Mathematical geologyPub Date : 2017-01-01Epub Date: 2016-10-08DOI: 10.1007/s00018-016-2388-6
Stephanie Chin, Maurita Hung, Christine E Bear
{"title":"Current insights into the role of PKA phosphorylation in CFTR channel activity and the pharmacological rescue of cystic fibrosis disease-causing mutants.","authors":"Stephanie Chin, Maurita Hung, Christine E Bear","doi":"10.1007/s00018-016-2388-6","DOIUrl":"10.1007/s00018-016-2388-6","url":null,"abstract":"<p><p>Cystic fibrosis transmembrane conductance regulator (CFTR) channel gating is predominantly regulated by protein kinase A (PKA)-dependent phosphorylation. In addition to regulating CFTR channel activity, PKA phosphorylation is also involved in enhancing CFTR trafficking and mediating conformational changes at the interdomain interfaces of the protein. The major cystic fibrosis (CF)-causing mutation is the deletion of phenylalanine at position 508 (F508del); it causes many defects that affect CFTR trafficking, stability, and gating at the cell surface. Due to the multiple roles of PKA phosphorylation, there is growing interest in targeting PKA-dependent signaling for rescuing the trafficking and functional defects of F508del-CFTR. This review will discuss the effects of PKA phosphorylation on wild-type CFTR, the consequences of CF mutations on PKA phosphorylation, and the development of therapies that target PKA-mediated signaling.</p>","PeriodicalId":88039,"journal":{"name":"Mathematical geology","volume":"28 1","pages":"57-66"},"PeriodicalIF":8.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11107731/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73214627","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Medical Geography: a Promising Field of Application for Geostatistics.","authors":"P Goovaerts","doi":"10.1007/s11004-008-9211-3","DOIUrl":"10.1007/s11004-008-9211-3","url":null,"abstract":"<p><p>The analysis of health data and putative covariates, such as environmental, socio-economic, behavioral or demographic factors, is a promising application for geostatistics. It presents, however, several methodological challenges that arise from the fact that data are typically aggregated over irregular spatial supports and consist of a numerator and a denominator (i.e. population size). This paper presents an overview of recent developments in the field of health geostatistics, with an emphasis on three main steps in the analysis of areal health data: estimation of the underlying disease risk, detection of areas with significantly higher risk, and analysis of relationships with putative risk factors. The analysis is illustrated using age-adjusted cervix cancer mortality rates recorded over the 1970-1994 period for 118 counties of four states in the Western USA. Poisson kriging allows the filtering of noisy mortality rates computed from small population sizes, enhancing the correlation with two putative explanatory variables: percentage of habitants living below the federally defined poverty line, and percentage of Hispanic females. Area-to-point kriging formulation creates continuous maps of mortality risk, reducing the visual bias associated with the interpretation of choropleth maps. Stochastic simulation is used to generate realizations of cancer mortality maps, which allows one to quantify numerically how the uncertainty about the spatial distribution of health outcomes translates into uncertainty about the location of clusters of high values or the correlation with covariates. Last, geographically-weighted regression highlights the non-stationarity in the explanatory power of covariates: the higher mortality values along the coast are better explained by the two covariates than the lower risk recorded in Utah.</p>","PeriodicalId":88039,"journal":{"name":"Mathematical geology","volume":"41 ","pages":"243-264"},"PeriodicalIF":0.0,"publicationDate":"2009-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2675168/pdf/nihms79499.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"28149698","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The Nu Expression for Probabilistic Data Integration","authors":"E. I. Polyakova, A. Journel","doi":"10.1007/S11004-007-9117-5","DOIUrl":"https://doi.org/10.1007/S11004-007-9117-5","url":null,"abstract":"","PeriodicalId":88039,"journal":{"name":"Mathematical geology","volume":"39 1","pages":"715-733"},"PeriodicalIF":0.0,"publicationDate":"2007-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/S11004-007-9117-5","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"52452415","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The Discrete Cosine Transform, a Fourier-related Method for Morphometric Analysis of Open Contours","authors":"C. H. Dommergues, J. Dommergues, É. Verrecchia","doi":"10.1007/S11004-007-9124-6","DOIUrl":"https://doi.org/10.1007/S11004-007-9124-6","url":null,"abstract":"","PeriodicalId":88039,"journal":{"name":"Mathematical geology","volume":"39 1","pages":"749-763"},"PeriodicalIF":0.0,"publicationDate":"2007-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/S11004-007-9124-6","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"52452472","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Two Supervised Neural Networks for Classification of Sedimentary Organic Matter Images from Palynological Preparations","authors":"Andrew F. Weller, A. Harris, J. Ware","doi":"10.1007/S11004-007-9120-X","DOIUrl":"https://doi.org/10.1007/S11004-007-9120-X","url":null,"abstract":"","PeriodicalId":88039,"journal":{"name":"Mathematical geology","volume":"46 1","pages":"657-671"},"PeriodicalIF":0.0,"publicationDate":"2007-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/S11004-007-9120-X","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"52452437","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Risk Assessment based on the Mathematical Model of Diffuse Exogenous Geological Processes","authors":"A. Viktorov","doi":"10.1007/S11004-007-9122-8","DOIUrl":"https://doi.org/10.1007/S11004-007-9122-8","url":null,"abstract":"","PeriodicalId":88039,"journal":{"name":"Mathematical geology","volume":"25 1","pages":"735-748"},"PeriodicalIF":0.0,"publicationDate":"2007-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/S11004-007-9122-8","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"52452456","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Avoiding Singularities in the Numerical Solution of the Motion of a Deformable Ellipse Immersed in a Viscous Fluid","authors":"K. Mulchrone","doi":"10.1007/S11004-007-9121-9","DOIUrl":"https://doi.org/10.1007/S11004-007-9121-9","url":null,"abstract":"","PeriodicalId":88039,"journal":{"name":"Mathematical geology","volume":"39 1","pages":"647-655"},"PeriodicalIF":0.0,"publicationDate":"2007-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/S11004-007-9121-9","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"52452447","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Hydraulic Conductivity Estimation via Fuzzy Analysis of Grain Size Data","authors":"J. Ross, M. Ozbek, G. Pinder","doi":"10.1007/S11004-007-9123-7","DOIUrl":"https://doi.org/10.1007/S11004-007-9123-7","url":null,"abstract":"","PeriodicalId":88039,"journal":{"name":"Mathematical geology","volume":"39 1","pages":"765-780"},"PeriodicalIF":0.0,"publicationDate":"2007-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/S11004-007-9123-7","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"52452464","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Understanding Geological Data Distribution and Orientation via Correspondence Analysis","authors":"M. F. Pereira, P. Lúcio","doi":"10.1007/S11004-007-9118-4","DOIUrl":"https://doi.org/10.1007/S11004-007-9118-4","url":null,"abstract":"","PeriodicalId":88039,"journal":{"name":"Mathematical geology","volume":"39 1","pages":"673-695"},"PeriodicalIF":0.0,"publicationDate":"2007-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/S11004-007-9118-4","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"52452428","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
J. Palarea‐Albaladejo, J. Martín-Fernández, J. Gómez-García
{"title":"A Parametric Approach for Dealing with Compositional Rounded Zeros","authors":"J. Palarea‐Albaladejo, J. Martín-Fernández, J. Gómez-García","doi":"10.1007/S11004-007-9100-1","DOIUrl":"https://doi.org/10.1007/S11004-007-9100-1","url":null,"abstract":"","PeriodicalId":88039,"journal":{"name":"Mathematical geology","volume":"39 1","pages":"625-645"},"PeriodicalIF":0.0,"publicationDate":"2007-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/S11004-007-9100-1","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"52452259","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}