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Increase in Serum Total IGF-I and Maintenance of Free IGF-I Following Intentional Weight Loss in Pre-menopausal Women at Increased Risk of Breast Cancer 绝经前乳腺癌风险增加的妇女有意减肥后血清总IGF-I的增加和游离IGF-I的维持

The open obesity journal Pub Date : 2010-01-24 DOI: 10.2174/1876823701002020063

M. Harvie, A. Renehan, J. Frystyk, A. Flyvbjerg, T. Mercer, R. Malik, J. Adams, J. Cuzick, A. Howell

{"title":"Increase in Serum Total IGF-I and Maintenance of Free IGF-I Following Intentional Weight Loss in Pre-menopausal Women at Increased Risk of Breast Cancer","authors":"M. Harvie, A. Renehan, J. Frystyk, A. Flyvbjerg, T. Mercer, R. Malik, J. Adams, J. Cuzick, A. Howell","doi":"10.2174/1876823701002020063","DOIUrl":"https://doi.org/10.2174/1876823701002020063","url":null,"abstract":"Intentional weight loss may reduce breast cancer risk through lowering levels of circulating free IGF-I but few studies have measured this longitudinally. We determined the effect of weight loss (=5% body weight) over 12 months, using an energy restriction and exercise programme, on an expanded panel of IGF-related peptides amongst 23 weight losing and 46 weight stable or gaining pre-menopausal women at increased risk of breast cancer, BMI (mean ± SD) 29.2 ± 6.2 kg/m2. Fasting measures of total and free IGF-I (ultra-filtration), and IGFBP-1, -2 and -3, body weight, body fat (DXA), intra-abdominal fat (MRI) were assessed at 6 and 12 months. \u0000 \u0000After 12 months, women who lost ≥ 5% of body weight had a significant increase in serum total IGF-I; mean (95% CI difference) 17 (2.3 to 34.0) μg/l, P < 0.05, and IGFBP-2; mean (95% CI ratio) 1.24 (1.06 to 1.46) P < 0.001, compared to weight stable/gaining women. Serum IGFBP-1 tended to increase in weight losers compared to the weight stable/gaining women; mean (95% CI ratio) 1.19 (0.97 to 1.45) P=0.09, whereas IGFBP-3 remained unchanged; mean (95% CI ratio) 1.02 (0.94 to 1.20] P=0.99. Weight loss did not significantly alter serum levels of free IGF-I; mean difference 0.1 (-0.1 to 3.4) μg/l, P=0.21. \u0000 \u0000Increased serum total IGF-I levels, and maintenance of free IGF-I despite increased concentrations of serum IGFBP-1 and -2 with weight loss, does not suggest intentional weight loss with diet and exercise mediates reduced risk through the circulating IGF-axis.","PeriodicalId":89505,"journal":{"name":"The open obesity journal","volume":"2 1","pages":"63-70"},"PeriodicalIF":0.0,"publicationDate":"2010-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68148779","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 9

Relationship between Insulin Sensitivity and Muscle Lipids may Differ with Muscle Group and Ethnicity. 胰岛素敏感性与肌肉脂质的关系可能因肌肉群和种族而异。

The open obesity journal Pub Date : 2010-01-01 DOI: 10.2174/1876823701002010137

Jeannine C Lawrence, Barbara A Gower, W Timothy Garvey, A Julian Muñoz, Betty E Darnell, Robert A Oster, Steven D Buchthal, Michael I Goran, Bradley R Newcomer

{"title":"Relationship between Insulin Sensitivity and Muscle Lipids may Differ with Muscle Group and Ethnicity.","authors":"Jeannine C Lawrence, Barbara A Gower, W Timothy Garvey, A Julian Muñoz, Betty E Darnell, Robert A Oster, Steven D Buchthal, Michael I Goran, Bradley R Newcomer","doi":"10.2174/1876823701002010137","DOIUrl":"10.2174/1876823701002010137","url":null,"abstract":"<p><p>Intramyocellular lipid (IMCL) has been inversely associated with insulin sensitivity in some, but not all, studies. This study utilized fast, high-resolution, magnetic resonance spectroscopic imaging (MRSI) to: investigate relationships between muscle lipids (IMCL and extramyocellular lipid (EMCL)) and insulin sensitivity in muscles of varying oxidative capacity, explore ethnic differences in these relationships, and determine whether a eucaloric, low-fat dietary intervention would reduce IMCL and increase insulin sensitivity. Subjects were 30 healthy, African-American (AA; n=14) and European-American (EA; n=16) males, BMI 26.49 (±5.57) kg/m(2), age 21.80 (±7.84) yrs. Soleus and tibialis anterior muscle lipids were quantified using MRSI. Insulin sensitivity was assessed via intravenous glucose tolerance test. A 2-week, eucaloric, low-fat diet intervention was conducted in a sub-group (n=12) subjects with assessments at baseline and post-intervention. Neither IMCL nor EMCL levels differed between ethnicities. In the total group, and within EA (but not AA), both tibialis anterior IMCL and EMCL were inversely associated with insulin sensitivity (P<0.05 for both); soleus muscle lipids were not associated with insulin sensitivity. Soleus, but not tibialis anterior, IMCL declined in both ethnic groups (average 25.3%; p<0.01) following dietary intervention; insulin sensitivity was unchanged. Results suggest that an association of muscle lipids with insulin sensitivity may be influenced by the oxidative capacity of the muscle group studied and may vary with ethnicity.</p>","PeriodicalId":89505,"journal":{"name":"The open obesity journal","volume":"2 ","pages":"137-144"},"PeriodicalIF":0.0,"publicationDate":"2010-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3202241/pdf/nihms327049.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40116427","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

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