Pathology research international最新文献_第9页

The prognostic value of lymph node cross-sectional cancer area in node-positive breast cancer: a comparison with N stage and lymph node ratio. 淋巴结横截癌面积对淋巴结阳性乳腺癌预后的价值:与N期及淋巴结比例的比较。

Pathology research international Pub Date : 2012-01-01 Epub Date: 2012-10-04 DOI: 10.1155/2012/161964

Yanxia Li, Earle Holmes, Karan Shah, Kevin Albuquerque, Anna Szpaderska, Cağatay Erşahin

{"title":"The prognostic value of lymph node cross-sectional cancer area in node-positive breast cancer: a comparison with N stage and lymph node ratio.","authors":"Yanxia Li, Earle Holmes, Karan Shah, Kevin Albuquerque, Anna Szpaderska, Cağatay Erşahin","doi":"10.1155/2012/161964","DOIUrl":"https://doi.org/10.1155/2012/161964","url":null,"abstract":"The number of positive axillary lymph nodes (LNs) is the only node-related factor for prognostic evaluation of breast cancer recognized by AJCC (TNM staging). However, N staging may not completely reflect LN tumor involvement due to the erroneous count of LNs in the presence of matted LNs and different tumor volume in LNs. Additionally, the positive/total LN ratio (LNR) has been shown to outperform N staging in survival prediction. In our study, to better quantify the tumor involvement of axillary LNs, we measured the cross-sectional cancer area (CSCA) of the positive LNs in 292 breast cancer patients diagnosed between 1998 and 2000 in our institution and compared its prognostic value to that of number of positive LNs (metLN)/N stage and LNR. Statistical analyses of these three LN-related factors were performed by Kaplan-Meier method and multivariate Cox's regression model. Patients were divided into three groups based on the different LN CSCA (<50, 50-500, and >500 mm(2)), or LNR (<0.1, 0.1-0.65, and >0.65), or N stage (N1-N3). Multivariate analysis demonstrated LNR was the most significant LN-related survival predictor with hazard ratio (HR) 25.0 (P = 0.001), compared to the metLN (HR 0.09, P = 0.052) and CSCA (HR 2.24, P = 0.323).","PeriodicalId":89212,"journal":{"name":"Pathology research international","volume":"2012 ","pages":"161964"},"PeriodicalIF":0.0,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2012/161964","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31001069","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 18

Pathophysiology of the Behçet's Disease. behaperet病的病理生理学。

Pathology research international Pub Date : 2012-01-01 Epub Date: 2011-10-01 DOI: 10.1155/2012/493015

Umit Türsen

引用次数: 29

Neuroinflammation as the proximate cause of signature pathogenic pattern progression in amyotrophic lateral sclerosis, AIDS, and multiple sclerosis. 神经炎症是肌萎缩性侧索硬化症、艾滋病和多发性硬化症发病模式进展的直接原因。

Pathology research international Pub Date : 2012-01-01 Epub Date: 2012-12-04 DOI: 10.1155/2012/169270

Lawrence M Agius

{"title":"Neuroinflammation as the proximate cause of signature pathogenic pattern progression in amyotrophic lateral sclerosis, AIDS, and multiple sclerosis.","authors":"Lawrence M Agius","doi":"10.1155/2012/169270","DOIUrl":"https://doi.org/10.1155/2012/169270","url":null,"abstract":"The realization of injury to large motor neurons is embedded within contextual reference to the parallel pathways of apoptosis and necrosis of system-patterned evolution. A widespread loss of cell components occurs intracellularly and involves a reactive participation to a neuroinflammation that potentially is immunologically definable. In such terms, sporadic and hereditary forms of amyotrophic sclerosis are paralleled by the components of a reactive nature that involve the aggregation of proteins and conformational misfolding on the one hand and a powerful oxidative degradation that overwhelms the proteasome clearance mechanisms. In such terms, global participation is only one aspect of a disorder realization that induces the development of the defining systems of modulation and of injury that involves the systems of consequence as demonstrated by the overwhelming immaturity of the molecular variants of mutated superoxide dismutase. It is further to such processes of neuroinflammatory consequence that the immune system is integral to the reactive involvement of neurons as patterns of disease recognition and as the system biology of prevalent voluntarily motor character. It is highly significant to recognize various inflammatory states in the nervous system as prototype variability in phenotype expression and as incremental progression in pathogenesis. In fact a determining definition of amyotrophic lateral sclerosis is an incremental phenotype modulation within the pathways of the consequential loss and depletion of motor cell components in the first instance. Neuroinflammation proves a pattern of the contextual spread of such pathogenic progression in the realization of end-stage injury states involving neurons and neuronal networks.","PeriodicalId":89212,"journal":{"name":"Pathology research international","volume":"2012 ","pages":"169270"},"PeriodicalIF":0.0,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2012/169270","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31151139","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7

Automated measurement of immature granulocytes: performance characteristics and utility in routine clinical practice. 未成熟粒细胞的自动测量:性能特点和在常规临床实践中的应用。

Pathology research international Pub Date : 2012-01-01 Epub Date: 2012-02-15 DOI: 10.1155/2012/483670

Balamurugan Senthilnayagam, Treshul Kumar, Jayapriya Sukumaran, Jeya M, Ramesh Rao K

{"title":"Automated measurement of immature granulocytes: performance characteristics and utility in routine clinical practice.","authors":"Balamurugan Senthilnayagam, Treshul Kumar, Jayapriya Sukumaran, Jeya M, Ramesh Rao K","doi":"10.1155/2012/483670","DOIUrl":"https://doi.org/10.1155/2012/483670","url":null,"abstract":"The granulocytic \"shift to left\" reflects marrow response to bacterial infection, and this may be quantified as band count or immature granulocyte count (IGC). The former value, used widely in neonatal sepsis, has been notoriously difficult to measure accurately and precisely. A reproducible, precise, and accurate counting of immature granulocyte counts may be possible with automation. This study of 200 febrile patients aimed at analysing the performance characteristics of automated immature granulocytes (AIGs) in predicting blood culture and their clinical utility. The absolute (IGC) and relative IG count (IG%) had area under curve (AUC) of 0.69 and 0.66. Moreover, the means of IGC and IG% between culture positive and negative groups were statistically significant suggesting that they are potential markers for bacteremia. IGC of 0.03 × 10(3) cu·mm and IG% of 0.5% offered sensitivity of 86.3% and 92.2%, respectively, and may be used for screening for bacteremia. Higher values, IGC > 0.3, and IG% > 3 had specificity greater than 90%, although the values were infrequent. It may not be long before that these automated hemograms are put into regular diagnostic use.","PeriodicalId":89212,"journal":{"name":"Pathology research international","volume":"2012 ","pages":"483670"},"PeriodicalIF":0.0,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2012/483670","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30528938","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 58

Molecular mechanisms of liver injury and hepatocarcinogenesis: focusing on the role of stress-activated MAPK. 肝损伤和肝癌发生的分子机制：关注应激激活的MAPK的作用。

Pathology research international Pub Date : 2012-01-01 Epub Date: 2012-05-14 DOI: 10.1155/2012/172894

Hayato Nakagawa, Shin Maeda

{"title":"Molecular mechanisms of liver injury and hepatocarcinogenesis: focusing on the role of stress-activated MAPK.","authors":"Hayato Nakagawa, Shin Maeda","doi":"10.1155/2012/172894","DOIUrl":"10.1155/2012/172894","url":null,"abstract":"Hepatocellular carcinoma (HCC) is the third most common cause of cancer mortality. Short-term prognosis of patients with HCC has improved recently due to advances in early diagnosis and treatment, but long-term prognosis is still unsatisfactory. Therefore, obtaining a further understanding of the molecular carcinogenic mechanisms and the unique pathogenic biology of HCC is important. The most characteristic process in hepatocarcinogenesis is underlying chronic liver injury, which leads to repeated cycles of hepatocyte death, inflammation, and compensatory proliferation and subsequently provides a mitogenic and mutagenic environment leading to the development of HCC. Recent in vivo studies have shown that the stress-activated mitogen-activated protein kinase (MAPK) cascade converging on c-Jun NH(2)-terminal kinase (JNK) and p38 plays a central role in these processes, and it has attracted considerable attention as a therapeutic target. However, JNK and p38 have complex functions and a wide range of cellular effects. In addition, crosstalk with each other and the nuclear factor-kappaB pathway further complicate these functions. A full understanding is essential to bring these observations into clinical settings. In this paper, we discuss the latest findings regarding the mechanisms of liver injury and hepatocarcinogenesis focusing on the role of the stress-activated MAPK pathway.","PeriodicalId":89212,"journal":{"name":"Pathology research international","volume":"2012 ","pages":"172894"},"PeriodicalIF":0.0,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2012/172894","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30666013","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 83

Pathologic Features of Behçet's Disease in the Tubuler Gut. 小管肠behaperet病的病理特点。

Pathology research international Pub Date : 2012-01-01 Epub Date: 2011-11-15 DOI: 10.1155/2012/216254

Tuba Kara, Duygu Düşmez Apa

引用次数: 8

Clear cell carcinomas of the mullerian system: does the pathogenesis vary depending on their nuclear grade and their association with endometriosis? An immunohistochemical analysis. 穆勒氏系统透明细胞癌：其发病机制是否因核分级和与子宫内膜异位症的关系而异？免疫组化分析。

Pathology research international Pub Date : 2012-01-01 Epub Date: 2012-11-01 DOI: 10.1155/2012/674748

Ahmad Alduaij, Katrine Hansen, Tahreem A Karim, Cunxian Zhang, Michelle M Lomme, C James Sung, W Dwayne Lawrence, M Ruhul Quddus

{"title":"Clear cell carcinomas of the mullerian system: does the pathogenesis vary depending on their nuclear grade and their association with endometriosis? An immunohistochemical analysis.","authors":"Ahmad Alduaij, Katrine Hansen, Tahreem A Karim, Cunxian Zhang, Michelle M Lomme, C James Sung, W Dwayne Lawrence, M Ruhul Quddus","doi":"10.1155/2012/674748","DOIUrl":"10.1155/2012/674748","url":null,"abstract":"Unlabelled: Clear cell carcinomas (CCC) of the mullerian system are considered high grade tumors, but morphologically, the cells of CCC show both low and high grade features. The aims of the current study were to categorize CCC into low and high nuclear grade types, correlate their association with endometriosis, and then observe possible variations in pathogenesis based on their expression of p53 and Ki-67. We studied 41 pure mullerian CCCs and designated each as either a high (HNG) or low (LNG) nuclear grade tumor. Morphologically, 17 (41%) CCCs were LNG and 24 (59%) were HNG. Nine (38%) HNG and 2 (12%) LNG tumors showed positive immunostaining with p53. Endometriosis was associated with 8 (47%) LNG tumors and 8 (33%) HNG CCCs. Of the 11 cases with p53 alteration, 4 (1 LNG and 3 HNG) were associated with endometriosis.Conclusions: HNG CCCs, irrespective of their association with endometriosis, have alterations of p53. In general, LNG ovarian and endometrial CCCs, irrespective of their association with endometriosis/adenomyosis, are less likely to show p53 alteration. It appears that mullerian CCCs may have variable pathogenesis depending on their nuclear grade and association with endometriosis. A larger study is needed to validate these findings.","PeriodicalId":89212,"journal":{"name":"Pathology research international","volume":"2012 ","pages":"674748"},"PeriodicalIF":0.0,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3503438/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31100298","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Immunoreactivity of the 14F7 Mab (Raised against N-Glycolyl GM3 Ganglioside) as a Positive Prognostic Factor in Non-Small-Cell Lung Cancer. 14F7单抗(针对N-Glycolyl GM3神经节苷脂)的免疫反应性作为非小细胞肺癌的阳性预后因素

Pathology research international Pub Date : 2012-01-01 Epub Date: 2012-02-26 DOI: 10.1155/2012/235418

Rancés Blanco, Charles E Rengifo, Mercedes Cedeño, Milagros Frómeta, Enrique Rengifo, Adriana Carr

{"title":"Immunoreactivity of the 14F7 Mab (Raised against N-Glycolyl GM3 Ganglioside) as a Positive Prognostic Factor in Non-Small-Cell Lung Cancer.","authors":"Rancés Blanco, Charles E Rengifo, Mercedes Cedeño, Milagros Frómeta, Enrique Rengifo, Adriana Carr","doi":"10.1155/2012/235418","DOIUrl":"https://doi.org/10.1155/2012/235418","url":null,"abstract":"Lung carcinoma is the leading cause of cancer-related mortality worldwide. Therefore, numerous studies are focusing on the assessment of other biological and molecular prognostic factors in these tumors. We evaluated the relationship between 14F7 Mab reactivity, pathological features, DNA-content and S-phase fraction (SPF), and their impact in the survival of NSCLC patients. Hematoxylin and eosin staining and immunohistochemistry optical microscopy assays as well as DNA content and SPF measuring using flow cytometry were performed. The 14F7 reactivity was widely observed in NSCLC sections, no depending of the clinicopathological characteristics. We also obtained differences in the intensity of reaction with 14F7 as well as in the SPF between diploid and aneuploid carcinomas. Patients with diploid tumors showing higher SPF and 14F7 reaction joint to a low mitotic index displayed higher survival rates. Our results are in agreement with the assumption of the possible positive prognostic value of 14F7 staining in NSCLC.","PeriodicalId":89212,"journal":{"name":"Pathology research international","volume":"2012 ","pages":"235418"},"PeriodicalIF":0.0,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2012/235418","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30556947","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 41

Animal Models in Behçet's Disease. behaperet病的动物模型。

Pathology research international Pub Date : 2012-01-01 Epub Date: 2012-02-27 DOI: 10.1155/2012/273701

Ozlem Yildirim

引用次数: 6

Bladder cancer detection using electrical impedance technique (tabriz mark 1). 电阻抗技术检测膀胱癌(tabriz mark 1)。

Pathology research international Pub Date : 2012-01-01 Epub Date: 2012-04-09 DOI: 10.1155/2012/470101

Ahmad Keshtkar, Zeinab Salehnia, Asghar Keshtkar, Behrooz Shokouhi

{"title":"Bladder cancer detection using electrical impedance technique (tabriz mark 1).","authors":"Ahmad Keshtkar, Zeinab Salehnia, Asghar Keshtkar, Behrooz Shokouhi","doi":"10.1155/2012/470101","DOIUrl":"https://doi.org/10.1155/2012/470101","url":null,"abstract":"Bladder cancer is the fourth most common malignant neoplasm in men and the eighth in women. Bladder pathology is usually investigated visually by cystoscopy. In this technique, biopsies are obtained from the suspected area and then, after needed procedure, the diagnostic information can be taken. This is a relatively difficult procedure and is associated with discomfort for the patient and morbidity. Therefore, the electrical impedance spectroscopy (EIS), a minimally invasive screening technique, can be used to separate malignant areas from nonmalignant areas in the urinary bladder. The feasibility of adapting this technique to screen for bladder cancer and abnormalities during cystoscopy has been explored and compared with histopathological evaluation of urinary bladder lesions. Ex vivo studies were carried out in this study by using a total of 30 measured points from malignant and 100 measured points from non-malignant areas of patients bladders in terms of their biopsy reports matching to the electrical impedance measurements. In all measurements, the impedivity of malignant area of bladder tissue was significantly higher than the impedivity of non-malignant area this tissue (P < 0.005).","PeriodicalId":89212,"journal":{"name":"Pathology research international","volume":"2012 ","pages":"470101"},"PeriodicalIF":0.0,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2012/470101","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30601105","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 45