BMC Medical Genomics最新文献

筛选
英文 中文
Intrauterine growth restriction induces persistent adipose inflammation and metabolic abnormalities in rats among various postnatal growth trajectories. 在不同的出生后生长轨迹中,宫内生长限制诱导大鼠持续的脂肪炎症和代谢异常。
IF 2 4区 医学
BMC Medical Genomics Pub Date : 2025-10-16 DOI: 10.1186/s12920-025-02221-5
Qian Hu, Zhenjie Zhang, Fan Yang, Zhenxin Fan, Yifei Li, Ping Li
{"title":"Intrauterine growth restriction induces persistent adipose inflammation and metabolic abnormalities in rats among various postnatal growth trajectories.","authors":"Qian Hu, Zhenjie Zhang, Fan Yang, Zhenxin Fan, Yifei Li, Ping Li","doi":"10.1186/s12920-025-02221-5","DOIUrl":"https://doi.org/10.1186/s12920-025-02221-5","url":null,"abstract":"<p><strong>Background: </strong>Intrauterine growth restriction (IUGR) with rapid postnatal catch-up growth has been associated with adipose tissue inflammation and metabolic dysfunction. The long-term persistence of these abnormalities and their relationship with different catch-up growth patterns remain unclear.</p><p><strong>Methods: </strong>To investigate the long-term metabolic consequences of IUGR in relation to different catch-up growth patterns. An experimental animal study using a rat model of IUGR induced by maternal protein restriction during gestation. Abdominal adipose tissue transcriptome profiles in male rats were analyzed at 3 and 9 months of age, considering variations in catch-up growth patterns. The primary outcomes included markers of adipose tissue inflammation and metabolic function.</p><p><strong>Results: </strong>Among IUGR offspring, approximately 50% demonstrated slow catch-up growth and remained undernourished at 3 months of age. Transcriptome analysis revealed persistent adipose tissue inflammation and metabolic alterations that progressed with age. These abnormalities were present in both rapid and slow catch-up growth groups, although offspring with rapid catch-up growth exhibited more adverse manifestations.</p><p><strong>Conclusion: </strong>IUGR was associated with long-term adipose tissue inflammation and metabolic dysfunction, independent of catch-up growth pattern. These findings suggest that IUGR may have lasting metabolic consequences regardless of postnatal growth trajectory.</p>","PeriodicalId":8915,"journal":{"name":"BMC Medical Genomics","volume":"18 1","pages":"161"},"PeriodicalIF":2.0,"publicationDate":"2025-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145306821","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Assessment of genetic and metabolite associations of branched chain amino acids with metabolic disease in the UK Biobank using Mendelian randomization. 在英国生物库中使用孟德尔随机化评估支链氨基酸与代谢性疾病的遗传和代谢物关联。
IF 2 4区 医学
BMC Medical Genomics Pub Date : 2025-10-16 DOI: 10.1186/s12920-025-02232-2
Jedrzej Konarkowski, Courtney Astore, Greg Gibson
{"title":"Assessment of genetic and metabolite associations of branched chain amino acids with metabolic disease in the UK Biobank using Mendelian randomization.","authors":"Jedrzej Konarkowski, Courtney Astore, Greg Gibson","doi":"10.1186/s12920-025-02232-2","DOIUrl":"https://doi.org/10.1186/s12920-025-02232-2","url":null,"abstract":"<p><strong>Background: </strong>As the building blocks of proteins and precursors of many other important compounds, amino acids play a vital role in the biochemical processes needed to sustain life. The branched-chain amino acids (BCAAs) are unique in their structure and function, as they are metabolized in muscle tissue and play important roles in protein synthesis and energy production. However, despite their physiological importance, relatively little integrative research has been conducted into the direct relationships between this class of metabolites and their effect on risk for metabolic diseases.</p><p><strong>Methods: </strong>Utilizing an integrative PheWAS approach using UK Biobank data, we were able to identify strong, high confidence, metabolite-disease correlations for the three BCAAs: leucine, isoleucine, and valine. Relationships were established through comparison of metabolite level-disease prevalence associations with polygenic scores for BCAAs, followed by Mendelian randomization analysis.</p><p><strong>Results: </strong>All BCAAs studied demonstrated especially strong relationships with type II diabetes, and robust relationships with obesity, hypertension, sleep apnea, and chronic kidney disease. We illustrate this with a set of metabolite prevalence-disease risk plots that suggest differing potential for disease based on varying levels of branched-chain amino acid metabolites. Similar results are observed with polygenic scores for plasma BCAAs. Mendelian randomization shows positive effects of leucine and isoleucine on hypertension, and either reverse causality or no clear directional relationship for other associations, notably effects of obesity and type II diabetes on all three BCAAs, with limited or borderline evidence for other outcomes.</p><p><strong>Conclusions: </strong>Overall, the results of our study highlight a relatively unexplored area of metabolite-disease associations and provide a blueprint for uncovering additional relationships using readily available biobank data.</p>","PeriodicalId":8915,"journal":{"name":"BMC Medical Genomics","volume":"18 1","pages":"163"},"PeriodicalIF":2.0,"publicationDate":"2025-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145306741","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Multi-modal characteristics of LncRNA-derived subtypes in colorectal cancer. 结直肠癌中lncrna衍生亚型的多模态特征
IF 2 4区 医学
BMC Medical Genomics Pub Date : 2025-10-16 DOI: 10.1186/s12920-025-02242-0
Minghao Xiong, Jie Li, Xue Li, Jiaojiao Zhao, Qin Liu, Mengjie Tu, Fanxin Zeng
{"title":"Multi-modal characteristics of LncRNA-derived subtypes in colorectal cancer.","authors":"Minghao Xiong, Jie Li, Xue Li, Jiaojiao Zhao, Qin Liu, Mengjie Tu, Fanxin Zeng","doi":"10.1186/s12920-025-02242-0","DOIUrl":"https://doi.org/10.1186/s12920-025-02242-0","url":null,"abstract":"","PeriodicalId":8915,"journal":{"name":"BMC Medical Genomics","volume":"18 1","pages":"162"},"PeriodicalIF":2.0,"publicationDate":"2025-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145306797","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Construction and validation of a lactylation-based gene signature for prognostic assessment and immune infiltration analysis in gastric adenocarcinoma. 用于胃腺癌预后评估和免疫浸润分析的基于乳酸化的基因标记的构建和验证。
IF 2 4区 医学
BMC Medical Genomics Pub Date : 2025-10-14 DOI: 10.1186/s12920-025-02244-y
Yu Zeng, Gaojian Zhuang, Wenjun Xie, Shiwei Guo, Shuping Wu, Jialin Chen
{"title":"Construction and validation of a lactylation-based gene signature for prognostic assessment and immune infiltration analysis in gastric adenocarcinoma.","authors":"Yu Zeng, Gaojian Zhuang, Wenjun Xie, Shiwei Guo, Shuping Wu, Jialin Chen","doi":"10.1186/s12920-025-02244-y","DOIUrl":"10.1186/s12920-025-02244-y","url":null,"abstract":"<p><strong>Background: </strong>Stomach adenocarcinoma (STAD) poses a major public health challenge across various populations, necessitating the construction of robust models for prognostic prediction and effective clinical therapies. Dysregulation of lactylation, a key regulatory mechanism in cell metabolism and gene expression, can either impede or promote tumor growth and metastasis.</p><p><strong>Methods: </strong>This study got into the bottom of TCGA-STAD-sourced transcriptome data to profile lactylation-related genes and construct a gene signature through LASSO regression. A nomogram was further created to assess the prognostic performance of this model. Our investigation primarily concentrated on the expression of Dehydrogenase/reductase 7 (DHRS7) in STAD, with the verification of its correlations with clinical characteristics, immune cell infiltration, and cellular signaling pathways.</p><p><strong>Results: </strong>DHRS7 expressed lower in STAD tissues, and that modulating DHRS7 levels could either promote or inhibit malignant behaviors associated with STAD. In the later stages of tumor progression, DHRS7 appeared to facilitate tumor growth through mechanisms such as immune evasion and activation of PI3K/AKT/mTOR signaling pathways, ultimately contributing to an unfavorable prognosis.</p><p><strong>Conclusions: </strong>DHRS7 has the potential to shift from acting as a tumor suppressor to functioning as an oncogene in modified TMEs, despite its lower expression levels in STAD tissues relative to normal tissues. This transformation accounts for the association between high DHRS7 expression in the later stages of STAD and a negative prognosis.</p>","PeriodicalId":8915,"journal":{"name":"BMC Medical Genomics","volume":"18 1","pages":"160"},"PeriodicalIF":2.0,"publicationDate":"2025-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12522653/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145290876","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Three intronic variants altering RNA splicing were identified in the CLCN5 gene by minigene assay. 通过微基因分析,在CLCN5基因中发现了3个改变RNA剪接的内含子变异。
IF 2 4区 医学
BMC Medical Genomics Pub Date : 2025-10-14 DOI: 10.1186/s12920-025-02230-4
Dan Qiao, Xuyan Liu, Irene Bottillo, Ran Zhang, Leping Shao
{"title":"Three intronic variants altering RNA splicing were identified in the CLCN5 gene by minigene assay.","authors":"Dan Qiao, Xuyan Liu, Irene Bottillo, Ran Zhang, Leping Shao","doi":"10.1186/s12920-025-02230-4","DOIUrl":"10.1186/s12920-025-02230-4","url":null,"abstract":"","PeriodicalId":8915,"journal":{"name":"BMC Medical Genomics","volume":"18 1","pages":"158"},"PeriodicalIF":2.0,"publicationDate":"2025-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12522890/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145290892","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
An intron SNP rs666088 in SLIT2 increases the risk of acute coronary syndrome in an Iranian population. SLIT2中的内含子SNP rs666088增加了伊朗人群急性冠状动脉综合征的风险。
IF 2 4区 医学
BMC Medical Genomics Pub Date : 2025-10-14 DOI: 10.1186/s12920-025-02224-2
Pooria Pakdaman, Nadereh Naderi, Narges Farshidi, Hossein Farshidi, Zahra Jafari, Mahsa Rahimzadeh
{"title":"An intron SNP rs666088 in SLIT2 increases the risk of acute coronary syndrome in an Iranian population.","authors":"Pooria Pakdaman, Nadereh Naderi, Narges Farshidi, Hossein Farshidi, Zahra Jafari, Mahsa Rahimzadeh","doi":"10.1186/s12920-025-02224-2","DOIUrl":"10.1186/s12920-025-02224-2","url":null,"abstract":"","PeriodicalId":8915,"journal":{"name":"BMC Medical Genomics","volume":"18 1","pages":"157"},"PeriodicalIF":2.0,"publicationDate":"2025-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12522833/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145290864","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Single-cell RNA-seq combined with bulk RNA-seq analysis identifies necroptosis-related genes as therapeutic targets for periodontitis. 单细胞RNA-seq结合大量RNA-seq分析确定坏死相关基因作为牙周炎的治疗靶点。
IF 2 4区 医学
BMC Medical Genomics Pub Date : 2025-10-14 DOI: 10.1186/s12920-025-02241-1
Feixiang Zhu, Mingyan Xu, Yixin Xiao, Hongfa Yao, Fan Liu, Songlin Shi, Rui Huang, Qianju Wu, Xiaoling Deng
{"title":"Single-cell RNA-seq combined with bulk RNA-seq analysis identifies necroptosis-related genes as therapeutic targets for periodontitis.","authors":"Feixiang Zhu, Mingyan Xu, Yixin Xiao, Hongfa Yao, Fan Liu, Songlin Shi, Rui Huang, Qianju Wu, Xiaoling Deng","doi":"10.1186/s12920-025-02241-1","DOIUrl":"10.1186/s12920-025-02241-1","url":null,"abstract":"<p><strong>Background: </strong>Necroptosis, a regulated form of programmed cell death, exacerbates inflammatory responses by releasing damage-associated molecular patterns and inflammatory factors. However, the specific mechanisms underlying necroptosis in periodontitis remain largely unclear. This study integrated single-cell RNA sequencing (scRNA-seq) and bulk RNA sequencing (RNA-seq) data to identify core necroptosis-related genes (NRGs) and validated these findings using external datasets and periodontitis samples collected during our research.</p><p><strong>Methods: </strong>Overlapping genes were identified through a comparative analysis of 114 NRGs sourced from GeneCards and marker genes specific to various cell types in the single-cell GSE171213 periodontitis dataset. Based on these genes, cells were categorized into high- and low-necroptosis score groups. Key NRGs were identified through intersection analysis of differentially expressed genes in the high necroptosis group using the GSE10334 bulk RNA-seq dataset, followed by Kyoto Encyclopedia of Genes and Genomes (KEGG)/ Gene Ontology (GO) enrichment analysis. Machine learning further identified hub genes associated with the inflammatory response in periodontitis. Consensus clustering analysis, clinical diagnostic model construction, gene set variation analysis, and gene set enrichment analysis were performed based on these hub genes. The model's predictive performance was validated using independent datasets and periodontitis tissue samples.</p><p><strong>Results: </strong>We identified 10 cell types in periodontitis tissues and observed changes in the abundance of various cell populations in affected samples. Furthermore, we selected 35 NRGs differentially expressed in specific cell populations, with neutrophils and macrophages showing higher necroptosis scores. By integrating bulk RNA-seq data, we further identified 29 key NRGs. KEGG/GO analysis indicated their enrichment in inflammatory response signaling pathways. Machine learning highlighted six hub genes (CSF3R, CSF2RB, BTG2, CXCR4, GPSM3, and SSR4), all of which were highly expressed in periodontitis tissues. Consensus clustering based on these genes divided patients with periodontitis into two subgroups with distinct expression profiles. The clinical diagnostic model constructed based on these six key genes exhibited excellent diagnostic performance. Both external independent validation sets and clinical sample tests confirmed high expression of these six key genes in periodontitis tissues.</p><p><strong>Conclusion: </strong>Our study identified six hub genes (CSF3R, CSF2RB, BTG2, CXCR4, GPSM3, and SSR4) highly expressed in periodontitis tissues and positively correlated with necroptosis. These genes may serve as therapeutic targets for inflammatory diseases like periodontitis.</p>","PeriodicalId":8915,"journal":{"name":"BMC Medical Genomics","volume":"18 1","pages":"159"},"PeriodicalIF":2.0,"publicationDate":"2025-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12523025/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145290862","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Identification of radiation-sensitive genes as biomarkers for biodosimetry: an ex vivo analysis of TNFRSF10B, ZMAT3, POLH, and PLK2 in human blood samples. 鉴定辐射敏感基因作为生物剂量学的生物标志物:人类血液样本中TNFRSF10B、ZMAT3、POLH和PLK2的离体分析
IF 2 4区 医学
BMC Medical Genomics Pub Date : 2025-10-10 DOI: 10.1186/s12920-025-02209-1
Mahsa Boogari, Hossein Mozdarani, Aziz Mahmoudzadeh, Amirabbas Ebrahimi
{"title":"Identification of radiation-sensitive genes as biomarkers for biodosimetry: an ex vivo analysis of TNFRSF10B, ZMAT3, POLH, and PLK2 in human blood samples.","authors":"Mahsa Boogari, Hossein Mozdarani, Aziz Mahmoudzadeh, Amirabbas Ebrahimi","doi":"10.1186/s12920-025-02209-1","DOIUrl":"10.1186/s12920-025-02209-1","url":null,"abstract":"","PeriodicalId":8915,"journal":{"name":"BMC Medical Genomics","volume":"18 1","pages":"156"},"PeriodicalIF":2.0,"publicationDate":"2025-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12512775/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145273598","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The role of genetic polymorphisms on drug response in Alzheimer's disease: a systematic review. 遗传多态性在阿尔茨海默病药物反应中的作用:系统综述。
IF 2 4区 医学
BMC Medical Genomics Pub Date : 2025-10-09 DOI: 10.1186/s12920-025-02225-1
Fresthel Monica M Climacosa, Eric David B Ornos, Nicole Clarence Louise L Gapaz, Mary Gale R Guantia, Joana Marie C Cruz, Rafael Vincent M Manalo, Melody L Yu, Almeera P Qureshi, Ajina C Carampel, Joannes Luke B Asis, John Carlo B Reyes, Aira B Dacasin, Veeda Michelle M Anlacan
{"title":"The role of genetic polymorphisms on drug response in Alzheimer's disease: a systematic review.","authors":"Fresthel Monica M Climacosa, Eric David B Ornos, Nicole Clarence Louise L Gapaz, Mary Gale R Guantia, Joana Marie C Cruz, Rafael Vincent M Manalo, Melody L Yu, Almeera P Qureshi, Ajina C Carampel, Joannes Luke B Asis, John Carlo B Reyes, Aira B Dacasin, Veeda Michelle M Anlacan","doi":"10.1186/s12920-025-02225-1","DOIUrl":"10.1186/s12920-025-02225-1","url":null,"abstract":"","PeriodicalId":8915,"journal":{"name":"BMC Medical Genomics","volume":"18 1","pages":"154"},"PeriodicalIF":2.0,"publicationDate":"2025-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12512622/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145257268","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Molecular mechanisms underlying the co-pathogenesis of abdominal aortic aneurysm and rheumatoid arthritis: evidence based on bioinformatics analysis and clinical data. 腹主动脉瘤和类风湿性关节炎共同发病的分子机制:基于生物信息学分析和临床数据的证据。
IF 2 4区 医学
BMC Medical Genomics Pub Date : 2025-10-09 DOI: 10.1186/s12920-025-02236-y
Youfu Wang, Ling Zhang, Wenhong Jiang, Quanxing Kuang, Xiao Qin
{"title":"Molecular mechanisms underlying the co-pathogenesis of abdominal aortic aneurysm and rheumatoid arthritis: evidence based on bioinformatics analysis and clinical data.","authors":"Youfu Wang, Ling Zhang, Wenhong Jiang, Quanxing Kuang, Xiao Qin","doi":"10.1186/s12920-025-02236-y","DOIUrl":"10.1186/s12920-025-02236-y","url":null,"abstract":"","PeriodicalId":8915,"journal":{"name":"BMC Medical Genomics","volume":"18 1","pages":"155"},"PeriodicalIF":2.0,"publicationDate":"2025-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12512918/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145257208","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术官方微信