{"title":"The Preliminary Study on the Histopathological Effect of Aqueous Extract of Zingiber officinale on Lead Acetate Induced Toxicity of Adult Sprague- Dawley Rats","authors":"Adebajo Ao","doi":"10.19080/apbij.2017.03.555611","DOIUrl":"https://doi.org/10.19080/apbij.2017.03.555611","url":null,"abstract":"Lead Acetate is one of the environmental pollutants that can threaten the life of living creatures in many ways. The use of plant derived herbal compounds in herbal preparations as alternative sources of medication has continued to play major roles in the general wellness of people all over the world Farombi 2003; Rajesh et al. [1], Ekor [2]. However the treatment with the extract of Zingiber officinale modulates the toxicity caused by lead acetate administration. The aim of this study is to investigate the ameliorative properties of ginger on lead acetate induced on kidney induced toxicity. A total of forty adult rats of weight 150 ± 20 g were used for this research. The animals were grouped into four (A, B, C and D) of 10 animals each. Group A-C was the treatment groups while group D served as the control. Group a received 0.4 g of Lead Acetate, Group B received 0.4 g of Lead Acetate and then 0.1g of Ginger, Group C received 0.1 g of Ginger and Group D received 1 ml of distilled water. The mode of administration was oral and the study was for 25 days after a 2 week acclimatization period. At the end of the experiment, the animals were sacrificed using ketamine and an anterior abdominal incision was performed and the kidney was excised. The organs were fixed in 10% formal Saline and processed for histology. The histological findings revealed cytoarchitectural distortion in the podocytes, dilation in the capsular space and cells with pyknotic nuclei in the distal and proximal convoluted tubules in the Group A and to lesser extent in Group B compared to normal cyto architectural photomicrographs obtained in the Group C and D. These findings thus underlined the protective effect of Zingiber officinale in Lead acetate induced toxicity as it affects ultrafiltration as well as tubular fluid reabsorption properties of the kidney.","PeriodicalId":8778,"journal":{"name":"Biochemistry international","volume":"147 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2017-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77802786","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Identification of Sex from Carotid Canal in South Indian Population","authors":"Makandar Uk","doi":"10.19080/apbij.2017.03.555610","DOIUrl":"https://doi.org/10.19080/apbij.2017.03.555610","url":null,"abstract":"There are many criteria for sexual diamorphism of crania after puberty such as prominence of superciliary arches, breadth of Foramen magnum, depth of diagastric groove, width of Zygomatic arches, length and breadth of mastoid process but least data is available for sexual dimorphism. As CC is a Greek word means sleep. Greek ancestors thought that, the internal carotid artery, sympathetic nerve plexus, venous plexus transmits through cc bring the sleep [2]. As CC is the large rounded foramen in the basal surface of petrous in front of Jugular foramen which gives passage for ICA. The cc is curved upwards, forwards and medially long axis of the petrous bone and opens in the foramen lacerum [3]. In recent advances of skull surgery, approaches to cavernous sinus and frontal skull base transzygomatic approach through middle skull base since ISA runs inside the temporal bone restricts the surgical procedure. Hence it is mandatory to preserve the ICA .hence if we know the sex we can predict the diameter of ICA [4]. Because in some cranial walls of the cc was found to be very thin hence vulnerable during the surgery around the clival region. Hence attempt was made to study the diameter of CC in crania of both sexes so that approaches to the cavernous sinus may save the ICA. It is also observed that 35% CC is dehiscence in the typantic cavity reminds otologist the anatomical knowledge of CC and temporal bone [5]. Moreover the study of sexual dimorphism has medicolegal, anthropological and anatomical important as metrical values of mesodermal values are uncertain.","PeriodicalId":8778,"journal":{"name":"Biochemistry international","volume":"160 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2017-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78323718","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Effect of Gestational Exposure to Monosodium Glutamate on the Structure of Fetal Rat Lung","authors":"Abdelmonem Awad Hegazy","doi":"10.19080/APBIJ.2017.03.555609","DOIUrl":"https://doi.org/10.19080/APBIJ.2017.03.555609","url":null,"abstract":"Lung diseases represent one of the leading causes of worldwide morbidity and mortality. The problem is expected to be worse in the future [1]. This necessitates investigating the possible environmental factors, habits and food types that might be engaged in pathogenesis of pulmonary diseases, particularly during the fetal life. This of particular importance as many drugs and substances taken by (or given to) the pregnant mothers can cross the placental barrier to affect their fetuses [2]. One of such substances is monosodium glutamate (MSG) that might affect the lungs of fetal mice after exposure of their mothers to it [3]. Various developmental changes in the animals’ offspring tissues might occur following MSG treatment [4]. Moreover, the administration of MSG in high concentrations for long period of time triggers the production of reactive oxygen species (ROS) coupled with impaired oxidant/ antioxidant balance leading to a state of oxidative stress [5]. The lung is more susceptible to oxidative injury than any other organ in the body because of constant exposure to air that might contain toxic particles or oxidant gases such as nitrogen oxide or ozone [6]. MSG is a well-known flavor enhancer used by both Western and Eastern populations. It is responsible for the delicious taste; and it is incorporated into a large number of solid and liquid foods. Experimental studies have established that the added MSG in foods influences palatability and preference [7]. Nowadays, MSG is commonly sold in the Egyptian supermarkets. Many Egyptians consume MSG in both ready and home-made foods, almost daily [8].","PeriodicalId":8778,"journal":{"name":"Biochemistry international","volume":"15 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2017-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75602967","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Th-1 Directing Immunostimulatory Effect of Calcined Jade Having Naturally Formed Nanoparticles in Swiss Albino Mice","authors":"F. Khan","doi":"10.19080/apbij.2017.03.555608","DOIUrl":"https://doi.org/10.19080/apbij.2017.03.555608","url":null,"abstract":"In present study, we evaluated the modulating potential of Calcined Jade (CJ) on cell mediated immunity in Swiss albino mice. CJ is a metasilicate of Calcium and magnesium prescribed along with other herbal formulations in folk medicine for various purposes. CJ was administered orally to the animals at a dose of 50, 75, 100 and 200 µg/kg body wt. for 10 days; modulation of the acquired immune responses was studiedin mice. In CJ treated animals, cell mediated immune response was observed by estimation of significant increase (p<0.01) in Delayed type hypersensitivity (DTH) response, Th-1 cytokines namely IL-2/IFN-γ and TNF-α in spleenocytes. We also evaluated the effect of CJ on macrophage surface antigen markers (CD-80/86) and found increased expression of CD-80. We report stimulating effect of CJ on Th-1 type of immune responses which may partly be due to the formation of nano particles during calcination process and further experiments using isolated nano particles may further validate the role of nano particles.","PeriodicalId":8778,"journal":{"name":"Biochemistry international","volume":"91 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2017-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79958210","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Probiotics What You Missed","authors":"A. Koleilat","doi":"10.19080/APBIJ.2017.03.555606","DOIUrl":"https://doi.org/10.19080/APBIJ.2017.03.555606","url":null,"abstract":"Probiotic is now worldwide, one of the main interests in the field of medicine. Many people use probiotic, prescribe it and recommend it. Millions of articles are produced as reviews and trials. Studies are done all over the world; symposia and congresses are very active in this field, even societies are formed to revive the probiotic kingdom. Commercially, probiotics have been over used and recommended by many companies. Probiotics became a must in infant feeding especially milk formulas. So what is probiotic and how do we have to approach this phenomenon?","PeriodicalId":8778,"journal":{"name":"Biochemistry international","volume":"186 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2017-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73015809","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Sternocleidomastoid Region: The “No Man’s Land” in Neck","authors":"Anurag Srivastava","doi":"10.19080/APBIJ.2017.03.555607","DOIUrl":"https://doi.org/10.19080/APBIJ.2017.03.555607","url":null,"abstract":"Sternocleidomastoid muscle is an important structure of the neck. This rhomboid shaped muscle lies obliquely in the neck, extending from manubrium sterni, and medial third of the clavicle antero-inferiorly to the mastoid process and occipital bone postero-superiorly. The muscle superficially crosses various vital structures in the neck such as trachea, oesophagus, common carotid artery, internal jugular vein, vagus nerve, symphathetic chain and jugular group of lymph nodes. It is supplied by the occipital and superior thyroid arteries and receives its nerve supply from 11th cranial (Spinal root of accessory) and 2nd & 3rd cervical (Proprioceptive and motor) nerves. Sternocleidomastoid muscle separates the two triangles in each half of the neck [1] (Figure 1). The Anterior Triangle is described as being bounded by mid line anteriorly, anterior border of sternocleidomastoid posteriorly and the lower border of mandible superiorly. The Posterior triangle is described as bounded by posterior border of sternocleidomastoid, anterior border of trapezius and middle third of clavicle inferiorly.","PeriodicalId":8778,"journal":{"name":"Biochemistry international","volume":"35 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2017-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77101153","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Protein L-Isoaspartate O-Methyltransferase (PCMT1): A Key Player of Spontaneously Arisen Protein Damage Repair","authors":"Burcu Biterge","doi":"10.19080/APBIJ.2017.03.555605","DOIUrl":"https://doi.org/10.19080/APBIJ.2017.03.555605","url":null,"abstract":"Methylation of aspartic acid residues was first described in the literature in erythrocytes as a possible step of repairing aged membrane proteins [1]. During the process of aging, L-aspartyl residues are spontaneously converted to L-isoaspartyl via the unstable intermediate L-succinimide which undergoes a spontaneous hydrolysis, generating a mixture of normal L-aspartate (15-30%) and abnormal L-isoaspartate (7085%), pointed out as steps 2 and 3 in Figure 1 respectively [2]. Accumulation of this abnormal form of aspartate is recognized as damage in the cell and therefore needs to be repaired [3].","PeriodicalId":8778,"journal":{"name":"Biochemistry international","volume":"82 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2017-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85142187","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A New Model for Training on Human Specimens in Surgical-Anatomical Skills Labs","authors":"H. Theeuwes","doi":"10.19080/APBIJ.2017.03.555604","DOIUrl":"https://doi.org/10.19080/APBIJ.2017.03.555604","url":null,"abstract":"Embalming human bodies is of all times, after the introduction of formaldehyde fixation for organic tissues in 1893 by the German physician Ferdinand Blum, the donated bodies could be used more efficiently for gross anatomy purposes than before Fox et al. [1]. Nowadays the demand for (embalmed) human bodies used for surgical training, besides normal anatomy teaching, has increased. Mostly fresh frozen human bodies, donated for science, are used for surgical trainings. Its realistic tissue handling and flexibility represent the main advantages of fresh frozen human bodies. The disadvantages however are also well known: risk of infection (additional testing is essential), degeneration, time pressure and single use are only some examples. The introduction of “light” or “soft’ embalming methods like Thiel’s, Duke’s or other new method’shave contributed to prolonging the natural characteristics of the donated bodies Thiel et al. [2-8]. All of these methods have made it possible to re-use embalmed bodies for multiple purposes. It is now possible to use the bodies more efficiently because they can be used multiple times. These new methods slow down the degeneration process for weeks without losing their natural characteristics. Still these methods were not developed for long time fixation and conservation of human flexible characteristics.","PeriodicalId":8778,"journal":{"name":"Biochemistry international","volume":"85 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2017-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84006067","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Cellular therapy, an autologous cellular point of care approach to satisfy patient needs","authors":"Falk Heinrichsohn","doi":"10.19080/APBIJ.2017.03.555603","DOIUrl":"https://doi.org/10.19080/APBIJ.2017.03.555603","url":null,"abstract":"Humans are, as we know since some time, a complex biological, energy related system manifested in a material field (Figure 1) of about 100 Trillion cells, surrounded and embedded in various energy related structures, communicating with its specific neural network, able to exchange and analyse information and with this, initiating impulses triggering biological, electrical and chemical related reaction at its cellular structure.Cellular treatment, Complementary and Alternative medicine (CAM) therapy are a potential alternative, even a disruptive, medical treatment in a Point of Care setting to support a chronic ill and aging population, where standard medical treatment has clearly shown it limitations.","PeriodicalId":8778,"journal":{"name":"Biochemistry international","volume":"15 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2017-07-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75012521","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Association of Hyperuricemia and Raised Atherogenic Index of Plasma with Hypertension","authors":"R. Ahmed","doi":"10.19080/apbij.2017.03.555602","DOIUrl":"https://doi.org/10.19080/apbij.2017.03.555602","url":null,"abstract":"Cardiovascular disease (CVD) is a major cause of global mortality and is a serious health problem in developed as well as in developing countries. In Bangladesh, deaths due to noncommunicable diseases (NCD), especially chronic diseases are increasing at an alarming rate. Among them CVD, cancers, chronic respiratory diseases, and diabetes are responsible for an increasing number of deaths [1]. CVD has become a significant burden on the health care service in Bangladesh. World Health Organization (WHO) reported that 27% of total deaths in Bangladesh were due to CVD [2]. CVD is the highest among all causes of death followed by diseases of the respiratory system [3].","PeriodicalId":8778,"journal":{"name":"Biochemistry international","volume":"50 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2017-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86127947","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}