Nuclear receptor signaling最新文献_第8页

Nuclear receptor corepressors and PPARgamma. 核受体辅抑制因子与ppγ。

Nuclear receptor signaling Pub Date : 2006-01-01 Epub Date: 2006-02-08 DOI: 10.1621/nrs.04003

Ronald N Cohen

引用次数: 32

The orphan Rev-erb nuclear receptors: a link between metabolism, circadian rhythm and inflammation? 孤儿Rev-erb核受体:代谢、昼夜节律和炎症之间的联系?

Nuclear receptor signaling Pub Date : 2006-01-01 Epub Date: 2006-04-28 DOI: 10.1621/nrs.04009

Sathiya N Ramakrishnan, George E O Muscat

{"title":"The orphan Rev-erb nuclear receptors: a link between metabolism, circadian rhythm and inflammation?","authors":"Sathiya N Ramakrishnan, George E O Muscat","doi":"10.1621/nrs.04009","DOIUrl":"https://doi.org/10.1621/nrs.04009","url":null,"abstract":"Nuclear hormone receptors (NRs) function as ligand dependent DNA binding proteins that translate physiological/nutritional signals into gene regulation. Dysfunctional NR signaling leads to many disorders in reproduction, inflammation, and metabolism. The opportunity to identify novel regulatory pathways in the context of human health and disease drives the challenge to unravel the biological function of the \"orphan nuclear hormone receptors\". For example, the Rev-erb (NR1D) subgroup (Rev-erbalpha/NR1D1 and Rev-erbbeta/NR1D2) of orphan NRs are transcriptional silencers and negative regulators of RORalpha mediated trans-activation. The NR1D subgroup is highly enriched in peripheral tissues with onerous energy demands including skeletal muscle, brown and white adipose, brain, liver and kidney. This alludes to the involvement of this subgroup in metabolism. In this context, Rev-erbalpha-/- mice have a dyslipidemic phenotype. Recent studies in vascular smooth and skeletal muscle cells also suggest that the NR1D subgroup modulates inflammation by regulating IkappaBalpha/NFkappaB dependent gene expression. Rev-erbalpha has been identified as a critical regulator (and target) of circadian rhythm, a factor in blood pressure control and inflammation. Finally, two recent reports have demonstrated: (i) lithium mediated regulation of Rev-erbalpha stability and (ii) E75 (the Drosophila orthologue of human Rev-erbalpha) is tightly bound by heme, and functions as a \"gas sensor\" through interaction with CO/NO and interferes with the repression of DHR3 (the Drosophila orthologue of human RORalpha). In conclusion, the role of these receptors at the cross-roads of metabolism, inflammation, and circadian cycling underscores the importance of understanding the organ-specific function of the NR1D subgroup in homeostasis.","PeriodicalId":87415,"journal":{"name":"Nuclear receptor signaling","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2006-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1621/nrs.04009","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"26061361","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 77

Estrogen signaling in the cardiovascular system. 心血管系统中的雌激素信号。

Nuclear receptor signaling Pub Date : 2006-01-01 Epub Date: 2006-07-07 DOI: 10.1621/nrs.04013

Jin Kyung Kim, Ellis R Levin

{"title":"Estrogen signaling in the cardiovascular system.","authors":"Jin Kyung Kim, Ellis R Levin","doi":"10.1621/nrs.04013","DOIUrl":"https://doi.org/10.1621/nrs.04013","url":null,"abstract":"Estrogen exerts complex biological effects through the two isoforms of estrogen receptors (ERs): ERalpha and ERbeta. Whether through alteration of gene expression or rapid, plasma membrane-localized signaling to non-transcriptional actions, estrogen-activated ERs have significant implications in cardiovascular physiology. 17-beta-estradiol (E2) generally has a protective property on the vasculature. Estrogen treatment is anti-atherogenic, protecting injured endothelial surfaces and lowering LDL oxidation in animal models. Increased NO production stimulated by E2 results in vasodilation of the coronary vascular bed, and involves rapid activation of phosphotidylinositol-3 kinase (PI3K)/Akt signaling to eNOS in carotid and femoral arteries. Both isoforms of ERs impact various vascular functions, modulating ion channel integrity, mitigating the response to arterial injury, inducing vasodilation, and preventing development of hypertension in animal models. In addition to reducing afterload by vasodilation, ERs have a direct antihypertrophic effect on the myocardium. E2-activated ERs (E2/ER) antagonize the hypertrophic pathway induced by vasoactive peptides such as angiotensin II by activating PI3K, subsequent MICIP gene expression, leading to the inhibition of calcineurin activity and the induction of hypertrophic genes. In models of ischemia-reperfusion, E2/ER is antiapoptotic for cardiomyocytes, exerting the protective actions via PI3K and p38 MAP kinases and suppressing the generation of reactive oxygen species. In sum, E2-activated ERs consistently and positively modulate multiple aspects of the cardiovascular system.","PeriodicalId":87415,"journal":{"name":"Nuclear receptor signaling","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2006-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1621/nrs.04013","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"26160487","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 69

A tale of two estrogen receptors (ERs): how differential ER-estrogen responsive element interactions contribute to subtype-specific transcriptional responses. 两个雌激素受体(er)的故事:不同的er -雌激素反应元件相互作用如何促进亚型特异性转录反应。

Nuclear receptor signaling Pub Date : 2006-01-01 Epub Date: 2006-07-07 DOI: 10.1621/nrs.04015

Jing Huang, Xiaodong Li, Tao Qiao, Robert A Bambara, Russell Hilf, Mesut Muyan

引用次数: 7

The unexpected science of estrogen receptor-beta selective agonists: a new class of anti-inflammatory agents? 雌激素受体- β选择性激动剂的意外科学:一类新的抗炎剂?

Nuclear receptor signaling Pub Date : 2006-01-01 Epub Date: 2006-07-07 DOI: 10.1621/nrs.04012

Heather A Harris

引用次数: 21

Estrogen receptor and aryl hydrocarbon receptor signaling pathways. 雌激素受体和芳烃受体信号通路。

Nuclear receptor signaling Pub Date : 2006-01-01 Epub Date: 2006-07-07 DOI: 10.1621/nrs.04016

Jason Matthews, Jan-Ake Gustafsson

引用次数: 251

Genome-wide approaches for identification of nuclear receptor target genes. 核受体靶基因鉴定的全基因组方法。

Nuclear receptor signaling Pub Date : 2006-01-01 Epub Date: 2006-07-07 DOI: 10.1621/nrs.04018

Luz E Tavera-Mendoza, Sylvie Mader, John H White

引用次数: 11

Characterization of skeletal phenotypes of TRalpha1 and TRbeta mutant mice: implications for tissue thyroid status and T3 target gene expression. TRalpha1和TRbeta突变小鼠骨骼表型的表征:对组织甲状腺状态和T3靶基因表达的影响

Nuclear receptor signaling Pub Date : 2006-01-01 Epub Date: 2006-07-07 DOI: 10.1621/nrs.04011

Patrick J O'Shea, J H Duncan Bassett, Sheue-yann Cheng, Graham R Williams

引用次数: 57

Nuclear receptor regulation gears up another Notch. 核受体调节又启动了一个Notch。

Nuclear receptor signaling Pub Date : 2006-01-01 Epub Date: 2006-02-08 DOI: 10.1621/nrs.04001

Borja Belandia, Malcolm G Parker

引用次数: 9

The cell-specific activity of the estrogen receptor alpha may be fine-tuned by phosphorylation-induced structural gymnastics. 雌激素受体α的细胞特异性活性可能被磷酸化诱导的结构体操微调。

Nuclear receptor signaling Pub Date : 2006-01-01 Epub Date: 2006-02-08 DOI: 10.1621/nrs.04005

Valentina Gburcik, Didier Picard

{"title":"The cell-specific activity of the estrogen receptor alpha may be fine-tuned by phosphorylation-induced structural gymnastics.","authors":"Valentina Gburcik, Didier Picard","doi":"10.1621/nrs.04005","DOIUrl":"https://doi.org/10.1621/nrs.04005","url":null,"abstract":"The estrogen receptor alpha (ERalpha) regulates the transcription of target genes by recruiting coregulator proteins through several domains including the two activation functions AF1 and AF2. The contribution of the N-terminally located AF1 activity is particularly important in differentiated cells, and for ERalpha to integrate inputs from other signaling pathways. However, how the phosphorylation of key residues influences AF1 activity has long remained mysterious, in part because the naturally disordered AF1 domain has resisted a structural characterization. The recent discovery of two coregulators that are specific for a phosphorylated form of AF1 suggests that phosphorylation, possibly in conjunction with the subsequent binding of these coregulators, may enforce a stable structure. The binding of the \"pioneer\" coregulators might facilitate the subsequent recruitment of yet other coregulators. Different AF1 folds may be enabled by the combinatorial action of posttranslational modifications and coregulator binding thereby fine-tuning ERalpha activities in a cell- and promoter-specific fashion.","PeriodicalId":87415,"journal":{"name":"Nuclear receptor signaling","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2006-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1621/nrs.04005","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25964263","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 14