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Redox regulation of Janus kinase: The elephant in the room. Janus激酶的氧化还原调控:房间里的大象。
JAK-STAT Pub Date : 2013-10-01 Epub Date: 2013-08-19 DOI: 10.4161/jkst.26141
Roy J Duhé
{"title":"Redox regulation of Janus kinase: The elephant in the room.","authors":"Roy J Duhé","doi":"10.4161/jkst.26141","DOIUrl":"https://doi.org/10.4161/jkst.26141","url":null,"abstract":"<p><p>The redox regulation of Janus kinases (JAKs) is a complex subject. Due to other redox-sensitive kinases in the kinome, redox-sensitive phosphatases, and cellular antioxidant systems and reactive oxygen species (ROS) production systems, the net biological outcomes of oxidative stress on JAK-dependent signal transduction vary according to the specific biological system examined. This review begins with a discussion of the biochemical evidence for a cysteine-based redox switch in the catalytic domain of JAKs, proceeds to consider direct and indirect regulatory mechanisms involved in biological experiments, and ends with a discussion of the role(s) of redox regulation of JAKs in various diseases. </p>","PeriodicalId":89791,"journal":{"name":"JAK-STAT","volume":"2 4","pages":"e26141"},"PeriodicalIF":0.0,"publicationDate":"2013-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4161/jkst.26141","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32023646","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 16
SOCS3: An essential physiological inhibitor of signaling by interleukin-6 and G-CSF family cytokines. SOCS3:白细胞介素-6和G-CSF家族细胞因子信号传导的重要生理抑制剂。
JAK-STAT Pub Date : 2013-10-01 Epub Date: 2013-06-11 DOI: 10.4161/jkst.25045
Christine A White, Nicos A Nicola
{"title":"SOCS3: An essential physiological inhibitor of signaling by interleukin-6 and G-CSF family cytokines.","authors":"Christine A White,&nbsp;Nicos A Nicola","doi":"10.4161/jkst.25045","DOIUrl":"https://doi.org/10.4161/jkst.25045","url":null,"abstract":"<p><p>SOCS3 is an inducible negative feedback inhibitor of cytokine signaling. Conditional deletion of SOCS3 in mice using the Cre-lox system has now been applied to a range of cell types in the steady-state and under inflammatory, pathogenic, or tumorigenic stress, with the resulting phenotypes demonstrating the effects of SOCS3 in physiological and disease contexts. Together with recent structural and biochemical studies on the mechanisms of SOCS3 binding to cytokine receptors and associated kinases, we now have a better understanding of the non-redundant roles of SOCS3 in the inhibition of cytokine signaling via the receptors gp130, G-CSFR, leptinR, and IL-12Rβ. This review discusses the known functional activities of SOCS3 in fertility and development, inflammation, innate and adaptive immunity, and malignancy as determined by genetic studies in mice. </p>","PeriodicalId":89791,"journal":{"name":"JAK-STAT","volume":"2 4","pages":"e25045"},"PeriodicalIF":0.0,"publicationDate":"2013-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4161/jkst.25045","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32022103","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 39
Diversification of dendritic cell subsets: Emerging roles for STAT proteins. 树突状细胞亚群的多样化:STAT蛋白的新角色。
JAK-STAT Pub Date : 2013-10-01 Epub Date: 2013-05-21 DOI: 10.4161/jkst.25112
Haiyan S Li, Stephanie S Watowich
{"title":"Diversification of dendritic cell subsets: Emerging roles for STAT proteins.","authors":"Haiyan S Li,&nbsp;Stephanie S Watowich","doi":"10.4161/jkst.25112","DOIUrl":"https://doi.org/10.4161/jkst.25112","url":null,"abstract":"<p><p>The term dendritic cell (DC) refers to a population of hematopoietic cells with critical roles in immunity, including immune activation in response to pathogen-elicited danger signals and immune tolerance. Aberrant DC activity is an important contributing factor in autoimmunity, while severe DC depletion accompanies certain immunodeficiency conditions. By contrast, DCs have become attractive candidates to manipulate in immune therapy. Recent studies show that STAT transcription factors have unique roles in DCs, a feature that might be exploited in future DC-based therapies. Here, we focus on the functions of STAT1, STAT3, and STAT5 in DC generation and DC-mediated immune responses. </p>","PeriodicalId":89791,"journal":{"name":"JAK-STAT","volume":"2 4","pages":"e25112"},"PeriodicalIF":0.0,"publicationDate":"2013-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4161/jkst.25112","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32022105","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 10
LIF-STAT signaling and trophoblast biology. liff - stat信号传导与滋养细胞生物学。
JAK-STAT Pub Date : 2013-10-01 Epub Date: 2013-06-27 DOI: 10.4161/jkst.25155
Pankaj Suman, Sudha Saryu Malhotra, Satish Kumar Gupta
{"title":"LIF-STAT signaling and trophoblast biology.","authors":"Pankaj Suman,&nbsp;Sudha Saryu Malhotra,&nbsp;Satish Kumar Gupta","doi":"10.4161/jkst.25155","DOIUrl":"https://doi.org/10.4161/jkst.25155","url":null,"abstract":"<p><p>Leukemia inhibitory factor (LIF) is a pleiotropic growth factor that regulates several biological functions. This review focuses on the LIF-dependent STAT activation and its impact on modulation of trophoblast functions during embryo implantation. LIF is mainly produced by the maternal endometrium at the time of implantation while its receptors are present both on the endometrium and trophoblasts. It might influence blastocyst attachment through STAT3 activation and expression of integrins. After attachment of the blastocyst, trophoblasts undergo proliferation and differentiation into invasive EVTs and non-invasive STBs. Under in vitro conditions, LIF regulates all these processes through activation of STAT- and MAPK-dependent signaling pathways. The observations that LIF and STAT3 knockout mice are infertile further strengthen the notion about the critical involvement of LIF-mediated signaling during embryo implantation. Hence, a better understanding of LIF-STAT signaling would help in improving fertility as use of LIF in in vitro blastocyst culture improves the implanting ability of blastocyst after IVF. </p>","PeriodicalId":89791,"journal":{"name":"JAK-STAT","volume":"2 4","pages":"e25155"},"PeriodicalIF":0.0,"publicationDate":"2013-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4161/jkst.25155","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32022106","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 65
Engaged for survival: From cadherin ligation to STAT3 activation. 参与生存:从钙粘蛋白连接到STAT3激活。
JAK-STAT Pub Date : 2013-10-01 Epub Date: 2013-12-06 DOI: 10.4161/jkst.27363
Mulu Geletu, Stephanie Guy, Rozanne Arulanandam, Hélène Feracci, Leda Raptis
{"title":"Engaged for survival: From cadherin ligation to STAT3 activation.","authors":"Mulu Geletu,&nbsp;Stephanie Guy,&nbsp;Rozanne Arulanandam,&nbsp;Hélène Feracci,&nbsp;Leda Raptis","doi":"10.4161/jkst.27363","DOIUrl":"https://doi.org/10.4161/jkst.27363","url":null,"abstract":"<p><p>In normal tissues or tumors, cells have extensive opportunities for adhesion to their neighbors. This state is mimicked by dense cell cultures. In this review, we integrate some recent findings on a key signal transducer, STAT3 (signal transducer and activator of transcription-3), whose activity is dramatically increased following cadherin-mediated cell to cell adhesion. Cadherin engagement, favored in dense cell cultures, causes a dramatic increase in total Rac/Cdc42 protein levels through inhibition of proteasomal degradation, which is followed by activation of IL-6 and STAT3. The cadherin/Rac/IL-6/STAT3 axis offers a potent survival signal that is a prerequisite for neoplastic transformation, as well as normal tissue function. </p>","PeriodicalId":89791,"journal":{"name":"JAK-STAT","volume":"2 4","pages":"e27363"},"PeriodicalIF":0.0,"publicationDate":"2013-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4161/jkst.27363","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32067676","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 21
STAT2 and IRF9: Beyond ISGF3. STAT2和IRF9:超越ISGF3。
JAK-STAT Pub Date : 2013-10-01 Epub Date: 2013-12-18 DOI: 10.4161/jkst.27521
Karin Fink, Nathalie Grandvaux
{"title":"STAT2 and IRF9: Beyond ISGF3.","authors":"Karin Fink,&nbsp;Nathalie Grandvaux","doi":"10.4161/jkst.27521","DOIUrl":"https://doi.org/10.4161/jkst.27521","url":null,"abstract":"<p><p>Cytokine signaling is mediated by the combinatorial usage of seven STAT proteins that form homo- or heterodimers involved in the regulation of specific transcriptional programs. Among STATs, STAT2 is classically known to dimerize with STAT1 and together with IRF9 forms the ISGF3 transcription factor complex that has long been considered a hallmark of activation by type I and type III interferons. However, accumulating evidence reveal distinct facets of STAT2 and IRF9 activity mediated by the segregation in alternative STAT1-independent complexes/pathways that are thought to trigger different transcriptional programs. The goal of this review is to summarize our current knowledge of the stimuli, regulatory mechanisms, and function of these alternative pathways. </p>","PeriodicalId":89791,"journal":{"name":"JAK-STAT","volume":"2 4","pages":"e27521"},"PeriodicalIF":0.0,"publicationDate":"2013-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4161/jkst.27521","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32093032","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 112
Genomic and computational approaches to dissect the mechanisms of STAT3's universal and cell type-specific functions. 基因组学和计算方法剖析STAT3的普遍和细胞类型特异性功能的机制。
JAK-STAT Pub Date : 2013-10-01 Epub Date: 2013-05-20 DOI: 10.4161/jkst.25097
Andrew Paul Hutchins, Diego Diez, Diego Miranda-Saavedra
{"title":"Genomic and computational approaches to dissect the mechanisms of STAT3's universal and cell type-specific functions.","authors":"Andrew Paul Hutchins,&nbsp;Diego Diez,&nbsp;Diego Miranda-Saavedra","doi":"10.4161/jkst.25097","DOIUrl":"https://doi.org/10.4161/jkst.25097","url":null,"abstract":"<p><p>STAT3 is the quintessential pleiotropic transcription factor with many biological roles throughout development as well as in multiple adult tissues. Its functional heterogeneity is encoded in the range of genome-wide binding patterns that specify different regulatory networks in distinct cell types. However, STAT3 does not display remarkable DNA binding preferences that may help correlate specific motifs with individual biological functions or cell types. Therefore, achieving a detailed understanding of the regulatory mechanisms that endow STAT3 (or any other pleiotropic transcription factor) with such a rainbow of functions is not only a central problem in biology but also a fiendishly difficult one. Here we describe key genomic and computational approaches that have shed light into this question, and present the two current models of STAT3 binding (universal and cell type-specific). We also discuss the role that the local epigenetic environment plays in the selection of STAT3 binding sites. </p>","PeriodicalId":89791,"journal":{"name":"JAK-STAT","volume":"2 4","pages":"e25097"},"PeriodicalIF":0.0,"publicationDate":"2013-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4161/jkst.25097","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32022104","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 28
Signal transducer and activator of transcription 3 (STAT3) signaling in retinal pigment epithelium cells. 视网膜色素上皮细胞中转录3 (STAT3)信号转导和激活因子。
JAK-STAT Pub Date : 2013-10-01 Epub Date: 2013-06-17 DOI: 10.4161/jkst.25434
Amit K Patel, Sarah Syeda, Abigail S Hackam
{"title":"Signal transducer and activator of transcription 3 (STAT3) signaling in retinal pigment epithelium cells.","authors":"Amit K Patel,&nbsp;Sarah Syeda,&nbsp;Abigail S Hackam","doi":"10.4161/jkst.25434","DOIUrl":"https://doi.org/10.4161/jkst.25434","url":null,"abstract":"<p><p>The retinal pigmented epithelium (RPE) is a monolayer of specialized epithelial cells located between the photoreceptors of the retina and the choroidal blood supply. The RPE is essential for maintaining retinal health and vision. Recent findings identified STAT3 as a newly recognized regulator of RPE survival, inflammatory response, visual cycle maintenance, and cytokine release. Additionally, STAT3 is implicated in retinal diseases that affect the RPE, including the common blinding disease age-related macular degeneration. Determining how STAT3 influences RPE functions ultimately may lead to novel therapeutics for retinal disease. In this review, we summarize the roles of JAK-STAT3 signaling in the RPE, and its potential contribution to retinal degenerations. </p>","PeriodicalId":89791,"journal":{"name":"JAK-STAT","volume":"2 4","pages":"e25434"},"PeriodicalIF":0.0,"publicationDate":"2013-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4161/jkst.25434","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32022108","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 14
JAK-STAT in lipid metabolism of adipocytes. JAK-STAT在脂肪细胞脂质代谢中的作用。
JAK-STAT Pub Date : 2013-10-01 Epub Date: 2013-12-06 DOI: 10.4161/jkst.27203
Dong Xu, Chunyan Yin, Sisi Wang, Yanfeng Xiao
{"title":"JAK-STAT in lipid metabolism of adipocytes.","authors":"Dong Xu,&nbsp;Chunyan Yin,&nbsp;Sisi Wang,&nbsp;Yanfeng Xiao","doi":"10.4161/jkst.27203","DOIUrl":"https://doi.org/10.4161/jkst.27203","url":null,"abstract":"<p><p>JAK-STAT signaling pathway plays an important role in the cells' development and homeostasis. Over the past decades, the studies have identified the role of the JAK-STAT pathway in cell proliferation and apoptosis. Here, we want to discuss that whether and how the JAK-STAT pathway affects the lipid metabolism of adipose tissue. A host of cytokines and hormones can regulate lipid metabolism through activating the JAK-STAT signaling pathway. Activated STATs can regulate lipid metabolism directly by influencing the expression of enzymes. We have summarized the relevant research and articles of JAK-STAT during the recent years. Within this review, we will introduce you the recent research and highlight the unresolved problems in understanding how JAK-STAT signaling pathway contribute to the lipid metabolism in mature adipocytes and preadipocytes. Dysregulation of the JAK-STAT pathway would lead to a multiple metabolism disorders and medicines for this signaling pathway maybe become a new idea for diseases such as metabolic syndrome, especially in children. </p>","PeriodicalId":89791,"journal":{"name":"JAK-STAT","volume":"2 4","pages":"e27203"},"PeriodicalIF":0.0,"publicationDate":"2013-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4161/jkst.27203","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32093031","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 52
IL-4, JAK-STAT signaling, and pain. IL-4, JAK-STAT信号和疼痛。
JAK-STAT Pub Date : 2013-10-01 Epub Date: 2014-01-02 DOI: 10.4161/jkst.27638
Melanie Busch-Dienstfertig, Sara González-Rodríguez
{"title":"IL-4, JAK-STAT signaling, and pain.","authors":"Melanie Busch-Dienstfertig,&nbsp;Sara González-Rodríguez","doi":"10.4161/jkst.27638","DOIUrl":"https://doi.org/10.4161/jkst.27638","url":null,"abstract":"<p><p>During inflammation, several mediators directly or indirectly induce pain including pro-inflammatory cytokines and there is evidence that the JAK-STAT pathway is involved in the formation of pronociceptive cytokines. The same pathway, however, is also of importance for anti-inflammatory cytokines such as IL-4 to counteract the inflammatory reaction and-as it seems based on the current literature-nociceptive symptoms. Current therapeutic approaches targeting molecules of the JAK-STAT signaling cascade are auspicious but as this review demonstrates, more experimental and clinical studies are required to decipher the specific contribution of this pathway in the modulation of pain. </p>","PeriodicalId":89791,"journal":{"name":"JAK-STAT","volume":"2 4","pages":"e27638"},"PeriodicalIF":0.0,"publicationDate":"2013-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4161/jkst.27638","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32067677","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 59
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