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Visible Light Promoted One-Pot, Three Component Reaction for the Synthesis of quinazolines 可见光促进一锅三组分反应合成喹唑啉类化合物
Chemical sciences journal Pub Date : 2020-01-01 DOI: 10.37421/csj.2020.11.206
Parshuram Mp, Vinod Tk, R. V, Pradip Bg
{"title":"Visible Light Promoted One-Pot, Three Component Reaction for the Synthesis of quinazolines","authors":"Parshuram Mp, Vinod Tk, R. V, Pradip Bg","doi":"10.37421/csj.2020.11.206","DOIUrl":"https://doi.org/10.37421/csj.2020.11.206","url":null,"abstract":"Highly efficient one-pot three component approach was developed for the synthesis of biological active quinazoline derivatives. By the application of visible light via SP3 C-H bond activation, desired products were obtained in high yields. The advantages of this method are application of green chemistry approach, avoidance of toxic organic solvents, easily available starting material, simple operation and shorter reaction times.","PeriodicalId":89336,"journal":{"name":"Chemical sciences journal","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70053325","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Synthesis of chirally pure 1-deoxy-d-xylulose-5-phosphate : A substrate for IspC assay to determine M. tb inhibitor. 手性纯1-脱氧-d-木醛糖-5-磷酸的合成:用于IspC测定结核分枝杆菌抑制剂的底物。
Chemical sciences journal Pub Date : 2013-12-30
Benson J Edagwa, Prabagaran Narayanasamy
{"title":"Synthesis of chirally pure 1-deoxy-d-xylulose-5-phosphate : A substrate for IspC assay to determine <i>M. tb</i> inhibitor.","authors":"Benson J Edagwa,&nbsp;Prabagaran Narayanasamy","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>1-Deoxy-D-xylulsose-5-phosphate (DXP) is a key intermediate in the non-mevalonate or methyl erythritol phosphate (MEP) pathway for the biosynthesis of isoprenoid, which are essential building blocks involved in the construction of pathogens growth. Since the homologous enzymes of this pathway are not present in vertebrates, including humans, the MEP pathway presents a viable source for antimicrobial drug targets. However, an insight into the features of the enzymes involved in this pathway has been plagued by lack of chirally pure substrates. Here in, we report an efficient synthesis of enantiomerically pure 1-deoxy-D-xylulose-5-phosphate from commercially available 1,2-<i>O</i>-isopropylidene-α-D-xylofuranose through Weinreb amide formation in shorter route.</p>","PeriodicalId":89336,"journal":{"name":"Chemical sciences journal","volume":"4 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2013-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4032121/pdf/nihms577167.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32369623","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Synthesis of chirally pure 1-deoxy-d-xylulose-5-phosphate : A substrate for IspC assay to determine M. tb inhibitor. 手性纯1-脱氧-d-木醛糖-5-磷酸的合成:用于IspC测定结核分枝杆菌抑制剂的底物。
Chemical sciences journal Pub Date : 2013-12-30 DOI: 10.4172/2150-3494.1000079
Benson J. Edagwa, P. Narayanasamy
{"title":"Synthesis of chirally pure 1-deoxy-d-xylulose-5-phosphate : A substrate for IspC assay to determine M. tb inhibitor.","authors":"Benson J. Edagwa, P. Narayanasamy","doi":"10.4172/2150-3494.1000079","DOIUrl":"https://doi.org/10.4172/2150-3494.1000079","url":null,"abstract":"1-Deoxy-D-xylulsose-5-phosphate (DXP) is a key intermediate in the non-mevalonate or methyl erythritol phosphate (MEP) pathway for the biosynthesis of isoprenoid, which are essential building blocks involved in the construction of pathogens growth. Since the homologous enzymes of this pathway are not present in vertebrates, including humans, the MEP pathway presents a viable source for antimicrobial drug targets. However, an insight into the features of the enzymes involved in this pathway has been plagued by lack of chirally pure substrates. Here in, we report an efficient synthesis of enantiomerically pure 1-deoxy-D-xylulose-5-phosphate from commercially available 1,2-O-isopropylidene-α-D-xylofuranose through Weinreb amide formation in shorter route.","PeriodicalId":89336,"journal":{"name":"Chemical sciences journal","volume":"4 2 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2013-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70980399","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Understanding Solvent Effects in the Solvolyses of 4-Fluorophenyl Chlorothionoformate. 了解4-氟苯基氯硫代甲酸酯溶剂分解过程中的溶剂效应。
Chemical sciences journal Pub Date : 2011-06-27 DOI: 10.4172/2150-3494.1000026
Mj D'Souza, Sm Hailey, B. Mahon, Dn Kevill
{"title":"Understanding Solvent Effects in the Solvolyses of 4-Fluorophenyl Chlorothionoformate.","authors":"Mj D'Souza, Sm Hailey, B. Mahon, Dn Kevill","doi":"10.4172/2150-3494.1000026","DOIUrl":"https://doi.org/10.4172/2150-3494.1000026","url":null,"abstract":"The solvolyses of 4-fluorophenyl chlorothionoformate (1) are studied in fifteen binary aqueous organic mixtures of widely varying nucleophilicity and ionizing power values. The specific rates of solvolyses of 1 are plotted against the specific rates of solvolysis observed for phenyl chloroformate (2) and deviations from the line-of-best-fit are observed in some of the highly ionizing aqueous fluoroalcohol mixtures. An analysis of the solvolytic data accumulated using the extended (two-term) Grunwald-Winstein equation confirms this deviant behavior and shows that dual bimolecular addition-elimination and unimolecular ionization channels occur in the solvolyses of 1.","PeriodicalId":89336,"journal":{"name":"Chemical sciences journal","volume":"2011 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2011-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70978832","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Understanding Solvent Effects in the Solvolyses of 4-Fluorophenyl Chlorothionoformate. 了解4-氟苯基氯硫代甲酸酯溶剂分解过程中的溶剂效应。
Chemical sciences journal Pub Date : 2011-06-27
Mj D'Souza, Sm Hailey, Bp Mahon, Dn Kevill
{"title":"Understanding Solvent Effects in the Solvolyses of 4-Fluorophenyl Chlorothionoformate.","authors":"Mj D'Souza, Sm Hailey, Bp Mahon, Dn Kevill","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The solvolyses of 4-fluorophenyl chlorothionoformate (1) are studied in fifteen binary aqueous organic mixtures of widely varying nucleophilicity and ionizing power values. The specific rates of solvolyses of 1 are plotted against the specific rates of solvolysis observed for phenyl chloroformate (2) and deviations from the line-of-best-fit are observed in some of the highly ionizing aqueous fluoroalcohol mixtures. An analysis of the solvolytic data accumulated using the extended (two-term) Grunwald-Winstein equation confirms this deviant behavior and shows that dual bimolecular addition-elimination and unimolecular ionization channels occur in the solvolyses of 1.</p>","PeriodicalId":89336,"journal":{"name":"Chemical sciences journal","volume":"2011 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2011-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3172719/pdf/nihms312034.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30149335","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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