Journal of systems and integrative neuroscience最新文献_第3页

Diagnostic value of transcranial sonography for patients with Parkinson’s disease in the chinese population：A meta and meta-regression analysis 经颅超声对中国人群帕金森病患者的诊断价值:荟萃和荟萃回归分析

Journal of systems and integrative neuroscience Pub Date : 2020-01-01 DOI: 10.15761/JSIN.1000214

Bo Liu, Wenjing Luo, Yingmin Mo, Chun-hua Wei, Min Han

{"title":"Diagnostic value of transcranial sonography for patients with Parkinson’s disease in the chinese population：A meta and meta-regression analysis","authors":"Bo Liu, Wenjing Luo, Yingmin Mo, Chun-hua Wei, Min Han","doi":"10.15761/JSIN.1000214","DOIUrl":"https://doi.org/10.15761/JSIN.1000214","url":null,"abstract":"Background: To evaluate the diagnostic accuracy of substantia nigra hyper-echogenicity by transcranial sonography (TCS) for the diagnosis of Parkinson’s disease (PD) in the Chinese population. Methods: We searched the electronic databases of Cochrane Central Register of Controlled Trials (CENTRAL), Pubmed, Embase, China National Knowledge Infrastructure (CNKI), Chinese Biomedical Database (CBM) up to Dec 2018 for related articles. All the published population-based studies investigating diagnostic value of TCS for PD patients in China were searched and evaluated. A meta and meta-regression analysis was performed to calculate the available data from each research. Meta—Disc 1.4 statistics software was used. Results: 23 studies with 1478 PD patients were analyzed. The pooled sensitivity, specificity, positive likelihood radio (LR+), negative 1ikellhood ratio (LR-) and diagnostic odds ratio (DOR) of TCS were 0.78 (95% confidence interval (CI): 0.75, 0.80), 0.87 (95% CI: 0.85, 0.89), 6.74 (95% CI: 5.04, 8.31), 0.23 (95% CI: 0.19, 0.28) and 31.32 (95% CI: 21.28, 46.09), respectively, for differentiating PD patients from healthy controls. The AUC and Q index was 0.9119 and 0.8442, respectively. In the subgroup and meta-regression analysis, we found that the important cause of heterogeneity was the sample size of PD patients (P=0.0051). Conclusion: TCS is an effective and useful tool to detect and distinguish PD from healthy controls in the Chinese individuals.","PeriodicalId":87318,"journal":{"name":"Journal of systems and integrative neuroscience","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67484749","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Linking autism to an imbalanced catabolism of synaptic monoamines 自闭症与突触单胺的不平衡分解代谢有关

Journal of systems and integrative neuroscience Pub Date : 2020-01-01 DOI: 10.15761/jsin.1000216

Dominique G. Béroule

{"title":"Linking autism to an imbalanced catabolism of synaptic monoamines","authors":"Dominique G. Béroule","doi":"10.15761/jsin.1000216","DOIUrl":"https://doi.org/10.15761/jsin.1000216","url":null,"abstract":"An interdisciplinary study of autism led to implicate a relatively poor catabolism of one of the monoamines released in the synapse, namely serotonin . This deficit would result from persistent epigenetic regulations of two enzymes (i.e.: MAOA- and COMT+) across neural differentiation, for counteracting an accidental excess of MAOA in the early gestation. Epigenetic traits would outlast this temporary excess and be inherited by generations of neurons, and possibly by next human generations. In addition, the late occurrence of autistic symptoms may be consistent with the rising of the MAOB enzyme that degrades another monoamine ( dopamine ), but only significantly around two years after birth. The consequent long-term imbalance of synaptic monoamines is assumed here to impact the architecture of sleep and learning [1], inducing a range of developmental problems. This theory is drawn on Guided Propagation Networks (GPNs), the computer simulations of which show the growth of aberrant structures when modulation parameters akin to monoamines do not satisfy inner learning constraints. Comparisons are made between a reference well-tuned network and others grown with shifted parameters, all using the same learning data. Unlike the reference network, impaired GPNs display features that have been observed in the autistic","PeriodicalId":87318,"journal":{"name":"Journal of systems and integrative neuroscience","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67485399","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Proposing FDA consideration for the treatment and prophylaxis of opioid and psychostimulant abuse to incorporate the induction of DNA guided dopamine homeostasis: Anti-reward deficiency restoration solution (ARDS). 建议美国食品和药物管理局考虑将 DNA 引导的多巴胺平衡诱导纳入阿片类药物和精神兴奋剂滥用的治疗和预防中：反奖赏缺乏恢复方案（ARDS）。

Journal of systems and integrative neuroscience Pub Date : 2020-01-01 Epub Date: 2020-12-15 DOI: 10.15761/JSIN.1000253

Kenneth Blum, John Giordano, David Baron, Thomas McLaughlin, Rajendra D Badgaiyan

{"title":"Proposing FDA consideration for the treatment and prophylaxis of opioid and psychostimulant abuse to incorporate the induction of DNA guided dopamine homeostasis: Anti-reward deficiency restoration solution (ARDS).","authors":"Kenneth Blum, John Giordano, David Baron, Thomas McLaughlin, Rajendra D Badgaiyan","doi":"10.15761/JSIN.1000253","DOIUrl":"10.15761/JSIN.1000253","url":null,"abstract":"Background: In face of an American opioid/psychostimulant crisis with overdose fatalities, due, in part, to the COVOD 19 pandemic, we are proposing a paradigm shift in response. Currently, The FDA has approved pharmaceuticals for the treatment of opioids, alcohol, and nicotine but not for psychostimulants or even cannabis.Proposition: To respond to the deadly overdose issue globally, we are proposing that the FDA embrace, for the treatment and prophylaxis of opioid and psychostimulant abuse, induction of DNA-guided, dopamine homeostasis. We refer to this novel therapeutic target as the Anti-Reward Deficiency Restoration Solution (ARDS).Expert opinion: This futuristic proposal regarding the FDA will provide important information that may ultimately lead to significant improvement in the recovery of individuals with opioid/psychostimulant and polydrug abuse issues, especially, those with genetically-induced dopamine deficiency.Conclusion: With large populations supporting these initial results, and possibly even additional candidate genes and single nucleotide polymorphisms, the neuroscience and neurological community may eventually have the clinical ability to classify addiction severity, according to genotype and possession of risk alleles. A promising goal is the identification of high risk vulnerability, along with the provision of a safe, non-addicting ARDS natural nutrigenomic, involving a therapeutic model that potentially up-regulates instead of down-regulates dopaminergic receptors, preferably, the D2 subtype, is one laudable goal.","PeriodicalId":87318,"journal":{"name":"Journal of systems and integrative neuroscience","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9670280/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40504701","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Profile of immune cell populations in an early-onset Parkinson’s disease patient (EOPD) 早发性帕金森病(EOPD)患者免疫细胞群特征

Journal of systems and integrative neuroscience Pub Date : 2020-01-01 DOI: 10.15761/jsin.1000232

Martin Eduardo Torres-Velasco, Jaquelín Leyva-Hernández, A. Arce-Sillas, M. Rodríguez‐Violante, L. Adalid-Peralta

引用次数: 0

Laser microdissection method for neurodegenerative diseases 神经退行性疾病的激光显微解剖方法

Journal of systems and integrative neuroscience Pub Date : 2020-01-01 DOI: 10.15761/jsin.1000239

Yamaoka H, S. T., Nagata K, Tsuji S, M. K, Hachiya N

引用次数: 0

Electroencephalography (EEG)-based detection, management, recovery and brain retraining tracking of Traumatic Brain Injury (TBI) when “Only Time Can Tell” 基于脑电图(EEG)的“只有时间能证明”的创伤性脑损伤(TBI)的检测、治疗、康复和脑再训练跟踪

Journal of systems and integrative neuroscience Pub Date : 2020-01-01 DOI: 10.15761/JSIN.1000230

Priya Miranda, Christopher D Cox, Michael Alexander, Lakey Jrt, S. Danev

{"title":"Electroencephalography (EEG)-based detection, management, recovery and brain retraining tracking of Traumatic Brain Injury (TBI) when “Only Time Can Tell”","authors":"Priya Miranda, Christopher D Cox, Michael Alexander, Lakey Jrt, S. Danev","doi":"10.15761/JSIN.1000230","DOIUrl":"https://doi.org/10.15761/JSIN.1000230","url":null,"abstract":"Traumatic brain injury (TBI) can be caused by accidents like road traffic accidents (RTA), sports injuries, and injuries at home. It is a major health issue, very often fatal and causing high morbidity, changing the lives of both the person injured and the families involved. Anticipating and preventing secondary injury and seizures post-trauma, defining severity of TBI, predicting TBI outcomes and arousal from coma or declaration of vegetative state or brain death form pivotal checkpoints in TBI management. Other challenges faced include identifying malingerers from genuine individuals with post-TBI morbidity, defining the severity of previous TBI in the field or previous injuries when reports are lost. Depending on both its severity and location it can cause a variety of post-TBI cognitive, sensory and tactile, and motor impairments. In such instances the present paper looks at how the electroencephalographs (EEG) like NeuralScan can and do contribute uniquely and significantly aiding in assessment, continuous/periodic evaluation during the course of recovery, brain-retraining and rehabilitation in evaluating temporal changes in neuronal functionality following TBI.","PeriodicalId":87318,"journal":{"name":"Journal of systems and integrative neuroscience","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67485998","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Disturbed calcium-vitamin D metabolism in patients on anti-epileptic drugs 抗癫痫药物对患者钙-维生素D代谢的影响

Journal of systems and integrative neuroscience Pub Date : 2020-01-01 DOI: 10.15761/JSIN.1000223

Dabla Pk, S. Sharma, Puri

{"title":"Disturbed calcium-vitamin D metabolism in patients on anti-epileptic drugs","authors":"Dabla Pk, S. Sharma, Puri","doi":"10.15761/JSIN.1000223","DOIUrl":"https://doi.org/10.15761/JSIN.1000223","url":null,"abstract":"Introduction: Epilepsy is a common chronic neurological disorder, usually requiring long term treatment with anti-epileptic drugs (AEDs). There is paucity in data in relation to the effect of AED on calcium metabolism in North India. In view of this the present study was undertaken to assess the effect of AED on calcium metabolism. Methods: The present cross-sectional study included epileptic patients of both sex attending the neurology OPD & IPD clinics. Patients were divided into three groups: - group1 included patients on monotherapy receiving 1 AED, group 2 on dual therapy receiving 2 AED and group 3 patients on polytherapy receiving>2 AED. Serum analysis of total calcium, phosphorus, alkaline phosphorus, ionised calcium & vitamin D levels were conducted. The data between the groups was analyzed by using 1 way analysis of variance (ANOVA). Results: The study included 150 patients in which 50 patients each belonged to groups1, 2 and 3 respectively. 60% patients were male. 86 patients had generalised epilepsy and 64 suffered from partial seizures. 42% of the patients were on AED treatment for>5 years. Serum levels of calcium and vitamin D were significantly decreased (p=.000 and p>0.05 respectively) in the polytherapy group in comparison to the mono and dual therapy groups. On the other hand, alkaline phosphatase & phosphorus levels were significantly increased in the polytherapy group (p=.000). Conclusion: Hypovitaminosis was commonly observed in the patients on AED, even at sub-therapeutic serum levels of the drug.","PeriodicalId":87318,"journal":{"name":"Journal of systems and integrative neuroscience","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67485241","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bilateral changes in cell density within the central auditory pathway upon chronic unilateral intra-cochlear stimulation 慢性单侧耳蜗内刺激对中枢听觉通路内双侧细胞密度的影响

Journal of systems and integrative neuroscience Pub Date : 2020-01-01 DOI: 10.15761/JSIN.1000215

D. Basta, S. Jansen, M. Gröschel, S. Schwitzer, P. Boyle, A. Ernst, R. Seidl

{"title":"Bilateral changes in cell density within the central auditory pathway upon chronic unilateral intra-cochlear stimulation","authors":"D. Basta, S. Jansen, M. Gröschel, S. Schwitzer, P. Boyle, A. Ernst, R. Seidl","doi":"10.15761/JSIN.1000215","DOIUrl":"https://doi.org/10.15761/JSIN.1000215","url":null,"abstract":"Cochlear implants have been applied successfully for the treatment of unilateral hearing loss with quite a surprising benefit. One reason for this successful treatment could be the occurrence of neuroplastic changes within the central auditory pathway upon a bimodal stimulation. Important parameters of the electro-stimulation which could trigger neuroplastic changes are largely unknown. The present study, therefore, investigated at a cellular level, the effect of different stimulation rates and intensities on key structures of the central auditory pathway. Normal-hearing guinea pigs were mechanically single-sided deafened through a standard HiFocus1j electrode array being inserted into the first turn of the cochlea. Four to five electrode contacts were available for stimulation. After eCAP-threshold based speech processor fitting, three experimental groups were stimulated 16 hours per day for 90 days. A HiRes ® -strategy, based on one of three stimulation rates, low-rate 275 pps/ch, mid-rate 1500 pps/ch, or high-rate 5000 pps/ch was used, with the animals living in a standardised free field auditory environment. Afterwards, the cell density was determined in key structures of the auditory pathway. Results were compared to those of unilateral implanted but not stimulated controls. A bilateral conservation of all the brain structures investigated was found in the low- and high-rate groups. A significant cell loss was observed in the mid-rate group. This group also showed the highest mean stimulation current. Unilateral intra-cochlear electrical-stimulation leads to bilateral central nervous changes which correlate with the stimulation current applied rather than the stimulation rate applied.","PeriodicalId":87318,"journal":{"name":"Journal of systems and integrative neuroscience","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67485324","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

New insights into America's epidemic of autism spectrum disorders. The simple solution 对美国自闭症谱系障碍流行的新见解。简单的解决方案

Journal of systems and integrative neuroscience Pub Date : 2020-01-01 DOI: 10.15761/JSIN.1000222

Strunecka A, Strunecky O

引用次数: 0

Journal of systems and integrative neuroscience Pub Date : 2020-01-01 DOI: 10.15761/JSIN.1000225

Priya Miranda, Christopher D Cox, Michael Alexander, S. Danev, J. Lakey

{"title":"Event-related-potential (ERP) markers of traumatic brain injury (TBI) severity and cognitive function – Understanding how the brain works and thinks post TBI","authors":"Priya Miranda, Christopher D Cox, Michael Alexander, S. Danev, J. Lakey","doi":"10.15761/JSIN.1000225","DOIUrl":"https://doi.org/10.15761/JSIN.1000225","url":null,"abstract":"One fact is that other injuries often co-occur with traumatic brain Injury (TBI), thus event related potentials (ERPs) elicited using electroencephalography (EEG) machines like NeuralScan by Medeia often reflect the sum of both injuries. The second fact is that cognitive function includes domains from knowledge, attention, memory and working memory, judgment and evaluation, reasoning and “computation” to problem solving and decision-making. The third is that cross-border mental or neurocognitive or non-traumatic brain disorders that exhibit similar symptoms post-TBI will exhibit impairments in similar domains. Therefore, what if observing similar a) altered EEG-functional connectivity in post-TBI as in Alzheimer’s, epileptic seizures, schizophrenia, stroke etc or b) altered network geometries in post- TBI as in CNS tumors, depression etc is the status quo? What if the reason we are not able to identify pathognomic ERP-markers of cognitive impairment post-TBI that are highly specific and sensitive is simply because we are not thinking as the brain does? What if trying to validate ERP markers of TBI-severity and cognitive function post-TBI in the same manner one validates a candidate diagnostic test is what’s wrong in the first place? Is it possible that domain- and symptom-based identification, management and treatment of cognitive-impairments or TBI-severity are the way to go?","PeriodicalId":87318,"journal":{"name":"Journal of systems and integrative neuroscience","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67485300","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1