Journal of the American Aging Association最新文献

Beneficial regulation of type I collagen and matrixmetalloproteinase-1 expression by estrogen, progesterone, and its combination in skin fibroblasts. 雌激素、孕激素及其联用对皮肤成纤维细胞I型胶原和基质金属蛋白酶-1表达的有益调节

Journal of the American Aging Association Pub Date : 2003-07-01 DOI: 10.1007/s11357-003-0006-7

Neena Philips, Jan Devaney

引用次数: 17

The effects of exogenous glutathione on reduced glutathione level, glutathione peroxidase and glutathione reductase activities of rats with different ages and gender after whole-body Γ-irradiation. 外源性谷胱甘肽对不同年龄、性别大鼠全身后还原型谷胱甘肽水平、谷胱甘肽过氧化物酶和谷胱甘肽还原酶活性的影响Γ-irradiation。

Journal of the American Aging Association Pub Date : 2003-07-01 DOI: 10.1007/s11357-003-0005-8

Mine Erden Inal, Asiye Akgün, Ahmet Kahraman

{"title":"The effects of exogenous glutathione on reduced glutathione level, glutathione peroxidase and glutathione reductase activities of rats with different ages and gender after whole-body Γ-irradiation.","authors":"Mine Erden Inal, Asiye Akgün, Ahmet Kahraman","doi":"10.1007/s11357-003-0005-8","DOIUrl":"https://doi.org/10.1007/s11357-003-0005-8","url":null,"abstract":"Age-and gender-related changes on reduced glutathione (GSH) level, glutathione peroxidase (GPx) and glutathione reductase (GR) activities in the liver of rat exposed to different dose of whole-body g-ray irradiation were determined. In addition, the effect of administration of exogenous GSH on endogenous GSH levels, GPx and GR activities was investigated. For this aim, male and female rats aged 1 and 5 moths were divided into two groups as g-ray and g-ray+GSH. Both groups were again divided into four groups as irradiated with 2, 4, 6 and 8 Gy doses. GSH level and GPx activity did not change with age while GR activity was decreased with age. Gender-dependent changes in GPx and GR activities were observed, but GSH values were not affect by sex. GSH levels, GPx and GR activities were not observed dose-associated changes of g-irradiation. GSH level and GPx activity in the 8Gy group were increased by GSH. GR activities of old male rats were found to be increased by glutathione in the 6 and 8Gy groups. These results indicate that radiation and administration of exogenous GSH affect gender-and age-dependent GSH level, GPx and GR activities in the rats.","PeriodicalId":89818,"journal":{"name":"Journal of the American Aging Association","volume":"26 3-4","pages":"55-8"},"PeriodicalIF":0.0,"publicationDate":"2003-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s11357-003-0005-8","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31373521","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 11

The effect of aging on phenylephrine response in normal subjects. 衰老对正常人苯肾上腺素反应的影响

Journal of the American Aging Association Pub Date : 2003-01-01 DOI: 10.1007/s11357-003-0001-z

Kenneth M Madden, Wayne C Levy, Arnold Jacobson, John R Stratton

{"title":"The effect of aging on phenylephrine response in normal subjects.","authors":"Kenneth M Madden, Wayne C Levy, Arnold Jacobson, John R Stratton","doi":"10.1007/s11357-003-0001-z","DOIUrl":"10.1007/s11357-003-0001-z","url":null,"abstract":"Introduction: With aging, cardiac responses to β-adrenergic stimulation decline but the responses to α1-stimulation are less clear. Moreover, whether aging, in the absence of disease, influences the left ventricular response to an increase in afterload is unclear. This study examined the effect of aging on heart rate (HR), blood pressure (BP), cardiac index (CI) and several left ventricular contractility measurements during α 1-stimulation with a phenylephrine infusion.Methods: Subjects were rigorously screened to be normal by history, physical, blood tests, ECG, ETT and echocardiogram. Twelve young (mean 26 years, all male) and 15 aged (69 years, 11 males) subjects were studied during 10 minute infusions of phenylephrine at 0.5 and 1.0 mcg/ kg/min. HR, BP and radionuclide ventriculographic cardiac volumes were measured.Results: Systolic BP increased more in the aged than in the young (22 vs. 13%, p=0.003), while heart rate (16 vs. 21%, p=0.05) fell less. Contractile responses to phenylephrine, including EF, stroke volume index (SVI), stroke work index and left ventricular contractility index were not altered with aging. Systemic vascular resistance (SVR) was higher at baseline and at each infusion rate, but there was no age-associate change in the response to PE.Conclusions: In a healthy normal aged population, a preserved SVI response in the setting of a higher baseline SVR results in an increased SBP response to α1-stimulation. Contractile responses to increased afterload are not altered with aging. Age-associated differences in the response to α1-stimulation are small and are explained by altered baroreflex sensitivity and a stiffer vasculature.","PeriodicalId":89818,"journal":{"name":"Journal of the American Aging Association","volume":"26 1-2","pages":"3-9"},"PeriodicalIF":0.0,"publicationDate":"2003-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3456817/pdf/11357_2003_Article_1.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31373517","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

AgingDB: A database for oxidative stress and calorie restriction in the study of aging. AgingDB:衰老研究中氧化应激和卡路里限制的数据库。

Journal of the American Aging Association Pub Date : 2003-01-01 DOI: 10.1007/s11357-003-0002-y

Dae Ui Park, Chul Hong Kim, Seong Eui Hong, Byung Pal Yu, Hae Young Chung

{"title":"AgingDB: A database for oxidative stress and calorie restriction in the study of aging.","authors":"Dae Ui Park, Chul Hong Kim, Seong Eui Hong, Byung Pal Yu, Hae Young Chung","doi":"10.1007/s11357-003-0002-y","DOIUrl":"https://doi.org/10.1007/s11357-003-0002-y","url":null,"abstract":"Aging can be characterized in all living organisms as the inevitable biological changes that occur with advancing age. The aging process is time-dependent and leads to functional declines and increased incidences of disease. The underlying pathphysiologic processes of aging may best be explained using several interacting biological processes: genomic activity, oxidative stress, and age-related disease processes, all of which modify the rate and progression of aging. In this report, we describe a database, termed AgingDB, used to retrieve information on the biomolecules known to be modulated during the aging process and by the life-prolonging action of caloric restriction (CR). To enhance the usefulness of AgingDB, we include data collected from studies of CR's anti-oxidative action on gene expression, oxidative stress, and many chronic age-related diseases. We organized AgingDB into two sections A) apoptosis and the various mitochondrial biomolecules that play a role in aging; B) nuclear transcription factors known to be_sensitive to oxidative environment. AgingDB features an imagemap of biomolecular signal pathways and visualized information that includes protein-protein interactions of biomolecules. Authorized users can submit a new biomolecule or edit an existing biomolecule to reflect latest developments. By making available the most update information through AgingDB, we expect to assist researchers who are exploring the molecular basis of age-related changes modified by the life-prolonging action of CR. For the reader's convenience and accessibility, AgingDB is freely available at http://agingdb.bio.pusan.ac.kr/.","PeriodicalId":89818,"journal":{"name":"Journal of the American Aging Association","volume":"26 1-2","pages":"11-7"},"PeriodicalIF":0.0,"publicationDate":"2003-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s11357-003-0002-y","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31373518","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Influence of diagnostic categories, age, and gender on antioxidative defense and lipid peroxidation in skeletal muscle of patients with neuromuscular diseases. 诊断类别、年龄和性别对神经肌肉疾病患者骨骼肌抗氧化防御和脂质过氧化的影响

Journal of the American Aging Association Pub Date : 2003-01-01 DOI: 10.1007/s11357-003-0004-9

Hans-Joerg Stuerenburg, Birgit Stangneth, Alfried Kohlschütter, Barbara Finckh

{"title":"Influence of diagnostic categories, age, and gender on antioxidative defense and lipid peroxidation in skeletal muscle of patients with neuromuscular diseases.","authors":"Hans-Joerg Stuerenburg, Birgit Stangneth, Alfried Kohlschütter, Barbara Finckh","doi":"10.1007/s11357-003-0004-9","DOIUrl":"https://doi.org/10.1007/s11357-003-0004-9","url":null,"abstract":"The influence of diagnostic categories, age, and gender on parameters of oxidative stress measured in 102 patients with neuromuscular diseases and 11 control subjects was assessed using a stepwise multiple linear regression model. Antioxidative enzyme activities, lipophilic antioxidants, and lipid peroxidation were analyzed in muscle biopsies. Mitochondrial myopathies and amyotrophic lateral sclerosis (ALS) are thought to be particularly susceptible to increased oxidative stress. In our study, mitochondrial myopathies emerged as a positive predictor of malondialdehyde (p < 0.05) and ALS as a negative predictor of alpha-tocopherol (p < 0.05). Although the primary atrophic process in ALS is not in muscle but in motoneurons, this finding could have therapeutic implications, as such patients might benefit from antioxidant supplementation. In our study age emerged as a negative predictor of the coenzyme Q10 concentration (p < 0.003), whereas the percentage of reduced coenzyme Q10 remained unchanged. Age emerged as a positive predictor of the activities of catalase (p < 0.01) and superoxide dismutase (p < 0.002), probably reflecting an enzymatic upregulation that compensates for the loss of coenzyme Q10. The increased activities of catalase and superoxide dismutase in females compared to males indicate a higher antioxidative potential in female muscle. Whether this increase contributes to a higher life expectancy of women remains to be investigated.","PeriodicalId":89818,"journal":{"name":"Journal of the American Aging Association","volume":"26 1-2","pages":"29-35"},"PeriodicalIF":0.0,"publicationDate":"2003-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s11357-003-0004-9","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31373520","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Copper deficiency: A potential model for determining the role of mitochondria in cardiac aging. 铜缺乏:确定线粒体在心脏老化中的作用的潜在模型。

Journal of the American Aging Association Pub Date : 2003-01-01 DOI: 10.1007/s11357-003-0003-x

W Thomas Johnson, Samuel M Newman

{"title":"Copper deficiency: A potential model for determining the role of mitochondria in cardiac aging.","authors":"W Thomas Johnson, Samuel M Newman","doi":"10.1007/s11357-003-0003-x","DOIUrl":"https://doi.org/10.1007/s11357-003-0003-x","url":null,"abstract":"Heart mitochondria experience age-related declines in cytochrome c oxidase (CCO) activity and increases in the generation of reactive oxygen species (ROS) that may contribute to loss of cardiac function and the development of disease that occur with advancing age. In a manner similar to aging, copper deficiency also suppresses heart CCO activity and has cardiovascular consequences related to increased peroxidation. Food restriction is often used as a tool to study oxidative mechanisms of aging and the present study examines the potential of copper deficiency to model the role of mitochondria in cardiac aging by determining if the effect of food restriction on CCO activity and oxidative stress in heart mitochondria parallels its effect on cardiac mitochondria during aging. Overall, copper deficiency severely inhibited CCO activity and increased both Mn superoxide dismutase (MnSOD) and glutathione peroxidase (GPX) in isolated heart mitochondria. However, a 20% reduction in food intake by copper-deficient rats increased CCO activity by 65% and decreased MnSOD activity by 25% but had no effect in rats fed adequate copper. Copper deficiency also reduced the carbonyl content of 80-100 kDa mitochondrial proteins, but the reduction in carbonyl content was unaffected by food restriction. Food restriction did, however, completely prevent the enlargement of cardiac mitochondria in copper-deficient rats. Together, these findings indicate that copper deficiency induces mitochondrial antioxidant enzyme activity and hypertrophy in cardiac tissue in response to reduced CCO activity and that food restriction may counteract these changes by reducing oxidative stress. Because the action of food restriction on CCO activity and mitochondrially generated oxidative stress are similar in copper deficiency and aging, copper deficiency may serve as a short-term model for studying the potential roles of mitochondria in cardiac aging.","PeriodicalId":89818,"journal":{"name":"Journal of the American Aging Association","volume":"26 1-2","pages":"19-28"},"PeriodicalIF":0.0,"publicationDate":"2003-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s11357-003-0003-x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31373519","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

32nd annual meeting of the American Aging Association, 17th annual meeting of the American College of Clinical Gerontology 第32届美国老龄协会年会，第17届美国临床老年学学会年会

Journal of the American Aging Association Pub Date : 2003-01-01 DOI: 10.1007/s11357-003-0007-6

引用次数: 0

Calorie restriction modulates redox-sensitive AP-1 during the aging process. 在衰老过程中，卡路里限制调节氧化还原敏感的AP-1。

Journal of the American Aging Association Pub Date : 2002-07-01 DOI: 10.1007/s11357-002-0011-2

Hyon Jeen Kim, Kyung Jin Jung, Arnold Young Seo, Jae Sue Choi, Byung Pal Yu, Hae Young Chung

{"title":"Calorie restriction modulates redox-sensitive AP-1 during the aging process.","authors":"Hyon Jeen Kim, Kyung Jin Jung, Arnold Young Seo, Jae Sue Choi, Byung Pal Yu, Hae Young Chung","doi":"10.1007/s11357-002-0011-2","DOIUrl":"https://doi.org/10.1007/s11357-002-0011-2","url":null,"abstract":"Oxidative stress is claimed to be a major cause of aging. Recent data suggest that calorie restriction (CR) prolongs life span by its ability to retard aging, possibly by regulating the intracellular redox status through its antioxidative actions. Currently, there is little information showing the influences of age and CR on the redox-sensitive transcription factor activator protein-1 (AP-1). In the present study, we investigated how age affects the status of AP-1 and whether CR modulates the age effect. For our study, we used the kidney from male Fischer 344 rats, ages 6, 12, 18, and 24 months fed ad libitum (AL) or a CR diet. Results from our study showed that AP-1 binding activity markedly increases with age, while CR keeps this activity at the level of 6-month-old rats. We found that c-Jun and c-Fos protein levels increase during aging, and that aging induces phosphorylation of c-Jun, which might enhance AP-1 transcriptional activity. For CR's action, we found that in the nucleus of aged rats, AP-1 activation was blunted by decreasing c-Jun and c-Fos levels and inhibiting c-Jun protein phosphorylation. Results also indicated that matrix metalloproteinase-13 and heme oxygenase-1, which have an AP-1 binding site in their promoter regions, have a similar tendency toward AP-1 binding activity. Based on the data of these findings, we concluded that AP-1 activity increases in rat kidney with age and that CR reduces AP-1 activity.","PeriodicalId":89818,"journal":{"name":"Journal of the American Aging Association","volume":"25 3","pages":"123-30"},"PeriodicalIF":0.0,"publicationDate":"2002-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s11357-002-0011-2","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31373512","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 11

Visco-elastic response of human skin and aging. 人体皮肤粘弹性反应与衰老。

Journal of the American Aging Association Pub Date : 2002-07-01 DOI: 10.1007/s11357-002-0009-9

Stanislav Doubal, Petr Klemera

{"title":"Visco-elastic response of human skin and aging.","authors":"Stanislav Doubal, Petr Klemera","doi":"10.1007/s11357-002-0009-9","DOIUrl":"https://doi.org/10.1007/s11357-002-0009-9","url":null,"abstract":"Unlabelled: The changes in visco-elastic properties of skin belong to the most conspicuous manifestations of cutaneous aging. In spite of apparent simplicity, the measurement of mechanical parameters of skin in vivo presents both theoretical and practical problems. Reproducibility, standardization, duration of measurement, discomfort for experimental subjects are the main complications. Measurement and analysis of transient deformation response to pressure stress provides theoretically consistent and practically applicable methodology.Experiment: The transient deformation response of skin was measured in two groups consisting of 15 healthy men and 17 healthy women. The range of age interval was 20 to 58 years. The deformation response was measured as reaction of skin on sudden change of pressure stress between two levels of loading on skin surface.Results: Transient response of human skin consists of sum of two exponential curves. A \"rapid\" exponential curve has time constant typically of order 10 ms, while \"slow\" exponential curve has a time constant of order 0.1 to 1s. Both time constants increase with chronological age. Time for drop of deformation on 12.5% of full deformation proved to be a simple and sensitive criterion of skin aging, with strong correlation with chronological age. Main advantage of the method: Measurement is quantitative and reproducible. Procedure is easy to repeat. Its average duration is approx. 2 minutes and it does not represent any discomfort for test subjects.","PeriodicalId":89818,"journal":{"name":"Journal of the American Aging Association","volume":"25 3","pages":"115-7"},"PeriodicalIF":0.0,"publicationDate":"2002-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s11357-002-0009-9","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31374156","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 19

Long-lived Ames dwarf mice: Oxidative damage to mitochondrial DNA in heart and brain. 长寿的艾姆斯侏儒鼠:心脏和大脑线粒体DNA的氧化损伤。

Journal of the American Aging Association Pub Date : 2002-07-01 DOI: 10.1007/s11357-002-0010-3

Alberto Sanz, Andrzej Bartke, Gustavo Barja

{"title":"Long-lived Ames dwarf mice: Oxidative damage to mitochondrial DNA in heart and brain.","authors":"Alberto Sanz, Andrzej Bartke, Gustavo Barja","doi":"10.1007/s11357-002-0010-3","DOIUrl":"https://doi.org/10.1007/s11357-002-0010-3","url":null,"abstract":"The single gene mutation of Ames dwarf mice increases their maximum longevity by around 40% but the mechanism(s) responsible for this effect remain to be identified. This animal model thus offers a unique possibility of testing the mitochondrial theory of aging. In this investigation, oxidative damage to mitochondrial DNA (mtDNA) was measured for the first time in dwarf and wild type mice of both sexes. In the brain, 8-oxo,7,8-dihydro-2'-deoxyguanosine (8-oxodG) in mtDNA was significantly lower in dwarfs than in their controls both in males (by 32%) and in females (by 36%). The heart of male dwarfs also showed significantly lower mtDNA 8-oxodG levels (30% decrease) than the heart of male wild type mice, whereas no differences were found in the heart of females. The results, taken together, indicate that the single gene mutation of Ames dwarfs lowers oxidative damage to mtDNA especially in the brain, an organ of utmost relevance for aging. Together with the previous evidence for relatively lower level of oxidative damage to mtDNA in both long-lived and caloric restricted animals, these findings suggest that lowering of oxidative damage to mtDNA is a common mechanism of life extension in these three different mammalian models.","PeriodicalId":89818,"journal":{"name":"Journal of the American Aging Association","volume":"25 3","pages":"119-22"},"PeriodicalIF":0.0,"publicationDate":"2002-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s11357-002-0010-3","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31374157","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 41