The open pediatric medicine journal最新文献_第5页

Primary Focal Segmental Glomerulosclerosis, an Important Component of Childhood Nephrotic Syndrome: Therapeutic Options and Genetic Basis 原发性局灶节段性肾小球硬化，儿童肾病综合征的重要组成部分:治疗选择和遗传基础

The open pediatric medicine journal Pub Date : 2009-01-02 DOI: 10.2174/1874309900802010039

J. Chan, K. Roth

引用次数: 0

Sacrosidase Trial in Chronic Nonspecific Diarrhea in Children 儿童慢性非特异性腹泻的萨克罗苷酶试验

The open pediatric medicine journal Pub Date : 2008-10-15 DOI: 10.2174/1874309900802010035

R. Rahhal, W. Bishop

{"title":"Sacrosidase Trial in Chronic Nonspecific Diarrhea in Children","authors":"R. Rahhal, W. Bishop","doi":"10.2174/1874309900802010035","DOIUrl":"https://doi.org/10.2174/1874309900802010035","url":null,"abstract":"Chronic nonspecific diarrhea in children, or toddler's diarrhea, is a frequently encountered entity in pediatric clinical practice. This disorder remains poorly understood. Suggested etiologies include malabsorption, dietary intake and motility abnormalities. We investigated the use of sacrosidase (a yeast sucrase supplement) in children with toddler's diar- rhea. The study outcome was clinical response to sacrosidase supplementation. Children, 1-6 years of age, with toddler's diarrhea were enrolled in an open prospective trial. Stooling patterns were obtained at baseline and while on supplementa- tion. Twelve patients were enrolled out of 40 patients who presented with chronic diarrhea. Eight patients did not respond to standard diet changes and were entered into the trial. With supplementation, 4 out of the 8 patients responded clinically with a decrease in mean daily stool frequency and an improvement in the mean daily stool consistency. Sacrosidase sup- plementation demonstrated a potential benefit in a subset of children with toddler's diarrhea. Response to sacrosidase may suggest excessive sucrose intake or unrecognized partial or complete sucrase deficiency in some children with toddler's diarrhea.","PeriodicalId":89037,"journal":{"name":"The open pediatric medicine journal","volume":"85 1","pages":"35-38"},"PeriodicalIF":0.0,"publicationDate":"2008-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83479659","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Differences in Exhaled Nitric Oxide in Non- and Mono- or Polysensitised Allergic Children with Asthma Bronchiale 非、单一或多致敏性支气管哮喘患儿呼出一氧化氮的差异

The open pediatric medicine journal Pub Date : 2008-06-23 DOI: 10.2174/1874309900802010030

L. Korsch, A. Hombach, C. Schnegg, Michael Weiss, E. Korsch

{"title":"Differences in Exhaled Nitric Oxide in Non- and Mono- or Polysensitised Allergic Children with Asthma Bronchiale","authors":"L. Korsch, A. Hombach, C. Schnegg, Michael Weiss, E. Korsch","doi":"10.2174/1874309900802010030","DOIUrl":"https://doi.org/10.2174/1874309900802010030","url":null,"abstract":"Rationale: Exhaled nitric oxide (eNO) is reported to be increased in the airways of patients with asthma bron- chiale. Objectives: To investigate eNO concentration and lung function in non-, mono- and polysensitised children with mild asthma bronchiale before and after exercise challenge. Findings: Investigation of a total of 59 children (49 mono- or polysensitised, 10 nonsensitised). No significant differences regarding age, gender, height and asthma medication. Significant difference between the groups regarding weight and subsequently BMI. ENO levels were only elevated in allergic asthmatic children (mean 37.0 ppb) compared to the non al- lergic children (mean 10.0 ppb, p < 0.0001). A correlation between eNO concentrations and the residual volume was es- tablished. ENO levels after exercise challenge were only slightly lower than before exercise. Conclusion: Elevated levels of eNO were only found in the group of asthmatic children with an allergic background. Therefore eNO can be used as a marker to differentiate between allergic and non allergic asthma. Asthmatic severity or therapy did not have a significant influence on the eNO levels. In patients with allergic asthma bronchiale eNO may be used as a helpful indicator in the adapting anti-inflammatory treatment. Although statistically significant in allergic chil- dren, the influence of exercise challenge on eNO levels is minimal.","PeriodicalId":89037,"journal":{"name":"The open pediatric medicine journal","volume":"29 1","pages":"30-34"},"PeriodicalIF":0.0,"publicationDate":"2008-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89495664","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

The Management of Paediatric Crohn’s Disease: Addressing Unmet Needs 儿科克罗恩病的管理:解决未满足的需求

The open pediatric medicine journal Pub Date : 2008-04-23 DOI: 10.2174/1874309900802010021

G. Veereman-Wauters, S. Cucchiara

引用次数: 3

Constipation is the Most Frequent Cause of Chronic Abdominal Pain in Children 便秘是儿童慢性腹痛最常见的原因

The open pediatric medicine journal Pub Date : 2008-03-27 DOI: 10.2174/1874309900802010016

V. Loening-Baucke, A. Swidsinski

引用次数: 3

Risk Factors for Spontaneous Intestinal Perforation in Extremely Low Birth Weight Infants 极低出生体重儿自发性肠穿孔的危险因素

The open pediatric medicine journal Pub Date : 2008-03-14 DOI: 10.2174/1874309900802010011

I. Ahmad, K. Davis, S. Emi, C. Uy, J. Sills

{"title":"Risk Factors for Spontaneous Intestinal Perforation in Extremely Low Birth Weight Infants","authors":"I. Ahmad, K. Davis, S. Emi, C. Uy, J. Sills","doi":"10.2174/1874309900802010011","DOIUrl":"https://doi.org/10.2174/1874309900802010011","url":null,"abstract":"Objective: Spontaneous intestinal perforations (SIP) in extremely low birth weight infants are distinctly different from necrotizing enterocolitis. The etiology of SIP is not well understood. Our objective was to identify perinatal therapeutic interventions that may increase the risk of spontaneous intestinal perforations. Methods: Medical records of extremely low birth weight infants (BW<1000g) admitted to a neonatal intensive care unit during 42-month period were studied. Infants with radiologic or histologic diagnosis of necrotizing enterocolitis were excluded. Information collected included maternal and infant demographics, perinatal risk factors, clinical findings and interventions, and exposure to medications before and after delivery. Chi square and paired t-tests were used to compare SIP patients to those with no perforation (NP). Mean values are given with standard error of the mean. Results: There were 13 SIP and 165 NP. There were more male infants (84.6% vs 49.1%, p<0.025) and more out born infants (61.5% vs 39.9%, p<0.05) in the SIP group. The use of maternal tertbutaline was higher in the SIP group (30.8% vs 9.1%, p<0.015). Early treatment with indomethacin (0-3days) was significantly higher in the SIP group (69.2% vs 27.9%, p=0.002). Hypotension requiring dopamine was significantly higher in the SIP group (69.2% vs 34.6%, p=0.017). Combined exposure to antenatal steroids and postnatal indomethacin was significantly higher in the SIP group (69.2% vs 36.4%, p=0.019), as was the combined early treatment with hydrocortisone and indomethacin (7.7% vs 0.6%, p=0.02). Conclusions: Early use of indomethacin, and co-exposure to antenatal or postnatal steroids is related to development of spontaneous intestinal perforation in extremely low birth weight infants. Prenatal exposure to maternal terbutaline and postnatal use of dopamine for hypotension increases the risk for SIP in these infants.","PeriodicalId":89037,"journal":{"name":"The open pediatric medicine journal","volume":"42 1","pages":"11-15"},"PeriodicalIF":0.0,"publicationDate":"2008-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87778754","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Risk of Vaccine Induced Diabetes in Children with a Family History of Type 1 Diabetes 有1型糖尿病家族史的儿童疫苗诱发糖尿病的风险

The open pediatric medicine journal Pub Date : 2008-02-13 DOI: 10.2174/1874309900802010007

J. Classen

引用次数: 5

Clustering of Cases of IDDM 2 to 4 Years after Hepatitis B Immunization is Consistent with Clustering after Infections and Progression to IDDM in Autoantibody Positive Individuals 乙型肝炎免疫后2 - 4年IDDM病例的聚集性与自身抗体阳性个体感染和进展为IDDM后的聚集性一致

The open pediatric medicine journal Pub Date : 2008-02-11 DOI: 10.2174/1874309900802010001

J. Classen

引用次数: 2

Pathology of the Central Autonomic Nervous System in Stillbirth 死产时中枢自主神经系统的病理

The open pediatric medicine journal Pub Date : 2007-09-18 DOI: 10.2174/1874309900701010001

L. Matturri, A. Lavezzi

引用次数: 11