International journal of child health and human development : IJCHD最新文献_第2页

Acute Stress Promotes Aggressive-Like Behavior in Rats Made Allergic to Tree Pollen. 急性应激促进对树花粉过敏的大鼠的攻击性行为。

International journal of child health and human development : IJCHD Pub Date : 2008-01-01

Leonardo H Tonelli, Akina Hoshino, Morgan Katz, Teodor T Postolache

{"title":"Acute Stress Promotes Aggressive-Like Behavior in Rats Made Allergic to Tree Pollen.","authors":"Leonardo H Tonelli, Akina Hoshino, Morgan Katz, Teodor T Postolache","doi":"","DOIUrl":"","url":null,"abstract":"It has been reported that allergies are associated with depression and possibly suicide in women. Aggression is an important behavioral component that predisposes depressed individuals to suicidal acts. In the present study we examined the relationship between allergies and aggression to determine a potential contribution of allergies in factors of risk for suicidal behavior. Because stress plays a critical role in the manifestation of clinical symptoms of allergies and also in suicidal behavior, we also studied the role of acute stress. Female inbred Brown Norway rats known for their susceptibility to respiratory allergies were sensitized and challenged with a mixture of tree pollen and evaluated in the resident-intruder test for detection of aggressive behaviors. They were also subjected to acute stress by sessions of inescapable forced swimming and re-evaluated in the resident intruder test. Animals made allergic to tree pollen and subjected to acute stress displayed increased aggressive-like behavior as compared with control-saline treated animals or to their own aggressive scores previous to the stress session. These results suggest that allergies and stress increases aggressive-like behavior, indicating that these conditions may be important factors promoting altered emotional reactivity with the potential to influence suicidal behavior.","PeriodicalId":87999,"journal":{"name":"International journal of child health and human development : IJCHD","volume":"1 3","pages":"305-312"},"PeriodicalIF":0.0,"publicationDate":"2008-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2900930/pdf/nihms-117683.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"29117400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Allergen Specific IgE, Number and Timing of Past Suicide Attempts, and Instability in Patients with Recurrent Mood Disorders. 复发性情绪障碍患者的过敏原特异性IgE、既往自杀次数和时间以及不稳定性。

International journal of child health and human development : IJCHD Pub Date : 2008-01-01

Teodor T Postolache, Darryl W Roberts, Patricia Langenberg, Olesja Muravitskaja, John W Stiller, Robert G Hamilton, Leonardo H Tonelli

{"title":"Allergen Specific IgE, Number and Timing of Past Suicide Attempts, and Instability in Patients with Recurrent Mood Disorders.","authors":"Teodor T Postolache, Darryl W Roberts, Patricia Langenberg, Olesja Muravitskaja, John W Stiller, Robert G Hamilton, Leonardo H Tonelli","doi":"","DOIUrl":"","url":null,"abstract":"Suicide and decompensation of mental illness peak in spring and, to a lesser extent, in fall. Several recent studies reported that suicide and decompensation peaks coincided with spring and fall aeroallergen peaks. Allergic symptoms occur as the result of a complex biochemical cascade initiated by IgE antibodies (sensitization) and allergens (triggers). Animal models have shown molecular/neurochemical changes in the brain, as well as relevant behavioral changes associated with this IgE-mediated biochemical cascade. These factors suggest that seasonal allergy could precipitate suicidality and mood instability. In the current study, we compared the prior suicide attempt and history of decompensation of mood disorders in allergen sensitive vs nonsensitive patients. Further, we compared the ratio of events (attempts and decompensations) during the allergy season to events occurring during the rest of the year. Patients with Major Depressive Disorder or Bipolar I or II Disorder (n=80) were studied. There were no statistical differences in any measurement performed between the allergen sensitive and nonsensitive patients. These negative results are not consistent with recent epidemiological studies supporting a predictive association between allergy and categorical measures of suicidality (ideation, attempts, and completion). Clinical samples are likely not adequate to study less than strong predictive associations with suicide and suicide risk factors.","PeriodicalId":87999,"journal":{"name":"International journal of child health and human development : IJCHD","volume":"1 3","pages":"297-304"},"PeriodicalIF":0.0,"publicationDate":"2008-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2586113/pdf/nihms52247.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"27867894","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Asthma and Mood Disorders. 哮喘和情绪障碍。

International journal of child health and human development : IJCHD Pub Date : 2008-01-01

Anupama Kewalramani, Mary E Bollinger, Teodor T Postolache

引用次数: 0

Changes in Severity of Allergy and Anxiety Symptoms Are Positively Correlated in Patients with Recurrent Mood Disorders Who Are Exposed to Seasonal Peaks of Aeroallergens. 暴露于空气过敏原季节性高峰的复发性情绪障碍患者的过敏和焦虑症状的严重程度变化呈正相关。

International journal of child health and human development : IJCHD Pub Date : 2008-01-01

Teodor T Postolache, Patricia Langenberg, Sarah A Zimmerman, Manana Lapidus, Hirsh Komarow, Jessica S McDonald, Nancy Furst, Natalya Dzhanashvili, Debra Scrandis, Jie Bai, Bernadine Postolache, Joseph J Soriano, Bernard Vittone, Alvaro Guzman, Jong-Min Woo, John Stiller, Robert G Hamilton, Leonardo H Tonelli

{"title":"Changes in Severity of Allergy and Anxiety Symptoms Are Positively Correlated in Patients with Recurrent Mood Disorders Who Are Exposed to Seasonal Peaks of Aeroallergens.","authors":"Teodor T Postolache, Patricia Langenberg, Sarah A Zimmerman, Manana Lapidus, Hirsh Komarow, Jessica S McDonald, Nancy Furst, Natalya Dzhanashvili, Debra Scrandis, Jie Bai, Bernadine Postolache, Joseph J Soriano, Bernard Vittone, Alvaro Guzman, Jong-Min Woo, John Stiller, Robert G Hamilton, Leonardo H Tonelli","doi":"","DOIUrl":"","url":null,"abstract":"Considering clinical and animal evidence suggesting a relationship between allergy and anxiety, we hypothesized that, from low to high aeroallergen exposure, changes in anxiety symptom scores in patients with primary mood disorders will correlate with changes in allergy symptom scores. We also anticipated that sensitization to tree pollen, as determined by allergen specific IgE antibodies, will predict a greater worsening of anxiety during exposure to tree pollen. 51 patients with unipolar or bipolar disorder (age: 19-63 years, 65% female) were recruited. Tree- pollen IgE positive subjects (12) were included as the experimental group and patients negative to a multi-allergen serological test (39) were included in the control group. Self reports of anxiety and allergy symptoms were obtained once during the peak airborne pollen counts and once during the period of low airborne pollen counts, as reported by two local pollen counting stations. Using linear regression models, we confirmed a significant positive association between allergy scores and anxiety scores (p<0.04); however, the IgE specific tree pollen positivity was not significantly associated with changes in anxiety scores. Because changes in anxiety scores relate to changes in depression scores, the relationship between allergy and anxiety involves states rather than only traits, and as such, our results lead to future efforts to uncover potential anxiety triggering, exacerbating or perpetuating role of allergens in vulnerable individuals.","PeriodicalId":87999,"journal":{"name":"International journal of child health and human development : IJCHD","volume":"1 3","pages":"313-322"},"PeriodicalIF":0.0,"publicationDate":"2008-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2678838/pdf/nihms86202.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"28164772","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mood Oscillations and Coupling Between Mood and Weather in Patients with Rapid Cycling Bipolar Disorder. 快速循环双相情感障碍患者的情绪波动和情绪与天气的耦合。

International journal of child health and human development : IJCHD Pub Date : 2008-01-01

Steven M Boker, Ellen Leibenluft, Pascal R Deboeck, Gagan Virk, Teodor T Postolache

{"title":"Mood Oscillations and Coupling Between Mood and Weather in Patients with Rapid Cycling Bipolar Disorder.","authors":"Steven M Boker, Ellen Leibenluft, Pascal R Deboeck, Gagan Virk, Teodor T Postolache","doi":"","DOIUrl":"","url":null,"abstract":"Rapid Cycling Bipolar Disorder (RCBD) outpatients completed twice-daily mood self-ratings for 3 consecutive months. These ratings were matched with local measurements of atmospheric pressure, cloud cover, and temperature. Several alternative second order differential equation models were fit to the data in which mood oscillations in RCBD were allowed to be linearly coupled with daily weather patterns. The modeling results were consistent with an account of mood regulation that included intrinsic homeostatic regulation as well as coupling between weather and mood. Models were tested first in a nomothetic method where models were fit over all individuals and fit statistics of each model compared to one another. Since substantial individual differences in intrinsic dynamics were observed, the models were next fit using an ideographic method where each individual's data were fit separately and best-fitting models identified. The best-fitting within-individual model for the largest number of individuals was also the best-fitting nomothetic model: temperature and the first derivative of temperature coupled to mood and no effect of barometric pressure or cloud cover. But this model was not the best-fitting model for all individuals, suggesting that there may be substantial individual differences in the dynamic association between weather and mood in RCBD patients. Heterogeneity in the parameters of the differential equation model of homeostatic equilibrium as well as the coupling of mood to an inherently unpredictable (i.e., nonstationary) process such as weather provide an alternative account for reported broadband frequency spectra of daily mood in RCBD.","PeriodicalId":87999,"journal":{"name":"International journal of child health and human development : IJCHD","volume":"1 2","pages":"181-203"},"PeriodicalIF":0.0,"publicationDate":"2008-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2651091/pdf/nihms80368.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"28026390","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0