Bioscience hypotheses最新文献_第10页

Rosiglitazone, not only potentially protects myocardium against complications of type 2 diabetes mellitus but also induces myocardium infarction: Possible mechanisms? 罗格列酮不仅可以保护心肌免受2型糖尿病并发症的影响，还可以诱导心肌梗死:可能的机制?

Bioscience hypotheses Pub Date : 2009-01-01 DOI: 10.1016/j.bihy.2009.03.004

Mingxiang Ye, Yuemin Wang, Xinliang Ma, Jianming Pei

引用次数: 0

The immune system as key to cancer treatment: Triggering its activity with microbial agents 免疫系统作为癌症治疗的关键:用微生物制剂触发其活性

Bioscience hypotheses Pub Date : 2009-01-01 DOI: 10.1016/j.bihy.2009.08.003

Marina Resendes de Sousa António, Dirk Schulze-Makuch

{"title":"The immune system as key to cancer treatment: Triggering its activity with microbial agents","authors":"Marina Resendes de Sousa António, Dirk Schulze-Makuch","doi":"10.1016/j.bihy.2009.08.003","DOIUrl":"10.1016/j.bihy.2009.08.003","url":null,"abstract":"<div><p>Traditional methods such as chemotherapy and radiation therapy offer only limited success in treating cancer. Part of the reason is related to our misunderstanding of what cancer is: it is not the cause but the consequence of a weakened living system. Localized cellular stress, caused by toxins, mutagens or radiation, coupled with a weakened systemic response or inability to support or defend the cells that are under attack, cause these cells to revert to an ancient, unicellular mode of survival, therefore cutting links with the overarching organism and defend themselves from the threat as if they were individual entities. We hypothesize that strengthening the organism, specifically the immune system, is a more promising approach toward a cure for cancer than attempting to exterminate cancer cells. The hypothesis can be tested by experiments that are designed to strengthen the immune system by both traditional means (e.g., ingestion of natural substances known to increase the activity of the immune system, such as fruits, vegetables, and nuts), diminish immune system inhibitors released by cancer cells (e.g., TGF-β), and by the injection of heat-killed or genetically altered pathogenic bacteria to trigger a massive response (fever response) of the immune system into the affected area and compare those results to traditionally used methods.</p></div>","PeriodicalId":87894,"journal":{"name":"Bioscience hypotheses","volume":"2 6","pages":"Pages 388-392"},"PeriodicalIF":0.0,"publicationDate":"2009-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.bihy.2009.08.003","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84317457","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Pulmonary artery calcification in racehorses may be related to transient and repeated increases in arterial pressure during exercise 赛马肺动脉钙化可能与运动时动脉压力的短暂和反复升高有关

Bioscience hypotheses Pub Date : 2009-01-01 DOI: 10.1016/j.bihy.2009.07.011

Matthew G. Teeter , Luis G. Arroyo , Jeremy D. Bakker , R. John Runciman , Laurent Viel

{"title":"Pulmonary artery calcification in racehorses may be related to transient and repeated increases in arterial pressure during exercise","authors":"Matthew G. Teeter , Luis G. Arroyo , Jeremy D. Bakker , R. John Runciman , Laurent Viel","doi":"10.1016/j.bihy.2009.07.011","DOIUrl":"10.1016/j.bihy.2009.07.011","url":null,"abstract":"<div><p>Calcification of the pulmonary artery has been found in a large number of racing horses. The majority of calcified lesions are found immediately distal to the primary arterial bifurcation. Increased arterial wall stress levels have been previously demonstrated at these locations, with the wall stress levels increasing under intra-luminal pressures associated with exercise. We hypothesize therefore that the formation of calcified lesions is mediated by transient and repeated increases in pulmonary artery intra-luminal pressure. The presence of calcified lesions would likely further exacerbate the levels of wall stress, leading to growth of the lesions. A level of wall stress may exist above which calcified lesions form, and a second level may exist above which the calcified lesions grow at an increased rate. A computer model of pulmonary artery wall stress with calcified lesions was created, and wall stress levels were found to be greatest at the periphery of the calcified lesions. Osteo/chondrocyte-like cells have also been found at the periphery of the calcified lesions and could be responsible for collagen deposition and lesion growth, mediated by local wall stress levels. These increased levels of wall stress could place racehorses at a greater risk of acute pulmonary arterial rupture at the site of the calcified lesions, due to the high levels of intra-luminal pressure within the pulmonary artery during exercise. The hypothesis may also have implications in the etiology of human vascular diseases.</p></div>","PeriodicalId":87894,"journal":{"name":"Bioscience hypotheses","volume":"2 6","pages":"Pages 417-421"},"PeriodicalIF":0.0,"publicationDate":"2009-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.bihy.2009.07.011","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86333802","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Leptospirosis and Goodpasture's Syndrome 钩端螺旋体病和good牧草综合征

Bioscience hypotheses Pub Date : 2009-01-01 DOI: 10.1016/j.bihy.2009.07.006

S.B. Craig, G.C. Graham, M.-A. Burns, M.F. Dohnt, R.J. Wilson, L.D. Smythe, D.B. Mckay

引用次数: 1

Revealing acupuncture meridian-like system by reactive oxygen species visualization 利用活性氧可视化揭示针刺类经络系统

Bioscience hypotheses Pub Date : 2009-01-01 DOI: 10.1016/j.bihy.2009.07.005

Jingke Guo, Shutao Liu, Xi Cheng, Jianwu Zhou, Lijng Ke, Xiaochao Chen, Yanyun Lin, Pingfan Rao

引用次数: 10

Title page/Editorial board 标题页/编委会

Bioscience hypotheses Pub Date : 2009-01-01 DOI: 10.1016/S1756-2392(09)00152-9

引用次数: 0

Could adrenal insufficiency serve as a predictor of immune reconstitution inflammatory syndrome (IRIS) in HIV disease? 肾上腺功能不全是否可作为HIV疾病中免疫重建炎症综合征(IRIS)的预测因子?

Bioscience hypotheses Pub Date : 2009-01-01 DOI: 10.1016/j.bihy.2009.06.008

Palanisamy Jayakumar , Esaki Muthu Shankar , Sundaramoorthy Ezhilnambi , Murugesan Karthikeyan

引用次数: 1

Surfing at wave fronts: The bidirectional movement of cargo particles driven by molecular motors 波前冲浪:由分子马达驱动的货物颗粒的双向运动

Bioscience hypotheses Pub Date : 2009-01-01 DOI: 10.1016/j.bihy.2009.03.010

Daniel Gomes Lichtenthäler, Carla Goldman

{"title":"Surfing at wave fronts: The bidirectional movement of cargo particles driven by molecular motors","authors":"Daniel Gomes Lichtenthäler, Carla Goldman","doi":"10.1016/j.bihy.2009.03.010","DOIUrl":"10.1016/j.bihy.2009.03.010","url":null,"abstract":"<div><p><span><span>We examine the properties of intracellular transport of particles (vesicles, organelles, </span>virus<span>, etc.) in the realm of models that describe the dynamics of interacting molecular motors moving along microtubules. We use a continuum description of motor distribution and argue that certain features of cargo movement have their origins on its ability to perturb the existing motor profile and to </span></span><em>surf</em><span><span> at the resulting shock wave fronts that separate regions of different motor concentrations. In this case, the observed bidirectionality of cargo movement is naturally associated with reversals of shock direction. Comparison of the quantitative results predicted by this model with available data suggests that the geometrical characteristics of cargo may be related to the extension and intensity of the perturbation they produce and thus, to their kinetics. Possible implications of these ideas to understand features of the movement of virus particles within the cell body are discussed in connection with their distinguished </span>morphological characteristics.</span></p></div>","PeriodicalId":87894,"journal":{"name":"Bioscience hypotheses","volume":"2 6","pages":"Pages 428-438"},"PeriodicalIF":0.0,"publicationDate":"2009-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.bihy.2009.03.010","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83427500","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

E2F1: A colon cancer specific putative tumor suppressor and a valuable therapeutic target E2F1:结肠癌特异性推定肿瘤抑制因子和有价值的治疗靶点

Bioscience hypotheses Pub Date : 2009-01-01 DOI: 10.1016/j.bihy.2009.04.012

Guodong Yang , Haiyan Fu , Xiaozhao Lu, Liang Jin, Jie Zhang, Libo Yao, Zifan Lu

{"title":"E2F1: A colon cancer specific putative tumor suppressor and a valuable therapeutic target","authors":"Guodong Yang , Haiyan Fu , Xiaozhao Lu, Liang Jin, Jie Zhang, Libo Yao, Zifan Lu","doi":"10.1016/j.bihy.2009.04.012","DOIUrl":"10.1016/j.bihy.2009.04.012","url":null,"abstract":"<div><p><span>Colon cancer is one of the leading causes of cancer-related death worldwide. Genetic changes leading to aberrant activation of APC/β-catenin/TCF (canonical Wnt) pathway are considered as the initiating step in colon cancer. Abundant studies revealed that colon cancer is “Wnt addiction” and reduced the Wnt signal is of therapeutic value. Deregulation of the Rb/E2F1 pathway, as a result of alterations in members of the pathway, is a hallmark of many human cancers, but mutations in this pathway are rare in colon cancers. In contrast, suppression of </span>E2F1<span> activity through mutation of the CDK8 pathway is common in colon cancer. Active E2F1 is found to repress the activity of β-catenin transcription and promote cell apoptosis. The mutually exclusive expression pattern and function between E2F1 and Wnt pathway suggest an antagonistic relationship between these two pathways in colon cancer evolution. We hypothesize that E2F1 functions as a barrier of aberrant Wnt signal, and that E2F1 repression is necessary for colon cancer development. This hypothesis suggests that reactivation of E2F1 might have therapeutic potential for most of the colon cancers, as most of the colon cancers have aberrantly activated Wnt signal.</span></p></div>","PeriodicalId":87894,"journal":{"name":"Bioscience hypotheses","volume":"2 5","pages":"Pages 313-315"},"PeriodicalIF":0.0,"publicationDate":"2009-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.bihy.2009.04.012","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91120759","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Cigarette smoking induces insulin resistance: Partly via ASP–C5L2 pathway? 吸烟诱导胰岛素抵抗:部分通过ASP-C5L2途径?

Bioscience hypotheses Pub Date : 2009-01-01 DOI: 10.1016/j.bihy.2009.04.008

Wenlong Li, Rutai Hui

引用次数: 3