Clinical medicine. Oncology最新文献_第4页

The effect of docetaxel (taxotere) on human gastric cancer cells exhibiting low-dose radiation hypersensitivity. 多西紫杉醇(泰索帝)对低剂量辐射超敏人胃癌细胞的影响。

Clinical medicine. Oncology Pub Date : 2008-01-01 Epub Date: 2008-03-28 DOI: 10.4137/cmo.s463

Elizabeth K Balcer-Kubiczek, Mona Attarpour, Jian Z Wang, William F Regine

{"title":"The effect of docetaxel (taxotere) on human gastric cancer cells exhibiting low-dose radiation hypersensitivity.","authors":"Elizabeth K Balcer-Kubiczek, Mona Attarpour, Jian Z Wang, William F Regine","doi":"10.4137/cmo.s463","DOIUrl":"https://doi.org/10.4137/cmo.s463","url":null,"abstract":"Low-dose radiation hypersensitivity (HRS) describes a phenomenon of excessive sensitivity to X ray doses <0.5 Gy. Docetaxel is a taxane shown to arrest cells in the G(2)/M phase of the cell cycle. Some previous studies suggested that HRS might result from the abrogation of the early G(2) checkpoint arrest. First we tested whether HRS occurs in gastric cancer-derived cells, and whether pre-treatment of cells with low docetaxel concentrations can enhance the magnitude of HRS in gastric cancer cells. The results demonstrated HRS at ~0.3 Gy and the synergy between 0.3 Gy and docetaxel (3 nM for 24 h), and the additivity of other drug/dose combinations. The synergistic effect was associated with a significant docetaxel-induced G(2) accumulation. Next, we evaluated in time-course experiments ATM kinase activity and proteins associated with the induction and maintenance of the early G(2) checkpoint. The results of multi-immunoblot analysis demonstrate that HRS does not correlate with the ATM-dependent early G(2) checkpoint arrest. We speculate that G(2) checkpoint adaptation, a phenomenon associated with a prolonged cell cycle arrest, might be involved in HRS. Our results also suggest a new approach for the improvement the effectiveness of docetaxel-based radiotherapy using low doses per fraction.","PeriodicalId":88451,"journal":{"name":"Clinical medicine. Oncology","volume":"2 ","pages":"301-11"},"PeriodicalIF":0.0,"publicationDate":"2008-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4137/cmo.s463","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30119992","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Response of cutaneous metastases from breast cancer to capecitabine. 乳腺癌皮肤转移对卡培他滨的反应。

Clinical medicine. Oncology Pub Date : 2008-01-01 Epub Date: 2008-04-18 DOI: 10.4137/cmo.s521

Kostandinos Sideras, Katie M Zahasky, Judith S Kaur

引用次数: 7

Primary MALT Type Skin Lymphoma-Is 'Wait and See' a Possible Strategy? 原发性MALT型皮肤淋巴瘤:“观望”是一种可能的策略吗?

Clinical medicine. Oncology Pub Date : 2008-01-01 Epub Date: 2008-03-19

Florentina Silvia Delli, Thomas Zaraboukas, Ioanna Mandekou-Lefaki

引用次数: 0

Molecular Mechanisms that Regulate Epidermal Growth Factor Receptor Inactivation. 调节表皮生长因子受体失活的分子机制。

Clinical medicine. Oncology Pub Date : 2008-01-01 Epub Date: 2008-02-09 DOI: 10.4137/cmo.s498

Brian P Ceresa, Phillip A Vanlandingham

{"title":"Molecular Mechanisms that Regulate Epidermal Growth Factor Receptor Inactivation.","authors":"Brian P Ceresa, Phillip A Vanlandingham","doi":"10.4137/cmo.s498","DOIUrl":"https://doi.org/10.4137/cmo.s498","url":null,"abstract":"The Epidermal Growth Factor Receptor (EGFR) is the prototypical receptor tyrosine kinase (RTK). These cell surface receptors are integral membrane proteins that bind ligands on their extracellular domain and relay that information to within the cell. The activated EGFR regulates diverse cell fates such as growth, proliferation, differentiation, migration, and apoptosis. These signaling properties are important for the appropriate development and maintenance of an organism. However, when inappropriately controlled, due to EGFR overexpression or hyperactivation, these signaling events are characteristic of many cancers. It remains unclear whether the uncontrolled EGFR activity leads to cell transformation or is a consequence of cell transformation. Regardless of the cause, increased EGFR activity serves both as a biomarker in the diagnosis of some cancers and is a molecular target for anti-cancer therapies. The promising results with current anti-EGFR therapies suggest that the receptor is a viable molecular target for a limited number of applications. However, to become an effective therapeutic target for other cancers that have elevated levels of EGFR activity, current approaches for inhibiting EGFR signaling will need to be refined. Here we describe the molecular mechanisms that regulate EGFR inactivation and discuss their potential as therapeutic targets for inhibiting EGFR signaling.","PeriodicalId":88451,"journal":{"name":"Clinical medicine. Oncology","volume":"2 ","pages":"47-61"},"PeriodicalIF":0.0,"publicationDate":"2008-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4137/cmo.s498","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"29974338","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 11

Signet-ring cell carcinoma arising in the gastric stump after duodenopancreatectomy for ductal adenocarcinoma of the pancreas: a case report. 胰管腺癌十二指肠胰切除术后胃残端出现印戒细胞癌1例报告。

Clinical medicine. Oncology Pub Date : 2008-01-01 Epub Date: 2008-03-27 DOI: 10.4137/cmo.s384

Woubet T Kassahun, Peter Lamesch, Christian Wittekind, Matthias Neid, Jens P Schneider, Joachim Mössner, Johann Hauss

{"title":"Signet-ring cell carcinoma arising in the gastric stump after duodenopancreatectomy for ductal adenocarcinoma of the pancreas: a case report.","authors":"Woubet T Kassahun, Peter Lamesch, Christian Wittekind, Matthias Neid, Jens P Schneider, Joachim Mössner, Johann Hauss","doi":"10.4137/cmo.s384","DOIUrl":"https://doi.org/10.4137/cmo.s384","url":null,"abstract":"The development of malignancy in the gastric stump following surgery for peptic ulcer disease is well recognized. There are also few reports on carcinomas occurring after surgery for malignant gastric disease. However, carcinoma of the gastric stump after duodenopancreatectomy is extremely rare. We describe what we believe to be an unusual case of signet-ring cell carcinoma of the gastric stump developing at the anastomotic site 5 years after duodenopancreatectomy for ductal adenocarcinoma of the pancreatic head. We performed remnant gastrectomy and Roux-en-Y gastrojejunostomy as a curative resection. This experience clearly underlies that g astric stump carcinoma (GSC) may mimic metastatic disease recurrence leading to diagnostic confusion after surgery for malignancy. Although an increased risk of gastric stump carcinoma after pancreatoduodenectomy for pancreatic cancer has not been established, the possibility of such a complication should be kept in mind when evaluating patients after gastric resection who present with symptoms of metastatic disease recurrence years after the primary operation. Investigations should be independent of the entity of the primary disease or its localization, since GSC may well be amenable to surgical cure as demonstrated in the presented case. Outpatient follow up results of the last four years indicated no recurrence in this case.","PeriodicalId":88451,"journal":{"name":"Clinical medicine. Oncology","volume":"2 ","pages":"109-12"},"PeriodicalIF":0.0,"publicationDate":"2008-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4137/cmo.s384","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"29975342","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7

Molecular Cloning and Functional Characterization of Mouse α3(IV)NC1. 小鼠α3(IV)NC1的克隆及功能表征

Clinical medicine. Oncology Pub Date : 2008-01-01 Epub Date: 2008-02-09 DOI: 10.4137/cmo.s461

Chandra Shekhar Boosani, Akulapalli Sudhakar

引用次数: 11

Oxaliplatin for metastatic colon cancer in a patient with renal failure. 奥沙利铂治疗一名肾功能衰竭患者的转移性结肠癌。

Clinical medicine. Oncology Pub Date : 2008-01-01 Epub Date: 2008-02-09 DOI: 10.4137/cmo.s412

Kenji Katsumata, Tetsuo Sumi, Tatehiko Wada, Yasuharu Mori, Masayuki Hisada, Hideaki Kawakita, Masanori Enomoto, Shoji Suzuki, Daisuke Matsuda, Akihiko Tsuchida, Tatsuya Aoki

{"title":"Oxaliplatin for metastatic colon cancer in a patient with renal failure.","authors":"Kenji Katsumata, Tetsuo Sumi, Tatehiko Wada, Yasuharu Mori, Masayuki Hisada, Hideaki Kawakita, Masanori Enomoto, Shoji Suzuki, Daisuke Matsuda, Akihiko Tsuchida, Tatsuya Aoki","doi":"10.4137/cmo.s412","DOIUrl":"10.4137/cmo.s412","url":null,"abstract":"Objective: Oxaliplatin, a key part of the standard regimen for colorectal cancer in Western countries, has become available in Japan. In a hemodialysis patient with cecal cancer, we investigated the efficacy, safety, pharmacokinetics, and dialysability of oxaliplatin.Methods: A 65-year-old man who had cecal cancer was treated with oxaliplatin (40 mg/m(2)) and l-leucovorin(l-LV) (200 mg/m(2)), which were administered simultaneously over 120 min via the side and main arms of a Y-tube, respectively. Then 5-FU (400 mg/m(2)) was administered rapidly via the side tube, followed by 5-FU (2,000 mg/m(2)) over 46 hours via the main tube. The patient had chronic renal failure due to diabetic nephropathy and hemodialysis was performed 3 times a week. Blood samples were collected from the dialyzer before and after each hemodialysis session to examine platinum clearance.Results: The patient received 3 courses of oxaliplatin before he died of cancer. During hemodialysis, the platinum level fell from 0.32 μg/mL to 0.15 μg/mL.Conclusion: Since patients with renal failure have various associated disorders and oxaliplatin has a long half-life, it is necessary to obtain more pharmacokinetic data to investigate its accumulation and dialysability during long-term treatment. Such data will assist in treating the rapidly increasing number of hemodialysis patients with colorectal cancer.","PeriodicalId":88451,"journal":{"name":"Clinical medicine. Oncology","volume":"2 ","pages":"97-101"},"PeriodicalIF":0.0,"publicationDate":"2008-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3161642/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"29975339","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Functional activities and immunohistochemical cellular distribution of glutathione s-transferases in normal, dysplastic, and squamous cell carcinoma human oral tissues. 谷胱甘肽s-转移酶在正常、发育不良和鳞状细胞癌人类口腔组织中的功能活性和免疫组织化学细胞分布。

Clinical medicine. Oncology Pub Date : 2008-01-01 Epub Date: 2008-03-28 DOI: 10.4137/cmo.s491

Peter J Giannini, Mark A Morse, Christopher M Weghorst, Ping Pei, Susan R Mallery

{"title":"Functional activities and immunohistochemical cellular distribution of glutathione s-transferases in normal, dysplastic, and squamous cell carcinoma human oral tissues.","authors":"Peter J Giannini, Mark A Morse, Christopher M Weghorst, Ping Pei, Susan R Mallery","doi":"10.4137/cmo.s491","DOIUrl":"https://doi.org/10.4137/cmo.s491","url":null,"abstract":"Clinical data show a strong correlation between tobacco and alcohol use and the development of oral squamous cell carcinoma (SCC). While this association implies that the oral mucosa actively metabolizes carcinogens, there is little information which depicts the carcinogen metabolizing enzymes within the oral cavity. Glutathione S-transferases (GSTs) primary function is to detoxify carcinogens by increasing their water solubility, GSTs represent key carcinogen metabolizing enzymes. Notably, individuals with a null phenotype for certain GST isoforms are at an increased risk to develop cancer. This study investigated the function and distribution of GSTs in human oral tissues. Our results from this pilot study showed a trend towards higher GST activities in SCC tissues relative to normal mucosa. Also, relative to normal tissues, the SCC and epithelial dysplasia samples showed a more intense and uniform GST intracellular distribution. GST activities are increased in many high grade cancers. Similarly, our data suggest that GST upregulation occurs in at least a subset of precancerous and malignant oral lesions.","PeriodicalId":88451,"journal":{"name":"Clinical medicine. Oncology","volume":"2 ","pages":"159-68"},"PeriodicalIF":0.0,"publicationDate":"2008-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4137/cmo.s491","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"28848510","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 8

A unique complication associated with concurrent chemoradiation for the treatment of locally advanced head and neck cancer. 局部晚期头颈癌同步放化疗的独特并发症。

Clinical medicine. Oncology Pub Date : 2008-01-01 Epub Date: 2008-04-01 DOI: 10.4137/cmo.s407

Oren Cahlon, Ashok Shaha, Nancy Lee

{"title":"A unique complication associated with concurrent chemoradiation for the treatment of locally advanced head and neck cancer.","authors":"Oren Cahlon, Ashok Shaha, Nancy Lee","doi":"10.4137/cmo.s407","DOIUrl":"https://doi.org/10.4137/cmo.s407","url":null,"abstract":"Background: Concurrent chemoradiation is becoming an increasingly popular treatment for patients with locally advanced head and neck cancer. The full extent of treatment related complications has not been completely documented in the literature.Methods: We present the case of a patient treated with definitive intensity modulated radiation therapy and concurrent carboplatin and fluorouracil for a locally advanced oral cavity and base of tongue cancer.Results: The patient suffered acute grade 4 dermatitis and mucositis during treatment. One month after completion of treatment, the patient was found to have permanent adherence of the tongue to the buccal mucosa as a result of severe scar tissue formation.Conclusions: As more patients undergo chemoradiation for the treatment of locally advanced head and neck cancer, the full extent of treatment related complications are being identified. To our knowledge, this is the first report of chemoradiation for head and neck cancer resulting in adherence of the tongue to the buccal mucosa.","PeriodicalId":88451,"journal":{"name":"Clinical medicine. Oncology","volume":"2 ","pages":"313-8"},"PeriodicalIF":0.0,"publicationDate":"2008-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4137/cmo.s407","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30119375","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Radionuclide Imaging of Apoptosis in Malignancies: Promise and Pitfalls of Tc-Hynic-rh-Annexin V Imaging. 恶性肿瘤细胞凋亡的放射性核素成像:Tc-Hynic-rh-Annexin V成像的希望与缺陷。

Clinical medicine. Oncology Pub Date : 2008-01-01 Epub Date: 2008-03-25 DOI: 10.4137/cmo.s349

M S Kartachova, M Verheij, B L van Eck, C A Hoefnagel, R A Valdes Olmos

引用次数: 8