Breast cancer online : BCO最新文献

{"title":"Successes and failures: an overview of lessons learnt in the creation of targeted therapy strategies for breast cancer","authors":"S. Johnston","doi":"10.1017/S1470903107006086","DOIUrl":"https://doi.org/10.1017/S1470903107006086","url":null,"abstract":"Therapies that target cancers according to their characteristics (estrogen receptor 1 ve or –ve, for example) have been a major development in treating cancers successfully and have led to an increase in survival rates. These successes have led to increased research into even more tightly focused therapies. But targeted therapies do not work for everyone, raising issues of (1) identifying patients and (2) developing therapies that reflect our increasing understanding of the complex and differentiated traits of tumors. New targeted therapies such as small molecule signal transduction inhibitors and monoclonal antibodies are being developed to address tumors at all stages of the cell proliferation cycle and it is hoped that they may eventually transform cancer into a fully treatable condition.","PeriodicalId":89901,"journal":{"name":"Breast cancer online : BCO","volume":"10 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2007-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1017/S1470903107006086","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"56921163","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Basic science (January 2007)","authors":"R. Sutherland, J. Scorer","doi":"10.1017/S1470903107006372","DOIUrl":"https://doi.org/10.1017/S1470903107006372","url":null,"abstract":"1. Belous AR, Hachey DL, Dawling S, Roodi N, Parl FF. Cytochrome P4501B1-mediated estrogen metabolism results in estrogen-deoxyribonucleoside adduct formation. Cancer Res 2007; 67: 812–817. 2. Bhati R, Gokmen-Polar Y, Sledge GW, Fan C, Nakshatri H, Ketelsen D, Borchers CH, Dial MJ, Patterson C, Klauber-DeMore N. 2-methoxyestradiol inhibits the anaphase-promoting complex and protein translation in human breast cancer cells. Cancer Res 2007; 67: 702–708. 3. Bosco EE, Wang Y, Xu H, Zilfou JT, Knudsen KE, Aronow BJ, Lowe SW, Knudsen ES. The retinoblastoma tumor suppressor modifies the therapeutic response of breast cancer. J Clin Invest 2007; 117: 218–228. 4. Buchholz S, Schally AV, Engel JB, Hohla F, Heinrich E, Koester F, Varga JL, Halmos G. Potentiation of mammary cancer inhibition by combination of antagonists of growth hormonereleasing hormone with docetaxel. Proc Natl Acad Sci USA 2007; 104: 1943–1946. 5. Chang MY, Boulden J, Sutanto-Ward E, Duhadaway JB, Soler AP, Muller AJ, Prendergast GC. Bin1 ablation in mammary gland delays tissue remodeling and drives cancer progression. Cancer Res 2007; 67: 100–107. 6. Climent J, Dimitrow P, Fridlyand J, Palacios J, Siebert R, Albertson DG, Gray JW, Pinkel D, Lluch A, Martinez-Climent JA. Deletion of chromosome 11q predicts response to anthracyclinebased chemotherapy in early breast cancer. Cancer Res 2007; 67: 818–826. 7. Donato LJ, Suh JH, Noy N. Suppression of mammary carcinoma cell growth by retinoic acid: the cell cycle control gene Btg2 is a direct target for retinoic acid receptor signaling. Cancer Res 2007; 67: 609–615. 8. Dong M, How T, Kirkbride KC, Gordon KJ, Lee JD, Hempel N, Kelly P, Moeller BJ, Marks JR, Blobe GC. The type III TGF-beta receptor suppresses breast cancer progression. J Clin Invest 2007; 117: 206–217. 9. Esslimani-Sahla M, Thezenas S, SimonyLafontaine J, Kramar A, Lavaill R, Chalbos D, Rochefort H. Increased expression of fatty acid synthase and progesterone receptor in early steps of human mammary carcinogenesis. Int J Cancer 2007; 120: 224–229. 10. Faivre EJ, Lange CA. Progesterone receptors upregulate Wnt-1 to induce epidermal growth factor receptor transactivation and c-Src-dependent sustained activation of Erk1/2 mitogen-activated protein kinase in breast cancer cells. Mol Cell Biol 2007; 27: 466–480. 11. Gestl SA, Leonard TL, Biddle JL, Debies MT, Gunther EJ. Dormant Wnt-initiated mammary cancer can participate in reconstituting functional mammary glands. Mol Cell Biol 2007; 27: 195–207. 12. Iliopoulos D, Fabbri M, Druck T, Qin HYR, Han SY, Huebner K. Inhibition of breast cancer cell growth in vitro and in vivo: effect of restoration of Wwox expression. Clin Cancer Res 2007; 13: 268–274. 13. Julien SG, Dube N, Read M, Penney J, Paquet M, Han Y, Kennedy BP, Muller WJ, Tremblay ML. Protein tyrosine phosphatase 1B deficiency or inhibition delays ErbB2-induced mammary tumorigenesis and protects from lung metastasis. Nat Genet 2007; 39: 338–346. 14. Korah R, Das K, Lindy ME, ","PeriodicalId":89901,"journal":{"name":"Breast cancer online : BCO","volume":"10 1","pages":"1-3"},"PeriodicalIF":0.0,"publicationDate":"2007-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1017/S1470903107006372","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"56921255","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Positive sentinel lymph nodes should be followed by axillary lymph node dissection","authors":"F. Hoehne, Helen Mabry, A. Giuliano","doi":"10.1017/S1470903107003847","DOIUrl":"https://doi.org/10.1017/S1470903107003847","url":null,"abstract":"The use of sentinel lymph node biopsy (SLNB) has revolutionized breast surgery for early stage breast cancer. SLNB accurately stages the axilla without the morbidity of axillary lymph node dissection (ALND). While allowing those patients with No disease to avoid a potentially morbid dissection, SLNB is a diagnostic procedure which identifies nodal disease and is not designed to replace ALND in patients with metastatic disease in the axilla. ALND provides regional disease control, assists physicians in making decisions for patients regarding systemic therapy, and may or may not have a survival advantage. The American College of Surgeons Oncology Group Z0011 study was constructed to determine whether there was a survival difference between completion ALND vs. observation in patients with a positive sentinel lymph node (SLN). Without strong data from randomized, controlled trials regarding the locoregional and long-term survival of patients who undergo observation after a positive SLN, patients should be offered completion ALND for a positive SLNB although ALND may offer no survival advantage.","PeriodicalId":89901,"journal":{"name":"Breast cancer online : BCO","volume":"10 1","pages":"1-4"},"PeriodicalIF":0.0,"publicationDate":"2007-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1017/S1470903107003847","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"56920580","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Basic science (December 2006)","authors":"R. Sutherland, J. Scorer","doi":"10.1017/S1470903107006360","DOIUrl":"https://doi.org/10.1017/S1470903107006360","url":null,"abstract":"","PeriodicalId":89901,"journal":{"name":"Breast cancer online : BCO","volume":"15 1","pages":"1-3"},"PeriodicalIF":0.0,"publicationDate":"2007-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1017/S1470903107006360","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"56921243","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Can surgery provoke the outgrowth of latent breast cancer? A unifying hypothesis","authors":"M. Retsky, R. Demicheli, W. Hrushesky, M. Baum, I. Gukas","doi":"10.1017/S1470903107005111","DOIUrl":"https://doi.org/10.1017/S1470903107005111","url":null,"abstract":"To explain bimodal relapse patterns, we have previously suggested that metastatic breast cancer growth commonly includes periods of temporary dormancy at both the single cell and avascular micrometas- tasis phases (with 1 year and 2 year half-lives respectively). We further suggested that primary surgery some- times initiates growth of distant dormant disease accelerating relapse. These iatrogenic events are common in that they occur in over half of all relapses. Surgery induced angiogenesis is mostly confined to premenopausal node positive patients in which case 20% of patients are so affected. We review here how this hypothesis explains a vairety of previously unrelated breast cancer phenomenon including 1) the mammography paradox for women age 40-49 untreated with adjuvant therapy, 2) the particularly high benefit of adjuvant chemother- apy for premenopausal node positive patients, 3) the heterogeneity of breast cancer, 4) the aggressiveness of cancer in young women, 5) the outcome differences with timing of surgery within the menstrual cycle, 6) the common myths regarding cancer spreading \"when the air hits it\" and treatment \"provoking\" the tumor, 7) the excess mortality of blacks over whites, and 8) reports from physicians 2000 years ago. In parallel to physicists who have long sought to explain all of physics with a unified field theory, we now suggest temporary dormancy together with surgery induced tumor growth provides a unifying theory for much of breat cancer.","PeriodicalId":89901,"journal":{"name":"Breast cancer online : BCO","volume":"10 1","pages":"1-6"},"PeriodicalIF":0.0,"publicationDate":"2007-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1017/S1470903107005111","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"56920622","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"For the use of ultrasound by surgeons","authors":"J. Dixon, E. J. Macaskill","doi":"10.1017/S1470903107003501","DOIUrl":"https://doi.org/10.1017/S1470903107003501","url":null,"abstract":"There is an increasing demand upon radiology departments for use of ultrasound as part of triple assessment of symptomatic breast disease. It has been shown that in the context of proper training both surgeons and radiologists achieve comparably high diagnostic sensitivity and specificity with ultrasound. This article outlines the arguments in favour of the use of ultrasound by surgeons in the breast clinic for diagnostic and therapeutic purposes.","PeriodicalId":89901,"journal":{"name":"Breast cancer online : BCO","volume":"39 1","pages":"1-3"},"PeriodicalIF":0.0,"publicationDate":"2007-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1017/S1470903107003501","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"56920518","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Management of close margins in invasive breast cancer","authors":"R. Bleicher, M. Morrow","doi":"10.1017/S1470903107005482","DOIUrl":"https://doi.org/10.1017/S1470903107005482","url":null,"abstract":"consider when assessing the adequacy of a surgical excision. Abstract Since clinical trials have demonstrated that breast conservation is safe and effective for treatment of invasive breast cancer, there has been considerable disagreement and controversy about what constitutes an acceptable margin in breast cancer. Dogmatic adherence to a set margin for all patients may cause a higher mastectomy rate than necessary, and thus it is important to understand how various clinical and pathologic factors affect local recurrence and outcome. This review discusses that controversy, as well as what factors should be considered when evaluating patients on an individual basis.","PeriodicalId":89901,"journal":{"name":"Breast cancer online : BCO","volume":"10 1","pages":"1-4"},"PeriodicalIF":0.0,"publicationDate":"2007-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1017/S1470903107005482","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"56920643","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Review of: A DGGE system for comprehensive mutation screening of BRCA1 and BRCA2 : application in a Dutch cancer clinic setting","authors":"V. Hayes","doi":"10.1017/S1470903107005743","DOIUrl":"https://doi.org/10.1017/S1470903107005743","url":null,"abstract":"of the original article: Rapid and reliable identification of deleterious changes in the breast cancer genes BRCA1 and BRCA2 has become one of the major issues in most DNA services laboratories. To rapidly detect all possible changes within the coding and splice site determining sequences of the breast cancer genes, we established a semiautomated denaturing gradient gel electrophoresis (DGGE) mutation scanning system. All exons of both genes are covered by the DGGE scan, comprising 120 amplicons. We use a semiautomated approach, amplifying all individual amplicons with the same PCR program, after which the amplicons are pooled. DGGE is performed using three slightly different gel conditions. Validation was performed using DNA samples with known sequence variants in 107 of the 120 amplicons; all variants were detected. This DGGE mutation scanning, in combination with a PCR test for two Dutch founder deletions in BRCA1 was then applied in 431 families in which 52 deleterious changes and 70 unclassified variants were found. Fifteen unclassified variants were not reported before. The system was easily adopted by five other laboratories, where in another 3593 families both exons 11 were analysed by the protein truncation test (PTT) and the remaining exons by DGGE. In total, a deleterious change (nonsense, frameshift, splice-site mutation or large deletion) was found in 661 families (16.4%), 462 in BRCA1 (11.5%), 197 in BRCA2 (4.9%), and in two index cases a deleterious change in both BRCA1 and BRCA2 was identified. Eleven deleterious changes in BRCA1 and 36 in BRCA2 had not been reported before. In conclusion, this DGGE mutation screening method for BRCA1 and BRCA2 is proven to be highly sensitive and is easy to adopt, which makes screening of large numbers of patients feasible. The results of screening of BRCA1 and BRCA2 in more than 4000 families present a valuable overview of mutations in the Dutch population. Journals Club Correspondence to: Dr Vanessa M. Hayes, Cancer Research Program, Garvan Institute of Medical Research, 384 Victoria Street, Darlinghurst, NSW 2010, Australia. E-mail: v.hayes@garvan.org.au; Tel: 61-2-92958345; Fax: 61-2-92958321 Received: 09/02/2007 Accepted: 14/02/2007 BCO/574/2007/JC https://www.cambridge.org/core/terms. https://doi.org/10.1017/S1470903107005743 Downloaded from https://www.cambridge.org/core. IP address: 207.241.231.81, on 27 Jul 2018 at 19:54:25, subject to the Cambridge Core terms of use, available at Page 2 of 3 Journals Club Review","PeriodicalId":89901,"journal":{"name":"Breast cancer online : BCO","volume":"10 1","pages":"1-3"},"PeriodicalIF":0.0,"publicationDate":"2007-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1017/S1470903107005743","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"56921088","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The use of radiation in the elderly","authors":"L. Schnaper, K. Hughes","doi":"10.1017/S1470903107003677","DOIUrl":"https://doi.org/10.1017/S1470903107003677","url":null,"abstract":"Despite the fact that breast cancer is predominantly a disease of postmenopausal women, there have been no uniform recommendations for both locoregional and systemic therapy for women over 70. Until recently, older women have been excluded from clinical trials. This study is the first randomized trial that addresses the use of radiation therapy following lumpectomy in a favorable cohort of elderly women.","PeriodicalId":89901,"journal":{"name":"Breast cancer online : BCO","volume":"10 1","pages":"1-3"},"PeriodicalIF":0.0,"publicationDate":"2007-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1017/S1470903107003677","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"56920526","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Robert B. Dickson","authors":"Robert Clarke's","doi":"10.1017/S1470903106006006","DOIUrl":"https://doi.org/10.1017/S1470903106006006","url":null,"abstract":"","PeriodicalId":89901,"journal":{"name":"Breast cancer online : BCO","volume":"9 1","pages":"1-2"},"PeriodicalIF":0.0,"publicationDate":"2006-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1017/S1470903106006006","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"56920908","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}