Clinical archives of bone and joint diseases最新文献

筛选

英文中文

Damage to the Rotator Cuff of the Shoulder and Tendon of the Long Biceps Head during Chronic Posttraumatic Instability of the Shoulder Joint 慢性创伤后肩关节不稳定时肩袖和长二头肌肌腱的损伤

Clinical archives of bone and joint diseases Pub Date : 2018-12-31 DOI: 10.23937/CABJD-2017/1710008

A.А. Danilenka, E. Makarevich

引用次数: 0

Metal-Assisted and Microwave-Accelerated Decrystallization: An Alternative Approach to Potential Treatment of Crystal Deposition Diseases. 金属辅助和微波加速脱晶：治疗晶体沉积症的另一种方法。

Clinical archives of bone and joint diseases Pub Date : 2017-01-01 Epub Date: 2017-10-13 DOI: 10.23937/cabjd-2017/1710002

Nishone Thompson, Zainab Boone Kukoyi, Carisse Lansiquot, Salih Toker, Bridgit Kioko, Hillary Ajifa, Chinenye Nwawulu, Oluseyi Daodu, Kadir Aslan

{"title":"Metal-Assisted and Microwave-Accelerated Decrystallization: An Alternative Approach to Potential Treatment of Crystal Deposition Diseases.","authors":"Nishone Thompson, Zainab Boone Kukoyi, Carisse Lansiquot, Salih Toker, Bridgit Kioko, Hillary Ajifa, Chinenye Nwawulu, Oluseyi Daodu, Kadir Aslan","doi":"10.23937/cabjd-2017/1710002","DOIUrl":"10.23937/cabjd-2017/1710002","url":null,"abstract":"<p><p>Gout is a painful and prevalent crystal deposition disease caused by the overproduction of Uric Acid (UA) in the body and the atypical deposition in human synovial joints as Monosodium Urate Monohydrate (MSUM). Conventional treatments, such as NSAIDs, cyclooxygenase-2 inhibitors, and systemic glucocorticoids often present harmful side-effects and are short-lived. Long-term therapies including xanthine oxidase inhibitors and the use of uricosuric agents have been developed and aim to lower the UA serum levels in the body. As regards to post-crystals deposition, our research laboratory recently proposed and demonstrated the use of the Metal-Assisted and Microwave-Accelerated Decrystallization (MAMAD) technique for the breakdown of organic and biological crystals on planar surfaces. The MAMAD technique is based on the combined use of microwave heating and Au NPs in solution. The interactions of the Au NPs with microwave's electromagnetic field result in an increase in the kinetic energy of Au NPs, and subsequently, an increase in the collisions with target crystals placed on planar surfaces leading to rapid crystal breakdown. In this regard, our laboratory aims to develop the MAMAD technique as an alternative treatment for crystal deposition diseases, particularly gout, with minimal invasion and side-effects as compared to current treatments. In this review article, we will summarize our previous findings and provide additional data detailing the effectiveness of the MAMAD technique as a rapid and efficient method for the breakdown of gout related crystals and L-alanine crystals (a model crystal).</p>","PeriodicalId":87232,"journal":{"name":"Clinical archives of bone and joint diseases","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8025928/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25573399","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

首页上一页