Vascular disease prevention最新文献

{"title":"Fenoldopam in cardiovascular surgery: A review","authors":"G. Landoni, Francesco Alfredo Garozzo, A. Mizzi, A. Zangrillo","doi":"10.2174/1567270000805010029","DOIUrl":"https://doi.org/10.2174/1567270000805010029","url":null,"abstract":"","PeriodicalId":88793,"journal":{"name":"Vascular disease prevention","volume":"5 1","pages":"223-226"},"PeriodicalIF":0.0,"publicationDate":"2008-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67887997","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Circadian Variation of Cardiovascular Events and Morning Blood Pressure Surge","authors":"R. Manfredini, B. Boari, R. Salmi, M. Gallerani, M. Felisatti, S. Mandini, A. Malagoni, F. Manfredini","doi":"10.2174/1567270000805010032","DOIUrl":"https://doi.org/10.2174/1567270000805010032","url":null,"abstract":"","PeriodicalId":88793,"journal":{"name":"Vascular disease prevention","volume":"5 1","pages":"246-251"},"PeriodicalIF":0.0,"publicationDate":"2008-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67888009","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Edema, Inflammation and Fibrosis - Comparison Between Catecholamine- and Hypoxia-Induced Pulmonary Injuries","authors":"B. Rassler","doi":"10.2174/1567270000805010027","DOIUrl":"https://doi.org/10.2174/1567270000805010027","url":null,"abstract":"","PeriodicalId":88793,"journal":{"name":"Vascular disease prevention","volume":"25 1","pages":"211-218"},"PeriodicalIF":0.0,"publicationDate":"2008-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67888149","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role of Ultrasound Vascular Imaging in the Acute Phase of Stroke","authors":"G. Malferrari, M. Zedde, N. Marcello","doi":"10.2174/1567270000805010033","DOIUrl":"https://doi.org/10.2174/1567270000805010033","url":null,"abstract":"","PeriodicalId":88793,"journal":{"name":"Vascular disease prevention","volume":"5 1","pages":"252-269"},"PeriodicalIF":0.0,"publicationDate":"2008-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67888943","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Trigeminocardiac Reflex as Oxygen Conserving Reflex in Humans: Its Ischemic Tolerance Potential","authors":"B. Schaller, K. Prank","doi":"10.2174/1567270000805010028","DOIUrl":"https://doi.org/10.2174/1567270000805010028","url":null,"abstract":"","PeriodicalId":88793,"journal":{"name":"Vascular disease prevention","volume":"5 1","pages":"219-222"},"PeriodicalIF":0.0,"publicationDate":"2008-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67887988","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Viewing the Cardiovascular Pathogenicity of Lp(a) from the Pro-Inflammatory Side","authors":"Binu B. Philips, A. Scanu","doi":"10.2174/1567270000805010019","DOIUrl":"https://doi.org/10.2174/1567270000805010019","url":null,"abstract":"","PeriodicalId":88793,"journal":{"name":"Vascular disease prevention","volume":"5 1","pages":"150-155"},"PeriodicalIF":0.0,"publicationDate":"2008-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67887883","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"C-Reactive Protein and Atherosclerosis: An Update","authors":"J. Torzewski, V. Hombach, G. Nienhaus","doi":"10.2174/1567270000805010023","DOIUrl":"https://doi.org/10.2174/1567270000805010023","url":null,"abstract":"","PeriodicalId":88793,"journal":{"name":"Vascular disease prevention","volume":"5 1","pages":"178-182"},"PeriodicalIF":0.0,"publicationDate":"2008-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67887950","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Colestimide on Reduction of Body Weight and Waist Circumference in Metabolic Syndrome Patients with Cardiovascular Risk Factors","authors":"M. Yamaoka-Tojo, T. Tojo, Rie Kosugi, N. Aoyama, S. Niwano, S. Kurokawa, T. Izumi","doi":"10.2174/1567270000805010024","DOIUrl":"https://doi.org/10.2174/1567270000805010024","url":null,"abstract":"Background and objective: Insulin resistance is thought to be central to the pathogenesis of abdominal obesity- linked metabolic syndrome (MetS). Colestimide, a 2-methylimidazole-epichlorohydrin polymer, is a new bile-acid- sequestering resin used to lower LDL cholesterol. In recent reports, bile acid-controlled signaling pathways have shown promise as novel drug targets to treat metabolic disorders, such as obesity, type 2 diabetes, hyperlipidemia, and athero- sclerosis. The aim of this study was to evaluate the efficacy of colestimide on weight loss in MetS patients. Methods: Sixty-one patients with MetS who had cardiovascular risk factors were randomized to receive lifestyle counsel- ing with or without colestimide treatment. The primary endpoint was achieved when the reduction in body weight is � 5%. Additionally, differences in the waist circumference and metabolic-associated profiles between the colestimide group and the control group, which received lifestyle modifications alone, were analyzed. Results: The numbers of participants who achieved � 5% weight loss significantly favored the colestimide group over the non-colestimide group (71.4% vs. 33.3%; p < 0.01). The mean reduction in waist circumference during the study period (average 22 weeks) was greater with colestimide than without it (10.1 � 5.4 vs. 7.1 � 5.2 cm, p < 0.05). Conclusions: The colestimide treatment together with lifestyle intervention was associated with reduction in body weight and waist circumference over a relatively short term in obese subjects. The combination of colestimide and lifestyle inter- vention may be useful for weight management in MetS patients with cardiovascular risk factors.","PeriodicalId":88793,"journal":{"name":"Vascular disease prevention","volume":"5 1","pages":"183-189"},"PeriodicalIF":0.0,"publicationDate":"2008-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67887958","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"C(6)-Ceramide-Coated Catheters Promote Re-Endothelialization of Stretch-Injured Arteries.","authors":"Sean M O'Neill,&nbsp;Dina K Olympia,&nbsp;Todd E Fox,&nbsp;J Tony Brown,&nbsp;Thomas C Stover,&nbsp;Kristy L Houck,&nbsp;Ronald Wilson,&nbsp;Peter Waybill,&nbsp;Mark Kozak,&nbsp;Steven W Levison,&nbsp;Norbert Weber,&nbsp;Linda M Karavodin,&nbsp;Mark Kester","doi":"10.2174/156727008785133809","DOIUrl":"https://doi.org/10.2174/156727008785133809","url":null,"abstract":"<p><p>OBJECTIVE: Drug eluting stents have recently been associated with the increased risk of adverse thrombogenic events and/or late luminal loss, which is highly associated with incomplete re-endothelialization. The increased risks behoove the design of alternative delivery modalities and/or drugs that do not compromise the re-endotheliaization process. The objective of the present study is to elucidate the biological mechanism(s) by which non-stent-based delivery modalities for the anti-proliferative lipid metabolite, C(6)-ceramide, could lead to a reduction in arterial injury after angioplasty. RESULTS: Immunohistochemical studies in rabbit and porcine models suggest that C(6)-ceramide-coated balloon catheters limit arterial stenosis without inhibiting endothelial wound healing responses. Specifically, C(6)-ceramide-coated balloon catheters reduce internal elastica injury with a corresponding reduction in medial fracture length in a 28-day porcine coronary artery stretch model. In addition, C(6)-ceramide decreases the formation of the fibrin matrix to possibly augment the subsequent wound healing response. We hypothesized that differential metabolism of exogenous ceramide by coronary endothelial and smooth muscle cells could explain the apparent discrepancy between the anti-proliferative actions of ceramide and the pro-wound healing responses of ceramide. Human coronary artery endothelial cells (HCAEC), in contrast to human coronary artery smooth muscle cells (HCASMC), preferentially express ceramide kinase and form ceramide-1-phosphate, which promotes endothelial cell survival. CONCLUSION: Differential metabolism of ceramide between HCASMC and HCAEC offers a mechanism by which ceramide preferentially limits smooth muscle cell growth, in the presence of active wound healing. The combinatorial ability of ceramide to limit vascular smooth muscle proliferation and promote re-endothelialization, offers the potential for C(6)-ceramide-coated catheters to serve as adjuncts to stent-based modalities or as a stand-alone treatment.</p>","PeriodicalId":88793,"journal":{"name":"Vascular disease prevention","volume":"5 3","pages":"200-210"},"PeriodicalIF":0.0,"publicationDate":"2008-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2174/156727008785133809","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"28535894","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Factors Affecting 30-Day Mortality in Chinese Patients with Acute Myocardial Infarction: A Registry-Based Cohort Study","authors":"I. Yu, W. Chan, Wei Li, C. Yue","doi":"10.2174/1567270000805010022","DOIUrl":"https://doi.org/10.2174/1567270000805010022","url":null,"abstract":"","PeriodicalId":88793,"journal":{"name":"Vascular disease prevention","volume":"5 1","pages":"174-177"},"PeriodicalIF":0.0,"publicationDate":"2008-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67887932","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}