The ... Midwest Symposium on Circuits and Systems conference proceedings : MWSCAS. Midwest Symposium on Circuits and Systems最新文献

Spurious Spike Elimination using Sparse Signal Processing Improves Seizure Onset Zone Delineation in Brief Intraoperative iEEG Recordings. 利用稀疏信号处理消除杂散尖峰改善术中简短脑电图记录中癫痫发作区域的描绘。

The ... Midwest Symposium on Circuits and Systems conference proceedings : MWSCAS. Midwest Symposium on Circuits and Systems Pub Date : 2025-08-01 Epub Date: 2025-11-25 DOI: 10.1109/mwscas53549.2025.11244470

Amir Hossein Ayyoubi, Behrang Fazli Besheli, Chandra Prakash Swamy, Jhan L Okkabaz, Kai J Miller, Gregory A Worrell, Nuri F Ince

{"title":"Spurious Spike Elimination using Sparse Signal Processing Improves Seizure Onset Zone Delineation in Brief Intraoperative iEEG Recordings.","authors":"Amir Hossein Ayyoubi, Behrang Fazli Besheli, Chandra Prakash Swamy, Jhan L Okkabaz, Kai J Miller, Gregory A Worrell, Nuri F Ince","doi":"10.1109/mwscas53549.2025.11244470","DOIUrl":"10.1109/mwscas53549.2025.11244470","url":null,"abstract":"Interictal epileptiform spikes and high frequency oscillations (HFOs) have proven to be promising neuro biomarkers for seizure onset zone (SOZ) identification in drug-resistant epilepsy. This study presents a sparse signal processing based denoising model for epileptiform spikes. The model was trained on expert-labeled events to remove artifacts and spurious detections from the initial candidate spike pool captured using an amplitude threshold-based detector. We hypothesize that interictal spikes exhibit a sparse representation with a limited number of atoms in analytical dictionary, whereas artifacts, due to their unstructured waveshape, lack such a representation. We employed orthogonal matching pursuit (OMP) with a Gabor analytical redundant dictionary for event representation and Random Forrest (RF) classifier for event classification. The optimal model was further evaluated over the intracranial EEG (iEEG) from 29 subjects during intraoperative monitoring (IOM). Denoising method significantly improved the SOZ delineation of spatial distribution of spike (36% to 52% in IOM). Additionally, we included HFO analysis results to provide further comparison with spikes yielding an average denoised SOZ ratio of 69% in IOM. These advancements could enhance clinical decision-making by offering reliable initial assessments during a brief intraoperative recording.","PeriodicalId":89019,"journal":{"name":"The ... Midwest Symposium on Circuits and Systems conference proceedings : MWSCAS. Midwest Symposium on Circuits and Systems","volume":"2025 ","pages":"666-670"},"PeriodicalIF":0.0,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12912716/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146222404","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Microcircuitry and oscillation features across model cortical regions. 模型皮层区域的微电路和振荡特征。

The ... Midwest Symposium on Circuits and Systems conference proceedings : MWSCAS. Midwest Symposium on Circuits and Systems Pub Date : 2025-01-01 Epub Date: 2025-11-25 DOI: 10.1109/mwscas53549.2025.11244537

Gregory Glickert, Khuram Choudhry, Ziao Chen, Drew B Headley, Satish S Nair

引用次数: 0

A 4-Channel 0.23mm ² Voltage-to-Time Converter AFE with 3.7μVrms Noise and 480nW Galvanic Impulse Uplink. 4通道0.23mm电压-时间转换器AFE，噪声3.7μVrms，电流脉冲上行链路480nW。

The ... Midwest Symposium on Circuits and Systems conference proceedings : MWSCAS. Midwest Symposium on Circuits and Systems Pub Date : 2024-08-01 Epub Date: 2024-09-16 DOI: 10.1109/mwscas60917.2024.10658812

Mehdi Bandali, Morgan Riley, Benjamin C Johnson

{"title":"A 4-Channel 0.23mm 2 Voltage-to-Time Converter AFE with 3.7μVrms Noise and 480nW Galvanic Impulse Uplink.","authors":"Mehdi Bandali, Morgan Riley, Benjamin C Johnson","doi":"10.1109/mwscas60917.2024.10658812","DOIUrl":"10.1109/mwscas60917.2024.10658812","url":null,"abstract":"We present a 4-channel 15kS/s Voltage-to-Time Converter (VTC) analog front-end (AFE) with a 0.49μW impulse-based galvanic uplink for a peripheral nerve interface. Multiple, low-noise, high-data-rate channels are needed to sense compound action potentials and measure their conduction velocity as they propagate down a peripheral nerve. To achieve high energy efficiency for these constraints, the AFE encodes and transmits data with time-domain charge-balanced impulses through an implantable galvanic link. Each channel consists of an integrator with charge-based sampling and amplification for rapid multiplexing. A shared VTC encodes the amplitude-domain outputs of each integrator into differential time-domain impulses. Since the timing can be synchronized with stimulation, this AFE achieves instant artifact recovery after rail-to-rail stimulation events. We designed this AFE in a 180 nm CMOS process, and the simulation results show an SNDR of 60 dB and noise of 3.7μVrms. Thanks to the new galvanic uplink protocol, this front-end only consumes 11.28μW including wireless data transmission for four channels.","PeriodicalId":89019,"journal":{"name":"The ... Midwest Symposium on Circuits and Systems conference proceedings : MWSCAS. Midwest Symposium on Circuits and Systems","volume":"2024 ","pages":"538-542"},"PeriodicalIF":0.0,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12512690/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145282035","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mitigating Effects of Packet Loss in Wireless Neural Data Transfer: Exploring the Influence of Low-Cost Recovery Methods on Spikes and HFOs in iEEG. 减轻无线神经数据传输中丢包的影响：探索低成本恢复方法对iEEG中峰值和hfo的影响。

The ... Midwest Symposium on Circuits and Systems conference proceedings : MWSCAS. Midwest Symposium on Circuits and Systems Pub Date : 2024-08-01 Epub Date: 2024-09-16 DOI: 10.1109/mwscas60917.2024.10658804

Amir Hossein Ayyoubi, Behrang Fazli Besheli, Chandra Prakash Swamy, Jhan L Okkabaz, Michael M Quach, Daniel J Curry, Nuri F Ince

{"title":"Mitigating Effects of Packet Loss in Wireless Neural Data Transfer: Exploring the Influence of Low-Cost Recovery Methods on Spikes and HFOs in iEEG.","authors":"Amir Hossein Ayyoubi, Behrang Fazli Besheli, Chandra Prakash Swamy, Jhan L Okkabaz, Michael M Quach, Daniel J Curry, Nuri F Ince","doi":"10.1109/mwscas60917.2024.10658804","DOIUrl":"10.1109/mwscas60917.2024.10658804","url":null,"abstract":"The wireless transmission of neural data may pose the risk of packet loss (PL), potentially compromising signal quality or, in extreme cases, causing complete data loss. Addressing lost packets is essential to ensure data integrity and preserve vital neural patterns. This study investigates the effect of PL interference on epilepsy neuro biomarkers, focusing specifically on interictal epileptiform spikes and high frequency oscillations (HFOs), and the performance of the low computational cost interpolation methods. We observed that 95% of spikes and 81% of HFOs could be recovered with linear interpolation at 5% PL, while 97% and 86%, respectively, with spline interpolation. Linear interpolation has the potential to recover neural events and reduce the noise floor with modest packet loss levels of up to 5% at a lower computational cost. However, for a higher level of PL, utilizing more intricate methodologies such as spline interpolation becomes imperative.","PeriodicalId":89019,"journal":{"name":"The ... Midwest Symposium on Circuits and Systems conference proceedings : MWSCAS. Midwest Symposium on Circuits and Systems","volume":"2024 ","pages":"591-595"},"PeriodicalIF":0.0,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11627232/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142803920","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Miniaturized Wireless, Battery-free Implant for In Vivo Musculoskeletal Stimulation. 一种用于体内肌肉骨骼刺激的小型无线无电池植入物。

The ... Midwest Symposium on Circuits and Systems conference proceedings : MWSCAS. Midwest Symposium on Circuits and Systems Pub Date : 2024-08-01 Epub Date: 2024-09-16 DOI: 10.1109/mwscas60917.2024.10658794

Abed Benbuk, Diogo Moniz-Garcia, Daniel Gulick, Alfredo Quinones-Hinojosa, Jennifer Blain Christen

引用次数: 0

On-Chip Active Pulse-Clamp Stimulation (APCS) for Rapid Recovery, Charge-Balanced Neural Stimulation. 片上有源脉冲钳刺激（APCS）快速恢复，电荷平衡神经刺激。

The ... Midwest Symposium on Circuits and Systems conference proceedings : MWSCAS. Midwest Symposium on Circuits and Systems Pub Date : 2024-08-01 Epub Date: 2024-09-16 DOI: 10.1109/mwscas60917.2024.10658858

Fnu Tala, Benjamin C Johnson

{"title":"On-Chip Active Pulse-Clamp Stimulation (APCS) for Rapid Recovery, Charge-Balanced Neural Stimulation.","authors":"Fnu Tala, Benjamin C Johnson","doi":"10.1109/mwscas60917.2024.10658858","DOIUrl":"10.1109/mwscas60917.2024.10658858","url":null,"abstract":"Rapid and charge-balanced electrical stimulation is imperative for neurostimulation implants aimed at chronic safety and closed-loop usage. We present an innovative stimulation technique, Active Pulse-Clamp Stimulation (APCS), designed to ensure dependable charge balance with rapid recovery. The APCS technique has two distinctive modes, linear and slewing modes, both incorporated into the on-chip APCS system. APCS employs discrete-time feedback to sense the residual voltage across the electrode's double-layer capacitance, expediting the settling of the electrode interface by either grounding (slewing) or clamping with an amplifier (linear). APCS combines the strengths of both biphasic stimulation and passive recharge, with a customizable recovery time constant set by the user while offering a guaranteed charge balance for safety. To showcase the proof-of-concept for APCS, we implemented the on-chip APCS using a 180nm CMOS process. We demonstrated combined APCS functionality using a benchtop electrode model and a real clinical deep brain stimulation (DBS) electrode in vitro.","PeriodicalId":89019,"journal":{"name":"The ... Midwest Symposium on Circuits and Systems conference proceedings : MWSCAS. Midwest Symposium on Circuits and Systems","volume":"2024 ","pages":"523-527"},"PeriodicalIF":0.0,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12507097/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145260111","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Synchronous iEEG Data Acquisition Framework for Dual Brain Interchange Systems. 双脑交换系统的同步脑电图数据采集框架。

The ... Midwest Symposium on Circuits and Systems conference proceedings : MWSCAS. Midwest Symposium on Circuits and Systems Pub Date : 2024-08-01 Epub Date: 2024-09-16 DOI: 10.1109/mwscas60917.2024.10658832

Amir Hossein Ayyoubi, Behrang Fazli Besheli, Chandra Prakash Swamy, Jhan L Okkabaz, Kai J Miller, Gregory A Worrell, Nuri F Ince

{"title":"A Synchronous iEEG Data Acquisition Framework for Dual Brain Interchange Systems.","authors":"Amir Hossein Ayyoubi, Behrang Fazli Besheli, Chandra Prakash Swamy, Jhan L Okkabaz, Kai J Miller, Gregory A Worrell, Nuri F Ince","doi":"10.1109/mwscas60917.2024.10658832","DOIUrl":"10.1109/mwscas60917.2024.10658832","url":null,"abstract":"This study presents a new data acquisition Framework for synchronous dual Brain Interchange (BIC) systems recording. The setup expands the capacity for data recording by offering access to up to 64 channels. The environment utilizes our Simulink model, incorporating functionalities for synchronization using a master clock and email-based status updates. We evaluated the framework in the lab simulations, and we observed a 38 ms post-synchronization delay between the systems. We also demonstrated that this error can be minimized to as low as 5 ms through adjustments in the master clock resolution and data buffer size. We estimated units' sampling frequency with high accuracy to avoid desynchronization. We evaluated the setup on the intracranial EEG (iEEG) recording simultaneously with the clinical system and performed spike detection on the post-synchronized iEEG. We observed over 95% similarity rate between the dual BIC and clinical system. Additionally, we explored the optimal configuration for ground and reference connections between systems to achieve the highest signal quality, along with investigating the implications of frequency interference in dual-system operations.","PeriodicalId":89019,"journal":{"name":"The ... Midwest Symposium on Circuits and Systems conference proceedings : MWSCAS. Midwest Symposium on Circuits and Systems","volume":"2024 ","pages":"1319-1323"},"PeriodicalIF":0.0,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11616790/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142782116","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Automated Design of Sigma-Delta Converters: From Know-How to AI-assisted Optimization Sigma-Delta转换器的自动化设计:从专有技术到人工智能辅助优化

The ... Midwest Symposium on Circuits and Systems conference proceedings : MWSCAS. Midwest Symposium on Circuits and Systems Pub Date : 2022-01-01 DOI: 10.1109/MWSCAS54063.2022.9859425

José M. de la Rosa

引用次数: 0

Cryogenic Characterization of Commercial Devices for Application of Quantum Computing Electronics 用于量子计算电子学应用的商用器件的低温特性

The ... Midwest Symposium on Circuits and Systems conference proceedings : MWSCAS. Midwest Symposium on Circuits and Systems Pub Date : 2022-01-01 DOI: 10.1109/MWSCAS54063.2022.9859526

Z. Jin, Xinzhe Wang, Futian Liang, Chengzhi Peng

引用次数: 0

Design of Multiplierless Wideband Compensator for Modified Cosine-Based Comb Decimator with Improved Aliasing Rejection 改进抗混叠的改进余弦梳状十进制器无乘法器设计

The ... Midwest Symposium on Circuits and Systems conference proceedings : MWSCAS. Midwest Symposium on Circuits and Systems Pub Date : 2022-01-01 DOI: 10.1109/MWSCAS54063.2022.9859493

G. Jovanovic-Dolecek

引用次数: 0