发布求助
文献互助 智能选刊 最新文献

International journal of immunological studies最新文献

筛选
英文 中文
Revelations in reptilian and avian immunology: a proposed evolutionary selection pressure for truncated immunoglobulin–Y 爬虫类和鸟类免疫学的启示:提出了截断免疫球蛋白y的进化选择压力
International journal of immunological studies Pub Date : 2014-01-01 DOI: 10.1504/IJIS.2014.066848
J. Meddings, L. Owens, G. Burgess, E. Ariel
{"title":"Revelations in reptilian and avian immunology: a proposed evolutionary selection pressure for truncated immunoglobulin–Y","authors":"J. Meddings, L. Owens, G. Burgess, E. Ariel","doi":"10.1504/IJIS.2014.066848","DOIUrl":"https://doi.org/10.1504/IJIS.2014.066848","url":null,"abstract":"We propose for the first time that antibody–dependent enhancement (ADE) of viral infection has served as an evolutionary selection pressure in which species that produce truncated immunoglobulin–Y (IgY) have had a selective advantage. The absence of the Fc region prevents binding of antibody–covered virions to cellular Fc receptors and to complement component C1q, thus preventing ADE by these mechanisms and limiting viral entry to cells. It logically follows that the range of cell types potentially infected would be reduced, slowing the invasive nature of viral infections. We briefly review the structure, function and evolution of IgY, the mechanisms of ADE, discuss how producing truncated immunoglobulins could limit ADE, and how future research can falsify or confirm this hypothesis.","PeriodicalId":89570,"journal":{"name":"International journal of immunological studies","volume":"2 1","pages":"29"},"PeriodicalIF":0.0,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1504/IJIS.2014.066848","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67133106","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
A suggestion for a new algorithm for the calculation of molecular structures 一个计算分子结构的新算法的建议
International journal of immunological studies Pub Date : 2014-01-01 DOI: 10.1504/IJIS.2014.066840
B. Arneth
{"title":"A suggestion for a new algorithm for the calculation of molecular structures","authors":"B. Arneth","doi":"10.1504/IJIS.2014.066840","DOIUrl":"https://doi.org/10.1504/IJIS.2014.066840","url":null,"abstract":"Algorithms available for the calculation of molecular structures of biomolecules only deliver reasonable results in a few cases. In particular, for complex biomolecules as proteins and nucleic acids, the results are only partly usable. Thus, molecular structures of immunological relevant molecules can only be determined experimentally by methods as X–ray analysis and nuclear magnetic resonance (NMR) spectroscopy. Perhaps, the difficulties with the algorithms used so far are that a large number of interactions are ignored. So far, electrostatic interactions as in hydrogen bonds have been considered, with addition of van der Waals interactions and hydrophobic forces. This work considers mass–charge interactions in addition to the Coulombic interactions as pure charge–charge interactions. This new type of interaction has recently been proposed, and turns out to be useful in the calculation of molecular structures. An efficient method of calculating molecular structures would lead to a better understanding of structures and would be a developmental leap for computational biology.","PeriodicalId":89570,"journal":{"name":"International journal of immunological studies","volume":"2 1","pages":"61"},"PeriodicalIF":0.0,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1504/IJIS.2014.066840","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67132897","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The dynamic microenvironment of pancreatic islet cell transplants precludes the use of common housekeeping genes 胰岛细胞移植的动态微环境排除了普通管家基因的使用
International journal of immunological studies Pub Date : 2014-01-01 DOI: 10.1504/IJIS.2014.066850
G. Shahaf, A. Kassem, J. Levinson, Jared Brazg, E. Lewis
{"title":"The dynamic microenvironment of pancreatic islet cell transplants precludes the use of common housekeeping genes","authors":"G. Shahaf, A. Kassem, J. Levinson, Jared Brazg, E. Lewis","doi":"10.1504/IJIS.2014.066850","DOIUrl":"https://doi.org/10.1504/IJIS.2014.066850","url":null,"abstract":"Background: Pancreatic islet graft survival is affected by early (<3 days) and late immune responses, displaying local CD3+ T cell predominance and loss of insulin production within a week. However, qRT–PCR gene expression profiles require normalisation to housekeeping genes that might be affected by metabolic, inflammatory, hypoxic, apoptotic, revascularisation–related and immune–cell infiltrate changes. Here, we examined eight housekeeping genes. Methods: Syngeneic and allogeneic mouse islet transplantations were performed; day 1 and 7 grafts were analysed for insulin and CD3 transcript levels, as normalised to each housekeeping gene. Results: Normalised qRT–PCR data was not uniform across transplant combinations and time from transplantation. 18s RNA was the superior housekeeping gene, as confirmed by valid changes in CD3 and insulin expression levels. Conclusions: While β–actin and GAPDH are the least–fitting housekeeping genes for the dynamic microenvironment of islet transplants, 18s RNA maintains authenticity across transplant combinations, time from transplantation and altered immune microenvironment.","PeriodicalId":89570,"journal":{"name":"International journal of immunological studies","volume":"2 1","pages":"42"},"PeriodicalIF":0.0,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1504/IJIS.2014.066850","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67133198","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Rotavirus causing acute gastroenteritis infection in children at our hospital (eastern region of Saudi Arabia) 我院(沙特阿拉伯东部地区)儿童轮状病毒引起的急性胃肠炎感染
International journal of immunological studies Pub Date : 2014-01-01 DOI: 10.1504/IJIS.2014.066843
Q. Ahmed
{"title":"Rotavirus causing acute gastroenteritis infection in children at our hospital (eastern region of Saudi Arabia)","authors":"Q. Ahmed","doi":"10.1504/IJIS.2014.066843","DOIUrl":"https://doi.org/10.1504/IJIS.2014.066843","url":null,"abstract":"Rotavirus infection causing acute gastroenteritis is quite prevalent. Main purpose of this study is to detect Rotavirus from faecal samples of children up to two years age. Retrospective study to investigate cases of Rotavirus antigen positive. The prevalence of rotavirus, as determined by STAT Rotavirus is a rapid enzyme immunoassay. Study is done from 1 January, 2011 to 31 December, 2012 at our hospital, Saudi Arabia. A total of 13,580 stools samples were screened in two years. Seventy percent (9491) of these were screened for infective cause and 30% (4062) for non–infective cause. We received 2531 (19.0%) for stool bacterial culture and sensitivity, 6013 (44.0%) for ova and parasites and 974 (7.0%) of requisitions for Rotavirus infection. Rotavirus requisitions were 974 out of which 182 (18.7%) positive for Rotavirus. In year 2011, out of 498 faecal sample 92 (18.5%) were positive and in 2012 out of 476 there were 90 (19.0%) positive. Rotavirus acute gastroenteritis is prevalent in our population.","PeriodicalId":89570,"journal":{"name":"International journal of immunological studies","volume":"3 1","pages":"55"},"PeriodicalIF":0.0,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1504/IJIS.2014.066843","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67132947","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Immunoproteomics: current approach for subunit vaccine design 免疫蛋白质组学:亚单位疫苗设计的当前方法
International journal of immunological studies Pub Date : 2014-01-01 DOI: 10.1504/IJIS.2014.066845
Sherkhane As, V. Gomase
{"title":"Immunoproteomics: current approach for subunit vaccine design","authors":"Sherkhane As, V. Gomase","doi":"10.1504/IJIS.2014.066845","DOIUrl":"https://doi.org/10.1504/IJIS.2014.066845","url":null,"abstract":"Immunoproteomics is used to design algorithms for mapping the potential B– and T–cell epitopes, identifying surface–associated proteins and the potential binding sites that lead to the development of new vaccines. This article reviews that the applications of immunoinformatics for designing in silico vaccination the molecular modelling. All these efforts of immunoinproteomics will save time and also reduce the cost. The experimental determination of epitopes is expensive in terms of time, cost, time as well as effort; however, there is need for computational methods for reliable identification of B–cell epitopes. In this review, we use different methods as well as many immunoproteomics algorithms, resources for the prediction of T– and B–cell immune epitopes for epitope vaccine development and protective immunity analysis.","PeriodicalId":89570,"journal":{"name":"International journal of immunological studies","volume":"2 1","pages":"16"},"PeriodicalIF":0.0,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1504/IJIS.2014.066845","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67133035","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Nuclex therapy for patients with chronic hepatitis C 慢性丙型肝炎患者的核治疗
International journal of immunological studies Pub Date : 2012-01-01 DOI: 10.1504/IJIS.2012.051236
Z. Tkachuk, V. M. Frolov, Y. A. Sotska, O. Kruglova
{"title":"Nuclex therapy for patients with chronic hepatitis C","authors":"Z. Tkachuk, V. M. Frolov, Y. A. Sotska, O. Kruglova","doi":"10.1504/IJIS.2012.051236","DOIUrl":"https://doi.org/10.1504/IJIS.2012.051236","url":null,"abstract":"The three-month treatment with Nuclex and a–2b IFN in the complex therapy of the main group of CHC patients resulted in a positive dynamics in the clinical and immunological indicators and improvement in the functional status of the liver. The reference group of the patients, which received only a–2b IFN, also showed the positive dynamics of the analysed indicators, although to a much smaller degree as compared to the main group. The viral loads in the main group patients substantially dropped: the majority of the patients from the main group (78.6%) after the end of the treatment had minimal levels of the viral loads ranging (150–499) × 103, while in some of the patients (10.7 %) the virus was not detected at all. In the reference group, the treatment outcome was 4.5 times less than in the main group. The obtained results to allow consider the application of Nuclex in the complex therapy of CHC patients.","PeriodicalId":89570,"journal":{"name":"International journal of immunological studies","volume":"1 1","pages":"349"},"PeriodicalIF":0.0,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1504/IJIS.2012.051236","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67133099","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Autoantibodies in patients with asthma: is there a link between asthma and autoimmunity? 哮喘患者的自身抗体:哮喘和自身免疫之间是否存在联系?
International journal of immunological studies Pub Date : 2012-01-01 DOI: 10.1504/IJIS.2012.051244
Theocharis G Konstantinidis, C. Tsigalou, A. Bisiklis, G. Romanidou, Eleni I Konstantinidou, T. Parasidis, T. Gioka, Georgia Kampouromiti, T. Constantinidis, D. Cassimos
{"title":"Autoantibodies in patients with asthma: is there a link between asthma and autoimmunity?","authors":"Theocharis G Konstantinidis, C. Tsigalou, A. Bisiklis, G. Romanidou, Eleni I Konstantinidou, T. Parasidis, T. Gioka, Georgia Kampouromiti, T. Constantinidis, D. Cassimos","doi":"10.1504/IJIS.2012.051244","DOIUrl":"https://doi.org/10.1504/IJIS.2012.051244","url":null,"abstract":"The objective of this study was to measure autoantibodies and the mean individual immune reactivity (IR) in children with asthma. The study group consisted of ten children with asthma and the control group of ten age-matched healthy subjects. In all patients IR and 24 autoantibodies (aAb) type G were measured by ELISA (Immunculus, Russia). The IR in asthmatics was 42% and was statistically significantly higher than this of control group 9% (p < 0.005). The level of aAbs (LuM, LuS, CoM and dsDNA) was also raised in the asthmatics. Anti-Adr aAbs was higher in one patient who required intense treatment for asthma with frequent use of corticosteroids. Anti-HMMP, insulin and IR aAbs were significantly lower in comparison to the control group (p < 0.05). This study confirms the high level of immunological activation in patients with asthma. The presence of autoantibodies implies that autoimmunity might have a role in the pathogenesis of asthma.","PeriodicalId":89570,"journal":{"name":"International journal of immunological studies","volume":"1 1","pages":"376"},"PeriodicalIF":0.0,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1504/IJIS.2012.051244","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67133279","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 7
Screening of novel epitopes in Klebsiella pneumoniae, as target for vaccine design 肺炎克雷伯菌新抗原表位的筛选，作为疫苗设计的靶点
International journal of immunological studies Pub Date : 2012-01-01 DOI: 10.1504/IJIS.2012.051235
L. H. El‐Sayed, Medhat A. Haroun, A. Hussein, E. Ashry, Tarek Adnan Ahmad
{"title":"Screening of novel epitopes in Klebsiella pneumoniae, as target for vaccine design","authors":"L. H. El‐Sayed, Medhat A. Haroun, A. Hussein, E. Ashry, Tarek Adnan Ahmad","doi":"10.1504/IJIS.2012.051235","DOIUrl":"https://doi.org/10.1504/IJIS.2012.051235","url":null,"abstract":"K. pneumoniae is the most common cause of nosocomial respiratory tract and premature intensive care infections, and the second most frequent cause of Gram-negative bacteraemia and urinary tract infections. Although immuno-prophylactic preparations appeared to offer the most suitable control, no vaccine trials were directed to prevent Klebsiella in all patient’s groups. Therefore, the screening for universal protein epitopes in all types of Klebsiella infections is the corner-stone to produce potent vaccines. Western blot was used for such purpose and highlighted five proteins produced in sufficient amounts, shared by all isolates and exerted a clear immunogenic response in different groups of infected patients. Literature review and further purification of outer membrane proteins (OMPs) revealed that those bands are the main OMP’s of Klebsiella. The conjugation of those OMPs to the main Klebsiella O-antigens would be the building block of a new potent vaccine.","PeriodicalId":89570,"journal":{"name":"International journal of immunological studies","volume":"1 1","pages":"336"},"PeriodicalIF":0.0,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1504/IJIS.2012.051235","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67133085","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
A hypothesis for the elimination of necrotic cell components: the elimination of necrotic cell components and the development of autoimmune diseases 坏死细胞成分消除的假设:坏死细胞成分的消除和自身免疫性疾病的发展
International journal of immunological studies Pub Date : 2012-01-01 DOI: 10.1504/IJIS.2012.051234
B. Arneth
{"title":"A hypothesis for the elimination of necrotic cell components: the elimination of necrotic cell components and the development of autoimmune diseases","authors":"B. Arneth","doi":"10.1504/IJIS.2012.051234","DOIUrl":"https://doi.org/10.1504/IJIS.2012.051234","url":null,"abstract":"Autoimmune diseases are known to be associated with autoantibodies against intracellular structures. Here, we describe the hypothesis that these diseases could develop as a result of the extensive production and release of intracellular substances into the serum. Autoimmune diseases may also develop as a result of defective elimination of multiple intracellular components and of proteins. Elimination defects may occur in any of several pathways, including those affecting apoptosis, cellular degradation (e.g., by macrophages), and soluble enzymes.","PeriodicalId":89570,"journal":{"name":"International journal of immunological studies","volume":"1 1","pages":"329"},"PeriodicalIF":0.0,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1504/IJIS.2012.051234","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67133027","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Biomedical applications of engineered nanoparticles in diagnosis and therapeutics 工程纳米颗粒在诊断和治疗中的生物医学应用
International journal of immunological studies Pub Date : 2012-01-01 DOI: 10.1504/IJIS.2012.051233
M. Khan, S. Moeez
{"title":"Biomedical applications of engineered nanoparticles in diagnosis and therapeutics","authors":"M. Khan, S. Moeez","doi":"10.1504/IJIS.2012.051233","DOIUrl":"https://doi.org/10.1504/IJIS.2012.051233","url":null,"abstract":"Nanoparticles are essentially tiny pieces of material that measure no more than an atom or two across. Because of their small size, they can interact easily on the same level with microscopic pathogens such as bacteria or viruses. They are also adaptable enough that they can be applied in different biotechnological applications, from fine electronics to innovative medical procedures in modern biomedical science. Substantial research has been done to develop a series of bio products based on nanoparticles, some of which have been applied for public applications in medical science. Nanoparticles have been proved useful in number of applications but potential implementation of nanoparticles lies in their medical applications. Their tiny pathogen-sized proportions naturally make them key candidates for the fight against various unwanted foreign pathogens of the human body; they can be delivered intravenously directly into your bloodstream to destroy viruses and bacteria as same as T-cells of the immune system. This technology gives a much-needed boost to medical applications for major untreatable diseases. These new products provide stable, safe, and effective alternatives for working with potentially hazardous biological for applications such as drug targeting, immunological studies, biosensor development, and biocatalysis.","PeriodicalId":89570,"journal":{"name":"International journal of immunological studies","volume":"1 1","pages":"319"},"PeriodicalIF":0.0,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1504/IJIS.2012.051233","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67132444","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
下一页 尾页
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整，为了账户安全，请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们：info@booksci.cn Book学术提供免费学术资源搜索服务，方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号：604180095
Book学术官方微信
小红书