Arbeiten aus dem Paul-Ehrlich-Institut (Bundesinstitut fur Impfstoffe und biomedizinische Arzneimittel) Langen/Hessen最新文献_第7页

Introduction to CHMP structures and procedures. 介绍CHMP的结构和程序。

Arbeiten aus dem Paul-Ehrlich-Institut (Bundesinstitut fur Impfstoffe und biomedizinische Arzneimittel) Langen/Hessen Pub Date : 2009-01-01

Christian K Schneider

引用次数: 0

Regulation of allergen products in Japan. 日本对过敏原产品的监管。

Arbeiten aus dem Paul-Ehrlich-Institut (Bundesinstitut fur Impfstoffe und biomedizinische Arzneimittel) Langen/Hessen Pub Date : 2009-01-01

Reiko Teshima

引用次数: 0

IVN201--therapy with a construct containing functional fusion peptides. IVN201——含有功能性融合肽的构建体治疗。

Arbeiten aus dem Paul-Ehrlich-Institut (Bundesinstitut fur Impfstoffe und biomedizinische Arzneimittel) Langen/Hessen Pub Date : 2009-01-01

Horst Rose

{"title":"IVN201--therapy with a construct containing functional fusion peptides.","authors":"Horst Rose","doi":"","DOIUrl":"","url":null,"abstract":"The new concept of immunotherapy with IVN201 against cat dander allergy combines two proprietary technology platforms: Intralymphatic immunotherapy (ILIT) with Modular-Antigen-Transportation (MAT) proteins. Intralymphatic immunotherapy (ILIT) is the injection of immunotherapeutics directly into the lymph node. Lymph nodes contain a high density of antigen presenting cells together with interacting T cells, which are necessary for allergen tolerance development. Therefore, this site-directed route of administration requires fewer injections of much smaller doses of the allergen than conventional administration routes to induce a highly effective, disease modifying immune response. ILIT was recently demonstrated in a clinical study to enhance safety and efficacy of immunotherapy and to reduce treatment time from 3 years to 8 weeks with only three injections, thereby significantly improving patient compliance. Patients subjectively perceived the intralymphatic injections less painful than a venous puncture. IVN201 is a functional fusion peptide which is a tailor-made recombinant allergen for ILIT with Fel d 1 as allergen module. It is designed to be rapidly taken up by antigen presenting cells in the lymph nodes and to improve the presentation of the allergen to the immune system. IVN201 was shown to induce allergen tolerance in a murine anaphylaxis model. Stimulation assays with basophil leukocytes isolated from allergic patients suggest an increased safety profile when compared to cat extract or recombinant Fel d 1. Therefore, MAT molecules are expected to be safer and more efficacious in inducing the desired immune response than recombinant allergens or allergen extracts in allergen immunotherapy when administered via the intralymphatic route.","PeriodicalId":88824,"journal":{"name":"Arbeiten aus dem Paul-Ehrlich-Institut (Bundesinstitut fur Impfstoffe und biomedizinische Arzneimittel) Langen/Hessen","volume":"96 ","pages":"319-27; discussion 327-8"},"PeriodicalIF":0.0,"publicationDate":"2009-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"29270419","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

BSP090--the follow-up to CREATE. BSP090——CREATE的后续。

Arbeiten aus dem Paul-Ehrlich-Institut (Bundesinstitut fur Impfstoffe und biomedizinische Arzneimittel) Langen/Hessen Pub Date : 2009-01-01

Florian Neske, Christian Schörner, Karl-Heinz Buchheit, Angèle Costanzo, Kay-Martin Hanschmann, Martin Himly, Thomas Holzhauser, Fatima Ferreira, Susanne Kaul, Stefan Vieths, Ronald van Ree

引用次数: 0

Protein families: implications for allergen nomenclature, standardisation and specific immunotherapy. 蛋白质家族:对过敏原命名、标准化和特异性免疫治疗的影响。

Arbeiten aus dem Paul-Ehrlich-Institut (Bundesinstitut fur Impfstoffe und biomedizinische Arzneimittel) Langen/Hessen Pub Date : 2009-01-01

Heimo Breiteneder

{"title":"Protein families: implications for allergen nomenclature, standardisation and specific immunotherapy.","authors":"Heimo Breiteneder","doi":"","DOIUrl":"","url":null,"abstract":"Allergens are embedded into the protein universe as members of large families and superfamilies of related proteins which is a direct consequence of their shared evolution. The classification of allergens by protein families offers a valuable frame of reference that allows the design of experiments to study cross-reactivity and allergenic potency of proteins. Information on protein family membership also complements the current official IUIS allergen nomenclature. All presently known allergens belong to one of 140 (1.4%) of the 10,340 protein families currently described by version 23.0 of the Pfam database. This is indicative of a strong bias among allergens towards certain protein architectures that are able to induce an IgE response in an atopic immune system. However, even small variations in the structure of a protein alter its immunological characteristics. Various isoforms of the major birch pollen allergen Bet v 1 were shown to possess highly variant immunogenic and allergenic properties. Ber e 1 and SFA8, two 2S albumins, were revealed to display differential capacities to polarise an immune response. Such data will be exploited in the future for the design of allergy vaccines.","PeriodicalId":88824,"journal":{"name":"Arbeiten aus dem Paul-Ehrlich-Institut (Bundesinstitut fur Impfstoffe und biomedizinische Arzneimittel) Langen/Hessen","volume":"96 ","pages":"249-54; discussion 254-6"},"PeriodicalIF":0.0,"publicationDate":"2009-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"29273199","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Compliance and convenience to immunotherapy. 免疫治疗的依从性和便利性。

Arbeiten aus dem Paul-Ehrlich-Institut (Bundesinstitut fur Impfstoffe und biomedizinische Arzneimittel) Langen/Hessen Pub Date : 2009-01-01

Jean Bousquet, Pascal Demoly

引用次数: 0

Specific immunotherapy by different allergen applications: subcutaneous, sublingual, oral or rectal administration and lymph node injection. 不同过敏原应用的特异性免疫治疗:皮下、舌下、口服或直肠给药和淋巴结注射。

Arbeiten aus dem Paul-Ehrlich-Institut (Bundesinstitut fur Impfstoffe und biomedizinische Arzneimittel) Langen/Hessen Pub Date : 2009-01-01

Jörg Kleine-Tebbe

引用次数: 0

Potential uses of NIR and IR spectroscopy in quality control of allergy vaccine production. 近红外光谱和红外光谱在过敏疫苗生产质量控制中的潜在应用。

Arbeiten aus dem Paul-Ehrlich-Institut (Bundesinstitut fur Impfstoffe und biomedizinische Arzneimittel) Langen/Hessen Pub Date : 2009-01-01

Yiwu Zheng, Xuxin Lai

{"title":"Potential uses of NIR and IR spectroscopy in quality control of allergy vaccine production.","authors":"Yiwu Zheng, Xuxin Lai","doi":"","DOIUrl":"","url":null,"abstract":"Background: Compared to conventional methods, infrared spectroscopy offers many potential uses in quality control of vaccine production. A major advantage is that the technique is non-invasive and non-destructive. In this study several possible uses of infrared spectroscopy in the control of allergy vaccines were investigated.Methods: Near infrared spectroscopy (NIR) was applied to determine the aluminium content in aluminium hydroxide formulations, the particle size of aluminium hydroxide, the protein adsorption level on aluminium adjuvant and the moisture content of lyophilized vaccines. Mid infrared spectroscopy (IR) was used to investigate protein structural changes during adsorption and release from aluminium hydroxide and the stability of the complex.Results: Based on the calibration models of NIR in different applications, it was demonstrated that NIR had great advantages for application in vaccine production. IR also showed advantages on structural analysis of adsorbed proteins.Discussion: Infrared spectroscopy as a physical, non-invasive, non-destructive method should receive more attention in vaccine research and production.","PeriodicalId":88824,"journal":{"name":"Arbeiten aus dem Paul-Ehrlich-Institut (Bundesinstitut fur Impfstoffe und biomedizinische Arzneimittel) Langen/Hessen","volume":"96 ","pages":"112-9; discussion 120"},"PeriodicalIF":0.0,"publicationDate":"2009-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"29272231","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Design of clinical trials with patch test allergens in The Netherlands. 荷兰用斑贴试验过敏原进行临床试验的设计。

Arbeiten aus dem Paul-Ehrlich-Institut (Bundesinstitut fur Impfstoffe und biomedizinische Arzneimittel) Langen/Hessen Pub Date : 2009-01-01

Thomas Rustemeyer

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Regulation, role and future of named patient products in Germany. 命名患者产品在德国的监管、作用和未来。

Arbeiten aus dem Paul-Ehrlich-Institut (Bundesinstitut fur Impfstoffe und biomedizinische Arzneimittel) Langen/Hessen Pub Date : 2009-01-01

Sibylle May, Susanne Kaul, Dirk Lüttkopf, Stefan Vieths

引用次数: 0