{"title":"Gene therapy for myocardial infarction-associated congestive heart failure: how far have we got?","authors":"H Kirk Hammond, Tong Tang","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>With the advancement of vectors, delivery methods, and newly identified molecular targets, preclinical studies have shown that gene transfer is effective in improving left ventricular contractility and attenuating deleterious left ventricular remodeling in myocardial infarction-associated congestive heart failure (CHF). We are optimistic that these favorable effects will also be seen when tested in patients with CHF associated with myocardial infarction, as well as in patients with CHF from other etiologies. Gene therapy has the potential to be tailored to meet the needs of individual patients. Moreover, when used in conjunction with pharmacological and device management of the patient with CHF, it provides hope for a brighter future for the 23 million patients worldwide with this devastating disease.</p>","PeriodicalId":88470,"journal":{"name":"Dialogues in cardiovascular medicine : DCM","volume":"14 1","pages":"27-51"},"PeriodicalIF":0.0,"publicationDate":"2009-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3119547/pdf/nihms-286869.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"29961145","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"GENE AND CELL THERAPY FOR LIFE-THREATENING CARDIAC ARRHYTHMIAS.","authors":"Michael R Rosen, Peter Danilo, Richard B Robinson","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Gene and cell therapies of cardiac arrhythmias are nascent fields whose raison d'etre derives from (1) the problematic state of arrhythmia treatment today (especially atrial and ventricular tachyarrhythmias for which drugs, devices and ablation remain more stopgaps then optimal interventions), and (2) the opportunity to learn and potentially treat and cure by exploring new technologies. The state of antiarrhythmic therapy and new directions being taken are reviewed.</p>","PeriodicalId":88470,"journal":{"name":"Dialogues in cardiovascular medicine : DCM","volume":"14 1","pages":"44-51"},"PeriodicalIF":0.0,"publicationDate":"2009-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2828741/pdf/nihms119505.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"28744516","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"PRIMARY AND SECONDARY PREVENTION OF STROKE","authors":"P. Gorelick","doi":"10.4324/9780203211410_chapter_2","DOIUrl":"https://doi.org/10.4324/9780203211410_chapter_2","url":null,"abstract":"We have made an attempt to systematize risk factors of primary and repeated ischemic strokes development. The divisions of the corrected and not corrected have been introduced in basis of systematization. The main tasks of primary and secondary prophylaxis of ischemic strokes have been distinguished. The realization of secondary prophylaxis is quite possible in modern stage and in the conditions of existing social and economic difficulties. So in comparison with the primary prophylaxis that sphere is less expensive. The affected possibility to the corrected risk factors has been determined, namely adequate therapy administered in time, complicated by the ischemic stroke development. The basic categories have been determined to carry out primary and secondary prophylaxis of ischemic strokes. They are teachers, psychologists, prophylaxis and curative institutions workers.","PeriodicalId":88470,"journal":{"name":"Dialogues in cardiovascular medicine : DCM","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70580794","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}