THE IMMUNOSUPPRESSIVE EFFECTS OF FR 900506 IN RATS RECEIVING HETEROTOPIC CARDIAC ALLOGRAFTS.

Surgical research communications Pub Date : 1987-01-01

P Lee, N Murase, S Todo, L Makowka, T Starzl

引用次数: 0

Abstract

The immunosuppressive effects of FR 900506 were studied in Lewis rats given ACI heterotopic heart allografts. Intramuscular doses of 0.02 mg/kg daily for 2 weeks extended graft survival slightly, and with doses up to 1.28 mg/kg for 2 weeks, there is long-term graft survival. If only 3 daily doses were given starting on day 4 after transplantation, graft survival for almost 3 months was accomplished in 4 of 6 animals who still bear functioning hearts.

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fr 900506对异位心脏移植大鼠的免疫抑制作用。

研究FR 900506对ACI异位心脏移植Lewis大鼠的免疫抑制作用。每天肌肉注射0.02 mg/kg的剂量，持续2周，可以略微延长移植物的存活时间，如果剂量达到1.28 mg/kg，持续2周，移植物可以长期存活。如果从移植后第4天开始每天给药3次，6只仍然具有功能心脏的动物中有4只移植存活了近3个月。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Surgical research communications

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