{"title":"Targeting the immune system for management of NSCLC: the revival?","authors":"M. Reck, J. Vansteenkiste, J. Brahmer","doi":"10.1007/s13665-012-0038-5","DOIUrl":"https://doi.org/10.1007/s13665-012-0038-5","url":null,"abstract":"","PeriodicalId":89672,"journal":{"name":"Current respiratory care reports","volume":"2 1","pages":"22-39"},"PeriodicalIF":0.0,"publicationDate":"2013-01-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s13665-012-0038-5","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"53271768","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Medical thoracoscopy","authors":"C. Daneshvar, D. Breen","doi":"10.1007/s13665-012-0037-6","DOIUrl":"https://doi.org/10.1007/s13665-012-0037-6","url":null,"abstract":"","PeriodicalId":89672,"journal":{"name":"Current respiratory care reports","volume":"2 1","pages":"47-53"},"PeriodicalIF":0.0,"publicationDate":"2013-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s13665-012-0037-6","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"53271660","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Bradley E Chipps, Robert S Zeiger, Alejandro Dorenbaum, Larry Borish, Sally E Wenzel, Dave P Miller, Mary Lou Hayden, Eugene R Bleecker, F Estelle R Simons, Stanley J Szefler, Scott T Weiss, Tmirah Haselkorn
{"title":"Assessment of asthma control and asthma exacerbations in the epidemiology and natural history of asthma: outcomes and treatment regimens (TENOR) observational cohort.","authors":"Bradley E Chipps, Robert S Zeiger, Alejandro Dorenbaum, Larry Borish, Sally E Wenzel, Dave P Miller, Mary Lou Hayden, Eugene R Bleecker, F Estelle R Simons, Stanley J Szefler, Scott T Weiss, Tmirah Haselkorn","doi":"10.1007/s13665-012-0025-x","DOIUrl":"10.1007/s13665-012-0025-x","url":null,"abstract":"<p><p>Patients with severe or difficult-to-treat asthma account for substantial asthma morbidity, mortality, and healthcare burden despite comprising only a small proportion of the total asthma population. TENOR, a multicenter, observational, prospective cohort study was initiated in 2001. It enrolled 4,756 adults, adolescents and children with severe or difficult-to-treat asthma who were followed semi-annually and annually for three years, enabling insight to be gained into this understudied population. A broad range of demographic, clinical, and patient self-reported assessments were completed during the follow-up period. Here, we present key findings from the TENOR registry in relation to asthma control and exacerbations, including the identification of specific subgroups found to be at particularly high-risk. Identification of the factors and subgroups associated with poor asthma control and increased risk of exacerbations can help physicians design individual asthma management, and improve asthma-related health outcomes for these patients.</p>","PeriodicalId":89672,"journal":{"name":"Current respiratory care reports","volume":"1 4","pages":"259-269"},"PeriodicalIF":0.0,"publicationDate":"2012-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3485530/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31035766","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ronina A Covar, Anne L Fuhlbrigge, Paul Williams, H William Kelly
{"title":"The Childhood Asthma Management Program (CAMP): Contributions to the Understanding of Therapy and the Natural History of Childhood Asthma.","authors":"Ronina A Covar, Anne L Fuhlbrigge, Paul Williams, H William Kelly","doi":"10.1007/s13665-012-0026-9","DOIUrl":"https://doi.org/10.1007/s13665-012-0026-9","url":null,"abstract":"<p><p>The Childhood Asthma Management Program (CAMP) has been in continuous existence for almost two decades, which makes it the largest randomized, placebo-controlled clinical trial with extended follow-up for children with mild to moderate asthma. As such, its cumulative data from baseline, active treatment, and post-treatment have proved to be an invaluable resource for not only assessing the efficacy and safety of long-term inhaled corticosteroid therapy in childhood, but for discovery of many other aspects of childhood asthma, including genetics and biomarkers.</p>","PeriodicalId":89672,"journal":{"name":"Current respiratory care reports","volume":"1 4","pages":"243-250"},"PeriodicalIF":0.0,"publicationDate":"2012-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s13665-012-0026-9","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31176281","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Non-pharmacological treatment of idiopathic pulmonary fibrosis","authors":"H. Adamali, Muhammad Anwar, A. Russell, J. Egan","doi":"10.1007/s13665-012-0031-z","DOIUrl":"https://doi.org/10.1007/s13665-012-0031-z","url":null,"abstract":"","PeriodicalId":89672,"journal":{"name":"Current respiratory care reports","volume":"1 1","pages":"208-215"},"PeriodicalIF":0.0,"publicationDate":"2012-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s13665-012-0031-z","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"53271613","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
F. Luppi, P. Spagnolo, S. Cerri, G. Sgalla, L. Richeldi
{"title":"Clinical trials in idiopathic pulmonary fibrosis: where we have been and where we are going","authors":"F. Luppi, P. Spagnolo, S. Cerri, G. Sgalla, L. Richeldi","doi":"10.1007/s13665-012-0030-0","DOIUrl":"https://doi.org/10.1007/s13665-012-0030-0","url":null,"abstract":"","PeriodicalId":89672,"journal":{"name":"Current respiratory care reports","volume":"38 1","pages":"216-223"},"PeriodicalIF":0.0,"publicationDate":"2012-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s13665-012-0030-0","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"53271553","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Connective Tissue Disease-associated Interstitial Lung Disease: A review.","authors":"Markus Gutsche, Glenn D Rosen, Jeffrey J Swigris","doi":"10.1007/s13665-012-0028-7","DOIUrl":"https://doi.org/10.1007/s13665-012-0028-7","url":null,"abstract":"<p><p>Interstitial lung disease (ILD) is commonly encountered in patients with connective tissue diseases (CTD). Besides the lung parenchyma, the airways, pulmonary vasculature and structures of the chest wall may all be involved, depending on the type of CTD. As a result of this so-called multi-compartment involvement, airflow limitation, pulmonary hypertension, vasculitis and extrapulmonary restriction can occur alongside fibro-inflammatory parenchymal abnormalities in CTD. Rheumatoid arthritis (RA), systemic sclerosis (SSc), poly-/dermatomyositis (PM/DM), Sjögren's syndrome (SjS), systemic lupus erythematosus (SLE), and undifferentiated (UCTD) as well as mixed connective tissue disease (MCTD) can all be associated with the development of ILD. Non-specific interstitial pneumonia (NSIP) is the most commonly observed histopathological pattern in CTD-ILD, but other patterns including usual interstitial pneumonia (UIP), organizing pneumonia (OP), diffuse alveolar damage (DAD) and lymphocytic interstitial pneumonia (LIP) may occur. Although the majority of patients with CTD-ILD experience stable or slowly advancing ILD, a small yet significant group exhibits a more severe and progressive course. Randomized placebo-controlled trials evaluating the efficacy of immunomodulatory treatments have been conducted only in SSc-associated ILD. However, clinical experience suggests that a handful of immunosuppressive medications are potentially effective in a sizeable portion of patients with ILD caused by other CTDs. In this manuscript, we review the clinical characteristics and management of the most common CTD-ILDs.</p>","PeriodicalId":89672,"journal":{"name":"Current respiratory care reports","volume":"1 ","pages":"224-232"},"PeriodicalIF":0.0,"publicationDate":"2012-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s13665-012-0028-7","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31025769","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Asthma clinical trials of American Lung Association/Asthma Clinical Research Centers (ALA-ACRC): what have we learned in 12 years?","authors":"K. Sumino, J. Holbrook, R. Wise, L. Rogers","doi":"10.1007/s13665-012-0024-y","DOIUrl":"https://doi.org/10.1007/s13665-012-0024-y","url":null,"abstract":"","PeriodicalId":89672,"journal":{"name":"Current respiratory care reports","volume":"76 1","pages":"251-258"},"PeriodicalIF":0.0,"publicationDate":"2012-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s13665-012-0024-y","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"53271402","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Diagnostic approach to interstitial lung disease","authors":"A. Gogali, A. Wells","doi":"10.1007/s13665-012-0029-6","DOIUrl":"https://doi.org/10.1007/s13665-012-0029-6","url":null,"abstract":"","PeriodicalId":89672,"journal":{"name":"Current respiratory care reports","volume":"1 1","pages":"199-207"},"PeriodicalIF":0.0,"publicationDate":"2012-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s13665-012-0029-6","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"53271479","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}