Translational medicine (Sunnyvale, Calif.)最新文献_第5页

Association between single nucleotide polymorphisms rs2200733 and rs10033464 at chromosome 4q25 and thyrotoxic atrial fibrillation 染色体4q25单核苷酸多态性rs2200733和rs10033464与甲状腺毒性心房颤动的相关性

Translational medicine (Sunnyvale, Calif.) Pub Date : 2022-11-25 DOI: 10.18705/2311-4495-2022-9-4-62-73

D. A. Ponomartseva, A. Y. Hushkina, A. Kostareva, A. Babenko

{"title":"Association between single nucleotide polymorphisms rs2200733 and rs10033464 at chromosome 4q25 and thyrotoxic atrial fibrillation","authors":"D. A. Ponomartseva, A. Y. Hushkina, A. Kostareva, A. Babenko","doi":"10.18705/2311-4495-2022-9-4-62-73","DOIUrl":"https://doi.org/10.18705/2311-4495-2022-9-4-62-73","url":null,"abstract":"Background. Thyrotoxic atrial fibrillation (TAF) genesis does not exclude a genetic component due to the difference in thyroid hormones effects on the cardiovascular system in similar patients. According to genomewide association studies (GWAS), the first locus associated with non-thyrotoxic atrial fibrillation (AF) was locus 4q25, and the first single-nucleotide polymorphisms in it identified as risk factors for AF were polymorphisms rs2200733 and rs10033464. Their connection with TAF remains unclear.Objective. To investigate the possible association of the two single nucleotide polymorphisms rs2200733 and rs10033464 with TAF.Design and methods. The association of TAF and other thyrotoxic cardiomyopathy manifestations with the studied polymorphisms was examined in a sample of 150 patients with Graves’ disease and overt thyrotoxicosis, 18.7 % of whom had TAF. Genotyping was preformed using real time PCR.Results. A significant predominance of TT genotype for both polymorphisms was revealed: p=0.038 for rs10033464, p<0.001 for rs2200733. TT genotype frequency in TAF patients compared with non-TAF participants: 7.4 % vs 1.6 % for rs10033464, 17.9 % vs 0.8 % for rs2200733. When assessing the frequency of genotypes depending on the presence of other thyrotoxic cardiomyopathy manifestations, TT genotype was more common in patients with ventricular premature beats, p=0.001.Conclusion. TT genotype of rs2200733 and rs10033464 polymorphisms at 4q25 locus is associated with a higher incidence of TAF and ventricular extrasystole in thyrotoxic patients.","PeriodicalId":89863,"journal":{"name":"Translational medicine (Sunnyvale, Calif.)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45966467","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Reasons for late diagnosis of pulmonary echinococcosis in a non-endemic area 非流行地区肺棘球蚴病诊断晚的原因

Translational medicine (Sunnyvale, Calif.) Pub Date : 2022-09-28 DOI: 10.18705/2311-4495-2022-9-3-81-87

I. A. Krylova, S. Levitsky, I. Shabalina, A. Semenova, I. Turabov

{"title":"Reasons for late diagnosis of pulmonary echinococcosis in a non-endemic area","authors":"I. A. Krylova, S. Levitsky, I. Shabalina, A. Semenova, I. Turabov","doi":"10.18705/2311-4495-2022-9-3-81-87","DOIUrl":"https://doi.org/10.18705/2311-4495-2022-9-3-81-87","url":null,"abstract":"Background. Diagnosis, treatment, prevention of echinococcosis remain relevant tasks for most Russian regions. One of the key problems is the diagnosis of this disease in non-endemic regions.Objective. To describe a clinical case of cystic echinococcosis of the lungs.Materials and methods. A multislice computed tomography of the chest with contrast enhancement, serological diagnosis and histological examination and subsequent surgical treatment of a 6-year-old patient were performed.Results. A case of cystic echinococcosis of the lungs in a 6-year-old boy is presented. Echinococcosis was diagnosed at the stage of a large diameter cyst during chest X-ray to exclude pneumonia. Surgical treatment was performed. The decrease in titers of antiparasitic antibodies in dynamics after the operation allowed to conclude that the patient had recovered. The presented clinical case demonstrates a typical error in the diagnosis of pulmonary echinococcosis. Cystic echinococcosis is a rare pathology in the Arkhangelsk region (up to 4 per year). This situation leads to late diagnosis of this helminthiasis. The main mistake in the diagnosis was the lack of alertness in relation to echinococcosis and, as a result, the establishment of an incorrect diagnosis — pneumonia.Conclusions. The use of multislice computed tomography of the chest with contrast enhancement, serological diagnosis and histological examination in combination allows you to accurately establish the diagnosis of echinococcosis of the lungs.","PeriodicalId":89863,"journal":{"name":"Translational medicine (Sunnyvale, Calif.)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46969068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hybrid revascularization of chronic occlusion of the aorto-femoral segment in a patient with critical ischemia of the lower limbs and ischemic heart disease 下肢严重缺血和缺血性心脏病患者主动脉-股骨段慢性闭塞的混合血运重建

Translational medicine (Sunnyvale, Calif.) Pub Date : 2022-09-28 DOI: 10.18705/2311-4495-2022-9-3-5-12

N. S. Susanin, M. A. Chernyavsky, A. Vanyurkin, V. A. Solovyov, Yu. K. Belova, N. S. Odintsov

{"title":"Hybrid revascularization of chronic occlusion of the aorto-femoral segment in a patient with critical ischemia of the lower limbs and ischemic heart disease","authors":"N. S. Susanin, M. A. Chernyavsky, A. Vanyurkin, V. A. Solovyov, Yu. K. Belova, N. S. Odintsov","doi":"10.18705/2311-4495-2022-9-3-5-12","DOIUrl":"https://doi.org/10.18705/2311-4495-2022-9-3-5-12","url":null,"abstract":"Backgound. The number of patients with Leriche’s syndrome has increased dramatically. Despite the compensatory development of collaterals, this condition most often leads to symptoms of intermittent claudication and can result in critical ischemia and amputations. TASC II guidelines recommend reconstructive surgery, but this approach is associated with high perioperative mortality. So far, only few studies reported the results of endovascular correction of the atherogenic process in the infrarenal aorta.Objective. To present a clinical case of hybrid revascularization of the aortofemoral segment in a patient with ischemic heart disease.Design and methods. A 68-year-old patient with Leriche’s syndrome underwent ultrasound of the brachiocephalic arteries, coronary angiography, and multispiral computed tomography with angiography. Subsequently, hybrid surgery was performed.Results. Given the critical ischemia of the lower extremities and comorbidities, a hybrid surgical intervention was performed: endarterectomy from the femoral arteries and endovascular recanalization of the occlusion of the aortoiliac segment using the “kissing stents” technique.Conclusions. The requirements for equipment and experience of the surgical team limit the widespread use of hybrid correction of an occlusive lesion of the infrarenal aorta. The lack of randomized trials creates uncertainty in the choice of revascularization tactics. In the framework of this clinical case, the effectiveness of hybrid surgery in the treatment of a patient with multifocal atherosclerosis has been proven.","PeriodicalId":89863,"journal":{"name":"Translational medicine (Sunnyvale, Calif.)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47143149","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

To the interpretation of frequency components of the heart rate variability 解释心率变异性的频率成分

Translational medicine (Sunnyvale, Calif.) Pub Date : 2022-09-28 DOI: 10.18705/2311-4495-2022-9-3-35-58

N. V. Kuzmenko, V. Tsyrlin, M. G. Pliss

{"title":"To the interpretation of frequency components of the heart rate variability","authors":"N. V. Kuzmenko, V. Tsyrlin, M. G. Pliss","doi":"10.18705/2311-4495-2022-9-3-35-58","DOIUrl":"https://doi.org/10.18705/2311-4495-2022-9-3-35-58","url":null,"abstract":"Assessing the sympathetic-vagal balance is an important task for predicting shifts in the functioning of the body when adapting to changing external conditions, as well as aging, various pathological processes and therapy. Today, the method of analyzing the spectrum of heart rate variability (HRV) for determining the sympathetic-vagal balance due to its simplicity and non-invasiveness has become widespread both in clinical practice and in experimental studies. The article analyzes the results of our own and literary studies of influence of various effects on hemodynamic parameters, the level of circulating catecholamines, sympathetic nervous activity, the baroreceptor reflex, and also on the components of the HRV spectrum (LF (low frequency), HF (high frequency) and LF/HF). Often different authors under the same impact register different changes. Reasons for this include different doses of drugs, nature/strength of exposure (for stress and exercise), time between drug administration and registration. In addition, the effect of some drugs can be enhanced in the case of pathology, such as hypertension. Based on the comparison of the vectors of changes in the studied parameters, we concluded that, using the frequency analysis of HRV, it is necessary to draw a conclusion about the sympatho-vagal balance with great care due to the ambiguous nature of LF component, but HF component gives information of the tone of the vagus with sufficient accuracy.","PeriodicalId":89863,"journal":{"name":"Translational medicine (Sunnyvale, Calif.)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48133524","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Influence of endothelial nitric oxide syntase gene polymorphism on prognosis in patients after coronary bypass grafting 内皮型一氧化氮合酶基因多态性对冠状动脉搭桥术患者预后的影响

Translational medicine (Sunnyvale, Calif.) Pub Date : 2022-09-28 DOI: 10.18705/2311-4495-2022-9-3-13-23

I. S. Magamadov, E. Skorodumova, V. Kostenko, L. Pivovarova, O. Ariskina, А. V. Siverina, E. G. Skorodumova

{"title":"Influence of endothelial nitric oxide syntase gene polymorphism on prognosis in patients after coronary bypass grafting","authors":"I. S. Magamadov, E. Skorodumova, V. Kostenko, L. Pivovarova, O. Ariskina, А. V. Siverina, E. G. Skorodumova","doi":"10.18705/2311-4495-2022-9-3-13-23","DOIUrl":"https://doi.org/10.18705/2311-4495-2022-9-3-13-23","url":null,"abstract":"Background. Development of personalized medicine and study of the genetic basis of cardiovascular diseases are promising areas in modern cardiology.Objective. To evaluate effect of NOS3 gene polymorphism on the prognosis in patients undergoing coronary artery bypass grafting (CABG).Design and methods. The study included 60 patients with stable coronary heart disease (CAD) and multivessel coronary disease according to the SYNTAX I score > 23. The first group included 39 patients — carriers of the 786CC and 786TC genotypes, the second — 21 patients with the 786TT genotype of the NOS3 gene. We accessed the severity of the systemic inflammatory response (SIR) in the postoperative period, the dynamics of changes in the ejection fraction (EF) of the left ventricle, as well as clinical data during 12 months after CABG.Results. The presence of heterozygous and homozygous variants (TC/CC) of the NOS3 gene is associated with a more pronounced and prolonged SIR in the postoperative period. The chances of developing symptoms of acute decompensation of chronic heart failure (CHF) within 12 months after CABG were significantly 4 higher in the group of carriers of TC/CC genotypes.Conclusions. In patients with CAD and carriage of the 786TC/786CC genotypes of the NOS3 gene undergoing CABG, there is a more pronounced and prolonged SIR in the postoperative period, as well as an increased risk of acute decompensation of CHF within 12 months after CABG.","PeriodicalId":89863,"journal":{"name":"Translational medicine (Sunnyvale, Calif.)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45666625","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The relationship between morphometric characteristics of venous drainages of arteriovenous malformations of the brain and types of clinical course 脑动静脉畸形静脉引流形态特征与临床病程类型的关系

Translational medicine (Sunnyvale, Calif.) Pub Date : 2022-09-28 DOI: 10.18705/2311-4495-2022-9-3-24-34

N. A. Mamonov, L. Rozhchenko, S. A. Goroschenko, K. Samochernykh

{"title":"The relationship between morphometric characteristics of venous drainages of arteriovenous malformations of the brain and types of clinical course","authors":"N. A. Mamonov, L. Rozhchenko, S. A. Goroschenko, K. Samochernykh","doi":"10.18705/2311-4495-2022-9-3-24-34","DOIUrl":"https://doi.org/10.18705/2311-4495-2022-9-3-24-34","url":null,"abstract":"Background. Arteriovenous malformations of the brain are a rare vascular pathology. Many studies focus on the features of venous drainage of arteriovenous malformations. The angioarchitectural and hemodynamic features of the venous component of arteriovenous malformations can influence on the patient management.Objective. To evaluate the relationship between the features of venous drainage of arteriovenous malformations of the brain and the types of clinical course. Design and methods. Survey included 61 adult patients of the neurosurgical department № 3 of the Polenov RNSI with arteriovenous malformations of the brain of supratentorial localization. Demographic and morphometric characteristics, as well as features of venous drainage of arteriovenous malformations, were assessed. Groups of patients were distinguished according to the type of the course of the disease.Results. The dependence of the hemorrhagic type of course on such factors as drainage exclusively into the deep vein system, as well as the presence of a combination of macrofistula with venous lacunae. The epileptic type was more typical for patients with superficial localization of the arteriovenous malformation. The torpid type of course had no distinctive features.Conclusion. Drainage exclusively into the deep vein system and the presence of a combination of macrofistula and venous lacunae is characteristic of the hemorrhagic type of course. The epileptic type of course was characterized by superficial localization of the malformation.","PeriodicalId":89863,"journal":{"name":"Translational medicine (Sunnyvale, Calif.)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45468515","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Preoperative risk factors for negative clinical outcomes in acute mesenteric thrombosis in surgical ICU 外科ICU中急性肠系膜血栓形成患者术前不良临床结果的危险因素

Translational medicine (Sunnyvale, Calif.) Pub Date : 2022-09-28 DOI: 10.18705/2311-4495-2022-9-3-70-80

A. D. Ponomareva, I. Leyderman, I. Kasherininov, I. Danilov, V. L. Belikov

{"title":"Preoperative risk factors for negative clinical outcomes in acute mesenteric thrombosis in surgical ICU","authors":"A. D. Ponomareva, I. Leyderman, I. Kasherininov, I. Danilov, V. L. Belikov","doi":"10.18705/2311-4495-2022-9-3-70-80","DOIUrl":"https://doi.org/10.18705/2311-4495-2022-9-3-70-80","url":null,"abstract":"Background. Acute mesenteric thrombosis (AMT) is a condition that develops with thrombosis in the vessels of the mesenteric pool, which causes hypoperfusion of the intestinal wall and leads to secondary inflammatory changes. Mortality in OMT is 80–85 %. Early diagnosis of OMT is difficult due to the lack of specific clinical signs and laboratory markers.Objective. To identify preoperative risk factors for adverse clinical outcomes in OMT.Design and Methods. A single-center retrospective observational cohort study included 47 patients diagnosed with OMT. The following patient data were analyzed: age, gender, body mass index (BMI), assessment of the patients’ condition according to the SOFA, APACHE II, EuroSCORE scales. Various laboratory parameters in the preoperative and postoperative periods were analyzed.Results. The incidence of oncological diseases and history of acute cerebrovascular accident (ACV) were significantly higher in the group of lethal outcomes of OMT than in the group of surviving patients. The correlation of higher serum levels of lactate, D-dimer, creatinine, leukocytosis and procalcitonin in the preoperative period with the development of an unfavorable clinical outcome was revealed.Conclusion. The main risk factors for the development of an unfavorable clinical outcome of mesenteric thrombosis in patients are the presence of malignant neoplasms, a history of stroke, a high level of mixed venous blood lactate, creatinine, D-dimers, procalcitonin, leukocytosis in the preoperative period.","PeriodicalId":89863,"journal":{"name":"Translational medicine (Sunnyvale, Calif.)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42654375","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of the profile of circulating extracellular vesicles of different cell origin and their activity in patients with postthromboembolic syndrome 不同细胞来源的循环细胞外小泡特征及其活性在血栓栓塞后综合征患者中的评估

Translational medicine (Sunnyvale, Calif.) Pub Date : 2022-09-28 DOI: 10.18705/2311-4495-2022-9-3-59-69

E. Zolotova, M. Simakova, O. Melnichnikova, O. Sirotkina, Y. Zhilenkova, O. Moiseeva, T. Vavilova

{"title":"Evaluation of the profile of circulating extracellular vesicles of different cell origin and their activity in patients with postthromboembolic syndrome","authors":"E. Zolotova, M. Simakova, O. Melnichnikova, O. Sirotkina, Y. Zhilenkova, O. Moiseeva, T. Vavilova","doi":"10.18705/2311-4495-2022-9-3-59-69","DOIUrl":"https://doi.org/10.18705/2311-4495-2022-9-3-59-69","url":null,"abstract":"Background. Chronic thromboembolic pulmonary hypertension (CTEPH) and chronic thromboembolic disease (CTEP) are manifestations of post-thromboembolic syndrome in patients with pulmonary embolism. Extracellular vesicles (EVs) are involved in the pathogenesis of these diseases due to the activation of the hemostasis system.Objective. Evaluation of the relative amount of EVs and their coagulation activity using the thrombin generation test in CTEP and CTEPH patients. Design and methods. The study included 21 patients: the CTEP group (n = 7) and the CTEPH group (n = 14); and 11 healthy donors. EVs were isolated with the Exo-FACS kit and analyzed by flow cytometry using fluorescently labeled antibodies. The activity of the microparticles was assessed in a thrombin generation test using a trigger reagent without the addition of TF using a plate fluorimeter.Results. The relative content of EVs of platelet and endothelial origin was increased in CTEPH and CTEP groups. The level of platelet EVs correlates with the levels of CRP and D-dimer. LT and ttPeak were significantly increased in patients with CTEPH.Conclusion. An increase in the level of platelet and endothelial EVs in patients with CTEPH and CTEP indicates the contribution of microvesiculation to the formation of post-thromboembolic syndrome. The activity of thrombin generation decrease under the action of TF-EVs could be a result of TF consumption in endothelial dysfunction, or prolonged activation of procoagulant pathways.","PeriodicalId":89863,"journal":{"name":"Translational medicine (Sunnyvale, Calif.)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45410763","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical effects of adaptive lung ventilation regime during weaning of mixed ICU patients 混合型ICU患者断奶期间适应性肺通气方案的临床效果

Translational medicine (Sunnyvale, Calif.) Pub Date : 2022-04-15 DOI: 10.18705/2311-4495-2022-9-1-39-48

R. A. Glavatskih, N. Davidova, I. Leyderman, G. Sobetova

{"title":"Clinical effects of adaptive lung ventilation regime during weaning of mixed ICU patients","authors":"R. A. Glavatskih, N. Davidova, I. Leyderman, G. Sobetova","doi":"10.18705/2311-4495-2022-9-1-39-48","DOIUrl":"https://doi.org/10.18705/2311-4495-2022-9-1-39-48","url":null,"abstract":"Background. Weaning from mechanical ventilation (MV) became one of the main problems of intensive care unit (ICU) physicians. Choosing the optimal mode of MV, which make possible to accelerate the process of weaning the patient, remain unresolved. A promising direction is the use of new adaptive ventilation modes.Objective. To compare the clinical efficacy of the iSV regimen with the traditional CPAP + PS (PSV) regimen in patients of a mixed ICU.Design and methods. 45 patients (age 31–81) were examined. Patients were on prolonged MV from 5 to 28 days. In group 1 pressure support (PSV) mode was used to adapt to spontaneous breathing. Group 2 consisted of patients in whom adaptive ventilation (iSV) mode was used.Results. Both modes of assisted ventilation provided effective respiratory support. In the PSV mode, on the 3rd and 5th days of weaning from MV, hypocapnia and a higher support by the pressure of spontaneous inspirations (PS) were noted. A higher daily energy requirement was revealed in PSV mode on day 3. The length of stay in ICU in iSV group was moderately decreased.Conclusion. Assisted ventilation modes PSV and iSV are effective in adapting patients to spontaneous breathing after prolonged MV. The iSV mode appears to cause less respiratory stress compared to the PSV mode. Assisted ventilation in iSV versus PSV can possibly reduce ICU length of stay.","PeriodicalId":89863,"journal":{"name":"Translational medicine (Sunnyvale, Calif.)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48099220","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Primary lymphomas of the central nervous system. Questions of epidemiology and treatment. Clinical example of multidisciplinary approach in therapy 中枢神经系统的原发性淋巴瘤。流行病学和治疗的问题。多学科治疗的临床实例

Translational medicine (Sunnyvale, Calif.) Pub Date : 2022-04-15 DOI: 10.18705/2311-4495-2022-9-1-49-59

N. Voinov, A. U. Ulitin, T. Chitanava, S. M. Sklyar, A. Petrov

{"title":"Primary lymphomas of the central nervous system. Questions of epidemiology and treatment. Clinical example of multidisciplinary approach in therapy","authors":"N. Voinov, A. U. Ulitin, T. Chitanava, S. M. Sklyar, A. Petrov","doi":"10.18705/2311-4495-2022-9-1-49-59","DOIUrl":"https://doi.org/10.18705/2311-4495-2022-9-1-49-59","url":null,"abstract":"Background. Currently, the frequency of occurrence of neoplasms is emerging in the world. Under conditions of a general tumor, brain tumors are rare (0.7–1.5 %). However, high mortality, disability, limited life expectancy of patients, high economic and social inferiority, raise concerns about the medical organization of care, development and social adaptation. Of particular importance among the causes of primary brain tumors is the congenital or acquired growth of immunodeficiency. The growth in the number of drug addicts led to the elimination of the annual epidemic at the end of the 70s and the increase in the number of patients with immunodeficiency syndrome (AIDS), due to which the growth of a brain tumor began to develop in this population group. The number of Russian patients with lymphoma is also steadily increasing.Objective. Consider an illustrative clinical case that reflects the expected continuity in patients with ordinary CNS lymphoma.Design and methods. A 50-year-old patient with moderate memory loss was examined using various methods: MRI, PET-CT and etc.Results. Based on histological and immunohistochemical studies, diffuse large B-cell lymphoma of the CNS was diagnosed. There was a positive trend in the reduction of tumor size after radiation therapy.Conclusion. Primary CNS lymphoma is becoming an active epidemiological problem of society, requiring comprehensive multidisciplinary monitoring. Only high vigilance in terms of lymphoma and well-coordinated work of multidisciplinary specialists can help to perform the correct diagnostics and patient management.","PeriodicalId":89863,"journal":{"name":"Translational medicine (Sunnyvale, Calif.)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43855941","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2