Alaska's Flora as a Treatment for Cancer.

International journal of biopharmaceutical sciences Pub Date : 2024-12-01 Epub Date: 2024-08-16
Vasiliki Papakotsi, Ashley M Murphy, Madeline L Vagts, Emma J Arsenault, Colin M McGill, Brian M Barth
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Abstract

Cancer is an extraordinarily complex illness, with many tumors ultimately developing resistance to the currently available therapeutics. This highlights a need for the discovery of new anticancer medicines. Natural products have been utilized for centuries by the indigenous people of Alaska for both spiritual and medicinal purposes and have traditionally been administered as medicine for a wide range of ailments from the common cold to cancer. These plants, including Devil's club, Labrador tea, Western skunk cabbage, and various species of wild berries such as blueberries, lingonberries, salmonberries, and high-bush cranberries, contain a wide variety of natural compounds with therapeutic potential. Various anthocyanins and polyphenols, including quercetin, as well as the pentacyclic triterpenoid ursolic acid, have been identified in these medicinal plants and have demonstrated antioxidant, anti-inflammatory, and anticancer activity. These ethnobotanicals and the unique compounds found within may be integral to the development of novel therapeutics for the treatment of cancer and other conditions.

阿拉斯加的植物群可以治疗癌症。
癌症是一种非常复杂的疾病,许多肿瘤最终会对目前可用的治疗方法产生抗药性。这凸显了发现新的抗癌药物的必要性。几个世纪以来,阿拉斯加的土著居民一直将天然产品用于精神和医疗目的,传统上,它被用作治疗从普通感冒到癌症等各种疾病的药物。这些植物,包括魔鬼俱乐部、拉布拉多茶、西方臭鼬卷心菜,以及各种野生浆果,如蓝莓、越橘、鲑鱼和高丛蔓越莓,含有多种具有治疗潜力的天然化合物。各种花青素和多酚,包括槲皮素,以及五环三萜熊果酸,已经在这些药用植物中被鉴定出来,并已证明具有抗氧化、抗炎和抗癌活性。这些民族植物药和其中发现的独特化合物可能是开发治疗癌症和其他疾病的新疗法的组成部分。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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