Biomedical Research and Therapy最新文献

{"title":"Association Between Interleukin 6 Immunohistochemical and Plasma Levels in Invasive Ductal Carcinoma Breast: A Cross-Sectional Study","authors":"Ankita Girdhar, Kalyani Raju, Krishna Prasad","doi":"10.15419/bmrat.v10i8.826","DOIUrl":"https://doi.org/10.15419/bmrat.v10i8.826","url":null,"abstract":"Background: Breast carcinoma (BC) is one of the most common malignancies in women, affecting 1 in 8.Interleukin 6 (IL6) is a proinflammatory cytokine. The role of IL6 pathways in breast cancer motivated the development of anti-IL6 agents or monoclonal antibodies, which inhibit the IL6/signal transducer and activator of transcription 3 (STAT3) pathway. This study aimed to determine the proportion and intensity of immunohistochemical (IHC) IL6 expression in invasive ductal carcinoma (IDC) breast tissue sections and estimate plasma IL6 levels using an enzyme-linked immunosorbent assay (ELISA) in the same patients to evaluate the association between IHC and plasma IL6 levels. Methods: This laboratory observational cross-sectional study examined new primary BC cases between January 2021 and June 2022. IL6 IHC was performed on tissue sections and analyzed using the histochemical (H)-score system. Plasma samples were taken from the same cases to estimate IL6 levels using an ELISA. The data were analyzed for an association between IHC and plasma IL6 levels in paired samples using SPSS software (version 22). Results: Among 50 IDC cases, the mean IHC-based IL6 H-score was 201.6 ± 88.4, and the mean ELISA-based plasma IL6 level was 68.13 ± 89.98 pg/mL. A slight positive correlation existed between IHC-based IL6 H-scores and ELISA-based plasma IL6 levels (p = 0.217). IHC-based IL6 H-scores were not associated with clinicopathological parameters. ELISA-based plasma IL6 levels were significantly associated with premenopausal status (p = 0.010), positive erb-b2 receptor tyrosine kinase 2 (ERBB2/HER2/NEU) expression (p = 0.040), low marker of proliferation Ki-67 (MKI67) index (p = 0.040), and the ERBB2/HER2/NEU enriched molecular category (p = 0.040). Conclusion: IHC-based IL6 H-scores increased with ELISA-based plasma IL6 levels among the cases. ELISA-based plasma IL6 levels were significantly associated with premenopausal status, positive ERBB2/HER2/NEU expression, low Ki-67 proliferative index, and the ERBB2/HER2/NEU enriched molecular category. Therefore, plasma IL6 could be a potential marker to assess prognosis in patients with IDC.","PeriodicalId":8870,"journal":{"name":"Biomedical Research and Therapy","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136036002","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hepatocellular adenoma in a child: a case report","authors":"Truong Dinh Khai, T. Phuong, Phung Nguyen Viet Hung, Le Minh Huy, Nguyen Ngoc Minh Khanh","doi":"10.15419/bmrat.v10i7.816","DOIUrl":"https://doi.org/10.15419/bmrat.v10i7.816","url":null,"abstract":"","PeriodicalId":8870,"journal":{"name":"Biomedical Research and Therapy","volume":null,"pages":null},"PeriodicalIF":0.9,"publicationDate":"2023-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43479010","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cavitary lesion from pulmonary nocardiosis in non-immunocompromised patients with chronic lung disease: A report of three cases","authors":"Khoa Nguyen-Dang, Vu Le-Thuong, Lam Nguyen-Ho, Nguyen Tran-Ngoc","doi":"10.15419/bmrat.v10i7.817","DOIUrl":"https://doi.org/10.15419/bmrat.v10i7.817","url":null,"abstract":"","PeriodicalId":8870,"journal":{"name":"Biomedical Research and Therapy","volume":null,"pages":null},"PeriodicalIF":0.9,"publicationDate":"2023-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47692732","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genes involved in premature aging and their association with age-related diseases: A mini review","authors":"Gopikrishna Agraharam, A. Girigoswami, Pemula Gowtham, K. Girigoswami","doi":"10.15419/bmrat.v10i7.819","DOIUrl":"https://doi.org/10.15419/bmrat.v10i7.819","url":null,"abstract":"","PeriodicalId":8870,"journal":{"name":"Biomedical Research and Therapy","volume":null,"pages":null},"PeriodicalIF":0.9,"publicationDate":"2023-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49441209","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Structural genomics and immunoinformatics analyses of non-structural protein 6 (NSP6) and its probable role in autophagy","authors":"N. Yashvardhini, D. Jha, P. Khan, Amit Kumar, K. Pranay","doi":"10.15419/bmrat.v10i7.818","DOIUrl":"https://doi.org/10.15419/bmrat.v10i7.818","url":null,"abstract":"","PeriodicalId":8870,"journal":{"name":"Biomedical Research and Therapy","volume":null,"pages":null},"PeriodicalIF":0.9,"publicationDate":"2023-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46420684","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An analysis of the impact of buthionine sulfoximine and N-nitro-L-arginine on blood pressure","authors":"B. Gungor, S. Akdur, C. Si̇lan, O. Coskun, H. E. Aksulu","doi":"10.15419/bmrat.v10i6.814","DOIUrl":"https://doi.org/10.15419/bmrat.v10i6.814","url":null,"abstract":"","PeriodicalId":8870,"journal":{"name":"Biomedical Research and Therapy","volume":null,"pages":null},"PeriodicalIF":0.9,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48188941","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exercise-induced improvement of neuropathic pain in rats: Possible role of oxidative stress","authors":"S. Ghasemi, A. Ghanbari, A. Rashidy-Pour, A. Bandegi","doi":"10.15419/bmrat.v10i6.813","DOIUrl":"https://doi.org/10.15419/bmrat.v10i6.813","url":null,"abstract":"","PeriodicalId":8870,"journal":{"name":"Biomedical Research and Therapy","volume":null,"pages":null},"PeriodicalIF":0.9,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48934784","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mesenchymal stem cell transplantation for infertility treatment: A review","authors":"R. Mirfakhraie, Maryam Vahdat Lasemi, M. Mehravar, Dorsa Halvachi, Maryam Salimi, E. Roshandel","doi":"10.15419/bmrat.v10i6.815","DOIUrl":"https://doi.org/10.15419/bmrat.v10i6.815","url":null,"abstract":"","PeriodicalId":8870,"journal":{"name":"Biomedical Research and Therapy","volume":null,"pages":null},"PeriodicalIF":0.9,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44901186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence of TECTA and GJB2 mutations in Asian children with nonsyndromic hearing loss: A meta-analysis","authors":"P. M. V. Hoang, Quang An Lam, M. X. Ngo, Anh Thu Ha Nguyen, Thanh Vu Nguyen, Chung Thuy Tran Phan","doi":"10.15419/bmrat.v10i6.812","DOIUrl":"https://doi.org/10.15419/bmrat.v10i6.812","url":null,"abstract":"","PeriodicalId":8870,"journal":{"name":"Biomedical Research and Therapy","volume":null,"pages":null},"PeriodicalIF":0.9,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45744115","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Successful treatment of pelvic venous incompetence by a single-stage combined laparoscopic intervention: A case report","authors":"A. Semendyaev, D. Stupin, M. Darenskaya, S. Kolesnikov, K. Pesterev, L. Kolesnikova","doi":"10.15419/bmrat.v10i5.807","DOIUrl":"https://doi.org/10.15419/bmrat.v10i5.807","url":null,"abstract":"","PeriodicalId":8870,"journal":{"name":"Biomedical Research and Therapy","volume":null,"pages":null},"PeriodicalIF":0.9,"publicationDate":"2023-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46916637","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}