International journal of transport phenomena最新文献

Effect of IF-WS₂ Nanolubricant on R134a Boiling on a Reentrant Cavity Surface. IF-WS2纳米润滑剂对R134a在回入腔表面沸腾的影响

International journal of transport phenomena Pub Date : 2020-06-01

M A Kedzierski, L Lin

引用次数: 0

Effect of IF-WS2 Nanolubricant on R134a Boiling on a Reentrant Cavity Surface. IF-WS2纳米润滑剂对R134a在再入腔表面沸腾的影响。

International journal of transport phenomena Pub Date : 2019-02-04 DOI: 10.1002/https://doi.org/10.6028/NIST.TN.2033

M. Kędzierski, L. Lin

引用次数: 4

A Fluorescence Based Measurement Technique to Quantify Water Contaminants at Pipe Surfaces During Flow. 基于荧光的测量技术，对流动过程中管道表面的水污染物进行定量。

International journal of transport phenomena Pub Date : 2017-01-01

Mark A Kedzierski

引用次数: 0

Numerical Analysis of the Influence of Low Frequency Vibration on Bubble Growth. 低频振动对气泡生长影响的数值分析。

International journal of transport phenomena Pub Date : 2017-01-01

D Han, Mark A Kedzierski

{"title":"Numerical Analysis of the Influence of Low Frequency Vibration on Bubble Growth.","authors":"D Han, Mark A Kedzierski","doi":"","DOIUrl":"","url":null,"abstract":"Numerical simulation of bubble growth during pool boiling under the influence of low frequency vibration was performed to understand the influence of common vibrations such as those induced by wind, highway transportation, and nearby mechanical devices on the performance of thermal systems that rely on boiling. The simulations were done for saturated R123 boiling at 277.6 K with a 15 K wall superheat. The numerical volume-of-fluid method (fixed grid) was used to define the liquid-vapor interface. The basic bubble growth characteristics including the bubble departure diameter and the bubble departure time were determined as a function of the bubble contact angle (20°-80°), the vibration displacement (10 µm-50 µm), the vibration frequency (5 Hz-25 Hz), and the initial vibration direction (positive or negative). The bubble parameters were shown to be strongly dependent on the bubble contact angle at the surface. For example, both the bubble departure diameter and the bubble departure time increased with the contact angle. At the same vibration frequency and the initial vibration direction, the bubble departure diameter and the bubble departure time both decreased with increasing vibration displacement. In addition, the vibration frequency had a greater effect on the bubble growth characteristics than did the vibration displacement. The vibration frequency effect was strongly influenced by the initial vibration direction. The pressure contour, the volume fraction of vapor phase, the temperature profile, and the velocity vector were investigated to understand these dynamic bubble behaviors. The limitation of the computational fluid dynamics approach was also described.","PeriodicalId":89574,"journal":{"name":"International journal of transport phenomena","volume":"15 1","pages":"37-52"},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5524383/pdf/nihms883045.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35202707","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of Glycocalyx on Drug Delivery Carriers Targeted to Endothelial Cells. 糖萼对内皮细胞药物递送载体的影响。

International journal of transport phenomena Pub Date : 2011-01-01

Andres J Calderon, Madiha Baig, Ben Pichette, Vladimir Muzykantov, Silvia Muro, David M Eckmann

{"title":"Effect of Glycocalyx on Drug Delivery Carriers Targeted to Endothelial Cells.","authors":"Andres J Calderon, Madiha Baig, Ben Pichette, Vladimir Muzykantov, Silvia Muro, David M Eckmann","doi":"","DOIUrl":"","url":null,"abstract":"Animal models have shown that coupling ligands, targeted to endothelium surface receptors, with drug delivery carriers (DDC) can optimize the treatment of diseases by specific vascular delivery. The endothelium is exposed to hydrodynamic forces that modulate the expression of these cellular adhesion molecules (CAMs) and affect the structural and biological activity of endothelial cells (ECs). In order to investigate how delivery of targeted DDC can be optimized, we investigated carriers binding to flow adapted ECs under flow conditions. Comparison of live ECs to fixed cells from our previous experiments give insight into the effect of receptor motility on the cell surface as well as the effect of other factors such as glycocalyx (a protective layer of carbohydrates on the surface of cells) and actin remodeling. A flow chamber model is used to investigate how DDC size variation alters binding under flow conditions. Binding experiments were done with and without glycocalyx in order to elucidate its protective effect. Using fluorescence microscopy we determined the real time binding and rolling speeds of DDC under flow conditions. We also demonstrate the presence of glycocalyx and image actin filament remodeling. The binding of 1 µm carriers to ECs decreased after flow adaptation, in both non-activated and TNF-α activated ECs compared to non-flow adapted live cells. After removal of the glycocalyx by degrading enzymes binding increased in quiescent ECs, but only increased in activated cells after 2 hr of perfusion with particles. The binding with 100 nm carriers also decreased after flow adaptation but to a lesser extent and partially increased after enzyme degradation. These experiments give insight as to how tunable affinity parameters can be optimized to enhance therapeutic capabilities.","PeriodicalId":89574,"journal":{"name":"International journal of transport phenomena","volume":"12 1-2","pages":"63-75"},"PeriodicalIF":0.0,"publicationDate":"2011-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3367256/pdf/nihms247398.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30675208","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Targeting delivery of drugs in the vascular system. 靶向输送血管系统中的药物。

International journal of transport phenomena Pub Date : 2011-01-01

Vladimir Muzykantov, Silvia Muro

{"title":"Targeting delivery of drugs in the vascular system.","authors":"Vladimir Muzykantov, Silvia Muro","doi":"","DOIUrl":"","url":null,"abstract":"Delivery and effects of therapeutics remain suboptimal. Most drugs do not have affinity to their targets. Biotherapeutics including enzymes and genetic materials require specific sub-cellular addressing not attainable naturally. Endothelium, lining the luminal surface of blood vessels, represents a key therapeutic target in many diseases. Studies in cell culture and animal models revealed that targeted delivery of therapeutics to, into and across endothelium can be achieved using carriers targeted to specific molecules expressed on the surface of the endothelial cells. For example, cell adhesion molecules represent attractive targets for drug delivery. Rational design of the drug delivery systems (e.g., selection of optimal geometry and affinity to specific epitopes) provides an unprecedented level of control of such parameters of drug delivery as pharmacokinetics, circulation in blood, binding to selected endothelial cell phenotypes, anchoring on cell surface or internalization into the endothelium, subsequent intracellular addressing and duration of the effects. We discusse here key aspects of design of endothelium-targeted drug delivery systems with potential for translation into the clinical domain.","PeriodicalId":89574,"journal":{"name":"International journal of transport phenomena","volume":"12 1-2","pages":"41-49"},"PeriodicalIF":0.0,"publicationDate":"2011-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4199305/pdf/nihms564946.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32758858","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Using 3-D dense packing models to predict surface tension change due to protein adsorption. 利用三维致密堆积模型预测蛋白质吸附导致的表面张力变化。

International journal of transport phenomena Pub Date : 2011-01-01

Joshua W Lampe, Portonovo S Ayyaswamy, David M Eckmann

{"title":"Using 3-D dense packing models to predict surface tension change due to protein adsorption.","authors":"Joshua W Lampe, Portonovo S Ayyaswamy, David M Eckmann","doi":"","DOIUrl":"","url":null,"abstract":"Protein adsorption modeling primarily focuses on the role of the complexities and differences in the role of the protein constituents. However, experimental evidence suggests that adsorption of human blood-borne protein molecules of widely varying size and purpose is more similar than different. A model, which treats proteins as hard, non-interacting spheres, explains the observed regularity of human blood borne protein adsorption as a result of the dominant role of the solvent in the adsorption process. Here we independently evaluate the efficacy of this model, and adjust the model to a dependence on molecular volume as opposed to molecular weight. In addition, we explore the role of adsorption-induced conformation or orientation changes, and demonstrate that volume invariant changes are well represented by this model and changes that include changes in the molecular volume are not. By focusing on molecular volume, the model can be applied to non-spherical molecules such as fibrinogen and accurately captures differences between BSA, multi-layer, and HSA, monolayer, adsorption. These findings confirm the importance of the solvent in protein adsorption, elucidate the importance of molecular volume on surface tension change, and suggest that this model is generally applicable.","PeriodicalId":89574,"journal":{"name":"International journal of transport phenomena","volume":"12 3-4","pages":"283-300"},"PeriodicalIF":0.0,"publicationDate":"2011-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3327165/pdf/nihms227631.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30582618","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

RAPID INDUCTION OF HETEROGENEOUS ICE NUCLEATION IN A BIOLOGICALLY COMPATIBLE COOLANT. 在生物相容的冷却剂中快速诱导非均相冰核。

International journal of transport phenomena Pub Date : 2011-01-01

Joshua Lampe, Diana Bull, Lance Becker

{"title":"RAPID INDUCTION OF HETEROGENEOUS ICE NUCLEATION IN A BIOLOGICALLY COMPATIBLE COOLANT.","authors":"Joshua Lampe, Diana Bull, Lance Becker","doi":"","DOIUrl":"","url":null,"abstract":"Hypothermia is gaining recognition as an important medical treatment. To treat local cases of injury such as stroke, or certain surgical procedures, there is a need to induce local hypothermia. To treat shock or cardiac arrest survivors, there is a need to rapidly induce global hypothermia. Rapid induction of hypothermia has been achieved in animal research, but it has yet to be achieved clinically using a simple, widely practicable method. The clinical need for therapeutic hypothermia represents an engineering opportunity to develop an easy to use coolant that is sterile, biologically compatible, and maximizes coolant heat capacity. Here we present an initial characterization of a prototype platform technology designed to create a sterile, biologically compatible, high heat capacity coolant that has the potential to be used in all of these clinical applications. The coolant is a specially processed micro-particulate ice saline slurry, that can be easily pumped into a patient through surgical tubing, syringes, or minimally invasive surgical instruments. The device induces heterogeneous ice nucleation in a saline stream that has been super-cooled from room temperature to a temperature below the saline freezing point. Currently, the device begins continuous production of ice slurry that contains ~30 % ice by mass within 10 minutes. The nominal ice particle diameter is smaller than 100 μm. This work represents a significant first step toward addressing clinical needs for rapid human cooling.","PeriodicalId":89574,"journal":{"name":"International journal of transport phenomena","volume":"12 3-4","pages":"307-317"},"PeriodicalIF":0.0,"publicationDate":"2011-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4420239/pdf/nihms367405.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33159969","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Fluorescence Based Measurement Technique to Quantify Water Contaminants at Pipe Surfaces During Flow. 一种基于荧光的管道表面水污染物定量测量技术。

International journal of transport phenomena Pub Date : 2006-09-01 DOI: 10.6028/NIST.IR.7355

M. Kedzierski

引用次数: 1