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T4-induced metamorphosis in Ambystoma gracile (Baird) from two populations: the effects of aging and temperature. 两个种群中细长绒瘤(Ambystoma gracile, Baird) t4诱导的变态:老化和温度的影响。
Biochemistry and experimental biology Pub Date : 1980-01-01
G W Eagleson, B A McKeown
{"title":"T4-induced metamorphosis in Ambystoma gracile (Baird) from two populations: the effects of aging and temperature.","authors":"G W Eagleson,&nbsp;B A McKeown","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>In order to determine the factors affecting the maturation of the functional hypothalamo-pituitary-thyroid axis, Ambystoma gracile (Baird) larvae of different ages and acclimated to different temperature regimes were exposed to a concentration of thyroxine (T4) which activates the pituitary-thyroid axis. A. gracile from a montane and low-altitude population were utilized. These studies, plus observations concerning spontaneous metamorphosis, indicated that populations of Ambystoma gracile are highly polymorphic as suggested by Sprules (1974 b). A. gracile populations consist of 'obligate transformers', 'obligate neotenes', and 'facultative transformers'--which will metamorphose depending on environmental conditions. The colder high-altitude conditions tend to select against facultative individuals, whereas the less certain low-altitude conditions permit a much higher proportion of animals that exhibit a facultative response with respect to metamorphosis. Interrelationships between environment and physiological parameters that determine morphology in salamanders are discussed with regard to these findings.</p>","PeriodicalId":8818,"journal":{"name":"Biochemistry and experimental biology","volume":"16 2","pages":"111-26"},"PeriodicalIF":0.0,"publicationDate":"1980-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18359902","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Studies on the responses of isolated intestine of the Giant African land snail (Archachatina marginata) to drugs. 非洲巨蜗牛离体肠对药物反应的研究。
Biochemistry and experimental biology Pub Date : 1980-01-01
J A Ojewole
{"title":"Studies on the responses of isolated intestine of the Giant African land snail (Archachatina marginata) to drugs.","authors":"J A Ojewole","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The effects of some drugs on the isolated intestine of the Giant African land snail (Archachatina marginata, Swainson) have been investigated. The isolated intestine of the snail contracted in response to chemical stimulation by some cholinergic and adrenergic drugs. Acetylcholine and its analogues; nicotine and dimethylphenylpiperazinium, contracted the tissue preparation in a dose-related manner. Some also contracted the tissue preparation. These results were taken to imply the presence of cholinergic and sympathetic innervations in the tissue. The receptors present in the muscle have been classified as: (1) \"nicotinic\" and \"muscarinic\" cholinoreceptors, and (2) \"alpha\"-adrenoceptors respectively.</p>","PeriodicalId":8818,"journal":{"name":"Biochemistry and experimental biology","volume":"16 1","pages":"31-7"},"PeriodicalIF":0.0,"publicationDate":"1980-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18228070","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Age dependent variations in choline and ethanolamine phosphorylating activities of rodents. 鼠类胆碱和乙醇胺磷酸化活性的年龄依赖性变化。
Biochemistry and experimental biology Pub Date : 1980-01-01
R K Upreti
{"title":"Age dependent variations in choline and ethanolamine phosphorylating activities of rodents.","authors":"R K Upreti","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The substrate concentration-velocity relationship as influenced by age of animal was determined. At all stages of growth of rat and mouse ethanolamine kinase activity responded with a hyperbolic pattern to substrate concentration. Choline kinase on the other hand, underwent \"enzyme differentiation\". In rat liver up to 4 days of age of animal, in mouse liver up to 7 days and in mouse kidney up to 15 days, choline kinase activity responded with a hyperbolic pattern; but from then onwards the response to substrate concentration was sigmoid. The results obtained pointed to the regulatory nature of choline kinase and a possible distinction between the proteins catalyzing the phosphorylation of the two bases.</p>","PeriodicalId":8818,"journal":{"name":"Biochemistry and experimental biology","volume":"16 3","pages":"221-6"},"PeriodicalIF":0.0,"publicationDate":"1980-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17330771","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Inhibitor effect of polyamines on reduction of cytochrome C by superoxide anion. 多胺对超氧阴离子还原细胞色素C的抑制作用。
Biochemistry and experimental biology Pub Date : 1980-01-01
A Vanella, A Rapisarda, R Pinturo, V Rizza
{"title":"Inhibitor effect of polyamines on reduction of cytochrome C by superoxide anion.","authors":"A Vanella,&nbsp;A Rapisarda,&nbsp;R Pinturo,&nbsp;V Rizza","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The interaction of polyamines with enzymatically generated free radicals was investigated. The superoxide anion (O-2) was generated in vitro using the xanthine oxidase-hypoxanthine system. Our results show that spermidine or spermine at different concentrations (20-200 mM) inhibit the reduction of cytochrome c; the highest levels of inhibition were obtained adding 200 mM spermidine or spermine. Putrescine (200 mM) affected the reduction of cytochrome c very little.</p>","PeriodicalId":8818,"journal":{"name":"Biochemistry and experimental biology","volume":"16 2","pages":"165-70"},"PeriodicalIF":0.0,"publicationDate":"1980-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17353281","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Lysosomal enzyme activity in hepatocytes and Kupffer cells from intact and partially hepatectomized rats. 完整和部分肝切除大鼠肝细胞和库普弗细胞的溶酶体酶活性。
Biochemistry and experimental biology Pub Date : 1980-01-01
D N Mayanskii, V I Scherbakoff, N N Mayanskaya, L E Panin
{"title":"Lysosomal enzyme activity in hepatocytes and Kupffer cells from intact and partially hepatectomized rats.","authors":"D N Mayanskii,&nbsp;V I Scherbakoff,&nbsp;N N Mayanskaya,&nbsp;L E Panin","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Using hepatectomized rats it was shown that immediately after partial liver removal (PLR) the Kupffer macrophages were accumulated in liver remnant. At the maximal mitotic activity (36 hours following PLR) the relative amount of Kupffer cells keeps low, but 72 hours later turns out to be higher again. The periodic changes of the Kupffer cell amount in hepatectomized rats are accompanied by remarkable increase (1.5-3 fold) of free and total lysosomal enzyme activity (acid DNA-ase, acid RNA-ase, cathepsin D). The activation of the Kupffer macrophage lysosomes goes ahead of labilization of hepatocyte lysosomal membranes. The blockade of mononuclear phagocyte system by means of carbonate iron overloading in the early prereplicative period leads to an as long as 10-12 hours retardation of hepatocyte proliferation. The role of Kupffer macrophages in reparative liver regeneration is discussed.</p>","PeriodicalId":8818,"journal":{"name":"Biochemistry and experimental biology","volume":"16 3","pages":"309-14"},"PeriodicalIF":0.0,"publicationDate":"1980-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18285091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Biliary excretion of tartrazine in obesity. 肥胖患者胆中酒黄石的排泄。
Biochemistry and experimental biology Pub Date : 1980-01-01
A A Adekunle
{"title":"Biliary excretion of tartrazine in obesity.","authors":"A A Adekunle","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>In a continuation of studies on the metabolism of foreign compounds under the influence of diet or other factors in relation to neoplasia development, male and female weanling rats, in-bred Wistar-derived rats (50-60 g) free from disease or infection were obesified with N, N-bis (B-chloroethyl)-4, 4-bipiperidine (BPN) prior to determining the biliary excretion of tartrazine. Obese and normal animals excreted the dye unchanged and in sex-related proportions.</p>","PeriodicalId":8818,"journal":{"name":"Biochemistry and experimental biology","volume":"16 2","pages":"171-4"},"PeriodicalIF":0.0,"publicationDate":"1980-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18359906","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Coil planet centrifuge - a new method for measurement of osmotic fragility of erythrocytes and its application in alcohol liver injuries. 螺旋行星离心机——测定红细胞渗透脆性的新方法及其在酒精性肝损伤中的应用。
Biochemistry and experimental biology Pub Date : 1980-01-01
H Nagata
{"title":"Coil planet centrifuge - a new method for measurement of osmotic fragility of erythrocytes and its application in alcohol liver injuries.","authors":"H Nagata","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The present study was designed to examine the osmotic resistance of erythrocytes measured by a new method-Coil Planet Centrifuge under the glutaraldehyde incubation, and to determine free cholesterol and adenine nucleotide contents of glutaraldehyde-treated erythrocytes compared with that of control erythrocytes. Glutaraldehyde increased the osmotic resistance of erythrocytes. Hemolysis end point of glutaraldehyde-treated erythrocytes shifted to hypo-osmolar side after 2.5 h hours incubation (p less than 0.001). Free cholesterol content of erythrocytes was not changed by the addition of glutaraldehyde, however, ATP content significantly increased when compared with controls (p less than 0.001). Moreover, the osmotic resistance of erythrocytes in 55 patients with alcoholic liver injuries and the relation between the disease were examined by Coil Planet Centrifuge. Hemolysis end point shifted to hypo-osmolar side in the patients, and our results suggest that the increase in osmotic resistance is partly responsible for the increase in the rigidity of erythrocytes. This new method was also helpful in evaluation in the clinical course of alcoholic liver injuries.</p>","PeriodicalId":8818,"journal":{"name":"Biochemistry and experimental biology","volume":"16 1","pages":"3-11"},"PeriodicalIF":0.0,"publicationDate":"1980-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17835490","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Coenzyme Q10 levels in rat heart of different age. 不同年龄大鼠心脏中辅酶Q10水平。
Biochemistry and experimental biology Pub Date : 1980-01-01
C Pignatti, M Cocchi, H Weiss
{"title":"Coenzyme Q10 levels in rat heart of different age.","authors":"C Pignatti,&nbsp;M Cocchi,&nbsp;H Weiss","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>CoQ10 is intrinsic to human tissues and is a vitamin, according to the basic science of nutrition. It is known that CoQ10, plays a role in the respiratory process, moreover it seems to be involved in the mechanism of blood coagulation. As a vitamin a deficiency of CoQ10 may be related to some disease, that is, first of all, a disease is bioenergetics. It has been demonstrated that during aging, other than a diminution of EFA (and an increase of palmitoleic and eicosatrienoic fatty acids), a decrease of about the 20-30% in the heart CoQ10 levels occurs in the rat. Perhaps these modifications may be intrinsic to the \"biochemical\" changes of aging.</p>","PeriodicalId":8818,"journal":{"name":"Biochemistry and experimental biology","volume":"16 1","pages":"39-42"},"PeriodicalIF":0.0,"publicationDate":"1980-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18228071","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effects of dietary fatty acids, prostaglandins and related compounds on the role of platelets in thrombosis. 膳食脂肪酸、前列腺素及相关化合物对血小板在血栓形成中的作用的影响。
Biochemistry and experimental biology Pub Date : 1980-01-01
K C Srivastava
{"title":"Effects of dietary fatty acids, prostaglandins and related compounds on the role of platelets in thrombosis.","authors":"K C Srivastava","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":8818,"journal":{"name":"Biochemistry and experimental biology","volume":"16 3","pages":"317-38"},"PeriodicalIF":0.0,"publicationDate":"1980-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17330772","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Characterization of serum cholinesterase variants by kinetic analysis and isoelectric focusing. 用动力学分析和等电聚焦表征血清胆碱酯酶变异。
Biochemistry and experimental biology Pub Date : 1980-01-01
U Gilbert, N Ragusa, A Vanella, V Rizza, S Conticello, S Mangiameli, C Triolo
{"title":"Characterization of serum cholinesterase variants by kinetic analysis and isoelectric focusing.","authors":"U Gilbert,&nbsp;N Ragusa,&nbsp;A Vanella,&nbsp;V Rizza,&nbsp;S Conticello,&nbsp;S Mangiameli,&nbsp;C Triolo","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Serum cholinesterase enzyme (E.C. 3.1.1.8) shows a considerable degree of genetically determined heterogeneity. In this communication we describe some kinetic properties of serum cholinesterase variants (Km and Vmax) from individuals predisposed to prolonged apneic periods after administration of the anesthetic, succinylcholine. Isoelectric focusing, in a narrow pH range (pH 4-6) of sera from normal and atypical phenotypes permitted the detection of differences in protein bands near the isoelectric pH of the enzyme.</p>","PeriodicalId":8818,"journal":{"name":"Biochemistry and experimental biology","volume":"16 4","pages":"349-55"},"PeriodicalIF":0.0,"publicationDate":"1980-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18359133","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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