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Impaired Phagocytosis in Peritonitis Exudate Secondary to Complement Consumption 补体消耗继发的腹膜炎渗出物吞噬功能受损
Surgical research communications Pub Date : 1988-01-01 DOI: 10.5282/UBM/EPUB.9498
A. Billing, D. Fröhlich, M. Jochum, H. Kortmann
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引用次数: 10
THE IMMUNOSUPPRESSIVE EFFECTS OF FR 900506 IN RATS RECEIVING HETEROTOPIC CARDIAC ALLOGRAFTS. fr 900506对异位心脏移植大鼠的免疫抑制作用。
Surgical research communications Pub Date : 1987-01-01
P Lee, N Murase, S Todo, L Makowka, T Starzl
{"title":"THE IMMUNOSUPPRESSIVE EFFECTS OF FR 900506 IN RATS RECEIVING HETEROTOPIC CARDIAC ALLOGRAFTS.","authors":"P Lee, N Murase, S Todo, L Makowka, T Starzl","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The immunosuppressive effects of FR 900506 were studied in Lewis rats given ACI heterotopic heart allografts. Intramuscular doses of 0.02 mg/kg daily for 2 weeks extended graft survival slightly, and with doses up to 1.28 mg/kg for 2 weeks, there is long-term graft survival. If only 3 daily doses were given starting on day 4 after transplantation, graft survival for almost 3 months was accomplished in 4 of 6 animals who still bear functioning hearts.</p>","PeriodicalId":89485,"journal":{"name":"Surgical research communications","volume":"1 ","pages":"325-331"},"PeriodicalIF":0.0,"publicationDate":"1987-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3089005/pdf/nihms249139.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30170596","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
IMMUNOSUPPRESSION WITH FR 900506 FOR CANINE KIDNEY AND LIVER TRANSPLANTATION. fr 900506对犬肾、肝移植的免疫抑制作用。
Surgical research communications Pub Date : 1987-01-01
S Todo, L Makowka, T Starzl
{"title":"IMMUNOSUPPRESSION WITH FR 900506 FOR CANINE KIDNEY AND LIVER TRANSPLANTATION.","authors":"S Todo, L Makowka, T Starzl","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The immunosuppressive effects of FR 900506 were investigated for one month after canine kidney and liver transplantation. Eight untreated kidney recipients lived for 8 to 19 days, mean 12.1. In contrast, the one month survival of dogs given FR 900506 in daily oral doses of 0.5, 1.0, and 1.5 mg/kg was 2/6, 3/6, and 4/6 respectively. The one month survival of liver recipients was 4/5 compared to one month survival of 1/8 in historical untreated controls. There was no evidence from biochemical tests of hepatotoxicity or nephrotoxicity.</p>","PeriodicalId":89485,"journal":{"name":"Surgical research communications","volume":"1 ","pages":"333-340"},"PeriodicalIF":0.0,"publicationDate":"1987-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3089006/pdf/nihms242100.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30170597","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
IN VITRO IMMUNOSUPPRESSIVE EFFECTS OF FR 900506 ON HUMAN T LYMPHOCYTE ALLOACTIVATION. fr 900506对人t淋巴细胞同种活化的体外免疫抑制作用。
Surgical research communications Pub Date : 1987-01-01
A Zeevi, R Duquesnoy, G Eiras, S Todo, L Makowka, T Starzl
{"title":"IN VITRO IMMUNOSUPPRESSIVE EFFECTS OF FR 900506 ON HUMAN T LYMPHOCYTE ALLOACTIVATION.","authors":"A Zeevi, R Duquesnoy, G Eiras, S Todo, L Makowka, T Starzl","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>FR 900506 (FR) is a new immunosuppressive drug which prolongs allograft survival. Our studies have compared the in vitro inhibitory effects of FR and Cyclosporine (CsA) on human lymphocyte proliferation. Considerably lower doses of FR were required to induce inhibition of lymphocyte proliferation induced by concanavalin A (ConA) stimulation or in primary mixed lymphocyte reactions (MLR) Similar differences between FR and CsA were observed with the secondary stimulation of alloactivated T cells generated in MLR or propagated from liver transplant biopsies These observations provide further evidence that FR is about 500 fold more potent than CsA and may be a useful immunosuppressive agent in organ transplantation.</p>","PeriodicalId":89485,"journal":{"name":"Surgical research communications","volume":"1 ","pages":"315-323"},"PeriodicalIF":0.0,"publicationDate":"1987-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3089009/pdf/nihms242131.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30170600","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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