Pathobiology of aging & age related diseases最新文献_第5页

Investigation and identification of etiologies involved in the development of acquired hydronephrosis in aged laboratory mice with the use of high-frequency ultrasound imaging. 利用高频超声波成像技术研究和确定老年实验鼠后天性肾积水的病因。

Pathobiology of aging & age related diseases Pub Date : 2014-08-01 eCollection Date: 2014-01-01 DOI: 10.3402/pba.v4.24932

Danielle A Springer, Michele Allen, Victoria Hoffman, Lauren Brinster, Matthew F Starost, Mark Bryant, Michael Eckhaus

{"title":"Investigation and identification of etiologies involved in the development of acquired hydronephrosis in aged laboratory mice with the use of high-frequency ultrasound imaging.","authors":"Danielle A Springer, Michele Allen, Victoria Hoffman, Lauren Brinster, Matthew F Starost, Mark Bryant, Michael Eckhaus","doi":"10.3402/pba.v4.24932","DOIUrl":"10.3402/pba.v4.24932","url":null,"abstract":"Laboratory mice develop naturally occurring lesions that affect biomedical research. Hydronephrosis is a recognized pathologic abnormality of the mouse kidney. Acquired hydronephrosis can affect any mouse, as it is caused by any naturally occurring disease that impairs free urine flow. Many etiologies leading to this condition are of particular significance to aging mice. Non-invasive ultrasound imaging detects renal pelvic dilation, renal enlargement, and parenchymal loss for pre-mortem identification of this condition. High-frequency ultrasound transducers produce high-resolution images of small structures, ideal for detecting organ pathology in mice. Using a 40 MHz linear array transducer, we obtained high-resolution images of a diversity of pathologic lesions occurring within the abdomen of seven geriatric mice with acquired hydronephrosis that enabled a determination of the underlying etiology. Etiologies diagnosed from the imaging results include pyelonephritis, neoplasia, urolithiasis, mouse urologic syndrome, and spontaneous hydronephrosis, and were confirmed at necropsy. A retrospective review of abdominal scans from an additional 149 aging mice shows that the most common etiologies associated with acquired hydronephrosis are mouse urologic syndrome and abdominal neoplasia. This report highlights the utility of high-frequency ultrasound for surveying research mice for age-related pathology, and is the first comprehensive report of multiple cases of acquired hydronephrosis in mice. ","PeriodicalId":89611,"journal":{"name":"Pathobiology of aging & age related diseases","volume":"4 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2014-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/7f/0f/PBA-4-24932.PMC4119937.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32602970","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The quality control theory of aging. 老化质量控制理论。

Pathobiology of aging & age related diseases Pub Date : 2014-05-23 eCollection Date: 2014-01-01 DOI: 10.3402/pba.v4.24835

Warren Ladiges

{"title":"The quality control theory of aging.","authors":"Warren Ladiges","doi":"10.3402/pba.v4.24835","DOIUrl":"https://doi.org/10.3402/pba.v4.24835","url":null,"abstract":"The quality control (QC) theory of aging is based on the concept that aging is the result of a reduction in QC of cellular systems designed to maintain lifelong homeostasis. Four QC systems associated with aging are 1) inadequate protein processing in a distressed endoplasmic reticulum (ER); 2) histone deacetylase (HDAC) processing of genomic histones and gene silencing; 3) suppressed AMPK nutrient sensing with inefficient energy utilization and excessive fat accumulation; and 4) beta-adrenergic receptor (BAR) signaling and environmental and emotional stress. Reprogramming these systems to maintain efficiency and prevent aging would be a rational strategy for increased lifespan and improved health. The QC theory can be tested with a pharmacological approach using three well-known and safe, FDA-approved drugs: 1) phenyl butyric acid, a chemical chaperone that enhances ER function and is also an HDAC inhibitor, 2) metformin, which activates AMPK and is used to treat type 2 diabetes, and 3) propranolol, a beta blocker which inhibits BAR signaling and is used to treat hypertension and anxiety. A critical aspect of the QC theory, then, is that aging is associated with multiple cellular systems that can be targeted with drug combinations more effectively than with single drugs. But more importantly, these drug combinations will effectively prevent, delay, or reverse chronic diseases of aging that impose such a tremendous health burden on our society. ","PeriodicalId":89611,"journal":{"name":"Pathobiology of aging & age related diseases","volume":"4 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2014-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3402/pba.v4.24835","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32392095","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 10

An association of metabolic syndrome constellation with cellular membrane caveolae. 代谢综合征星座与细胞膜小泡的关系。

Pathobiology of aging & age related diseases Pub Date : 2014-02-12 eCollection Date: 2014-01-01 DOI: 10.3402/pba.v4.23866

Wei-Zheng Zhang

引用次数: 12

The Microbiome of Aging and Age-Related Disease 衰老和年龄相关疾病的微生物组

Pathobiology of aging & age related diseases Pub Date : 2014-01-01 DOI: 10.3402/pba.v4.26730

W. Ladiges

引用次数: 0

p53 as an intervention target for cancer and aging. P53作为癌症和衰老的干预靶点。

Pathobiology of aging & age related diseases Pub Date : 2013-10-08 DOI: 10.3402/pba.v3i0.22702

Paul Hasty, Barbara A Christy

引用次数: 61

A novel radial water tread maze tracks age-related cognitive decline in mice. 一种新的径向水踏迷宫追踪小鼠与年龄相关的认知衰退。

Pathobiology of aging & age related diseases Pub Date : 2013-10-04 eCollection Date: 2013-01-01 DOI: 10.3402/pba.v3i0.20679

Christina Pettan-Brewer, Dylan V Touch, Jesse C Wiley, Heather C Hopkins, Peter S Rabinovitch, Warren C Ladiges

{"title":"A novel radial water tread maze tracks age-related cognitive decline in mice.","authors":"Christina Pettan-Brewer, Dylan V Touch, Jesse C Wiley, Heather C Hopkins, Peter S Rabinovitch, Warren C Ladiges","doi":"10.3402/pba.v3i0.20679","DOIUrl":"https://doi.org/10.3402/pba.v3i0.20679","url":null,"abstract":"There is currently no treatment and cure for age-related dementia and cognitive impairment in humans. Mice suffer from age-related cognitive decline just as people do, but assessment is challenging because of cumbersome and at times stressful performance tasks. We developed a novel radial water tread (RWT) maze and tested male C57BL/6 (B6) and C57BL/6 x Balb/c F1 (CB6F1) mice at ages 4, 12, 20, and 28 months. B6 mice showed a consistent learning experience and memory retention that gradually decreased with age. CB6F1 mice showed a moderate learning experience in the 4 and 12 month groups, which was not evident in the 20 and 28 month groups. In conclusion, CB6F1 mice showed more severe age-related cognitive impairment compared to B6 mice and might be a suitable model for intervention studies. In addition, the RWT maze has a number of operational advantages compared to currently accepted tasks and can be used to assess age-related cognition impairment in B6 and CB6F1 mice as early as 12 months of age. ","PeriodicalId":89611,"journal":{"name":"Pathobiology of aging & age related diseases","volume":"3 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2013-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3402/pba.v3i0.20679","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31791304","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 13

Pathology is a critical aspect of preclinical aging studies. 病理学是临床前衰老研究的一个重要方面。

Pathobiology of aging & age related diseases Pub Date : 2013-08-20 eCollection Date: 2013-01-01 DOI: 10.3402/pba.v3i0.22451

Warren Ladiges, Yuji Ikeno, Denny Liggitt, Piper M Treuting

{"title":"Pathology is a critical aspect of preclinical aging studies.","authors":"Warren Ladiges, Yuji Ikeno, Denny Liggitt, Piper M Treuting","doi":"10.3402/pba.v3i0.22451","DOIUrl":"https://doi.org/10.3402/pba.v3i0.22451","url":null,"abstract":"Experimental design for mouse aging studies has historically involved lifespan, but it is now clear that survival data without pathology data limit the information that can be obtained on aging animals. This limitation becomes more serious when interventions of any sort are implemented. Pathology gives an insight into the health of an animal by revealing lesions not readily observable in the live animal. As such, it is a snapshot of disease conditions at the time of death. Therefore, a long-term goal is to establish pathology information as an essential component of studies involving health span and lifespan of aging animals. Given that pathology assessment is essential to help define the progression of lesions associated with aging, the real challenge is including it in aging studies because there is currently a lack of specialized expertise and resources. An increase in the level and scope of pathology assessment of tissues from old mice involved in aging studies is needed. A focus on the correlation of pathology data with longitudinal and cross-sectional lifespan data and health span physiology data can be established by enhancing standard histologic assessment of lesions observed in tissues from old mice. An environment for the development and integration of pathology data into aging studies of mice is needed to encourage more pathologists and other scientists to specialize in pathology of aging, and establish relevant standards to compare with other species including humans. Such results will have an important positive impact on aging studies because of the significant empowerment on data analyses and interpretation. ","PeriodicalId":89611,"journal":{"name":"Pathobiology of aging & age related diseases","volume":"3 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2013-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3402/pba.v3i0.22451","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31678376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 17

Do Ames dwarf and calorie-restricted mice share common effects on age-related pathology? 艾姆斯侏儒老鼠和卡路里限制老鼠在与年龄相关的病理上有共同的影响吗?

Pathobiology of aging & age related diseases Pub Date : 2013-06-20 Print Date: 2013-01-01 DOI: 10.3402/pba.v3i0.20833

Yuji Ikeno, Gene B Hubbard, Shuko Lee, Sara M Dube, Lisa C Flores, Madeline G Roman, Andrzej Bartke

{"title":"Do Ames dwarf and calorie-restricted mice share common effects on age-related pathology?","authors":"Yuji Ikeno, Gene B Hubbard, Shuko Lee, Sara M Dube, Lisa C Flores, Madeline G Roman, Andrzej Bartke","doi":"10.3402/pba.v3i0.20833","DOIUrl":"https://doi.org/10.3402/pba.v3i0.20833","url":null,"abstract":"Since 1996, aging studies using several strains of long-lived mutant mice have been conducted. Among these studies, Ames dwarf mice have been extensively examined to seek clues regarding the role of the growth hormone/insulin-like growth factor-1 axis in the aging process. Interestingly, these projects demonstrate that Ames dwarf mice have physiological characteristics that are similar to those seen with calorie restriction, which has been the most effective experimental manipulation capable of extending lifespan in various species. However, this introduces the question of whether Ames dwarf and calorie-restricted (CR) mice have an extended lifespan through common or independent pathways. To answer this question, we compared the disease profiles of Ames dwarf mice to their normal siblings fed either ad libitum (AL) or a CR diet. Our findings show that the changes in age-related diseases between AL-fed Ames dwarf mice and CR wild-type siblings were similar but not identical. Moreover, the effects of CR on age-related pathology showed similarities and differences between Ames dwarf mice and their normal siblings, indicating that calorie restriction and Ames dwarf mice exhibit their anti-aging effects through both independent and common mechanisms. ","PeriodicalId":89611,"journal":{"name":"Pathobiology of aging & age related diseases","volume":"3 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2013-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3402/pba.v3i0.20833","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31532524","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 20

Fatal myocardial fibrosis in an aged chimpanzee (Pan troglodytes). 老年黑猩猩(类人猿)致死性心肌纤维化。

Pathobiology of aging & age related diseases Pub Date : 2013-06-10 Print Date: 2013-01-01 DOI: 10.3402/pba.v3i0.21073

Audrey Baldessari, Jessica Snyder, Joel Ahrens, Robert Murnane

引用次数: 10

Stem Cells and AgingSan Antonio Nathan Shock Aging Center 2013 Conference on Aging, Mayan Ranch, Texas Hill Country, Bandera, TX 干细胞和衰老圣安东尼奥内森冲击衰老中心2013年衰老会议，玛雅牧场，德克萨斯丘陵，班德拉，德克萨斯州

Pathobiology of aging & age related diseases Pub Date : 2013-01-01 DOI: 10.3402/pba.v3i0.23389

{"title":"Stem Cells and AgingSan Antonio Nathan Shock Aging Center 2013 Conference on Aging, Mayan Ranch, Texas Hill Country, Bandera, TX","authors":"","doi":"10.3402/pba.v3i0.23389","DOIUrl":"https://doi.org/10.3402/pba.v3i0.23389","url":null,"abstract":"The San Antonio Nathan Shock Center Conferences have attracted international speakers and participants since 1995. This annual conference, held in Bandera, Texas, addresses a different topic in the biology of aging each year. The venue’s intimate setting, relatively remote location and common areas are ideal for a small conference (80100 participants) where informal intellectual interchange supplements that of the formal sessions. The 2013 meeting, part of an annual series sponsored by the Nathan Shock Center of Excellence in the Biology of Aging and the Barshop Institute for Longevity and Aging Studies at the University of Texas Health Science Center San Antonio, addressed the concept that stem cells play a role in healthy aging. Abstracts from posters presented at the meeting are presented in this special proceedings issue to provide an overview of the breadth and depth of the program. The abstracts are organized into four session topics, which include: (1) The neurogenic niche; (2) Muscle stem cells in aging; (3) Reprogramming in aging; and (4) Better aging through stem cells. (Published: 11 December 2013) Citation: Pathobiology of Aging & Age-related Diseases 2013, 3 : 23389 - http://dx.doi.org/10.3402/pba.v3i0.23389","PeriodicalId":89611,"journal":{"name":"Pathobiology of aging & age related diseases","volume":"3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2013-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3402/pba.v3i0.23389","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69870293","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0