The e-journal of neonatology research最新文献

Spontaneous Rhythmic Contractions (Vasomotion) of the Isolated, Pressurized Ductus Arteriosus of Preterm, but Not Term, Fetal Mice. 早产儿(非足月)胎儿小鼠离体受压动脉导管的自发节律性收缩(血管舒缩)。

The e-journal of neonatology research Pub Date : 2012-01-01

Megan Vucovich, Noah Ehinger, Stanley D Poole, Fred S Lamb, Jeff Reese

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Mapping the New World of Necrotizing Enterocolitis (NEC): Review and Opinion. 描绘坏死性小肠结肠炎 (NEC) 的新世界：回顾与观点。

The e-journal of neonatology research Pub Date : 2012-01-01

Phillip Gordon, Robert Christensen, Jörn-Hendrik Weitkamp, Akhil Maheshwari

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Editorial: From Advocacy to Action 社论:从倡导到行动

The e-journal of neonatology research Pub Date : 2011-06-01 DOI: 10.1177/0973217920110201

A. Gambhir

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Ileal Immunoglobulin Binding by the Neonatal Fc Receptor: A Previously Unrecognized Mechanism of Protection in the Neonatal Rat Model of Necrotizing Enterocolitis? 新生儿Fc受体结合回肠免疫球蛋白:一种先前未被认识的坏死性小肠结肠炎新生大鼠模型保护机制?

The e-journal of neonatology research Pub Date : 2011-03-03

Jonathan R Swanson, Tamas Jilling, Jing Lu, Jessica B Landseadel, Marek Marcinkiewicz, Phillip V Gordon

{"title":"Ileal Immunoglobulin Binding by the Neonatal Fc Receptor: A Previously Unrecognized Mechanism of Protection in the Neonatal Rat Model of Necrotizing Enterocolitis?","authors":"Jonathan R Swanson, Tamas Jilling, Jing Lu, Jessica B Landseadel, Marek Marcinkiewicz, Phillip V Gordon","doi":"","DOIUrl":"","url":null,"abstract":"Background: Mucosal apoptosis is the initiating event in models of necrotizing enterocolitis (NEC) within rodents. It is possible there are species-specific differences that make apoptosis a more prominent feature of NEC in rodents than in humans.Hypothesis: A lower threshold for mucosal apoptosis in the rodent distal intestine might have evolutionary advantages (via enhanced opsonization with the neonatal Fc receptor [FcRn]), since many short-gestation mammals are comparatively premature (histomorphologically) but are protected from NEC by breast milk.Methods: We utilized a rat intestinal epithelial cell (IEC-18) model to determine if cell death alters FcRn - IgG binding, and rodent models of NEC to determine if cell death results in increased opsonization of IgG. Cultured IEC-18 cells were treated with H2O2 and analyzed. Neonatal Sprague-Dawley rats were cold and hypoxia stressed and intestinal sections were frozen for analysis.Results: IgG binding was increased in H2O2-treated cells. Co-incubation of treated cells with either insulin-like growth factor or tunicamycin decreased IgG binding. Sprague-Dawley rats formula fed with exogenous bacteria showed a significant decrease in intestinal FcRn mRNA but increased ileal IgG binding.Conclusions: We speculate that FcRn plays a role in passive opsonization and subsequent bacterial pathogen clearance, making rodents resistant to NEC.","PeriodicalId":89856,"journal":{"name":"The e-journal of neonatology research","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2011-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4122316/pdf/nihms490609.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32570678","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Editorial: Follow up of NICU graduates: Neurodevelopmental Status and Handicaps 社评:新生儿重症监护病房毕业生的随访:神经发育状况和残疾

The e-journal of neonatology research Pub Date : 2004-06-01 DOI: 10.1177/0973217920040201

Sudershan Kumari

{"title":"Editorial: Follow up of NICU graduates: Neurodevelopmental Status and Handicaps","authors":"Sudershan Kumari","doi":"10.1177/0973217920040201","DOIUrl":"https://doi.org/10.1177/0973217920040201","url":null,"abstract":"Several studies during last two decade have reported an increasing survival rate of high-risk neonates discharged from neonatal intensive care units (NICU)(l-4). In developed countries this has been achieved mainly due to decreasing mortality of very low birth weight ( < l 500gm) and extremely low birth weight babies (<lOOOgm). These rates have been achieved with several interventions for better perinatal care and include: DAntenatal (prenatal steroids, management of preterm labour, bacterial vaginosis, intrauterine growth retardation, premature membrane rupture and other pregnancy complication). DLabour management for prevention of birth asphyxia, hypothermia, and drugs during labour and stabilization of neonate before transport to higher center. D Advances in technology for monitoring, intensive care, mechanical ventilation, postnatal surfactant, management of various systemic problems etc. Klausen et al (5) reported first population based follow up of NICU graduates at preschool age and observed that preschool children with conditions that require NICU care had poor health status and health related quality oflife in a range of domains compared to healthy children (physical abilities, development, temperament & behavior etc). However, despite technological advances for improved neonatal /perinatal care, rates of cerebral palsy and neurodevelopmental handicaps at follow up has not decreased as survival of more high risk has increased the absolute number of NICU survivals with neurological deficit(6). Some workers have reported a shift from higher to very low birth weight babies from industrialized countries where survival of micropremies is increasingly reported with regard to incidence of handicaps and neurosensory problems. In Indian context, we have problems of high birth rate, static incidence of low birth weight babies ( <2500gms; 2/3 are growth retarded) at 30% of","PeriodicalId":89856,"journal":{"name":"The e-journal of neonatology research","volume":"4 1","pages":"1-6"},"PeriodicalIF":0.0,"publicationDate":"2004-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79194568","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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