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Journal of the cardiometabolic syndrome最新文献

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Metformin Mitigates Radiation-Induced Endothelial Cell Damage by Attenuating Oxidative Stress, DNA Damage, and Apoptosis 二甲双胍通过减轻氧化应激、DNA损伤和细胞凋亡减轻辐射诱导的内皮细胞损伤
Journal of the cardiometabolic syndrome Pub Date : 2025-12-23 DOI: 10.51789/cmsj.2026.6.e6
Eunhui Seo, Hyunkwan Seo, Kyu Chan Lee
{"title":"Metformin Mitigates Radiation-Induced Endothelial Cell Damage by Attenuating Oxidative Stress, DNA Damage, and Apoptosis","authors":"Eunhui Seo, Hyunkwan Seo, Kyu Chan Lee","doi":"10.51789/cmsj.2026.6.e6","DOIUrl":"https://doi.org/10.51789/cmsj.2026.6.e6","url":null,"abstract":"Background and Objectives: Radiation-induced endothelial injury is a major contributor to cardiovascular complications among cancer survivors.Metformin, an antidiabetic drug with well-established pleiotropic effects, has been reported to exert protective actions beyond glucose regulation.This study aimed to investigate whether metformin mitigates radiationinduced cytotoxicity in human endothelial cells.Methods: EA.hy926 endothelial cells were pretreated with metformin (0.1, 0.2, 0.5, or 1 mM) for 24 hours prior to exposure to 5 Gy of ionizing radiation.Cell viability was assessed using the Cell Counting Kit assay, and Western blot analysis was performed to evaluate phosphorylated and total levels of DNA-dependent protein kinase catalytic subunit (DNA-PKcs), ataxia-telangiectasia mutated (ATM), and H2AX-key proteins involved in DNA double-strand break repair.Results: Radiation significantly decreased cell viability and increased phosphorylation of DNA-PKcs, ATM, and H2AX.Metformin pretreatment significantly improved viability at 0.5 and 1 mM in a dose-dependent manner, while lower concentrations (0.1 and 0.2 mM) showed a non-significant upward trend.Metformin also markedly reduced phosphorylation of DNA damage response proteins at 0.5 and 1 mM, whereas total protein levels of DNA-PKcs, ATM, and H2AX remained unchanged, indicating selective inhibition of protein activation.Conclusions: Metformin exerts a radioprotective effect in human endothelial cells by enhancing cell viability and attenuating radiation-induced DNA damage signaling.These findings suggest the potential clinical utility of metformin in preventing radiation-induced vascular injury.","PeriodicalId":87477,"journal":{"name":"Journal of the cardiometabolic syndrome","volume":"6 1","pages":"84-84"},"PeriodicalIF":0.0,"publicationDate":"2025-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"http://e-cmsj.org/Synapse/Data/PDFData/9982CMSJ/cmsj-6-e6.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147883106","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Macrophage Metabolic Reprogramming After Myocardial Infarction 心肌梗死后巨噬细胞代谢重编程
Journal of the cardiometabolic syndrome Pub Date : 2023-01-01 DOI: 10.51789/cmsj.2023.3.e16
Linqi Zeng, Shuai Song, Xiaokai Zhang, Zihang Huang, A. Sun, Junbo Ge
{"title":"Macrophage Metabolic Reprogramming After Myocardial Infarction","authors":"Linqi Zeng, Shuai Song, Xiaokai Zhang, Zihang Huang, A. Sun, Junbo Ge","doi":"10.51789/cmsj.2023.3.e16","DOIUrl":"https://doi.org/10.51789/cmsj.2023.3.e16","url":null,"abstract":"","PeriodicalId":87477,"journal":{"name":"Journal of the cardiometabolic syndrome","volume":"46 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80431005","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
What Is the Role of Aspirin in Primary Prevention in Patients With Elevated Lp(a)? 阿司匹林在Lp(a)升高患者一级预防中的作用是什么?
Journal of the cardiometabolic syndrome Pub Date : 2023-01-01 DOI: 10.51789/cmsj.2023.3.e7
S. Tsimikas
{"title":"What Is the Role of Aspirin in Primary Prevention in Patients With Elevated Lp(a)?","authors":"S. Tsimikas","doi":"10.51789/cmsj.2023.3.e7","DOIUrl":"https://doi.org/10.51789/cmsj.2023.3.e7","url":null,"abstract":"","PeriodicalId":87477,"journal":{"name":"Journal of the cardiometabolic syndrome","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88766798","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Exercise Training and Cardiovascular Health: Mechanisms, Benefits, and Therapeutic Implications in Cardiovascular Disease 运动训练和心血管健康:心血管疾病的机制、益处和治疗意义
Journal of the cardiometabolic syndrome Pub Date : 2023-01-01 DOI: 10.51789/cmsj.2023.3.e20
D. Seo, J. Bae, Xinxing Li, Jin Han
{"title":"Exercise Training and Cardiovascular Health: Mechanisms, Benefits, and Therapeutic Implications in Cardiovascular Disease","authors":"D. Seo, J. Bae, Xinxing Li, Jin Han","doi":"10.51789/cmsj.2023.3.e20","DOIUrl":"https://doi.org/10.51789/cmsj.2023.3.e20","url":null,"abstract":"","PeriodicalId":87477,"journal":{"name":"Journal of the cardiometabolic syndrome","volume":"268 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83005566","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
An Attempt to Predict Cardiometabolic Risk Factors Using Cardiorespiratory Fitness and Muscular Strength 利用心肺适能和肌肉力量预测心脏代谢危险因素的尝试
Journal of the cardiometabolic syndrome Pub Date : 2023-01-01 DOI: 10.51789/cmsj.2023.3.e19
B. Kim
{"title":"An Attempt to Predict Cardiometabolic Risk Factors Using Cardiorespiratory Fitness and Muscular Strength","authors":"B. Kim","doi":"10.51789/cmsj.2023.3.e19","DOIUrl":"https://doi.org/10.51789/cmsj.2023.3.e19","url":null,"abstract":"","PeriodicalId":87477,"journal":{"name":"Journal of the cardiometabolic syndrome","volume":"234 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74963237","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Impact of Obesity on Long Term Mortality and Major Cardiovascular Events After Off-Pump Coronary Artery Bypass Surgery: A Single Center Retrospective Study 肥胖对非体外循环冠状动脉搭桥术后长期死亡率和主要心血管事件的影响:一项单中心回顾性研究
Journal of the cardiometabolic syndrome Pub Date : 2023-01-01 DOI: 10.51789/cmsj.2023.3.e12
J. Song, Jung-Hwan Kim, Y. Youn, H. Kim, K. Yoo, Hyun-Chel Joo
{"title":"Impact of Obesity on Long Term Mortality and Major Cardiovascular Events After Off-Pump Coronary Artery Bypass Surgery: A Single Center Retrospective Study","authors":"J. Song, Jung-Hwan Kim, Y. Youn, H. Kim, K. Yoo, Hyun-Chel Joo","doi":"10.51789/cmsj.2023.3.e12","DOIUrl":"https://doi.org/10.51789/cmsj.2023.3.e12","url":null,"abstract":"","PeriodicalId":87477,"journal":{"name":"Journal of the cardiometabolic syndrome","volume":"52 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84674808","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Post-Pregnancy Hypertension in Women With a History of Hypertensive Disorders of Pregnancy 妊娠期有高血压病史妇女的妊娠后高血压
Journal of the cardiometabolic syndrome Pub Date : 2023-01-01 DOI: 10.51789/cmsj.2023.3.e4
B. Kim, J. Shin
{"title":"Post-Pregnancy Hypertension in Women With a History of Hypertensive Disorders of Pregnancy","authors":"B. Kim, J. Shin","doi":"10.51789/cmsj.2023.3.e4","DOIUrl":"https://doi.org/10.51789/cmsj.2023.3.e4","url":null,"abstract":"","PeriodicalId":87477,"journal":{"name":"Journal of the cardiometabolic syndrome","volume":"73 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84793187","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Adropin: A New Biomarker in Coronary Artery Disease Adropin:冠状动脉疾病的新生物标志物
Journal of the cardiometabolic syndrome Pub Date : 2023-01-01 DOI: 10.51789/cmsj.2023.3.e8
D. Cho
{"title":"Adropin: A New Biomarker in Coronary Artery Disease","authors":"D. Cho","doi":"10.51789/cmsj.2023.3.e8","DOIUrl":"https://doi.org/10.51789/cmsj.2023.3.e8","url":null,"abstract":"","PeriodicalId":87477,"journal":{"name":"Journal of the cardiometabolic syndrome","volume":"69 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86099679","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Optimal Duration and De-escalation Strategy of Antiplatelet Agents and Anticoagulation Agents in Korean Patients Undergoing Percutaneous Coronary Intervention 韩国经皮冠状动脉介入治疗患者抗血小板和抗凝药物的最佳持续时间和降压策略
Journal of the cardiometabolic syndrome Pub Date : 2023-01-01 DOI: 10.51789/cmsj.2023.3.e5
J. Lee, Sang Ho
{"title":"The Optimal Duration and De-escalation Strategy of Antiplatelet Agents and Anticoagulation Agents in Korean Patients Undergoing Percutaneous Coronary Intervention","authors":"J. Lee, Sang Ho","doi":"10.51789/cmsj.2023.3.e5","DOIUrl":"https://doi.org/10.51789/cmsj.2023.3.e5","url":null,"abstract":"","PeriodicalId":87477,"journal":{"name":"Journal of the cardiometabolic syndrome","volume":"69 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85305292","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Declaration of Conflict of Interest for Editors and Editorial Board Member’s Articles 编辑和编辑委员会成员文章的利益冲突声明
Journal of the cardiometabolic syndrome Pub Date : 2023-01-01 DOI: 10.51789/cmsj.2023.3.e13
{"title":"Declaration of Conflict of Interest for Editors and Editorial Board Member’s Articles","authors":"","doi":"10.51789/cmsj.2023.3.e13","DOIUrl":"https://doi.org/10.51789/cmsj.2023.3.e13","url":null,"abstract":"","PeriodicalId":87477,"journal":{"name":"Journal of the cardiometabolic syndrome","volume":"30 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82420355","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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