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Monomeric and dimeric forms of soluble receptors can differ in their neutralization potential. 单体和二聚体形式的可溶性受体在其中和电位上是不同的。
Behring Institute Mitteilungen Pub Date : 1995-06-01
L Lauffer, E J Kanzy, R Köhler, R Kurrle, K Enssle, F R Seiler
{"title":"Monomeric and dimeric forms of soluble receptors can differ in their neutralization potential.","authors":"L Lauffer,&nbsp;E J Kanzy,&nbsp;R Köhler,&nbsp;R Kurrle,&nbsp;K Enssle,&nbsp;F R Seiler","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Recombinant soluble forms of transmembrane receptors can be produced in monomeric and dimeric versions. Binding affinity and neutralization potential of these different forms of soluble receptors depend on the quaternary structure of their ligands. Monomeric ligands will be bound with equal affinity by both forms, whereas trimeric ligands, e.g. members of the tumor necrosis factor family of ligands, interact with much higher affinity with dimeric soluble receptors than with monomeric ones.</p>","PeriodicalId":8816,"journal":{"name":"Behring Institute Mitteilungen","volume":" 96","pages":"21-31"},"PeriodicalIF":0.0,"publicationDate":"1995-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18581090","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Signal transduction by the IL-1 type I receptor: evidence for the involvement of a receptor-coupled protein kinase. IL-1型受体的信号转导:受体偶联蛋白激酶参与的证据。
Behring Institute Mitteilungen Pub Date : 1995-06-01
M Martin, R Brigelius-Flohé, K Resch
{"title":"Signal transduction by the IL-1 type I receptor: evidence for the involvement of a receptor-coupled protein kinase.","authors":"M Martin,&nbsp;R Brigelius-Flohé,&nbsp;K Resch","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>A novel serine/threonine specific protein kinase was found to be associated with the type I IL-1 receptor in the murine T cell lines D10N and EL-4. This kinase was identified in immunoprecipitates from IL-1 stimulated T-cells by its ability to phosphorylate exogenous substrates in the presence of radiolabeled ATP. An endogenous protein, most likely a member of the IL-1 R1 complex, was also phosphorylated. The activation of the kinase is specific for IL-1, neither TNF nor phorbol esters were able to activate the IL-1 RI associated kinase activity. The IL-1 receptor antagonist had no intrinsic activity and inhibited the activation of the kinase. The activation of the kinase was rapid and detectable after 30 seconds of IL-1 stimulation. A minimal model of the IL-RI signal transduction complex is discussed, presenting this novel serine/threonine kinase as a constituent of the complex.</p>","PeriodicalId":8816,"journal":{"name":"Behring Institute Mitteilungen","volume":" 96","pages":"32-44"},"PeriodicalIF":0.0,"publicationDate":"1995-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18581092","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Activation of gene transcription by IL-4, IL-13 and IFN-gamma through a shared DNA binding motif. IL-4、IL-13和ifn - γ通过共享的DNA结合基序激活基因转录。
Behring Institute Mitteilungen Pub Date : 1995-06-01
I Köhler, P Alliger, E P Rieber
{"title":"Activation of gene transcription by IL-4, IL-13 and IFN-gamma through a shared DNA binding motif.","authors":"I Köhler,&nbsp;P Alliger,&nbsp;E P Rieber","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Both interleukin-4 (IL-4) and interleukin-13 (IL-13) induce the transcription factor NF-IL4 (nuclear factor IL-4) which preexists in an inactive form and binds to an IL-4 responsive element (IL-4RE) in the promoter regions of IL-4/IL-13-dependent genes. UV-crosslinking and SDS gel electrophoresis indicate that NF-IL4 consists of at least two DNA-binding components of 50 kDa and 100-130 kDa. The IL-4 responsive element is also recognized by an interferon-gamma (IFN-gamma)-induced DNA binding protein for which a Mr of 50 kDa has been determined. A common DNA binding motif for different transcription factors might provide the basis for the frequently observed functional antagonism between IL-4/IL-13 and IFN-gamma. The activation of transcription factors by IL-4/IL-13 and IFN-gamma could be blocked by inhibitors of tyrosine kinases and ser/thr phosphatases but not by a PKC inhibitor, suggesting related signal transduction pathways for these cytokines.</p>","PeriodicalId":8816,"journal":{"name":"Behring Institute Mitteilungen","volume":" 96","pages":"78-86"},"PeriodicalIF":0.0,"publicationDate":"1995-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18581096","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
How cytokines control immunoglobulin class switching. 细胞因子如何控制免疫球蛋白类转换。
Behring Institute Mitteilungen Pub Date : 1995-06-01
M Lorenz, S Jung, A Radbruch
{"title":"How cytokines control immunoglobulin class switching.","authors":"M Lorenz,&nbsp;S Jung,&nbsp;A Radbruch","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>B lymphocytes can alter the class of antibody they produce by immunoglobulin class switch recombination. This recombination is targeted by distinct cytokines to particular switch regions. Prior to switch recombination, the same cytokines induce transcription through the targeted switch regions and generate IH \"switch\" transcripts. To show whether the two events are functionally related, we have replaced the endogenous interleukin-4 (IL-4) dependent promoter of murine I gamma 1 switch transcripts by an heterologous promoter, the human metallothionein IIA (hMT) promoter. Indeed, switch recombination can be targeted to IgG1 by the hMT promoter. In mutant mice, which cannot generate processed switch transcripts, switch recombination cannot be targeted to IgG1 by the hMT promoter. Thus, IL-4 targets switch recombination to IgG1 by induction of processed switch transcripts.</p>","PeriodicalId":8816,"journal":{"name":"Behring Institute Mitteilungen","volume":" 96","pages":"97-102"},"PeriodicalIF":0.0,"publicationDate":"1995-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18581099","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Therapeutic interference with interferon-gamma (IFN-gamma) and soluble IL-4 receptor (sIL-4R) in allergic diseases. 干扰素- γ (ifn - γ)和可溶性IL-4受体(sIL-4R)在过敏性疾病中的治疗性干扰
Behring Institute Mitteilungen Pub Date : 1995-06-01
S Nasert, M Millner, U Herz, G Lack, U Wahn, E W Gelfand, H Renz
{"title":"Therapeutic interference with interferon-gamma (IFN-gamma) and soluble IL-4 receptor (sIL-4R) in allergic diseases.","authors":"S Nasert,&nbsp;M Millner,&nbsp;U Herz,&nbsp;G Lack,&nbsp;U Wahn,&nbsp;E W Gelfand,&nbsp;H Renz","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Allergic sensitization is controlled by CD4+ T cells. A complex interaction between antigen-presenting cells, T- and B-cells results in the production of (allergen) specific IgE. Analysis of the lymphokine profile of lymphocytes from patients with bronchialasthma and atopic dermatitis revealed an imbalance in cytokine production. An enhanced production of IL-4 was accompanied by low or absent amounts of IFN-gamma. Since both cytokines play a central role in the regulation of IgE, it was examined whether therapeutic interference on the level of cytokine production may provide an useful tool to alter lymphocyte functions in allergic diseases. Two different model systems were employed to study the effects of soluble IL-4R (sIL-4R) under in vitro and in vivo conditions. (1) A mouse model system for allergic sensitization and increased airways responsiveness (AR) was employed to examine whether in vivo treatment with recombinant murine sIL-4R may prevent the development of allergic sensitization. It was found that local treatment through the airways and the lung as carried out by aersolization of the receptor offered a route of application that prevented the development of allergen-induced and allergen-dependent immediate hypersensitivity responses including the development of increased AR. (2). The in vitro effects of humans sIL-4R on functions of mononuclear cells prepared from two patients with most severe atopic dermatitis were examined. Incubation of lymphocytes with allergens in the presence and absence of sIL-4R indicated that the soluble receptor suppressed allergen-induced lymphocyte proliferation and allergen-dependent IgE, IgG and IgM production. In addition a complete suppression of allergen-specific IgE production was detected in the presence of sIL-4R. These data suggest that sIL-4R may provide a useful drug to modify lymphocyte-dependent immune functions in allergic diseases.</p>","PeriodicalId":8816,"journal":{"name":"Behring Institute Mitteilungen","volume":" 96","pages":"118-30"},"PeriodicalIF":0.0,"publicationDate":"1995-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18582415","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A genetic approach for the analysis of cytokine function in vivo. 体内细胞因子功能分析的遗传学方法。
Behring Institute Mitteilungen Pub Date : 1995-06-01
W Müller
{"title":"A genetic approach for the analysis of cytokine function in vivo.","authors":"W Müller","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":8816,"journal":{"name":"Behring Institute Mitteilungen","volume":" 96","pages":"95-6"},"PeriodicalIF":0.0,"publicationDate":"1995-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18581098","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Regulation of IL-1 activity by soluble IL-1 receptors. 可溶性IL-1受体对IL-1活性的调节。
Behring Institute Mitteilungen Pub Date : 1995-06-01
R Kurrle, L Lauffer, J Röder, E J Kanzy, K H Enssle, F R Seiler
{"title":"Regulation of IL-1 activity by soluble IL-1 receptors.","authors":"R Kurrle,&nbsp;L Lauffer,&nbsp;J Röder,&nbsp;E J Kanzy,&nbsp;K H Enssle,&nbsp;F R Seiler","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":8816,"journal":{"name":"Behring Institute Mitteilungen","volume":" 96","pages":"45-57"},"PeriodicalIF":0.0,"publicationDate":"1995-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18581093","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A molecular basis for T-dependent B cell activation. t依赖性B细胞活化的分子基础。
Behring Institute Mitteilungen Pub Date : 1995-06-01
P Lane
{"title":"A molecular basis for T-dependent B cell activation.","authors":"P Lane","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>This review has concentrated on the key molecules which regulate T-dependent B cell activation in the context of the structural architecture within secondary lymphoid tissue where B cell immune responses occur. CD40L clearly plays a key role in driving B cells to proliferate within germinal centers, and although the data is conflicting, there is some evidence that the induction of CD40L is dependent on costimulation through CD28.</p>","PeriodicalId":8816,"journal":{"name":"Behring Institute Mitteilungen","volume":" 96","pages":"7-12"},"PeriodicalIF":0.0,"publicationDate":"1995-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18581095","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Avery-Landsteiner Prize awarded to Tim R. Mosmann, professor and chairman of the Department of Immunology of the University of Alberta in Edmonton/Alberta, Canada. 艾弗里-兰德斯坦纳奖授予加拿大埃德蒙顿/阿尔伯塔省阿尔伯塔大学免疫学系主任、教授蒂姆·莫斯曼。
Behring Institute Mitteilungen Pub Date : 1995-06-01
F Melchers
{"title":"Avery-Landsteiner Prize awarded to Tim R. Mosmann, professor and chairman of the Department of Immunology of the University of Alberta in Edmonton/Alberta, Canada.","authors":"F Melchers","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":8816,"journal":{"name":"Behring Institute Mitteilungen","volume":" 96","pages":"3 p preceding table of contents"},"PeriodicalIF":0.0,"publicationDate":"1995-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18581091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cytokines, differentiation and functions of subsets of CD4 and CD8 T cells. CD4和CD8 T细胞亚群的细胞因子、分化和功能。
Behring Institute Mitteilungen Pub Date : 1995-06-01
T R Mosmann
{"title":"Cytokines, differentiation and functions of subsets of CD4 and CD8 T cells.","authors":"T R Mosmann","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":8816,"journal":{"name":"Behring Institute Mitteilungen","volume":" 96","pages":"1-6"},"PeriodicalIF":0.0,"publicationDate":"1995-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18582413","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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