Journal of signal transduction最新文献_第10页

Integrin signaling, cell survival, and anoikis: distinctions, differences, and differentiation. 整合素信号，细胞存活，和异常:区别，差异和分化。

Journal of signal transduction Pub Date : 2011-01-01 Epub Date: 2011-07-13 DOI: 10.1155/2011/738137

Pierre H Vachon

引用次数: 134

Jak2-Independent Activation of Stat3 by Intracellular Angiotensin II in Human Mesangial Cells. 细胞内血管紧张素II在人系膜细胞中独立激活Stat3的作用。

Journal of signal transduction Pub Date : 2011-01-01 Epub Date: 2011-09-12 DOI: 10.1155/2011/257862

Rekha Singh

{"title":"Jak2-Independent Activation of Stat3 by Intracellular Angiotensin II in Human Mesangial Cells.","authors":"Rekha Singh","doi":"10.1155/2011/257862","DOIUrl":"https://doi.org/10.1155/2011/257862","url":null,"abstract":"Ang II is shown to mediate the stimulatory effect of high glucose on TGF-b1 and extracellular matrix proteins in glomerular mesangial cells. Also inhibition of Ang II formation in cell media (extracellular) and lysates (intracellular) blocks high-glucose effects on TGF-b1 and matrix more effectively compared to inhibition of extracellular Ang II alone. To investigate whether intracellular Ang II can stimulate TGF-b1 and matrix independent of extracellular Ang II, cultured human mesangial cells were transfected with Ang II to increase intracellular Ang II levels and its effects on TGF-b1 and matrix proteins were determined. Prior to transfection, cells were treated with candesartan to block extracellular Ang II-induced responses via cell membrane AT1 receptors. Transfection of cells with Ang II resulted in increased levels of intracellular Ang II which was accompanied by increased production of TGF-b1, collagen IV, fibronectin, and cell proliferation as well. On further examination, intracellular Ang II was found to activate Stat3 transcription factor including increased Stat3 protein expression, tyrosine 705 phosphorylation, and DNA-binding activity. Treatment with AG-490, an inhibitor of Jak2, did not block intracellular Ang II-induced Stat3 phosphorylation at tyrosine 705 residue indicating a Jak2-independent mechanism used by intracellular Ang II for Stat3 phosphorylation. In contrast, extracellular Ang II-induced tyrosine 705 phosphorylation of Stat3 was inhibited by AG-490 confirming the presence of a Jak2-dependent pathway. These findings suggest that intracellular Ang II increases TGF-b1 and matrix in human mesangial cells and also activates Stat3 transcription factor without involvement of the extracellular Ang II signaling pathway.","PeriodicalId":89176,"journal":{"name":"Journal of signal transduction","volume":"2011 ","pages":"257862"},"PeriodicalIF":0.0,"publicationDate":"2011-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2011/257862","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30139371","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 12

Receptor tyrosine kinases in kidney development. 肾脏发育中的受体酪氨酸激酶。

Journal of signal transduction Pub Date : 2011-01-01 Epub Date: 2011-03-03 DOI: 10.1155/2011/869281

Renfang Song, Samir S El-Dahr, Ihor V Yosypiv

引用次数: 21

Regulation of suppressors of cytokine signaling as a therapeutic approach in autoimmune diseases, with an emphasis on multiple sclerosis. 调节细胞因子信号的抑制因子作为自身免疫性疾病的治疗方法，重点是多发性硬化症。

Journal of signal transduction Pub Date : 2011-01-01 Epub Date: 2011-11-01 DOI: 10.1155/2011/635721

Vinod S Ramgolam, Silva Markovic-Plese

{"title":"Regulation of suppressors of cytokine signaling as a therapeutic approach in autoimmune diseases, with an emphasis on multiple sclerosis.","authors":"Vinod S Ramgolam, Silva Markovic-Plese","doi":"10.1155/2011/635721","DOIUrl":"https://doi.org/10.1155/2011/635721","url":null,"abstract":"Multiple sclerosis (MS) is an inflammatory demyelinating, presumably autoimmune disease of the central nervous system (CNS). Among the available MS therapies, interferon (IFN)β and the recently introduced statins have been reported to exert their immunomodulatory effects through the induction of SOCS1 and SOCS3 in various inflammatory cell subsets. The SOCS proteins negatively regulate cytokine and Toll-like receptors- (TLR-) induced signaling in the inflammatory cells. SOCS1 and SOCS3 have been reported to play an important role in the regulation of Th17-cell differentiation through their effects on the cells of the innate and adaptive immune systems. IFNβ and statins inhibit Th17-cell differentiation directly and indirectly via induction of SOCS1 and SOCS3 expression in monocytes, dendritic cells (DCs), and B-cells. Due to their rapid induction and degradation, and SOCS-mediated regulation of multiple cytokine-signaling pathways, they represent an attractive therapeutic target in the autoimmune diseases, and particularly relapsing remitting (RR) MS.","PeriodicalId":89176,"journal":{"name":"Journal of signal transduction","volume":"2011 ","pages":"635721"},"PeriodicalIF":0.0,"publicationDate":"2011-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2011/635721","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30295499","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 27

Functional Diversity of the Schistosoma mansoni Tyrosine Kinases. 曼氏血吸虫酪氨酸激酶的功能多样性。

Journal of signal transduction Pub Date : 2011-01-01 Epub Date: 2011-06-15 DOI: 10.1155/2011/603290

Lívia G A Avelar, Laila A Nahum, Luiza F Andrade, Guilherme Oliveira

引用次数: 13

The role of specific mitogen-activated protein kinase signaling cascades in the regulation of steroidogenesis. 特定丝裂原激活的蛋白激酶信号级联在类固醇生成调控中的作用。

Journal of signal transduction Pub Date : 2011-01-01 Epub Date: 2011-01-05 DOI: 10.1155/2011/821615

Pulak R Manna, Douglas M Stocco

{"title":"The role of specific mitogen-activated protein kinase signaling cascades in the regulation of steroidogenesis.","authors":"Pulak R Manna, Douglas M Stocco","doi":"10.1155/2011/821615","DOIUrl":"https://doi.org/10.1155/2011/821615","url":null,"abstract":"Mitogen-activated protein kinases (MAPKs) comprise a family of serine/threonine kinases that are activated by a large variety of extracellular stimuli and play integral roles in controlling many cellular processes, from the cell surface to the nucleus. The MAPK family includes four distinct MAPK cascades, that is, extracellular signal-regulated kinase 1/2 (ERK1/2), p38 MAPK, c-Jun N-terminal kinase or stress-activated protein kinase, and ERK5. These MAPKs are essentially operated through three-tiered consecutive phosphorylation events catalyzed by a MAPK kinase kinase, a MAPK kinase, and a MAPK. MAPKs lie in protein kinase cascades. The MAPK signaling pathways have been demonstrated to be associated with events regulating the expression of the steroidogenic acute regulatory protein (StAR) and steroidogenesis in steroidogenic tissues. However, it has become clear that the regulation of MAPK-dependent StAR expression and steroid synthesis is a complex process and is context dependent. This paper summarizes the current level of understanding concerning the roles of the MAPK signaling cascades in the regulation of StAR expression and steroidogenesis in different steroidogenic cell models.","PeriodicalId":89176,"journal":{"name":"Journal of signal transduction","volume":"2011 ","pages":"821615"},"PeriodicalIF":0.0,"publicationDate":"2011-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2011/821615","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"29910540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 103

Role of RNA-Binding Proteins in MAPK Signal Transduction Pathway. rna结合蛋白在MAPK信号转导通路中的作用

Journal of signal transduction Pub Date : 2011-01-01 Epub Date: 2011-04-05 DOI: 10.1155/2011/109746

Reiko Sugiura, Ryosuke Satoh, Shunji Ishiwata, Nanae Umeda, Ayako Kita

{"title":"Role of RNA-Binding Proteins in MAPK Signal Transduction Pathway.","authors":"Reiko Sugiura, Ryosuke Satoh, Shunji Ishiwata, Nanae Umeda, Ayako Kita","doi":"10.1155/2011/109746","DOIUrl":"https://doi.org/10.1155/2011/109746","url":null,"abstract":"Mitogen-activated protein kinases (MAPKs), which are found in all eukaryotes, are signal transducing enzymes playing a central role in diverse biological processes, such as cell proliferation, sexual differentiation, and apoptosis. The MAPK signaling pathway plays a key role in the regulation of gene expression through the phosphorylation of transcription factors. Recent studies have identified several RNA-binding proteins (RBPs) as regulators of MAPK signaling because these RBPs bind to the mRNAs encoding the components of the MAPK pathway and regulate the stability of their transcripts. Moreover, RBPs also serve as targets of MAPKs because MAPK phosphorylate and regulate the ability of RBPs to bind and stabilize target mRNAs, thus controlling various cellular functions. In this review, we present evidence for the significance of the MAPK signaling in the regulation of RBPs and their target mRNAs, which provides additional information about the regulatory mechanism underlying gene expression. We further present evidence for the clinical importance of the posttranscriptional regulation of mRNA stability and its implications for drug discovery.","PeriodicalId":89176,"journal":{"name":"Journal of signal transduction","volume":"2011 ","pages":"109746"},"PeriodicalIF":0.0,"publicationDate":"2011-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2011/109746","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30020332","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 33

Fish Suppressors of Cytokine Signaling (SOCS): Gene Discovery, Modulation of Expression and Function. 鱼类细胞因子信号抑制因子(SOCS):基因发现、表达调控和功能。

Journal of signal transduction Pub Date : 2011-01-01 Epub Date: 2011-12-13 DOI: 10.1155/2011/905813

Tiehui Wang, Bartolomeo Gorgoglione, Tanja Maehr, Jason W Holland, Jose L González Vecino, Simon Wadsworth, Christopher J Secombes

{"title":"Fish Suppressors of Cytokine Signaling (SOCS): Gene Discovery, Modulation of Expression and Function.","authors":"Tiehui Wang, Bartolomeo Gorgoglione, Tanja Maehr, Jason W Holland, Jose L González Vecino, Simon Wadsworth, Christopher J Secombes","doi":"10.1155/2011/905813","DOIUrl":"https://doi.org/10.1155/2011/905813","url":null,"abstract":"The intracellular suppressors of cytokine signaling (SOCS) family members, including CISH and SOCS1 to 7 in mammals, are important regulators of cytokine signaling pathways. So far, the orthologues of all the eight mammalian SOCS members have been identified in fish, with several of them having multiple copies. Whilst fish CISH, SOCS3, and SOCS5 paralogues are possibly the result of the fish-specific whole genome duplication event, gene duplication or lineage-specific genome duplication may also contribute to some paralogues, as with the three trout SOCS2s and three zebrafish SOCS5s. Fish SOCS genes are broadly expressed and also show species-specific expression patterns. They can be upregulated by cytokines, such as IFN-γ, TNF-α, IL-1β, IL-6, and IL-21, by immune stimulants such as LPS, poly I:C, and PMA, as well as by viral, bacterial, and parasitic infections in member- and species-dependent manners. Initial functional studies demonstrate conserved mechanisms of fish SOCS action via JAK/STAT pathways.","PeriodicalId":89176,"journal":{"name":"Journal of signal transduction","volume":"2011 ","pages":"905813"},"PeriodicalIF":0.0,"publicationDate":"2011-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2011/905813","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30353517","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 83

Involvement of phosphatases in proliferation, maturation, and hemoglobinization of developing erythroid cells. 磷酸酶在发育中的红细胞增殖、成熟和血红蛋白化中的作用。

Journal of signal transduction Pub Date : 2011-01-01 Epub Date: 2011-07-14 DOI: 10.1155/2011/860985

Eitan Fibach

{"title":"Involvement of phosphatases in proliferation, maturation, and hemoglobinization of developing erythroid cells.","authors":"Eitan Fibach","doi":"10.1155/2011/860985","DOIUrl":"https://doi.org/10.1155/2011/860985","url":null,"abstract":"Production of RBCs is triggered by the action of erythropoietin (Epo) through its binding to surface receptors (Epo-R) on erythroid precursors in the bone marrow. The intensity and the duration of the Epo signal are regulated by several factors, including the balance between the activities of kinesase and phosphatases. The Epo signal determines the proliferation and maturation of the precursors into hemoglobin (Hb)-containing RBCs. The activity of various protein tyrosine phosphatases, including those involved in the Epo pathway, can be inhibited by sodium orthovanadate (Na(3)VO(4), vanadate). Adding vanadate to cultured erythroid precursors of normal donors and patients with β-thalassemia enhanced cell proliferation and arrested maturation. This was associated with an increased production of fetal hemoglobin (HbF). Increased HbF in patients with β-hemoglobinopathies (β-thalassemia and sickle cell disease) ameliorates the clinical symptoms of the disease. These results raise the possibility that specific and nontoxic inhibitors of phosphatases may be considered as a therapeutic modality for elevating HbF in patients with β-hemoglobinopathies as well as for intensifying the Epo response in other forms of anemia.","PeriodicalId":89176,"journal":{"name":"Journal of signal transduction","volume":"2011 ","pages":"860985"},"PeriodicalIF":0.0,"publicationDate":"2011-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2011/860985","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30028742","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7

Relevance of VEGF and nephrin expression in glomerular diseases. 肾小球疾病中VEGF和nephrin表达的相关性

Journal of signal transduction Pub Date : 2011-01-01 Epub Date: 2011-07-26 DOI: 10.1155/2011/718609

Claudia A Bertuccio

引用次数: 11