificity, positive predictive value, and negative predictive value were 100% for detecting sigmoid plate erosion, dura exposure, incus erosion, stapes erosion, and malleus-incus joint discontinuity through preoperative CT. Conclusions: Intraoperative findings and HRCT have shown better results with good correlation of diagnostic value regarding the comparisons between recorded observations, especially in detecting sigmoidal plate erosion, dural exposure, incus and stapes erosion, and malleus-incus joint discontinuity. Preoperative CT scan is beneficial and contributory in the decision of indicating surgery to patients.","PeriodicalId":89906,"journal":{"name":"Clinical medicine insights. Ear, nose and throat","volume":"6 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81766781","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 9

Innovative Use of Google Cardboard in Clinical Examination of Patients of Vertigo 谷歌纸板在眩晕患者临床检查中的创新应用

Clinical medicine insights. Ear, nose and throat Pub Date : 2019-01-01 DOI: 10.1177/1179550619882012

A. Yeolekar, K. Shinde, H. Qadri

{"title":"Innovative Use of Google Cardboard in Clinical Examination of Patients of Vertigo","authors":"A. Yeolekar, K. Shinde, H. Qadri","doi":"10.1177/1179550619882012","DOIUrl":"https://doi.org/10.1177/1179550619882012","url":null,"abstract":"Background: Vertigo is 1 of the most prominent and frequent neurological symptom. It is estimated that about 30% of all people need medical care once in their life due to this index symptom. The neurological expertise required is usually scarce in underprivileged areas. One has to look for spontaneous nystagmus, and perform Dix–Hallpike maneuver and Head Impulse test specifically to differentiate central from peripheral vertigo. The nystagmus, that is spontaneous, involuntary to-and-fro movement of the eyeball which aids in the diagnosis, can be better elicited by Frenzel glasses, Munich glasses. These devices consist of the combination of magnifying glasses and a lighting system to detect eye movements better than routine examination. Objective: To test usefulness of modified Google cardboard as Frenzel glasses in poor resource setting. Study design: A modified Google cardboard was used in 52 consecutive cases of vertigo and compared with examination with naked eye. The device consists of 2 magnifying lenses, 1 for each eye with power of +24 dioptres. Observation: The tool was found to be better for identifying spontaneous nystagmus, in Dix–Hallpike maneuver and during head impulse test as compared with the naked eye owing to the property of magnification and inhibition of fixation. Being a cheaper alternative and handy, it could be carried by every doctor in any setting.","PeriodicalId":89906,"journal":{"name":"Clinical medicine insights. Ear, nose and throat","volume":"19 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78706117","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Management of an Unusual Intranasal Foreign Body Abutting the Cribriform Plate: A Case Report and Review of Literature 不寻常鼻内异物靠近筛板的处理:1例报告及文献复习

Clinical medicine insights. Ear, nose and throat Pub Date : 2019-01-01 DOI: 10.1177/1179550619858606

M. Gray, C. Kappauf, S. Govindaraj

引用次数: 2