Nanobiotechnology : the journal at the intersection of nanotechnology, molecular biology, and biomedical sciences最新文献_第7页

Phosphorylcholine Group-immobilized Surface Prepared on Polydimethylsiloxane Membrane by In Situ Reaction for Its Reduced Biofouling 原位反应制备聚二甲基硅氧烷膜上磷酸胆碱基固定化表面及其减少生物污染的研究

Nanobiotechnology : the journal at the intersection of nanotechnology, molecular biology, and biomedical sciences Pub Date : 2007-05-01 DOI: 10.1007/S12030-008-9006-0

K. Ishihara, B. Ando, M. Takai

引用次数: 13

Mesoporous Silica Nanoparticles for Cancer Therapy: Energy-Dependent Cellular Uptake and Delivery of Paclitaxel to Cancer Cells. 用于癌症治疗的介孔二氧化硅纳米颗粒:能量依赖的细胞摄取和紫杉醇到癌细胞的传递。

Nanobiotechnology : the journal at the intersection of nanotechnology, molecular biology, and biomedical sciences Pub Date : 2007-05-01 DOI: 10.1007/s12030-008-9003-3

Jie Lu, Monty Liong, Sean Sherman, Tian Xia, Michael Kovochich, Andre E Nel, Jeffrey I Zink, Fuyuhiko Tamanoi

{"title":"Mesoporous Silica Nanoparticles for Cancer Therapy: Energy-Dependent Cellular Uptake and Delivery of Paclitaxel to Cancer Cells.","authors":"Jie Lu, Monty Liong, Sean Sherman, Tian Xia, Michael Kovochich, Andre E Nel, Jeffrey I Zink, Fuyuhiko Tamanoi","doi":"10.1007/s12030-008-9003-3","DOIUrl":"https://doi.org/10.1007/s12030-008-9003-3","url":null,"abstract":"Biocompatible mesoporous silica nanoparticles, containing the fluorescence dye fluorescein isothiocyanate (FITC), provide a promising system to deliver hydrophobic anticancer drugs to cancer cells. In this study, we investigated the mechanism of uptake of fluorescent mesoporous silica nanoparticles (FMSN) by cancer cells. Incubation with FMSN at different temperatures showed that the uptake was higher at 37 degrees C than at 4 degrees C. Metabolic inhibitors impeded uptake of FMSN into cells. The inhibition of FMSN uptake by nocodazole treatment suggests that microtubule functions are required. We also report utilization of mesoporous silica nanoparticles to deliver a hydrophobic anticancer drug paclitaxel to PANC-1 cancer cells and to induce inhibition of proliferation. Mesoporous silica nanoparticles may provide a valuable vehicle to deliver hydrophobic anticancer drugs to human cancer cells.","PeriodicalId":88286,"journal":{"name":"Nanobiotechnology : the journal at the intersection of nanotechnology, molecular biology, and biomedical sciences","volume":"3 2","pages":"89-95"},"PeriodicalIF":0.0,"publicationDate":"2007-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s12030-008-9003-3","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"28527045","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 169

Advances in Nano Biotic/Abiotic Hybrid Systems: Protein-Based Engineered Devices 纳米生物/非生物混合系统的进展:基于蛋白质的工程装置

Nanobiotechnology : the journal at the intersection of nanotechnology, molecular biology, and biomedical sciences Pub Date : 2007-05-01 DOI: 10.1007/S12030-008-9008-Y

Hyo-Jick Choi, D. Wendell, C. Montemagno

引用次数: 7

Synthesis and characterization of enzyme-Au bioconjugates: HRP and fluorescein-labeled HRP 酶-金生物偶联物的合成和表征:HRP和荧光素标记的HRP

Nanobiotechnology : the journal at the intersection of nanotechnology, molecular biology, and biomedical sciences Pub Date : 2007-04-26 DOI: 10.1007/S12030-007-0002-6

A. Cans, S. Dean, F. Reyes, C. Keating

引用次数: 19

Drug and gene delivery using gold nanoparticles 利用金纳米颗粒来传递药物和基因

Nanobiotechnology : the journal at the intersection of nanotechnology, molecular biology, and biomedical sciences Pub Date : 2007-04-26 DOI: 10.1007/S12030-007-0005-3

Gang Han, P. Ghosh, Mrinmoy De, V. Rotello

引用次数: 176

Detection of human viral RNA via a combined fluorescence and SERS molecular beacon assay. 通过荧光和 SERS 分子信标联合测定法检测人类病毒 RNA。

Nanobiotechnology : the journal at the intersection of nanotechnology, molecular biology, and biomedical sciences Pub Date : 2007-01-01 Epub Date: 2007-05-03 DOI: 10.1007/s12030-007-0003-5

M Y Sha, S Penn, G Freeman, W E Doering

{"title":"Detection of human viral RNA via a combined fluorescence and SERS molecular beacon assay.","authors":"M Y Sha, S Penn, G Freeman, W E Doering","doi":"10.1007/s12030-007-0003-5","DOIUrl":"10.1007/s12030-007-0003-5","url":null,"abstract":"A dual-mode molecular beacon on a multiplexed substrate has been developed and applied to the measurement of unlabeled human viral RNA. The detection system is based on a combined surface-enhanced Raman scattering (SERS) and fluorescent molecular beacon assay that is assembled on Nanobarcodes™ particles. In this assay, a molecular beacon probe terminated with a fluorescent Raman label dye is conjugated to the metallic Nanobarcodes™ particles. The molecular beacon probe is a single-stranded oligonucleotide that has been designed with a hairpin structure that holds the dye at 3'-end close to the particle surface when the probe is attached through a 5'-thiol group. In this configuration, the SERS spectrum of the label was obtained and its fluorescence quenched because the dye is in very close proximity to a noble metal surface with nanoscale features (Nanobarcodes™ particles). The SERS signal decreased and the fluorescence signal increased when target viral RNA was captured by this molecular beacon probe. In addition, a hepatitis C virus reverse transcriptase-polymerase chain reaction (HCV RT-PCR) product was detected using this dual-mode beacon. The development of a multiplexed, label-free assay system with the reassurance offered by detection of two distinctly separate signals offers significant benefits for rapid molecular diagnostics.","PeriodicalId":88286,"journal":{"name":"Nanobiotechnology : the journal at the intersection of nanotechnology, molecular biology, and biomedical sciences","volume":"3 1","pages":"23-30"},"PeriodicalIF":0.0,"publicationDate":"2007-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7091242/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37776487","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Antimicrobial surfaces of viologen-quaternized poly((2-dimethyl amino)ethyl methacrylate)-Si(100) hybrids from surface-initiated atom transfer radical polymerization 表面引发原子转移自由基聚合的聚(2-二甲基氨基)甲基丙烯酸乙酯季铵盐-Si(100)杂化物的抗菌表面

Nanobiotechnology : the journal at the intersection of nanotechnology, molecular biology, and biomedical sciences Pub Date : 2006-09-01 DOI: 10.1007/BF02697267

F. Xu, S. Yuan, S. Pehkonen, E. Kang, K. Neoh

引用次数: 22

Electrochemical properties of hydrogenase on glass carbon electrodes modified with carbon nanotubes 碳纳米管修饰的玻璃碳电极上加氢酶的电化学性质

Nanobiotechnology : the journal at the intersection of nanotechnology, molecular biology, and biomedical sciences Pub Date : 2006-09-01 DOI: 10.1007/BF02697268

Ai-Rong Liu, D. Qian, Meng Chen, T. Wakayama, C. Nakamura, N. Zorin, J. Miyake

引用次数: 0

Simultaneous detection of DNA-binding proteins using exo-Taq-based reaction 基于外显子taq的反应同时检测dna结合蛋白

Nanobiotechnology : the journal at the intersection of nanotechnology, molecular biology, and biomedical sciences Pub Date : 2006-09-01 DOI: 10.1007/BF02697266

T. Fukumori, H. Miyachi, K. Yokoyama

引用次数: 0

Three approaches to assembling nano-bio-machines using molecular motors 利用分子马达组装纳米生物机器的三种方法

Nanobiotechnology : the journal at the intersection of nanotechnology, molecular biology, and biomedical sciences Pub Date : 2006-09-01 DOI: 10.1007/BF02697265

Y. Hiratsuka, T. Kamei, N. Yumoto, T. Uyeda

引用次数: 8