JAK-STAT最新文献_第9页

Mutual cytokine crosstalk between colon cancer cells and microenvironment initiates development of distant metastases. 结肠癌细胞与微环境之间的相互细胞因子串扰启动远处转移的发展。

JAK-STAT Pub Date : 2013-04-01 DOI: 10.4161/jkst.23810

Petr Vaňhara, Karel Souček

引用次数: 7

Egr2 and Egr3 are the unique regulators for systemic autoimmunity. Egr2和Egr3是系统自身免疫的独特调节因子。

JAK-STAT Pub Date : 2013-04-01 DOI: 10.4161/jkst.23952

Shuji Sumitomo, Keishi Fujio, Tomohisa Okamura, Kazuhiko Yamamoto

引用次数: 21

Making milk: A new link between STAT5 and Akt1. 产奶：STAT5和Akt1之间的新联系。

JAK-STAT Pub Date : 2013-04-01 DOI: 10.4161/jkst.23228

Carrie H Oliver, Christine J Watson

{"title":"Making milk: A new link between STAT5 and Akt1.","authors":"Carrie H Oliver, Christine J Watson","doi":"10.4161/jkst.23228","DOIUrl":"10.4161/jkst.23228","url":null,"abstract":"The transcription factor STAT5A is essential for two processes during mammary gland development. First, it controls the development of luminal progenitor cells from stem cells(1) and second, it has a role during pregnancy where it is required for alveologenesis(2) (,) (3) the production of clusters of luminal cells that synthesize and secrete milk during lactation. Thus, deletion of STAT5A in late pregnancy results in lactation failure. Alveologenesis requires the proliferation of a different lineage of luminal epithelial cells in response to the pregnancy hormones progesterone and prolactin, the latter of which activates STAT5. Prolactin is required additionally during lactation to ensure adequate milk production and the transcription of several milk protein genes has been shown to be regulated by STAT5.(4) (,) (5) On the other hand, the PI3K/Akt pathway is essential for the synthesis of other milk components such as lipids and lactose.(6) In recent elegant work from Lewis Chodosh's laboratory, published in Genes and Development, these two pathways are now shown to be directly linked.(7) More specifically, it is shown that the PI3K/Akt pathway induces autocrine prolactin production and that this is required for the initiation of lactation. ","PeriodicalId":89791,"journal":{"name":"JAK-STAT","volume":"2 2","pages":"e23228"},"PeriodicalIF":0.0,"publicationDate":"2013-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/0a/31/jkst-2-e23228.PMC3710317.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31752417","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

JAK-STAT and feeding. JAK-STAT和喂食。

JAK-STAT Pub Date : 2013-04-01 DOI: 10.4161/jkst.23675

Sharon R Ladyman, David R Grattan

{"title":"JAK-STAT and feeding.","authors":"Sharon R Ladyman, David R Grattan","doi":"10.4161/jkst.23675","DOIUrl":"https://doi.org/10.4161/jkst.23675","url":null,"abstract":"The regulation of energy balance requires a complex system to homeostatically maintain the adult body at a precise set point. The central nervous system, particularly the hypothalamus, plays a key role in integrating a variety of signals that can relay information about the body's energy stores. As part of this system, numerous cytokines and hormones contribute to the regulation of food intake and energy homeostasis. Cytokines, and some hormones, are known to act through JAK-STAT intracellular signaling pathways. The hormone leptin, which plays a vital role in appetite regulation, signals through the JAK-STAT pathway, and it is through this involvement that the JAK-STAT pathway has become an established component in the mechanisms regulating food intake within the body. Emerging research, however, is now showing that this involvement of JAK-STAT is not limited to its activation by leptin. Furthermore, while the JAK-STAT pathway may simply act to transmit the anorectic signal of circulating factors, this intracellular signaling pathway may also become impaired when normal regulation of energy balance is disrupted. Thus, altered JAK-STAT signaling may contribute to the breakdown of the normal homeostatic mechanisms maintaining body weight in obesity. ","PeriodicalId":89791,"journal":{"name":"JAK-STAT","volume":"2 2","pages":"e23675"},"PeriodicalIF":0.0,"publicationDate":"2013-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4161/jkst.23675","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31752423","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 35

Anti-STAT6 CTL activity in Stat6 (-/-) mice: A cautionary tale. Stat6(-/-)小鼠抗Stat6 CTL活性:一个警世故事。

JAK-STAT Pub Date : 2013-04-01 DOI: 10.4161/jkst.24554

Mark H Kaplan, Judy K Cundiff, Jill Stader Smith, Carla J Aldrich

引用次数: 0

Mechanisms of chronic JAK-STAT3-SOCS3 signaling in obesity. 慢性JAK-STAT3-SOCS3信号在肥胖中的作用机制。

JAK-STAT Pub Date : 2013-04-01 DOI: 10.4161/jkst.23878

Claudia M Wunderlich, Nadine Hövelmeyer, F Thomas Wunderlich

引用次数: 138

Identification of STAT target genes in adipocytes. 脂肪细胞STAT靶基因的鉴定。

JAK-STAT Pub Date : 2013-04-01 DOI: 10.4161/jkst.23092

Peng Zhao, Jacqueline M Stephens

引用次数: 28

Changing partners at the dance: Variations in STAT concentrations for shaping cytokine function and immune responses to viral infections. 跳舞时改变舞伴:STAT浓度的变化对细胞因子功能的影响和对病毒感染的免疫反应。

JAK-STAT Pub Date : 2013-01-01 DOI: 10.4161/jkst.23504

Lara E Kallal, Christine A Biron

{"title":"Changing partners at the dance: Variations in STAT concentrations for shaping cytokine function and immune responses to viral infections.","authors":"Lara E Kallal, Christine A Biron","doi":"10.4161/jkst.23504","DOIUrl":"https://doi.org/10.4161/jkst.23504","url":null,"abstract":"Differential use of cellular and molecular components shapes immune responses, but understanding of how these are regulated to promote defense and health during infections is still incomplete. Examples include signaling from members of the Janus activated kinase-signal transducer and activator of transcription (JAK-STAT) cytokine family. Following receptor stimulation, individual JAK-STAT cytokines have preferences for particular key STAT molecules to lead to specific cellular responses. Certain of these cytokines, however, can conditionally activate alternative STATs as well as elicit pleiotropic and paradoxical effects. Studies examining basal and infection conditions are revealing intrinsic and induced cellular differences in various intracellular STAT concentrations to control the biological consequences of cytokine exposure. The system can be likened to changing partners at a dance based on competition and relative availability, and sets a framework for understanding the particular conditions promoting subset biological functions of cytokines as needed during evolving immune responses to infections. ","PeriodicalId":89791,"journal":{"name":"JAK-STAT","volume":"2 1","pages":"e23504"},"PeriodicalIF":0.0,"publicationDate":"2013-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4161/jkst.23504","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31751450","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 9

Circulating miRNAs as new activators of the JAK-STAT3 pathway. 循环mirna作为JAK-STAT3通路的新激活因子。

JAK-STAT Pub Date : 2013-01-01 DOI: 10.4161/jkst.22996

David Lam, Benjamin Barré, Catherine Guette, Olivier Coqueret

引用次数: 4

The role of JAK-STAT signaling within the CNS. JAK-STAT信号在中枢神经系统中的作用。

JAK-STAT Pub Date : 2013-01-01 DOI: 10.4161/jkst.22925

Celine S Nicolas, Mascia Amici, Zuner A Bortolotto, Andrew Doherty, Zsolt Csaba, Assia Fafouri, Pascal Dournaud, Pierre Gressens, Graham L Collingridge, Stephane Peineau

引用次数: 0