Journal of the Mississippi Academy of Sciences. Mississippi Academy of Sciences最新文献

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LASER PROBE WITH INTEGRATED CONTACT COOLING FOR SUBSURFACE TISSUE THERMAL REMODELING. 集成接触式冷却的激光探针用于皮下组织热重塑。

Journal of the Mississippi Academy of Sciences. Mississippi Academy of Sciences Pub Date : 2018-04-01

Chun-Hung Chang, Nathaniel M Fried

{"title":"LASER PROBE WITH INTEGRATED CONTACT COOLING FOR SUBSURFACE TISSUE THERMAL REMODELING.","authors":"Chun-Hung Chang, Nathaniel M Fried","doi":"","DOIUrl":"","url":null,"abstract":"Over 6.5 million women in the United States suffer from female stress urinary incontinence (SUI). Only ~200,000 women choose surgery. There may be a role for a non-surgical, minimally invasive procedure that provides thermal shrinkage/remodeling of submucosal collagen in the endopelvic fascia. This study describes design, characterization, and preliminary testing of a novel probe with integrated contact cooling for potential use in transvaginal laser treatment of SUI. Laser energy at a deeply penetrating, near-infrared wavelength of 1075 nm was delivered through a 600-μm-core fiber optic patchcord into a 90° side-firing probe head (19 × 22 mm) with integrated flow cell and sapphire window cooled to -2°C by circulating an alcohol-based solution. An inflatable balloon attached to the probe insured contact with vaginal wall. A force sensor and thermocouples monitored pressure and temperature. Thermal lesions were created in vaginal tissue of three cadavers (power = 4.6-6.4 W; spot diameter = 5.2 mm; time = 30 s). Thermal lesion areas measured 3.1-4.6 mm2, while preserving the vaginal wall to a depth of 0.8-1.1 mm. Consistent tissue contact and cooling was maintained using the force sensors. Preliminary cadaver studies demonstrated subsurface treatment of endopelvic fascia with partial preservation of the vaginal wall. Future studies will optimize parameters for thermal remodeling with further tissue surface preservation.","PeriodicalId":89178,"journal":{"name":"Journal of the Mississippi Academy of Sciences. Mississippi Academy of Sciences","volume":"63 2 Suppl 1","pages":"202-205"},"PeriodicalIF":0.0,"publicationDate":"2018-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6388701/pdf/nihms984446.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37007624","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

β-ESTRADIOL INDUCES CYTOTOXIC EFFECTS TO HUMAN T-LYMPHOMA (JURKAT) CELLS THROUGH OXIDATIVE STRESS. β-雌二醇通过氧化应激诱导人t淋巴瘤细胞的细胞毒性作用。

Journal of the Mississippi Academy of Sciences. Mississippi Academy of Sciences Pub Date : 2015-04-01

Clement Yedjou, Joseph Cameron, Ariane T Mbemi, Paul Tchounwou

{"title":"β-ESTRADIOL INDUCES CYTOTOXIC EFFECTS TO HUMAN T-LYMPHOMA (JURKAT) CELLS THROUGH OXIDATIVE STRESS.","authors":"Clement Yedjou, Joseph Cameron, Ariane T Mbemi, Paul Tchounwou","doi":"","DOIUrl":"","url":null,"abstract":"β-estradiol is the most potent estrogen of a group of endogenous estrogen steroids which includes estrone and estriol. This steroid hormone is the most potent natural estrogen, produced mainly by the ovary, placenta, and in smaller amounts by the adrenal cortex, and the male testes. Although β-estradiol protects the renal and cardiovascular systems, the mechanisms involved remain unclear. In this research, we performed the MTT [3-(4, 5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide] assay to evaluate the effect of β-estradiol on human T-lymphoma (Jurkat) cells upon 24 and 48 hours, respectively. Lipid peroxidation assay was also performed to estimate the levels of malondialdehyde (MDA) production in β-estradiol-treated cells. The results of MTT assay demonstrated that low, physiological levels of β-estradiol induce cellular proliferation in Jurkat T-cells. At higher dose of exposure, β-estradiol decreases the viability of Jurkat T-cells compared to the control cells. Data generated from lipid peroxidation assay resulted in a significant increase (p < 0.05) in MDA production in β-estradiol treated sample. Upon 48 h of exposure, MDA concentrations in the sample [µM] (mean ±SE, n = 3) compared to untreated control were 4.9 ± 1.7, 8.1 ± 1,6 11.5 ± 2.2, 21.1 ± 2.3, 19.5 ± 1.4, and 21.5 ± 2.6 in 0, 1, 2, 4, 8, and 16 µM β-estradiol, respectively. In summary, findings from this study demonstrated that high dose of β-estradiol is cytotoxic to Jurkat T-cells. This cytotoxicity is found to be associated with oxidative stress.","PeriodicalId":89178,"journal":{"name":"Journal of the Mississippi Academy of Sciences. Mississippi Academy of Sciences","volume":"60 Suppl 1","pages":"279-283"},"PeriodicalIF":0.0,"publicationDate":"2015-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4550313/pdf/nihms685662.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34030994","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Binding and Selectivity of Halides with Macrocyclic polyamines. 卤化物与大环多胺的结合及选择性。

Journal of the Mississippi Academy of Sciences. Mississippi Academy of Sciences Pub Date : 2009-07-01

Md Alamgir Hossain, Musabbir A Saeed

引用次数: 0