{"title":"Cholera, Iron and Mental Illness in Nineteenth-Century Saint John, NB","authors":"Paul Te Cusacki","doi":"10.4172/2155-6180.1000341","DOIUrl":"https://doi.org/10.4172/2155-6180.1000341","url":null,"abstract":"Saint John has a very high rate of Sz in its mainly Irish population. In this paper I examine the possible cause of iron from cast iron piping along with iron in the diet that lead to a weakened immune system and consequent contagious disease such as Cholera. Cholera may do damage to the DNA of fertile women who pass it on to their offspring.","PeriodicalId":87294,"journal":{"name":"Journal of biometrics & biostatistics","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2017-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41759787","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"More on the Robust Solution for Epidemiology: Nineteenth-CenturyQuebec","authors":"Paul Te Cusacki","doi":"10.4172/2155-6180.1000342","DOIUrl":"https://doi.org/10.4172/2155-6180.1000342","url":null,"abstract":"Here we consider the Robust Solution as applied to the cholera epidemic in Lower Canada (Quebec) in 1832. We find that the mathematics from that procedure provides the mathematical foundation or the study. The rate of growth of the virus must be kept below 14% to terminate the spread of the disease.","PeriodicalId":87294,"journal":{"name":"Journal of biometrics & biostatistics","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2017-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42923340","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Comparisons of Modeling Approaches for Evaluating the LongitudinalAssociation in a Clustered Healthcare Intervention Study","authors":"Yulan Liang","doi":"10.4172/2155-6180.1000340","DOIUrl":"https://doi.org/10.4172/2155-6180.1000340","url":null,"abstract":"This paper addresses methodology issues related to evidence-based healthcare research, specifically when evaluating and analyzing the hospital practice environments (HPE) impacts on the patient health outcomes are conducted in longitudinal intervention survey studies. HPE include the spatially clustered hospital characteristics, including practice environment scale (PES) measures, hospital facilities, nursing staffing and nursing attributes. The longitudinal associations between HPE and patient smoking cessation counseling (SCC) activities, and patient heart failure (HF) outcomes are examined. Various longitudinal and hierarchical modeling are compared including linear mixed models with restricted maximum likelihood estimation, generalized estimating equations with quasi-likelihood estimation, hierarchical linear regression models with nonparametric generalized least squares estimations, and repeated ANOVA. Moreover, both pre-modeling including the items/dimension reduction issues for longitudinal item-response hospital survey data and post-modeling (the mediation analysis) are discussed and conducted. Results show some methodology and solution differences when including the spatial or temporal correlations of HPE simultaneously for examining the longitudinal effects of HPE on HF core outcome measures adjusted or potentially mediated by SCC and nurse staffing environmental variables. This may have implications and potential impact for healthcare decision-making. Patients can benefit from these research findings.","PeriodicalId":87294,"journal":{"name":"Journal of biometrics & biostatistics","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2017-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49188247","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A New Method for Analysis of Biomolecules Using the BSM-SG Atomic Models","authors":"S. Sargoytchev","doi":"10.4172/2155-6180.1000339","DOIUrl":"https://doi.org/10.4172/2155-6180.1000339","url":null,"abstract":"Biomolecules and particularly proteins and DNA exhibit some mysterious features that cannot find satisfactory explanation by quantum mechanical modes of atoms. One of them, known as a Levinthal’s paradox, is the ability to preserve their complex three-dimensional structure in appropriate environments. Another one is that they possess some unknown energy mechanism. The Basic Structures of Matter Supergravitation Unified Theory (BSM-SG) allows uncovering the real physical structures of the elementary particles and their spatial arrangement in atomic nuclei. The resulting physical models of the atoms are characterized by the same interaction energies as the quantum mechanical models, while the structure of the elementary particles influence their spatial arrangement in the nuclei. The resulting atomic models with fully identifiable parameters and angular positions of the quantum orbits permit studying the physical conditions behind the structural and bonding restrictions of the atoms connected in molecules. A new method for a theoretical analysis of biomolecules is proposed. The analysis of a DNA molecule leads to formulation of hypotheses about the energy storage mechanism in DNA and its role in the cell cycle synchronization. This permits shedding a light on the DNA feature known as a C-value paradox. The analysis of a tRNA molecule leads to formulation of a hypothesis about a binary decoding mechanism behind the 20 flavors of the complex aminoacyle-tRNA synthetases - tRNA, known as a paradox.","PeriodicalId":87294,"journal":{"name":"Journal of biometrics & biostatistics","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2017-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4172/2155-6180.1000339","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48990784","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"On Finding the Upper Confidence Limit for a Binomial Proportion when Zero Successes are Observed","authors":"Courtney E. McCracken, S. Looney","doi":"10.4172/2155-6180.1000338","DOIUrl":"https://doi.org/10.4172/2155-6180.1000338","url":null,"abstract":"We consider confidence interval estimation for a binomial proportion when the data have already been observed and x, the observed number of successes in a sample of size n, is zero. In this case, the main objective of the investigator is usually to obtain a reasonable upper bound for the true probability of success, i.e., the upper limit of a one-sided confidence interval. In this article, we use observed interval length and p-confidence to evaluate eight methods for finding the upper limit of a confidence interval for a binomial proportion when x is known to be zero. Long-run properties such as expected interval length and coverage probability are not applicable because the sample data have already been observed. We show that many popular approximate methods that are known to have good long-run properties in the general setting perform poorly when x=0 and recommend that the Clopper-Pearson exact method be used instead.","PeriodicalId":87294,"journal":{"name":"Journal of biometrics & biostatistics","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2017-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4172/2155-6180.1000338","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46391756","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Comparison of the Hemoglobin Amount between Old and Young Persons in Bosnia and Herzegovina","authors":"Senol Dogan, Esra Mermer","doi":"10.4172/2155-6180.1000337","DOIUrl":"https://doi.org/10.4172/2155-6180.1000337","url":null,"abstract":"Hemoglobin is a unique protein, which is responsible for oxygen and carbon dioxide transportation all the body. The protein location is inside the erythrocytes and the special oval shape makes it easily pass through blood walls to supply oxygen to the tissues and organs. It is supposed that the hemoglobin amount could change depending on the person`s age, gender or nationality. We designed a research to see the molecular differences among Bosnian and Turkish young person`s whose age interval is 18-23 and old person`s age interval is 43-65. Totally 300 person`s, 50 from each Bosnian/ Turkish Female/Male and 50 old male and 50 old female were selected for the research. The students` the hemoglobin amount has been recorded individually and presented in a table. As a result of the measurement, The Turkish females average has the lowest hemoglobin Turkish males average shows the maximum amount of hemoglobin, 12.01 g/dl and 14.65 g/dl respectively. When the female gets older their the hemoglobin amount increase in their blood, 7.3% in Bosnian and 12.2% in Turkish. On the other side, the male blood the hemoglobin amount is almost similar by aging, Bosnian male hemoglobin just increase 0.74%, but in Turkish male 1.3% decrease. The result shows that female the hemoglobin amount is affected by age more than male.","PeriodicalId":87294,"journal":{"name":"Journal of biometrics & biostatistics","volume":" ","pages":"0-0"},"PeriodicalIF":0.0,"publicationDate":"2017-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4172/2155-6180.1000337","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47841302","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Misconceptions and Perceptions on Breast Cancer Risk in Kilifi SouthSubcounty","authors":"L. Alii","doi":"10.4172/2155-6180.1000336","DOIUrl":"https://doi.org/10.4172/2155-6180.1000336","url":null,"abstract":"The objective was to find out the misconceptions and perceptions associated with breast cancer in Kilifi south subcounty. A survey was conducted on a random sample of women in Kilifi South with no history of breast cancer. The Survey instrument were questionnaires which included measures of perceptions and misconceptions of breast cancer for themselves and for the average woman, perceptions of risk factors that influenced their risk and the average woman’s risk for breast cancer. Descriptive statistics, chi-square tests and spearman’s correlations were used to analyze the data. A spearman’s correlation coefficient showed that, women’s perceptions on Witchcraft as a cause for cancer were related to Cancer being a curse. The correlation was statistically significant at 5% level of significance, (R=0. 5182, S=4462.4, p=0.0003016). A Pearson’s chi-square test also confirmed this (χ2=47.407, P-value=0.000). This probably explains why the uptake of screening services provided by the government in the health centers across the counties has not been effective.","PeriodicalId":87294,"journal":{"name":"Journal of biometrics & biostatistics","volume":" ","pages":"0-0"},"PeriodicalIF":0.0,"publicationDate":"2017-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46348887","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nathaniel S O'Connell, Lin Dai, Yunyun Jiang, Jaime L Speiser, Ralph Ward, Wei Wei, Rachel Carroll, Mulugeta Gebregziabher
{"title":"Methods for Analysis of Pre-Post Data in Clinical Research: A Comparison of Five Common Methods.","authors":"Nathaniel S O'Connell, Lin Dai, Yunyun Jiang, Jaime L Speiser, Ralph Ward, Wei Wei, Rachel Carroll, Mulugeta Gebregziabher","doi":"10.4172/2155-6180.1000334","DOIUrl":"https://doi.org/10.4172/2155-6180.1000334","url":null,"abstract":"<p><p>Often repeated measures data are summarized into pre-post-treatment measurements. Various methods exist in the literature for estimating and testing treatment effect, including ANOVA, analysis of covariance (ANCOVA), and linear mixed modeling (LMM). Under the first two methods, outcomes can either be modeled as the post treatment measurement (ANOVA-POST or ANCOVA-POST), or a change score between pre and post measurements (ANOVA-CHANGE, ANCOVA-CHANGE). In LMM, the outcome is modeled as a vector of responses with or without Kenward-Rogers adjustment. We consider five methods common in the literature, and discuss them in terms of supporting simulations and theoretical derivations of variance. Consistent with existing literature, our results demonstrate that each method leads to unbiased treatment effect estimates, and based on precision of estimates, 95% coverage probability, and power, ANCOVA modeling of either change scores or post-treatment score as the outcome, prove to be the most effective. We further demonstrate each method in terms of a real data example to exemplify comparisons in real clinical context.</p>","PeriodicalId":87294,"journal":{"name":"Journal of biometrics & biostatistics","volume":"8 1","pages":"1-8"},"PeriodicalIF":0.0,"publicationDate":"2017-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4172/2155-6180.1000334","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36787378","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"On the Relation between the Comprehension Ability and the NeocortexVerbal Areas","authors":"A. Michaud","doi":"10.4172/2155-6180.1000331","DOIUrl":"https://doi.org/10.4172/2155-6180.1000331","url":null,"abstract":"General description of the human neocortex verbal areas and exploration of the manner in which the synaptic neurolinguistic structure that develops in these areas after birth establishes our comprehension ability. Description of the manner in which the neurolinguistic subjective model of reality that develops in these areas can be made to evolve towards objective representation.","PeriodicalId":87294,"journal":{"name":"Journal of biometrics & biostatistics","volume":"8 1","pages":"0-0"},"PeriodicalIF":0.0,"publicationDate":"2017-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42185753","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Relative Biochemical Basis of Susceptibility in Commercial WheatVarieties against Angoumois Grain Moth, Sitotroga cerealella (Olivier) andConstruction of its Life Table","authors":"M. SafianMurad, Z. Batool","doi":"10.4172/2155-6180.1000333","DOIUrl":"https://doi.org/10.4172/2155-6180.1000333","url":null,"abstract":"A study was conducted to evaluate the relative biochemical basis of susceptibility of six commercial wheat varieties grown in Khyber Pakhtunkhwa, Pakistan, against angoumois grain moth, Sitotroga cerealella (Olivier) (Lepidoptera: Gelechiidae) and construction of its life table at 28 ± 1°C, 65 ± 5 R.H.% and L:D 16:8 hours under laboratory environment. The results were evaluated on the basis of mean pest S. cerealella emergence, percent damage, and percent weight loss, male and female emerged along susceptibility index, 1000 grains weight, hardness and chemical composition of test wheat materials. Life table parameters of S. cerealella on highly susceptible and least susceptible wheat varieties were compared. On the basis of susceptibility index, variety Sirin (5.002) was recorded least susceptible and variety Pirsbak-2005 (7.832) recorded as highly susceptible. The chemical composition based on protein and carbohydrate contents (11.15%, 72.54%) revealed that the variety Sirin was recorded least susceptible, while variety Pirsabak-2005 (12.68%, 75.00%) was noted as highly susceptible. On the basis of life table, the net reproductive rate (10.9) on variety Pirsabak-2005 was higher than variety Sirin (9.4), and the intrinsic rate of increase was also higher on Pirsabak-2005 (30.7) than Sirin (15.9). With respect to doubling time being index of resistance, this time in Pirsabak-2005 was almost half (0.01 days) of the Sirin (0.02 days), which means that S. cerealella can develop more quickly on Pirsabak-2005 germplasm. In summation, relatively least susceptible wheat variety Sirin can be used to increase the level and diversify the basis of resistance to S. cerealella in the resistance breeding programs.","PeriodicalId":87294,"journal":{"name":"Journal of biometrics & biostatistics","volume":" ","pages":"0-0"},"PeriodicalIF":0.0,"publicationDate":"2017-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49341285","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}