Journal of the Society for Integrative Oncology最新文献_第4页

Zyflamend in men with high-grade prostatic intraepithelial neoplasia: results of a phase I clinical trial. Zyflamend治疗男性高级别前列腺上皮内瘤变:一项I期临床试验的结果

Journal of the Society for Integrative Oncology Pub Date : 2009-01-01

Jillian L Capodice, Prakash Gorroochurn, A Sam Cammack, Goluboff Eric, James M McKiernan, Mitchell C Benson, Brian A Stone, Aaron E Katz

{"title":"Zyflamend in men with high-grade prostatic intraepithelial neoplasia: results of a phase I clinical trial.","authors":"Jillian L Capodice, Prakash Gorroochurn, A Sam Cammack, Goluboff Eric, James M McKiernan, Mitchell C Benson, Brian A Stone, Aaron E Katz","doi":"","DOIUrl":"","url":null,"abstract":"Subjects diagnosed with high-grade prostatic intraepithelial neoplasia (HGPIN) at biopsy are at increased risk for developing prostate cancer (CaP). A prospective clinical trial was done to determine the safety and tolerability of a novel herbal amalgam, Zyflamend (New Chapter, Inc., Brattleboro, VT), with various dietary supplements in subjects with HGPIN. Men ages 40 to 75 years with HGPIN were eligible. Subjects were evaluated for 18 months. Every 3 months, standard blood chemistries and prostate-specific antigen (PSA) were monitored. Rebiopsy was done every 6 months. Tissue was evaluated for HGPIN or CaP and stained for cyclooxygenase-2, nuclear factor kappaB (NF-kappaB), interleukin-6, and thromboxane. Twenty-three subjects were evaluable. The median age was 64.1 years (range 46-75 years), and the mean (+/- SD) PSA level was 6.13 +/- 3.56 ng/mL. Side effects, when present, were mild and gastrointestinal in nature. There were no reported serious adverse events or toxicities. No significant changes in blood chemistries, testosterone, or cardiac function were noted. Forty-eight percent of subjects demonstrated a 25 to 50% decrease in PSA after 18 months. Of subjects who had the 18-month biopsy, 60% (9 of 15) had benign tissue, 26.7% (4 of 15) had HGPIN in one core, and 13.3% (2 of 15) had CaP at 18 months. A reduction in serum C-reactive protein was observed (95% confidence interval [CI] 0.7-1.7, p = .045). Immunoreactive staining demonstrated a reduction in NF-kappaB in the 18-month samples (95% CI 0.8-3.0, p = .017). Zyflamend alone and in combination with various dietary supplements is associated with minimal toxicity and no serious adverse events when administered orally for 18 months. Further studies are warranted to evaluate these agents in patients who are at risk for CaP.","PeriodicalId":87409,"journal":{"name":"Journal of the Society for Integrative Oncology","volume":"7 2","pages":"43-51"},"PeriodicalIF":0.0,"publicationDate":"2009-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"28203188","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

CVT-E002 stimulates the immune system and extends the life span of mice bearing a tumor of viral origin. CVT-E002刺激免疫系统，延长携带病毒源肿瘤的小鼠的寿命。

Journal of the Society for Integrative Oncology Pub Date : 2009-01-01

Sandra C Miller, Danielle Delorme, Jacqueline J Shan

引用次数: 0

Acupuncture for nonpalliative radiation therapy-related fatigue: feasibility study. 针刺治疗非姑息性放射治疗相关疲劳:可行性研究。

Journal of the Society for Integrative Oncology Pub Date : 2009-01-01 DOI: 10.2310/7200.2009.0008

J. Mao, T. Styles, A. Cheville, J. Wolf, S. Fernandes, J. Farrar

{"title":"Acupuncture for nonpalliative radiation therapy-related fatigue: feasibility study.","authors":"J. Mao, T. Styles, A. Cheville, J. Wolf, S. Fernandes, J. Farrar","doi":"10.2310/7200.2009.0008","DOIUrl":"https://doi.org/10.2310/7200.2009.0008","url":null,"abstract":"The purpose of this study was to determine the feasibility of an acupuncture clinical trial to prevent radiation therapy (RT)-induced fatigue. We conducted a cross-sectional survey study and a single-arm acupuncture clinical trial among patients undergoing RT. Patients with a Karnofsky score of less than 60, severe anemia, or substantial psychological diagnoses were excluded. Patients received up to 12 treatments of acupuncture over the entire course of their RT. The Lee Fatigue Scale (LFS) was administered at baseline, in the middle of RT, and at the end of RT, along with the Patient Global Impression of Change (PGIC). Among the 48 of 53 (91% response rate) survey participants, 20 (42%) reported that they would participate if the study were available, 13 (27%) would not participate, and 15 (31%) were unsure. Among the 16 trial participants, average fatigue and energy domains of the LFS remained stable during and after RT, without any expected statistical decline owing to RT. Based on the PGIC at the end of RT, 2 subjects (13%) reported their fatigue as worse, 8 (50%) as stable, and 6 (37%) as better. Acupuncture has the potential to prevent RT-related fatigue, which will need to be confirmed by conducting a randomized controlled trial.","PeriodicalId":87409,"journal":{"name":"Journal of the Society for Integrative Oncology","volume":"7 2 1","pages":"52-8"},"PeriodicalIF":0.0,"publicationDate":"2009-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2310/7200.2009.0008","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68605271","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 39

Impact of healing touch on pediatric oncology outpatients: pilot study. 治疗触摸对儿科肿瘤科门诊患者的影响:初步研究。

Journal of the Society for Integrative Oncology Pub Date : 2009-01-01

Kathi J Kemper, Nancy B Fletcher, Craig A Hamilton, Thomas W McLean

{"title":"Impact of healing touch on pediatric oncology outpatients: pilot study.","authors":"Kathi J Kemper, Nancy B Fletcher, Craig A Hamilton, Thomas W McLean","doi":"","DOIUrl":"","url":null,"abstract":"Healing Touch (HT) is a biofield therapy used to enhance well-being. We conducted a pilot study to assess its effects in pediatric oncology patients. We enrolled patients in the continuation or consolidation phase of therapy. Patients or their parent completed simple visual analogue scales (VASs; 0-10) for relaxation, vitality, overall well-being, stress, anxiety, and depression before and after a 20-minute period of rest and a standardized HT treatment. Patients' heart rates were monitored and later analyzed for heart rate variability (HRV) characteristics. Of the nine patients, all completed VASs and six had usable HRV data. The average age was 9 years. VAS scores for stress decreased significantly more for HT treatment than for rest (HT: 4.4-1.7; rest: 2.3-2.3; p = .03). The HRV characteristic of total power was significantly lower during HT than for rest (HT 599 +/- 221; rest: 857 +/- 155; p = .048), and sympathetic activity was somewhat but not significantly lower (HT: 312 +/- 158; rest: 555 +/- 193; p = .06). HT is associated with lowered stress and changes in HRV. Further studies are needed to understand the mechanisms of these effects in larger samples and to explore the impact on additional clinically relevant measures.","PeriodicalId":87409,"journal":{"name":"Journal of the Society for Integrative Oncology","volume":"7 1","pages":"12-8"},"PeriodicalIF":0.0,"publicationDate":"2009-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"28203183","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Acupuncture for nonpalliative radiation therapy-related fatigue: feasibility study. 针刺治疗非姑息性放射治疗相关疲劳:可行性研究。

Journal of the Society for Integrative Oncology Pub Date : 2009-01-01

Jun James Mao, Terry Styles, Andrea Cheville, James Wolf, Shawn Fernandes, John T Farrar

{"title":"Acupuncture for nonpalliative radiation therapy-related fatigue: feasibility study.","authors":"Jun James Mao, Terry Styles, Andrea Cheville, James Wolf, Shawn Fernandes, John T Farrar","doi":"","DOIUrl":"","url":null,"abstract":"The purpose of this study was to determine the feasibility of an acupuncture clinical trial to prevent radiation therapy (RT)-induced fatigue. We conducted a cross-sectional survey study and a single-arm acupuncture clinical trial among patients undergoing RT. Patients with a Karnofsky score of less than 60, severe anemia, or substantial psychological diagnoses were excluded. Patients received up to 12 treatments of acupuncture over the entire course of their RT. The Lee Fatigue Scale (LFS) was administered at baseline, in the middle of RT, and at the end of RT, along with the Patient Global Impression of Change (PGIC). Among the 48 of 53 (91% response rate) survey participants, 20 (42%) reported that they would participate if the study were available, 13 (27%) would not participate, and 15 (31%) were unsure. Among the 16 trial participants, average fatigue and energy domains of the LFS remained stable during and after RT, without any expected statistical decline owing to RT. Based on the PGIC at the end of RT, 2 subjects (13%) reported their fatigue as worse, 8 (50%) as stable, and 6 (37%) as better. Acupuncture has the potential to prevent RT-related fatigue, which will need to be confirmed by conducting a randomized controlled trial.","PeriodicalId":87409,"journal":{"name":"Journal of the Society for Integrative Oncology","volume":"7 2","pages":"52-8"},"PeriodicalIF":0.0,"publicationDate":"2009-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3569525/pdf/nihms-438876.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"28203189","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evidence-based clinical practice guidelines for integrative oncology: complementary therapies and botanicals (2009). 综合肿瘤学循证临床实践指南:补充疗法和植物疗法(2009)。

Journal of the Society for Integrative Oncology Pub Date : 2009-01-01

Stephen M Sagar

引用次数: 0

Cancer-induced cachexia: a guide for the oncologist. 癌症诱发的恶病质:肿瘤学家指南。

Journal of the Society for Integrative Oncology Pub Date : 2009-01-01

Norleena Gullett, Peter Rossi, Omer Kucuk, Peter A S Johnstone

{"title":"Cancer-induced cachexia: a guide for the oncologist.","authors":"Norleena Gullett, Peter Rossi, Omer Kucuk, Peter A S Johnstone","doi":"","DOIUrl":"","url":null,"abstract":"Cancer-induced cachexia (CIC) is a paraneoplastic syndrome that may account for up to 20% of deaths in cancer patients. Cachexia includes distinct metabolic changes that are the result of an acute-phase response (APR) mounted by the host as a reaction to tumor cells. These changes include increased muscle proteolysis, increased fat lipolysis, and increased hepatic production of acute-phase proteins such as C-reactive protein and fibrinogen. This APR pathogenesis is an important consideration in trying to treat cachectic patients as most therapies do not target the APR and its subsequent metabolic effects. Although there is currently no cure for CIC, the oncologist frequently encounters cachectic patients in practice, and evidence-based management is needed. We review the current data for assessment of starvation and cachexia, providing guidelines for management that include serum markers and functional assessment. In addition, a review of current therapies is provided, including hypercaloric feeding and nutritional intervention to address starvation, as well as data on appetite stimulants such as corticosteroids and megestrol acetate. Experimental therapies are also discussed, including nonsteroidal antiinflammatory drugs, tumor necrosis factor alpha antagonists, tetrahydrocannabinol, growth hormone, ghrelin, oxandrolone, and omega-3 fatty acids.","PeriodicalId":87409,"journal":{"name":"Journal of the Society for Integrative Oncology","volume":"7 4","pages":"155-69"},"PeriodicalIF":0.0,"publicationDate":"2009-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"28483329","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Acupuncture for fatigue during radiation therapy: points made. 放射治疗中疲劳的针灸:穴位。

Journal of the Society for Integrative Oncology Pub Date : 2009-01-01

Deng Gary

引用次数: 0

Evidence-based clinical practice guidelines for integrative oncology: complementary therapies and botanicals. 综合肿瘤学循证临床实践指南:补充疗法和植物疗法。

Journal of the Society for Integrative Oncology Pub Date : 2009-01-01

Gary E Deng, Moshe Frenkel, Lorenzo Cohen, Barrie R Cassileth, Donald I Abrams, Jillian L Capodice, Kerry S Courneya, Trish Dryden, Suzanne Hanser, Nagi Kumar, Dan Labriola, Diane W Wardell, Stephen Sagar

引用次数: 0

Evidence-based clinical practice guidelines for integrative oncology: complementary therapies and botanicals. 综合肿瘤学循证临床实践指南:补充疗法和植物疗法。

Journal of the Society for Integrative Oncology Pub Date : 2009-01-01 DOI: 10.2310/7200.2009.0019

G. Deng, M. Frenkel, L. Cohen, B. Cassileth, D. Abrams, J. Capodice, K. Courneya, T. Dryden, S. Hanser, Nagi B. Kumar, D. Labriola, D. Wardell, S. Sagar

{"title":"Evidence-based clinical practice guidelines for integrative oncology: complementary therapies and botanicals.","authors":"G. Deng, M. Frenkel, L. Cohen, B. Cassileth, D. Abrams, J. Capodice, K. Courneya, T. Dryden, S. Hanser, Nagi B. Kumar, D. Labriola, D. Wardell, S. Sagar","doi":"10.2310/7200.2009.0019","DOIUrl":"https://doi.org/10.2310/7200.2009.0019","url":null,"abstract":"In recent years, the term integrative medicine has gained acceptance in medical academia. The Consortium of Academic Health Centers for Integrative Medicine defi nes this term as “the practice of medicine that reaffi rms the importance of the relationship between practitioner and patient, focuses on the whole person, is informed by evidence, and makes use of all appropriate therapeutic approaches, healthcare professionals, and disciplines to achieve optimal health and healing.” 1 Integrative oncology has been specifi cally described as both a science and a philosophy that focuses on the complex health of people with cancer and proposes an array of approaches to accompany the conventional therapies of surgery, chemotherapy, molecular therapeutics, and radiotherapy to facilitate health. 2 The SIO and its Medline -indexed journal ( Journal of the Society of Integrative Oncology ), founded by leading oncologists and oncology professionals from major cancer centers and organizations, promote quality research and appropriate application of useful, adjunctive complementary modalities T he Society for Integrative Oncology (SIO) is an international organization dedicated to encouraging scientifi c evaluation, dissemination of evidence-based information, and appropriate clinical integration of complementary therapies. Practice guidelines have been developed by the authors and endorsed by the Executive Committee of the SIO. Guidelines are a work in progress; they will be updated as needed and are available on the SIO Web site ().","PeriodicalId":87409,"journal":{"name":"Journal of the Society for Integrative Oncology","volume":"7 3 1","pages":"85-120"},"PeriodicalIF":0.0,"publicationDate":"2009-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2310/7200.2009.0019","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68604970","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 259