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The Role of the Microbiome in Cancer and the Development of Cancer Therapeutics. 微生物组在癌症中的作用和癌症治疗的发展。
International journal of biopharmaceutical sciences Pub Date : 2020-09-01 Epub Date: 2020-09-05
Kaitlyn C Belknap, Andrea L Cote, Colin M McGill, Cheryl P Andam, Brian M Barth
{"title":"The Role of the Microbiome in Cancer and the Development of Cancer Therapeutics.","authors":"Kaitlyn C Belknap,&nbsp;Andrea L Cote,&nbsp;Colin M McGill,&nbsp;Cheryl P Andam,&nbsp;Brian M Barth","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Cancer is caused by a compilation of hereditary and environmental factors. In the past decade, next-generation sequencing has revealed the extent to which the microbiome influences the maintenance of homeostasis and therefore the prevention of diseases such as cancer. Current research efforts explore the interaction between cancer and the microbiome, and the results are anticipated to transform how clinicians approach cancer treatment. There is a plausible transition from the use of human genetic biomarkers to microbiomic biomarkers for genomic diagnostics. Considering the expanding knowledge of the ways in which the microbiome can affect the development of cancer, clinicians treating cancer patients should be considerate of how the microbiome can influence the host-drug or microbiome-cancer interactions. Recognition of the importance of the microbiome within the field of oncology is pertinent to understanding and furthering cancer development and treatment.</p>","PeriodicalId":87276,"journal":{"name":"International journal of biopharmaceutical sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7993822/pdf/nihms-1680228.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25528465","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Epigenetics and Sphingolipid Metabolism in Health and Disease. 健康和疾病中的表观遗传学和鞘脂代谢。
International journal of biopharmaceutical sciences Pub Date : 2018-10-01 Epub Date: 2018-01-22 DOI: 10.31021/ijbs.20181105
Weiyuan Wang, Paul T Toran, Rachel Sabol, Timothy J Brown, Brian M Barth
{"title":"Epigenetics and Sphingolipid Metabolism in Health and Disease.","authors":"Weiyuan Wang,&nbsp;Paul T Toran,&nbsp;Rachel Sabol,&nbsp;Timothy J Brown,&nbsp;Brian M Barth","doi":"10.31021/ijbs.20181105","DOIUrl":"https://doi.org/10.31021/ijbs.20181105","url":null,"abstract":"<p><p>Sphingolipids represent one of the major classes of bioactive lipids. Studies of sphingolipids have intensified in the past several years, revealing their roles in nearly all cell biological processes. In addition, epigenetic regulation has gained substantial interest due to its role in controlling gene expression and activity without changing the genetic code. In this review, we first introduce a brief background on sphingolipid biology, highlighting its role in pathophysiology. We then illustrate the concept of epigenetic regulation, focusing on how it affects the metabolism of sphingolipids. We further discuss the roles of bioactive sphingolipids as epigenetic regulators themselves. Overall, a better understanding of the relationship between epigenetics and sphingolipid metabolism may help to improve the development of sphingolipid-targeted therapeutics.</p>","PeriodicalId":87276,"journal":{"name":"International journal of biopharmaceutical sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6326171/pdf/nihms964366.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36847990","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 5
Combinatorial Efficacy of Quercitin and Nanoliposomal Ceramide for Acute Myeloid Leukemia. 槲皮素与纳米脂质体神经酰胺联合治疗急性髓系白血病疗效观察。
International journal of biopharmaceutical sciences Pub Date : 2018-01-01 Epub Date: 2018-01-31 DOI: 10.31021/ijbs.20181106
Colin M McGill, Timothy J Brown, Lindsey N Fisher, Sally J Gustafson, Kriya L Dunlap, Adam J Beck, Paul T Toran, David F Claxton, Brian M Barth
{"title":"Combinatorial Efficacy of Quercitin and Nanoliposomal Ceramide for Acute Myeloid Leukemia.","authors":"Colin M McGill,&nbsp;Timothy J Brown,&nbsp;Lindsey N Fisher,&nbsp;Sally J Gustafson,&nbsp;Kriya L Dunlap,&nbsp;Adam J Beck,&nbsp;Paul T Toran,&nbsp;David F Claxton,&nbsp;Brian M Barth","doi":"10.31021/ijbs.20181106","DOIUrl":"https://doi.org/10.31021/ijbs.20181106","url":null,"abstract":"<p><p>Acute myeloid leukemia (AML) is an aggressive hematological malignancy with limited treatment options. Inflammation is often a contributing factor to the development and progression of AML, and related diseases, and can potentiate therapy failure. Previously, we had identified anti-inflammatory roles and anti-AML efficacy for blueberry extracts. The present study extended these observations to determine that the polyphenol quercetin inhibited neutral sphingomyelinase (N-SMase) activity and exerted anti-AML efficacy. Moreover, quercetin was shown to exert combinatorial anti-AML efficacy with nanoliposomal ceramide. Overall, this demonstrated that quercetin could block the pro-inflammatory actions of N-SMase and augment the efficacy of anti-AML therapeutics, including ceramide-based therapeutics.</p>","PeriodicalId":87276,"journal":{"name":"International journal of biopharmaceutical sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6349237/pdf/nihms959615.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36962155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 5
Therapeutic Effect of Blueberry Extracts for Acute Myeloid Leukemia. 蓝莓提取物对急性髓系白血病的治疗作用。
International journal of biopharmaceutical sciences Pub Date : 2018-01-01 Epub Date: 2018-01-02
Colin M McGill, Timothy J Brown, Yuan-Yin Cheng, Lindsey N Fisher, Sriram S Shanmugavelandy, Sally J Gustafson, Kriya L Dunlap, Mary Ann Lila, Mark Kester, Paul T Toran, David F Claxton, Brian M Barth
{"title":"Therapeutic Effect of Blueberry Extracts for Acute Myeloid Leukemia.","authors":"Colin M McGill,&nbsp;Timothy J Brown,&nbsp;Yuan-Yin Cheng,&nbsp;Lindsey N Fisher,&nbsp;Sriram S Shanmugavelandy,&nbsp;Sally J Gustafson,&nbsp;Kriya L Dunlap,&nbsp;Mary Ann Lila,&nbsp;Mark Kester,&nbsp;Paul T Toran,&nbsp;David F Claxton,&nbsp;Brian M Barth","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Acute myeloid leukemia (AML) is an aggressive hematological malignancy with high incidence in the aging population. In addition, AML is one of the more common pediatric malignancies. Unfortunately, both of these patient groups are quite sensitive to chemotherapy toxicities. Investigation of blueberries specifically as an anti-AML agent has been limited, despite being a prominent natural product with no reported toxicity. In this study, blueberry extracts are reported for the first time to exert a dietary therapeutic effect in animal models of AML. Furthermore, <i>in vitro</i> studies revealed that blueberry extracts exerted anti-AML efficacy against myeloid leukemia cell lines as well as against primary AML, and specifically provoked Erk and Akt regulation within the leukemia stem cell subpopulation. This study provides evidence that blueberries may be unique sources for anti-AML biopharmaceutical compound discovery, further warranting fractionation of this natural product. More so, blueberries themselves may provide an intriguing dietary option to enhance the anti-AML efficacy of traditional therapy for subsets of patients that otherwise may not tolerate rigorous combinations of therapeutics.</p>","PeriodicalId":87276,"journal":{"name":"International journal of biopharmaceutical sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5875929/pdf/nihms919519.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35967676","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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