Current medicinal chemistry. Immunology, endocrine & metabolic agents最新文献_第5页

GLUT4 Traffic: Perspectives from Cultured Muscle Cells GLUT4运输:来自培养肌肉细胞的观点

Current medicinal chemistry. Immunology, endocrine & metabolic agents Pub Date : 2005-03-31 DOI: 10.2174/1568013053586478

L. JeBailey, V. Randhawa, M. Ishiki, A. Klip

引用次数: 0

Editorial [Hot Topic: Glucose Transporters (Guest Editor: Eddy Karnieli)] 社论[热门话题:葡萄糖转运蛋白(特邀编辑:Eddy Karnieli)]

Current medicinal chemistry. Immunology, endocrine & metabolic agents Pub Date : 2005-03-31 DOI: 10.2174/1568013053586423

E. Karnieli

引用次数: 0

The GLUTs Family - Lessons from Transgenic Mice GLUTs家族——来自转基因小鼠的教训

Current medicinal chemistry. Immunology, endocrine & metabolic agents Pub Date : 2005-03-31 DOI: 10.2174/1568013053586496

K. Hartil, R. Weldon, Y. Seki, M. J. Charron

引用次数: 1

GLUT4 Goes Abnormal: Disregulation of the Insulin-Responsive Glucose Transporter in Abnormal Metabolic States GLUT4异常:异常代谢状态下胰岛素反应性葡萄糖转运蛋白的失调

Current medicinal chemistry. Immunology, endocrine & metabolic agents Pub Date : 2005-03-31 DOI: 10.2174/1568013053586405

M. Armoni, C. Harel, E. Karnieli

引用次数: 7

Dietary Salt and Disease Prevention: A Global Perspective 膳食盐与疾病预防:全球视角

Current medicinal chemistry. Immunology, endocrine & metabolic agents Pub Date : 2005-01-31 DOI: 10.2174/1568013053005445

G. B. Gomez, F. Cappuccio

引用次数: 9

Combating Obesity by Targeting Nuclear Receptors 通过靶向核受体来对抗肥胖

Current medicinal chemistry. Immunology, endocrine & metabolic agents Pub Date : 2005-01-31 DOI: 10.2174/1568013053005427

J. Sternbach

引用次数: 6

The Atherosclerosis Time-Line and the Role of the Endothelium 动脉粥样硬化时间线和内皮细胞的作用

Current medicinal chemistry. Immunology, endocrine & metabolic agents Pub Date : 2005-01-31 DOI: 10.2174/1568013053005409

R. Kharbanda, R. Macallister

{"title":"The Atherosclerosis Time-Line and the Role of the Endothelium","authors":"R. Kharbanda, R. Macallister","doi":"10.2174/1568013053005409","DOIUrl":"https://doi.org/10.2174/1568013053005409","url":null,"abstract":"Atherosclerosis remains a major cause of morbidity and mortality worldwide. Conventional risk factors do not completely account for the development of atherosclerosis and its complications. Accumulating data suggest that endothelial dysfunction has independent prognostic implications. It has been implicated in the initiation of atherosclerosis, the precipitation of acute ischaemia, and the determination of the extent of injury following such complications. Atherosclerosis develops as a consequence of lipid accumulation in the vessel wall, a co-existent inflammatory response and proliferation of smooth muscle cells; endothelial dysfunction can be added to this pathogenic triad. The endothelium regulates numerous blood vessel functions, including vascular tone, cell adhesiveness, and coagulation through the production of mediators. The best characterized of these are the vasodilators, nitric oxide (NO), prostacyclin, and endothelium derived hyperpolarising factor (EDHF), and the vasoconstrictors thromboxane and endothelin. Endothelial dysfunction may encourage the adhesion and transmigration of monocytes and platelets to initiate and promote atherosclerosis. In addition, endothelial dysfunction may precipitate the acute complications of atherosclerosis through vasospasm and thrombosis, and may be a determinant of the transition from stable chronic atherosclerosis, to the development of acute coronary syndromes. Understanding of the biology of the endothelium in atherosclerosis may lead to novel therapies that will retard its progression, and reduce the incidence or consequences of acute complications.","PeriodicalId":88234,"journal":{"name":"Current medicinal chemistry. Immunology, endocrine & metabolic agents","volume":"5 1","pages":"47-52"},"PeriodicalIF":0.0,"publicationDate":"2005-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2174/1568013053005409","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67897468","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 15

The Antioxidant Properties of Greek Foods and the Flavonoid Content of the Mediterranean Menu 希腊食物的抗氧化特性及地中海菜单中的类黄酮含量

Current medicinal chemistry. Immunology, endocrine & metabolic agents Pub Date : 2005-01-31 DOI: 10.2174/1568013053005508

E. Vasilopoulou, K. Georga, M. Joergensen, A. Naska, A. Trichopoulou

{"title":"The Antioxidant Properties of Greek Foods and the Flavonoid Content of the Mediterranean Menu","authors":"E. Vasilopoulou, K. Georga, M. Joergensen, A. Naska, A. Trichopoulou","doi":"10.2174/1568013053005508","DOIUrl":"https://doi.org/10.2174/1568013053005508","url":null,"abstract":"The Mediterranean diet is currently attracting interest because of its health benefits that may be due, in part, to the high content of this diet in antioxidant phytochemicals. The variety and amount of phytochemical s taken with the consumption of primary and composite foods of the Mediterranean diet may provide better antiatherogenic properties than single phytochemicals. Flavonoids are the most important group of plant antioxidants. The Mediterranean diet is characterized by high intake of olive oil, fruit, vegetables, cereals, and legumes, some of which are good sources of flavonoids. Flavonoids consist of six principal classes: flavones, flavonols, flavan-3-ols, flavanones, anthocyanidins and isoflavones. The flavonoid intake from a traditional Greek plant-based weekly menu was calculated and the daily average flavonoid intake was found 118.6 mg/d, of which flavanones contribute 32% (38.5 mg/d), catechins (the most important group of flavan-3-ols) contribute 28% (32.7 mg/d), flavonols 22% (26.4 mg/d), anthocyanidins 9% (11 mg/d), flavones 8% (8.7 mg/d) and isoflavones contribute 1% (1.3 mg/d). Herbs and spices, which are commonly used in the traditional Greek cuisine, although added in small quantities, significantly contribute to the flavonol and flavone intake due to frequent consumption. The Greek version of the Mediterranean diet with its high consumption of fruit and vegetables is characterized by high intake of flavonoids in comparison to diets in northern European countries.","PeriodicalId":88234,"journal":{"name":"Current medicinal chemistry. Immunology, endocrine & metabolic agents","volume":"5 1","pages":"33-45"},"PeriodicalIF":0.0,"publicationDate":"2005-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2174/1568013053005508","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67897618","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 55

The Role of Insulin Resistance and Hyperinsulinemia in Cancer Causation 胰岛素抵抗和高胰岛素血症在癌症发病中的作用

Current medicinal chemistry. Immunology, endocrine & metabolic agents Pub Date : 2005-01-31 DOI: 10.2174/1568013053005517

E. Giovannucci

引用次数: 9

Dietary Prevention of Coronary Heart Disease 饮食预防冠心病

Current medicinal chemistry. Immunology, endocrine & metabolic agents Pub Date : 2005-01-31 DOI: 10.1007/978-1-59745-330-1_17

M. Lorgeril, P. Salen

引用次数: 0