Immunology, endocrine & metabolic agents in medicinal chemistry最新文献

{"title":"Inhibitory Role of Resveratrol in the Development of Profibrogenesis and Fibrosis Mechanisms","authors":"Marzeea Ahmad Raka, Abida Tisha, Salma Khan, Tasfiq Zaman Paran, N. Ahmed, M. M. Mohib, Md. Abu Taher Sagor, Sarif Mohiuddin","doi":"10.2174/1871522218666180523102923","DOIUrl":"https://doi.org/10.2174/1871522218666180523102923","url":null,"abstract":"","PeriodicalId":88256,"journal":{"name":"Immunology, endocrine & metabolic agents in medicinal chemistry","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42254819","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anti-Obesity Effect of Lactoferrin; Subgroup Analysis Excluding Subjects with Obese and/or Hyper-LDL Cholesterolemia","authors":"Tomoji Ono, M. Murakoshi, Akira Uchiyama","doi":"10.2174/1871522218666180530074349","DOIUrl":"https://doi.org/10.2174/1871522218666180530074349","url":null,"abstract":"","PeriodicalId":88256,"journal":{"name":"Immunology, endocrine & metabolic agents in medicinal chemistry","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43399226","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Meet Our Editor-in-Chief","authors":"R. Morishita","doi":"10.2174/187152221801180905151147","DOIUrl":"https://doi.org/10.2174/187152221801180905151147","url":null,"abstract":"","PeriodicalId":88256,"journal":{"name":"Immunology, endocrine & metabolic agents in medicinal chemistry","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2174/187152221801180905151147","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45200370","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"How Moringa oleifera Supplementation Affects T-cell Subsets and Circulating Angiogenic, Myeloid, and Endothelial Cells in Mice with Alloxan-induced Diabetes","authors":"Muobarak J. Tuorky, Abdel-Aziz A Zidan, Enas A. Abdul Baki","doi":"10.2174/1871522218666180430153004","DOIUrl":"https://doi.org/10.2174/1871522218666180430153004","url":null,"abstract":"","PeriodicalId":88256,"journal":{"name":"Immunology, endocrine & metabolic agents in medicinal chemistry","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48204523","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Docking Studies and Stereo Quality Assessment of Glucose Transporter Member-4 (GLUT4)","authors":"A. P. Karlapudi, T. Venkateswarulu, Vamsi Lohit Kanumuri, K. Srirama, V. Kodali","doi":"10.2174/1871522218666180420113240","DOIUrl":"https://doi.org/10.2174/1871522218666180420113240","url":null,"abstract":"","PeriodicalId":88256,"journal":{"name":"Immunology, endocrine & metabolic agents in medicinal chemistry","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42280481","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Therapeutic Apheresis in Metabolic Syndrome.","authors":"V A Voinov","doi":"10.2174/1871522218666180608114536","DOIUrl":"10.2174/1871522218666180608114536","url":null,"abstract":"<p><strong>Background: </strong>The metabolic syndrome unites three pathologies of the person - obesity, arterial hypertension and diabetes. In recent years the progressing of such distribution covering from 2.5% to 3.8% of the population with increase twice each 10-15 years is noted. Even at maintenance of level of sugar at diabetes accumulation of the secondary metabolites breaking small vessels isn't excluded. At the same time many life-endangering complications develop.</p><p><strong>Objective: </strong>To identify the possibilities of plasmapheresis in the prevention and treatment of complications of metabolic syndrome.</p><p><strong>Method: </strong>Analysis of the world literature data on complications of metabolic syndrome and methods of their treatment.</p><p><strong>Results: </strong>At metabolic syndrome the frequency of strokes and myocardial infarctions there is twice more often than in population. For 5-9 years the general life expectancy decreases. Disorders of microcirculation at diabetes lead to a retinopathy with total loss of sight, a nephropathy from the outcome in a renal failure, to polyneuropathy and diabetic foot syndrome with high risk of high level amputations of the lower extremities. At the same time medicamentous therapy is not able to prevent such complications and almost only way of removal of these pathological metabolites is therapeutic apheresis, mainly the plasmapheresis. Data from our own studies confirm the effectiveness of such tactics.</p><p><strong>Conclusion: </strong>Plasmapheresis has to be applied not only to the correction of already critical conditions, but also to their prevention.</p>","PeriodicalId":88256,"journal":{"name":"Immunology, endocrine & metabolic agents in medicinal chemistry","volume":"18 1","pages":"38-54"},"PeriodicalIF":0.0,"publicationDate":"2018-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/cb/49/IEMAMC-18-38.PMC6174637.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36626385","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of <i>Moringa oleifera</i> on Insulin Levels and Folliculogenesis in Polycystic Ovary Syndrome Model with Insulin Resistance.","authors":"Dessy Amelia,&nbsp;Budi Santoso,&nbsp;Bambang Purwanto,&nbsp;Muhammad Miftahussurur,&nbsp;Hermanto Tri Joewono","doi":"10.2174/1871522218666180426100754","DOIUrl":"https://doi.org/10.2174/1871522218666180426100754","url":null,"abstract":"<p><strong>Background: </strong>Insulin resistance is a frequent metabolic disorder in Polycystic Ovary Syndrome (PCOS). Moringa oleifera has been shown to increase insulin expres-sion and decrease the degree of insulin in diabetes mellitus, therefore it is expected that Moringa oleifera could decrease insulin levels and increase folliculogenesis in PCOS.</p><p><strong>Objective: </strong>To prove the effect of Moringa oleifera leaf extract in various doses might decrease the insulin levels and increase folliculogenesis in female PCOS-insulin resistant rats.</p><p><strong>Methods: </strong>The three month old white rat of Wistar strain (Rattus norvegicus) 100-130 grams were divided into five groups (n=8) including normal control, PCOS-insulin re-sistance, PCOS-insulin resistance given metformin and PCOS-resistance insulin were giv-en Moringa oleifera leaf extract in two doses. Then, the PCOS model-insulin resistance by injection of testosterone propionate for 28 days. After 14 days treatment, we analysed insulin levels and folliculogenesis.</p><p><strong>Results: </strong>The PCOS control group showed a significant increase in insulin levels compared to the normal control group. The insulin levels from group treatment with Moringa oleifera leaf extract of 250 mg/kgBW was significantly lower than the PCOS control group. Ovarian histology analysis found that the number and diameter of follicle of PCOS control group showed a significant decrease compared to normal control group. In addition, the treatment with metformin and leaf Moringa oleifera dose 250 mg/kgBW and 500 mg/kgBW showed significant increase of folliculogenesis compared to PCOS control group.</p><p><strong>Conclusions: </strong>Moringa oleifera could lowering the blood insulin levels, subsequently decreasing the androgen thus allowed the increasing of folliculogenesis in PCOS.</p>","PeriodicalId":88256,"journal":{"name":"Immunology, endocrine & metabolic agents in medicinal chemistry","volume":"18 1","pages":"22-30"},"PeriodicalIF":0.0,"publicationDate":"2018-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2174/1871522218666180426100754","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36625947","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Structural Similarity of Predicted Chickens MHC Regulatory Factors and Bacterial Organisms","authors":"M. Khosravi","doi":"10.2174/1871522217666170802123320","DOIUrl":"https://doi.org/10.2174/1871522217666170802123320","url":null,"abstract":"","PeriodicalId":88256,"journal":{"name":"Immunology, endocrine & metabolic agents in medicinal chemistry","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2017-08-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45941479","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Purified Fraction of Ocimum tenuiflorum (L) Inhibits LTC4, LTA4 and COX-2 Activities, Down-Regulates mRNA Expression in HL-60 Cells and Reduces Lung Inflammation in an OVA Induced Asthma Model in BALB/c Mice","authors":"K. Soni, N. Raut, T. Lawal, U. Patel, G. Mahady","doi":"10.2174/1871522217666170907100513","DOIUrl":"https://doi.org/10.2174/1871522217666170907100513","url":null,"abstract":"","PeriodicalId":88256,"journal":{"name":"Immunology, endocrine & metabolic agents in medicinal chemistry","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2017-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47681671","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Olmesartan on Glucose Metabolism Involving Angiotensin Converting Enzyme 2","authors":"Hirotomo Nakaoka, M. Mogi, H. Kan‐no, K. Tsukuda, H. Bai, Bao-Shuai Shan, M. Kukida, Toshifumi Yamauchi, Akinori Higaki, M. Horiuchi","doi":"10.2174/1871522217666171019150511","DOIUrl":"https://doi.org/10.2174/1871522217666171019150511","url":null,"abstract":"","PeriodicalId":88256,"journal":{"name":"Immunology, endocrine & metabolic agents in medicinal chemistry","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2017-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68024329","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}