The Open autoimmunity journal最新文献_第2页

Editorial- Dual and Opposite Actions of Cytokines in Autoimmune Inflammatory Demyelination 编辑-细胞因子在自身免疫性炎症性脱髓鞘中的双重和相反作用

The Open autoimmunity journal Pub Date : 2010-07-14 DOI: 10.2174/1876894601002040139

B. Gran, B. Becher

{"title":"Editorial- Dual and Opposite Actions of Cytokines in Autoimmune Inflammatory Demyelination","authors":"B. Gran, B. Becher","doi":"10.2174/1876894601002040139","DOIUrl":"https://doi.org/10.2174/1876894601002040139","url":null,"abstract":"The biological actions of cytokines in the immune system and specifically in autommunity have been carefully studied in the last few decades [1], in particular after Mosmann and Coffman observed that certain T helper cell populations could be categorised based on the cytokines they produce [2]. It was perhaps inevitable that progress in our knowledge of cytokine biology would generate simplified paradigms that have been challenged and refined over time. In the early stages of the definition of Th1 and Th2 cells, it was readily acknowledged by Mosmann and Coffman that “Further divisions of helper T cells may have to be recognized before a complete picture of helper T-cell function can be obtained” [3] and this is indeed what happened when Th3 [4] and more recently Th17 [5-7], Th9 [8, 9], and Th22 [10] subsets were recognised. While Th1, Th2 and regulatory T cells display a high degree of stability and can even enter the pool of memory cells, Th17 and other newly described populations appear to not truly represent a stable committed lineage. It now appears most likely that significant plasticity in T cell function enables them to produce even more varied combinations of cytokines that are “customised” to the systemic and local requirement of the immune system [11, 12].","PeriodicalId":89633,"journal":{"name":"The Open autoimmunity journal","volume":"2 1","pages":"139-140"},"PeriodicalIF":0.0,"publicationDate":"2010-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68151650","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

IL-22 vs. IL-22: The Tissue Matters~!2009-08-25~!2009-11-04~!2010-07-14~! IL-22与IL-22:组织关系

The Open autoimmunity journal Pub Date : 2010-07-14 DOI: 10.2174/1876894601002040181

Katharina Kreymborg

引用次数: 10

Diverse and Opposing Roles of IL-27 in Immunity~!2009-11-04~!2009-12-16~!2010-07-14~! IL-27在免疫中的不同和对立作用2009-11-04 2009-12-16 2010-07-14

The Open autoimmunity journal Pub Date : 2010-07-14 DOI: 10.2174/1876894601002040187

Zoe Fonseca-Kelly

引用次数: 4

IL-17A in Autoimmune Inflammation of the Central Nervous System: A Promising Therapeutic Target in Multiple Sclerosis?~!2009-09-21~!2009-10-28~!2010-07-14~! 中枢神经系统自身免疫性炎症中的IL-17A:多发性硬化症的一个有希望的治疗靶点

The Open autoimmunity journal Pub Date : 2010-07-14 DOI: 10.2174/1876894601002040171

B. Ciric

{"title":"IL-17A in Autoimmune Inflammation of the Central Nervous System: A Promising Therapeutic Target in Multiple Sclerosis?~!2009-09-21~!2009-10-28~!2010-07-14~!","authors":"B. Ciric","doi":"10.2174/1876894601002040171","DOIUrl":"https://doi.org/10.2174/1876894601002040171","url":null,"abstract":"Discovery of the IL-23/Th17 axis brought to an end the era of the Th1/Th2 paradigm and radically advanced our understanding of autoimmunity. Experimental autoimmune encephalitis (EAE), an animal model of multiple sclerosis (MS), was highly instrumental in discovery of the IL-23/Th17 axis and the ensuing rapid progress in the field. Despite an early start and subsequent intense focus on the role of this axis in EAE and MS, some basic questions remained controver- sial, such as the role of IL-17A, a signature cytokine of Th17 lineage. Copious production of IL-17A combined with its pro-inflammatory effects offered a plausible explanation for the pronounced encephalitogenicity of Th17 cells. A body of experimental data from a number of laboratories demonstrated its important, if not essential, role in EAE, thus pointing to this cytokine as a promising therapeutic target in MS. Findings that MS lesions contain high percentages of Th17 and Tc17 cells and large quantities of IL-17A, similar to EAE, further supported this view. Unexpectedly, two recent findings raised doubts that IL-17A should still be considered an attractive target in MS: contradictory to previous findings, both overexpression and genetic deficiency or neutralization of IL-17A had no significant effect in EAE; in a clinical trial, treatment with anti-IL-12/23p40 antibody did not have a beneficial effect in MS, which came as a surprise since analo- gous approaches efficaciously suppressed EAE. Here we review findings about the role of IL-17A in EAE, with an em- phasis on its potential as a therapeutic target in MS.","PeriodicalId":89633,"journal":{"name":"The Open autoimmunity journal","volume":"2 1","pages":"171-180"},"PeriodicalIF":0.0,"publicationDate":"2010-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68151746","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

A Paradoxical Effect of Systemic IL-23 in EAE – Limitation of Autoimmune Inflammatory Demyelination 系统性IL-23在EAE中的矛盾作用——自身免疫性炎症脱髓鞘的局限性

The Open autoimmunity journal Pub Date : 2010-07-14 DOI: 10.2174/1876894601002040141

T. Touil, N. Chu, U. Bohlmann, P. Bargsten, L. Yonghai, D. Fitzgerald, Guang-Xian Zhang, B. Becher, A. Rostami, B. Gran

引用次数: 1

Antiphospholipid Antibodies and Autoimmune Diseases~!2009-10-09~!2009-10-22~!2010-03-11~! 抗磷脂抗体与自身免疫性疾病~!

The Open autoimmunity journal Pub Date : 2010-03-17 DOI: 10.2174/1876894601002020038

G. Remondino, A. Allievi

引用次数: 1

Clinical Management of Antiphospholipid Syndrome-Related Thrombosis~!2009-09-14~!2009-09-17~!2010-03-11~! 抗磷脂综合征相关血栓形成的临床处理2009-09-14 2009-09-17 2010-03-11

The Open autoimmunity journal Pub Date : 2010-03-17 DOI: 10.2174/1876894601002020067

G. Espinosa, R. Cervera

引用次数: 1

Critical Update of the Antiphospholipid Syndrome Criteria~!2009-10-17~!2009-10-20~!2010-03-11~! 抗磷脂综合征标准的重要更新2009-10-17 2009-10-20 2010-03-11

The Open autoimmunity journal Pub Date : 2010-03-17 DOI: 10.2174/1876894601002020018

V. Pengo, A. Ruffatti

引用次数: 4

Antigen Specificity of Antiphospholipid Syndrome-Related Antiphospholipid Antibodies~!2009-09-28~!2009-11-02~!2010-03-11~! 抗磷脂综合征相关抗磷脂抗体抗原特异性研究

The Open autoimmunity journal Pub Date : 2010-03-11 DOI: 10.2174/1876894601002020021

R. Forastiero

{"title":"Antigen Specificity of Antiphospholipid Syndrome-Related Antiphospholipid Antibodies~!2009-09-28~!2009-11-02~!2010-03-11~!","authors":"R. Forastiero","doi":"10.2174/1876894601002020021","DOIUrl":"https://doi.org/10.2174/1876894601002020021","url":null,"abstract":"The antiphospholipid syndrome (APS) is an autoimmune disorder characterized by the presence of antiphos- pholipid antibodies (aPL) and clinically by vascular thrombosis and/or recurrent pregnancy morbidity. The APS- associated aPL are mostly directed against � 2-glycoprotein I (� 2GPI) and prothrombin. In contrast, aPL linked to infec- tious disorders are primarily directed against phospholipids and do not tend to be associated with the clinical manifesta- tions of APS. This distinction, however, was later found not to be absolute. Patients with lepromatous leprosy have a high prevalence of true antibodies to � 2GPI, but they do not develop thromboembolic complications. Current evidence suggests that autoantibodies to � 2GPI from APS patients preferentially bind to critical epitopes in domain I of � 2GP1, and leprosy- related aPL recognizing � 2GPI tend to be directed against domain V. The position of the epitope in the � 2GPI molecule seems to be crucial in defining the pathogenicity of aPL. In addition, an increasing number of other phospholipids-binding proteins with central functions in the regulation of blood coagulation and fibrinolysis are also targeted by APS-related autoantibodies. This review intends to highlight the diverse antigen specificity of aPL and likely further studies would help to understand the different clinical behavior of patients with APS and infections-related aPL.","PeriodicalId":89633,"journal":{"name":"The Open autoimmunity journal","volume":"2 1","pages":"21-27"},"PeriodicalIF":0.0,"publicationDate":"2010-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68151437","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

A Comprehensive Review of Thrombogenic Mechanisms in APS~!2009-10-13~!2009-10-19~!2010-03-11~! APS血栓形成机制综述2009-10-13 2009-10-19 2010-03-11

The Open autoimmunity journal Pub Date : 2010-03-11 DOI: 10.2174/1876894601002020058

Renan A Aguilar-valenzuela, L. Martínez-Martínez, S. Pierangeli

引用次数: 4