Journal of receptor, ligand and channel research最新文献_第2页

The role of the human Duffy antigen receptor for chemokines in malaria susceptibility: current opinions and future treatment prospects. 人类达菲抗原受体趋化因子在疟疾易感性中的作用：当前观点与未来治疗前景。

Journal of receptor, ligand and channel research Pub Date : 2016-01-01 Epub Date: 2016-09-26 DOI: 10.2147/JRLCR.S99725

Francis B Ntumngia, Richard Thomson-Luque, Camilla V Pires, John H Adams

{"title":"The role of the human Duffy antigen receptor for chemokines in malaria susceptibility: current opinions and future treatment prospects.","authors":"Francis B Ntumngia, Richard Thomson-Luque, Camilla V Pires, John H Adams","doi":"10.2147/JRLCR.S99725","DOIUrl":"10.2147/JRLCR.S99725","url":null,"abstract":"The Duffy antigen receptor for chemokine (DARC) is a nonspecific receptor for several proinflammatory cytokines. It is homologous to the G-protein chemokine receptor superfamily, which is suggested to function as a scavenger in many inflammatory-and proinflammatory-related diseases. G-protein chemokine receptors are also known to play a critical role in infectious diseases; they are commonly used as entry vehicles by infectious agents. A typical example is the chemokine receptor CCR5 or CXCR4 used by HIV for infecting target cells. In malaria, DARC is considered an essential receptor that mediates the entry of the human and zoonotic malaria parasites Plasmodium vivax and Plasmodium knowlesi into human reticulocytes and erythrocytes, respectively. This process is mediated through interaction with the parasite ligand known as the Duffy binding protein (DBP). Most therapeutic strategies have been focused on blocking the interaction between DBP and DARC by targeting the parasite ligand, while strategies targeting the receptor, DARC, have not been intensively investigated. The rapid increase in drug resistance and the lack of new effective drugs or a vaccine for malaria constitute a major threat and a need for novel therapeutics to combat disease. This review explores strategies that can be used to target the receptor. Inhibitors of DARC, which block DBP-DARC interaction, can potentially provide an effective strategy for preventing malaria caused by P. vivax.","PeriodicalId":88546,"journal":{"name":"Journal of receptor, ligand and channel research","volume":"9 ","pages":"1-11"},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/0c/dd/nihms841077.PMC5608092.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35384004","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

mTOR signaling in mice with dysfunctional cardiac ryanodine receptor ion channel. ryanodine受体离子通道功能障碍小鼠的mTOR信号传导。

Journal of receptor, ligand and channel research Pub Date : 2015-01-01 DOI: 10.2147/JRLCR.S78410

Tai-Qin Huang, Min-Xu Zou, Daniel A Pasek, Gerhard Meissner

{"title":"mTOR signaling in mice with dysfunctional cardiac ryanodine receptor ion channel.","authors":"Tai-Qin Huang, Min-Xu Zou, Daniel A Pasek, Gerhard Meissner","doi":"10.2147/JRLCR.S78410","DOIUrl":"https://doi.org/10.2147/JRLCR.S78410","url":null,"abstract":"Simultaneous substitution of three amino acid residues in the calmodulin binding domain (W3587A/L3591D/F3603A, ADA) of the cardiac ryanodine receptor ion channel (RyR2) impairs calmodulin inhibition of RyR2 and causes cardiac hypertrophy and early death of Ryr2ADA/ADA mice. To determine the physiological significance of growth promoting signaling molecules, the protein and phosphorylation levels of Ser/Thr kinase mTOR and upstream and downstream signaling molecules were determined in hearts of wild-type and Ryr2ADA/ADA mice. Phosphorylation of mTOR at Ser-2448, and mTOR downstream targets p70S6 kinase at Thr-389, S6 ribosomal protein at Ser-240/244, and 4E-BP1 at Ser-65 were increased. However, there was no increased phosphorylation of mTOR upstream kinases PDK1 at Ser-241, AKT at Thr-308, AMPK at Thr-172, and ERK1/2 at Thr-202/Tyr204. To confirm a role for mTOR signaling in the development of cardiac hypertrophy, rapamycin, an inhibitor of mTOR, was injected into wild-type and mutant mice. Rapamycin decreased mouse heart-to-body weight ratio, improved cardiac performance, and decreased phosphorylation of mTOR and downstream targets p70S6K and S6 in 10-day-old Ryr2ADA/ADA mice but did not extend longevity. Taken together, the results link a dysfunctional RyR2 to an altered activity of signaling molecules that regulate cardiac growth and function.","PeriodicalId":88546,"journal":{"name":"Journal of receptor, ligand and channel research","volume":"8 ","pages":"43-51"},"PeriodicalIF":0.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2147/JRLCR.S78410","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34022204","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Tachykinins and Neurokinin Receptors in Bone Marrow Functions: Neural-Hematopoietic Link. 快激素和神经激素受体在骨髓功能中的作用:神经-造血联系。

Journal of receptor, ligand and channel research Pub Date : 2010-04-01 DOI: 10.2147/jrlcr.s6509

Tilman E Klassert, Shyam A Patel, Pranela Rameshwar

引用次数: 12

Hydrophobicity profiles in G protein-coupled receptor transmembrane helical domains. G蛋白偶联受体跨膜螺旋结构域的疏水性。

Journal of receptor, ligand and channel research Pub Date : 2010-01-01 DOI: 10.2147/JRLCR.S14437

Chiquito J Crasto

引用次数: 8

ATP8A1 activity and phosphatidylserine transbilayer movement. ATP8A1活性与磷脂酰丝氨酸跨双分子层运动。

Journal of receptor, ligand and channel research Pub Date : 2008-01-01 DOI: 10.2147/jrlcr.s3773

Eric Soupene, Dwi Utami Kemaladewi, Frans A Kuypers

{"title":"ATP8A1 activity and phosphatidylserine transbilayer movement.","authors":"Eric Soupene, Dwi Utami Kemaladewi, Frans A Kuypers","doi":"10.2147/jrlcr.s3773","DOIUrl":"https://doi.org/10.2147/jrlcr.s3773","url":null,"abstract":"The asymmetric distribution of the amino-containing phospholipids, phosphatidyl-serine (PS) and phosphatidyl-ethanolamine (PE), across the two leaflets of red blood cell (RBC) membrane is essential to the function and survival of the cell. PS and PE are sequestered in the inner leaflet by an ATP-dependent transport activity of a membrane protein known as the RBC flippase that specifically moves amino-phospholipids from the outer to the inner leaflet. The enucleated RBC lacks the means to replace damaged enzymes and inactivation of the flippase can lead to the unwarranted exposure of PS on the cell surface. Loss in the ability to maintain phospholipid asymmetry is exacerbated in RBC disorders and PS-exposing RBCs present in the circulation play a significant role in the pathology of hemoglobinopathies. We identified the Atp8a1 protein, a member of the family of the P(4)-type ATPases, as a RBC flippase candidate. Atp8a1 is expressed in RBC precursors and is present in the membrane of mature red cells. The flippase activity of the protein was established in purified secretory vesicles of Saccharomyces cerevisiae. ATPase activity was stimulated by PS and PE. In addition, Atp8a1 can move PS molecules across the leaflets of the vesicle membrane in presence of ATP.","PeriodicalId":88546,"journal":{"name":"Journal of receptor, ligand and channel research","volume":"1 ","pages":"1-10"},"PeriodicalIF":0.0,"publicationDate":"2008-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2147/jrlcr.s3773","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"28771704","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 35