{"title":"Biochemistry of Meiotic Recombination: Formation, Processing, and Resolution of Recombination Intermediates.","authors":"Kirk T Ehmsen, Wolf-Dietrich Heyer","doi":"10.1007/7050_2008_039","DOIUrl":"10.1007/7050_2008_039","url":null,"abstract":"<p><p>Meiotic recombination ensures accurate chromosome segregation during the first meiotic division and provides a mechanism to increase genetic heterogeneity among the meiotic products. Unlike homologous recombination in somatic (vegetative) cells, where sister chromatid interactions prevail and crossover formation is avoided, meiotic recombination is targeted to involve homologs, resulting in crossovers to connect the homologs before anaphase of the first meiotic division. The mechanisms responsible for homolog choice and crossover control are poorly understood, but likely involve meiosis-specific recombination proteins, as well as meiosis-specific chromosome organization and architecture. Much progress has been made to identify and biochemically characterize many of the proteins acting during meiotic recombination. This review will focus on the proteins that generate and process heteroduplex DNA, as well as those that process DNA junctions during meiotic recombination, with particular attention to how recombination activities promote crossover resolution between homologs.</p>","PeriodicalId":88493,"journal":{"name":"Genome dynamics and stability","volume":"3 ","pages":"91"},"PeriodicalIF":0.0,"publicationDate":"2008-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2809983/pdf/nihms155146.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"28667581","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Spo11 and the Formation of DNA Double-Strand Breaks in Meiosis.","authors":"Scott Keeney","doi":"10.1007/7050_2007_026","DOIUrl":"https://doi.org/10.1007/7050_2007_026","url":null,"abstract":"<p><p>Meiotic recombination is carried out through a specialized pathway for the formation and repair of DNA double-strand breaks made by the Spo11 protein, a relative of archaeal topoisomerase VI. This review summarizes recent studies that provide insight to the mechanism of DNA cleavage by Spo11, functional interactions of Spo11 with other proteins required for break formation, mechanisms that control the timing of recombination initiation, and evolutionary conservation and divergence of these processes.</p>","PeriodicalId":88493,"journal":{"name":"Genome dynamics and stability","volume":"2 ","pages":"81-123"},"PeriodicalIF":0.0,"publicationDate":"2008-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/7050_2007_026","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30005381","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Meiotic Recombination in Schizosaccharomyces pombe: A Paradigm for Genetic and Molecular Analysis.","authors":"Gareth Cromie, Gerald R Smith","doi":"10.1007/7050_2007_025","DOIUrl":"https://doi.org/10.1007/7050_2007_025","url":null,"abstract":"<p><p>The fission yeast Schizosaccharomyces pombe is especially well-suited for both genetic and biochemical analysis of meiotic recombination. Recent studies have revealed ~50 gene products and two DNA intermediates central to recombination, which we place into a pathway from parental to recombinant DNA. We divide recombination into three stages - chromosome alignment accompanying nuclear \"horsetail\" movement, formation of DNA breaks, and repair of those breaks - and we discuss the roles of the identified gene products and DNA intermediates in these stages. Although some aspects of recombination are similar to those in the distantly related budding yeast Saccharomyces cerevisiae, other aspects are distinctly different. In particular, many proteins required for recombination in one species have no clear ortholog in the other, and the roles of identified orthologs in regulating recombination often differ. Furthermore, in S. pombe the dominant joint DNA molecule intermediates contain single Holliday junctions, and intersister joint molecules are more frequent than interhomolog types, whereas in S. cerevisiae interhomolog double Holliday junctions predominate. We speculate that meiotic recombination in other organisms shares features of each of these yeasts.</p>","PeriodicalId":88493,"journal":{"name":"Genome dynamics and stability","volume":"3 ","pages":"195"},"PeriodicalIF":0.0,"publicationDate":"2008-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/7050_2007_025","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"28715561","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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