Asian Pacific Journal of Cancer Biology最新文献_第8页

A Case of Nodular Fasciitis of the Breast Previously Misdiagnosed as Breast Carcinoma; A Case Report 乳腺结节性筋膜炎误诊为乳腺癌1例病例报告

Asian Pacific Journal of Cancer Biology Pub Date : 2021-11-29 DOI: 10.31557/apjcb.2021.6.4.339-341

E. Nazar, E. Hashemi, S. Ahmadi, Keyvan Baloochi

引用次数: 0

A Study on BCR-ABL Kinase Domain Mutations in Chronic Myeloid Leukemia from Western India 西印度慢性髓系白血病BCR-ABL激酶结构域突变的研究

Asian Pacific Journal of Cancer Biology Pub Date : 2021-10-11 DOI: 10.31557/apjcb.2021.6.3.225-227

P. Gadhia, Jessica Jeejan, Vishma Shah, M. Patel, S. Vaniawala

引用次数: 0

The Expression, Morphology, and Clinical Characteristics of Fibroblast Growth Factor-10 in Breast Cancer 成纤维细胞生长因子-10在乳腺癌中的表达、形态和临床特征

Asian Pacific Journal of Cancer Biology Pub Date : 2021-10-11 DOI: 10.31557/apjcb.2021.6.3.219-224

Samira Molashahi, D. Farhud, M. Saffari, E. Ebrahimi, Amirnader Emamirazavi, R. Shirkoohi

{"title":"The Expression, Morphology, and Clinical Characteristics of Fibroblast Growth Factor-10 in Breast Cancer","authors":"Samira Molashahi, D. Farhud, M. Saffari, E. Ebrahimi, Amirnader Emamirazavi, R. Shirkoohi","doi":"10.31557/apjcb.2021.6.3.219-224","DOIUrl":"https://doi.org/10.31557/apjcb.2021.6.3.219-224","url":null,"abstract":"Background: Fibroblast growth factor-10 (FGF-10) is a member of a superfamily with characteristics of epithelial cell proliferation and embryonic development and is assumed to have a role in a phenomenon called the epithelial-mesenchymal transition (EMT). The previous study has revealed the critical role of FGF-10 in type III EMT in breast cancer cell lines. The mentioned finding, demonstrates the possible role of this factor in type III EMT in cancers with different origins such as breast. The present study investigated the expression of FGF-10 as a mitotic-inducing growth factor, normally has a low expression in breast tissues amongst breast cancer patients. Materials and Methods: 67 breast cancer tissues and 8 normal breast tissues were randomly selected from the Iran national tumor bank. The FGF-10 gene expression analysis was performed after the RNA expression using the real-time RTPCR, which was followed by the Student’s t-test statistical analysis. Results: The findings revealed that the relative expression of FGF-10 was elevated in tumor tissues as compared with normal breast tissues, and the higher expression had a direct correlation with the progression of clinical and pathologic staging. The expression was also significantly higher in triple-negative breast cancer and p53 null tissues. Conclusion: Taken together, it is suggested that, although in some variables it was not significant but generally the invasion and migration in tumor tissues are the same as in-vitro analysis as indicated before, and the expression has a direct relationship with the molecular presentation and clinical -pathological progression. ","PeriodicalId":8848,"journal":{"name":"Asian Pacific Journal of Cancer Biology","volume":"35 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81356425","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

MDM2 (T309G) Gene Polymorphism Determines the Susceptibility of Hepatocellular Carcinoma in Bangladesh MDM2 (T309G)基因多态性决定了孟加拉国肝细胞癌的易感性

Asian Pacific Journal of Cancer Biology Pub Date : 2021-09-22 DOI: 10.31557/apjcb.2021.6.3.213-217

M. Hosen, Narwana Khaleque, Sajib Chakraborty, M. Mahtab, Y. Kabir

{"title":"MDM2 (T309G) Gene Polymorphism Determines the Susceptibility of Hepatocellular Carcinoma in Bangladesh","authors":"M. Hosen, Narwana Khaleque, Sajib Chakraborty, M. Mahtab, Y. Kabir","doi":"10.31557/apjcb.2021.6.3.213-217","DOIUrl":"https://doi.org/10.31557/apjcb.2021.6.3.213-217","url":null,"abstract":"Background: Hepatocellular carcinoma (HCC) is one of the fatal cancer types worldwide, and a variety of genetic factors are considered to be associated with this incidence. MDM2 gene plays a pivotal role in various pathways, which are essential to combat tumor formation. The study aimed to find out the associations of MDM2 (T309G, rs2279744) gene polymorphism with the development of HCC in the Bangladeshi population. Methods: A case-control study on 100 HCC patients and 110 control subjects was conducted. The genotyping of the MDM2 (T309G) gene was done using PCR-RFLP methods. Results: The percentage of TT and GG genotypes were significantly different (p<0.01) among the study subjects. There were four genotyping groups, while the subjects with TT genotypes were considered the reference group. Patients with GG genotypes were at high risk of developing HCC (OR, 3.6; 95 % CI, 1.64–7.80; p<0.01) compared to the control. On the other hand, the association of TG genotypes with HCC was not statistically significant (OR, 1.8; 95 % CI, 0.91–3.40, p>0.05). In addition, patients having either GG or TG genotypes showed higher risk for HCC compared to control group (OR = 2.20; 95% CI = 1.21–4.14; P < 0.05). Conclusion: Our study suggested that the MDM2 gene may have a strong association with the development of HCC, and the GG allele could serve as an essential determinant to identify the higher risk of HCC in the Bangladeshi population.","PeriodicalId":8848,"journal":{"name":"Asian Pacific Journal of Cancer Biology","volume":"31 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85845261","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 8

Betel Quid, Smoking and Alcohol Dependency among Patients with Oral Potentially Malignant Disorders and Oral Cancer in Sri Lanka; A Preliminary Case-control Study 斯里兰卡口腔潜在恶性疾病和口腔癌患者的槟榔、吸烟和酒精依赖初步病例对照研究

Asian Pacific Journal of Cancer Biology Pub Date : 2021-09-08 DOI: 10.31557/apjcb.2021.6.3.207-212

Sumali Randhini Sumithrarachchi, W.A.Udari.C. Pemasiri, A. Pathiranage, P. Jayasooriya

{"title":"Betel Quid, Smoking and Alcohol Dependency among Patients with Oral Potentially Malignant Disorders and Oral Cancer in Sri Lanka; A Preliminary Case-control Study","authors":"Sumali Randhini Sumithrarachchi, W.A.Udari.C. Pemasiri, A. Pathiranage, P. Jayasooriya","doi":"10.31557/apjcb.2021.6.3.207-212","DOIUrl":"https://doi.org/10.31557/apjcb.2021.6.3.207-212","url":null,"abstract":"Introduction: Oral cancer and Oral Potentially Malignant Disorders (OPMDs) arising due to risk habits like betel quid (BQ) chewing, smoking and alcohol use are preventable despite the high prevalence and poor survival rates. However, dependence to risk habits has become a barrier to prevent OPMDs and oral cancer. Objectives: This study was conducted to determine the dependence to risk habits among patients with such oral lesions, and the quitting among dependent users after diagnosis. Materials and method: A case-control study was conducted among 100 participants, 50 diagnosed with OPMDs and oral cancer from two Oral and Maxillo Facial clinics in Sri Lanka and a similar control group without any oral lesions. All participants practiced one or more risk habits such as BQ chewing, smoking and/or alcohol use. Dependence was assessed using Sinhala language translations of standardized scales such as Betel Quid Dependence Scale for BQ chewers, Fagerstrom Test for Nicotine Dependence for tobacco smokers and CAGE (“Cut down”, “Annoyed”, “Guilty” and “Eye opener”) scale for alcohol users. Results: Dependence on habits was more among the case group (BQ-93%; smoking-14%; alcohol-66%). Quitting rates of BQ and alcohol among those who were diagnosed with oral cancer [BQ (89%), alcohol (89%)] were higher (p<0.05) than those with OPMDs [BQ (50%), alcohol (22%)]. Lack of awareness due to low socio-economic status (97%) was a significant association for BQ dependence (p=0.01).Conclusion: In conclusion, development of OPMDs and oral cancer increases with dependence to BQ chewing, smoking and alcohol use. Increased awareness about OPMDs and its risk of malignancy is needed among public. Prevention of dependence to these risk habits also becomes essential. \u0000 ","PeriodicalId":8848,"journal":{"name":"Asian Pacific Journal of Cancer Biology","volume":"32 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81986243","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Hematologic Presentations of COVID-19 Can be Misinterpreted as Acute Myeloid Leukemia COVID-19的血液学表现可能被误解为急性髓性白血病

Asian Pacific Journal of Cancer Biology Pub Date : 2021-09-08 DOI: 10.31557/apjcb.2021.6.3.231-233

H. Tabriz, E. Nazar, Fatemeh Jazayeri, A. Javadi

引用次数: 2

Significance of Immunohistochemical Expression of Survivin in Renal Cell Carcinoma Survivin在肾细胞癌中免疫组化表达的意义

Asian Pacific Journal of Cancer Biology Pub Date : 2021-08-12 DOI: 10.31557/apjcb.2021.6.3.201-205

M. Mohammed, N. Ahmed

{"title":"Significance of Immunohistochemical Expression of Survivin in Renal Cell Carcinoma","authors":"M. Mohammed, N. Ahmed","doi":"10.31557/apjcb.2021.6.3.201-205","DOIUrl":"https://doi.org/10.31557/apjcb.2021.6.3.201-205","url":null,"abstract":"Background: Evasion of apoptosis is an essential alteration for cellular genetic mutation. Survivin is a member of inhibitor of apoptosis protein (IAP) family. Under normal conditions, Survivin is expressed in embryonic and fetal tissues and markedly diminished in mature, differentiated adult tissues. Survivin was found to be re-expressed in multiple solid and hematological human malignant neoplasms. The purpose of this study was to evaluate the expression of Survivin in renal cell carcinoma (RCC), and to find statistically significant associations between Survivin and the tested Clinicopathological parameters.Methods: 39 patients with RCCs who underwent nephrectomy were included in the study. From each RCC specimen, two tissue sections were obtained; one was stained by H&E stain to determine both RCC phenotype and Fuhrman’s nuclear grades. The second tissue section was immunohistochemically stained by anti-human Survivin antibody. Results: The study revealed statistically significant associations between Survivin expression in RCC specimens and RCC histological types (p =0.002), high tumor grade (p< 0.001) and advanced tumor stage (p< 0.001). Conclusion: The study revealed that Survivin is positively correlated to poorly differentiated RCCs with high Fuhrman’s nuclear grade and advanced tumor stage. ","PeriodicalId":8848,"journal":{"name":"Asian Pacific Journal of Cancer Biology","volume":"29 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90152250","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Poor Man’s Cell-block Preparation, a Novel Idea which Can be Applied to Basic Health Care Facilities in Resource-poor Settings 穷人的细胞块制备，一个可以应用于资源贫乏环境的基本卫生保健设施的新想法

Asian Pacific Journal of Cancer Biology Pub Date : 2021-07-09 DOI: 10.31557/APJCB.2021.6.3.173-179

Huzaifa Saleem, Mehwish Javed, A. Saleem, Sadia Atif, Rabia Rafi

{"title":"Poor Man’s Cell-block Preparation, a Novel Idea which Can be Applied to Basic Health Care Facilities in Resource-poor Settings","authors":"Huzaifa Saleem, Mehwish Javed, A. Saleem, Sadia Atif, Rabia Rafi","doi":"10.31557/APJCB.2021.6.3.173-179","DOIUrl":"https://doi.org/10.31557/APJCB.2021.6.3.173-179","url":null,"abstract":" Objective: To determine the diagnostic yield of cell blocks, prepared by the vapour fixation method, using laboratory supplies easily available at any low resource laboratory setup or outpatient department of a basic healthcare unit. Methods: Prospective descriptive study was carried out at Healthways Laboratories Rawalpindi, for 6 months from 1st January 2017 to 30th June 2017. Walk in patients referred to the lab for FNAC were selected by non probability convenient sampling. After preparing FNAC slides from first pass, the patients were briefed about the cell block material and after informed consent second dedicated passes were done to make cell blocks. Results: Out of 47 cases, there were 25 (53.2 %) breast lumps, 8 (17%) superficial collections, 7 (15.1%) lymphadenopathies, 6 (12.8%) thyroid swellings and 1 salivary gland swelling. Technique yielded moderate to high cellularity in 33 (70.2%) cases, 16 from malignant and 1 from benign breast lumps, 5 from thyroid, 3 from reactive and 3 from metastatic lymphnodes, 3 from abscesses, 1 from lipoma and 1 from salivary gland. Low cellularity 14 (29.8%) cases were from 5 benign and 3 malignant breast lumps, 2 hematomas and 1 case each from thyroid, metastatic lymphnode, abscess and lipoma. Good cellularity was achieved in 16 (84.2%) of 19 cases of malignant breast lesions, 3 (15.8%) were hypo cellular of which 1 was non-diagnostic on FNAC smear. Cell block diagnosis was comparable to FNAC in 35 of 47 (74.4%) cases. Non diagnostic cases on cell block were more, 13 versus 3 cases on FNAC. The kappa value of agreement in diagnosis was 0.64. Conclusions: Poor man’s cell block method is simplest and effective method of cell block preparation which must be advocated at basic healthcare units and low tech laboratory. Its diagnostic potential must be further explored.","PeriodicalId":8848,"journal":{"name":"Asian Pacific Journal of Cancer Biology","volume":"19 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85270789","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Comprehensive Analysis of the Expression and Prognosis for DCTPP1 gene in Breast Cancer 乳腺癌DCTPP1基因表达及预后的综合分析

Asian Pacific Journal of Cancer Biology Pub Date : 2021-07-09 DOI: 10.31557/APJCB.2021.6.3.195-200

T. Hoang, Thi Thu Huong Bui, T. Nguyễn

{"title":"Comprehensive Analysis of the Expression and Prognosis for DCTPP1 gene in Breast Cancer","authors":"T. Hoang, Thi Thu Huong Bui, T. Nguyễn","doi":"10.31557/APJCB.2021.6.3.195-200","DOIUrl":"https://doi.org/10.31557/APJCB.2021.6.3.195-200","url":null,"abstract":"Background: Breast cancer is a common malignancy in women. DCTPP1 is a potential target for the development of antitumor drugs, and plays an important role in the process of DNA replication. Aims: To investigate the biological role of DCTPP1 gene, as well as its expression in breast cancer and its relation to patient prognosis. Materials and Methods: Breast cancer data was derived from the TCGA database. Using the UALCAN database, the expression level of DCTPP1 mRNA in breast cancer tissues was investigated. The expression of DCTPP1 in various pathological types of breast cancer was studied using the Human Protein Atlas. UALCAN was also used to investigate the relationship between DCTPP1 gene expression and breast cancer patient prognosis. Bioinformatics studied the proteins related to DCTPP1 expression and their roles in the GeneMANIA and WebGestalt databases. Results: DCTPP1 mRNA was significantly expressed in breast cancer compared to normal breast tissue (P<0.001). DCTPP1 was shown to be highly expressed in breast cancer tissues from different pathological types and stages (P<0.001). The DCTPP1 protein was expressed at a higher frequency in breast cancer than in normal breast tissue. When compared to patients with low DCTPP1 expression, patients with high DCTPP1 expression had a considerably shorter overall survival time. The 20 proteins related to DCTPP1 expression were mostly located in the nucleus and membrane, and were involved in biological regulation, stimulus response, metabolic process, and other processes, according to gene ontology analysis. It plays an important role in protein binding, ion binding, and nucleic acid binding. Conclusion: DCTPP1 is highly expressed in breast cancer, and is associated to a poor prognosis for patients with breast cancer. DCTPP1 may be a potential therapy and intervention target for breast cancer.","PeriodicalId":8848,"journal":{"name":"Asian Pacific Journal of Cancer Biology","volume":"4 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74907475","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Histopathologic Characteristics of Invasive and Non-invasive Ductal Tumors have Relationship with Different Phenotypes of ER / PR Receptors in Breast Cancer Patients 乳腺癌浸润性和非浸润性导管肿瘤的组织病理学特征与ER / PR受体不同表型的关系

Asian Pacific Journal of Cancer Biology Pub Date : 2021-07-09 DOI: 10.31557/APJCB.2021.6.3.181-185

R. Golmohammadi, M. Mohajeri, A. Jarrahi, A. Moslem, A. Pejhan, A. Gohari

{"title":"Histopathologic Characteristics of Invasive and Non-invasive Ductal Tumors have Relationship with Different Phenotypes of ER / PR Receptors in Breast Cancer Patients","authors":"R. Golmohammadi, M. Mohajeri, A. Jarrahi, A. Moslem, A. Pejhan, A. Gohari","doi":"10.31557/APJCB.2021.6.3.181-185","DOIUrl":"https://doi.org/10.31557/APJCB.2021.6.3.181-185","url":null,"abstract":"Objective: Contradictory reports have been published regarding the expression levels of the hormone receptors of estrogen and progesterone (ER / PR) and theirclinical importance in diagnosis of breast cancer. The aim of this study was to evaluate the relationship between pathological features of invasive and non-invasive ductal tumors by different ER / PR phenotypes. Methods: This descriptive-analytical study was performed on 74 specimens of breast cancer referred to Isfahan Hospitals for diagnosis between 2015 - 2018. After fixation of the specimens in formalin, tissue passage, cross section and H / E staining, the specimens were divided into two groups: non- invasive and Invasive ductal Carcinoma. After removing of mask, expression of different ER / PR phenotypes was performed using primary monoclonal antibody and immunohistochemically methods. Results: From 74 malignant specimens, 61 (82.4%) were in the category of invasive ductal tumors and 13 cases (17.6%) were in the category of non-invasive ductal tumors. Out of 73 patients with positive ER or PR phenotype 47 samples (63.5%) had ER + / PR +phenotypes, 6 samples had (8.1%) ER+ / PR –phenotype, 20 samples (27%) had ER- / PR + phenotype and only one sample (1.4%) had the ER- / PR- phenotype and was in the category of invasive ductal tumors. There was not detected ER- / PR- phenotype expression in non-invasive ductal tumor. Further analysis showed that there were not significant difference between ER / PR phenotype and tumor stage (p =0.36) or with tumor Grade (P=0.38), high age of menopause or post menopause (P> 0.05). Conclusion: Our data shows that expression of ER- / PR- phenotype only was detected in invasive ductal tumor. It is thought that the tumor type maybe affects the expression of different types of ER / PR hormone receptor phenotypes in breast cancer patients.","PeriodicalId":8848,"journal":{"name":"Asian Pacific Journal of Cancer Biology","volume":"48 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87579303","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2