Timely topics in medicine. Cardiovascular diseases最新文献

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Multimodal effects of available drugs for ischemic stroke. 缺血性卒中现有药物的多模态效应。
Michael Chen, Magdy Selim
{"title":"Multimodal effects of available drugs for ischemic stroke.","authors":"Michael Chen,&nbsp;Magdy Selim","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Recent research demonstrates the complexity and variety of pathophysiologic processes underlying cerebral ischemia. This review will focus on the multimodal effects of the various drugs currently used for stroke prevention. The most recent clinical studies of each will also be reviewed, and the implications for clinical use and future research discussed. An evolving approach for stroke prevention will include a combination of antiplatelets, increased use of statins, ACE inhibitors and possibly vitamin therapy.</p>","PeriodicalId":87159,"journal":{"name":"Timely topics in medicine. Cardiovascular diseases","volume":"9 ","pages":"E29"},"PeriodicalIF":0.0,"publicationDate":"2005-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25742753","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Statin-associated neuromyotoxicity. Statin-associated neuromyotoxicity。
Steven K Baker, Mark A Tarnopolsky
{"title":"Statin-associated neuromyotoxicity.","authors":"Steven K Baker,&nbsp;Mark A Tarnopolsky","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The sequelae of cardiovascular disease contribute significantly to morbidity and mortality in developed nations. As a class, the statins have been shown to measurably reduce the burden of atherosclerotic illness. However, muscle- and, more recently, nerve-related toxicity have emerged as potential complications leading to treatment withdrawal. Generally, the myopathic signs and symptoms of tenderness, myalgias, cramping and elevated serum creatine kinase (CK) activity are fully reversible after drug discontinuation. Growing evidence suggests that latent or previously minimal symptomatic muscle disease may predispose to the development of myopathy. Less information is available regarding the natural history of the sensorimotor neuropathy, but it appears to be less reversible if large fiber function is clinically manifest. Pathophysiologic clues regarding the potential causes of statin myopathy with or without neuropathy are discussed with particular attention paid to the implications of disrupted mevalonate metabolism. For example, secondary defects in isoprenoid biosynthesis are expected to impair the production of a variety of intermediaries such as dolichols, which are crucial for N-linked glycosylation; geranylgeranyl pyrophosphate, which is necessary for coenzyme Q10 and G-protein synthesis; farnesyl-pyrophosphate, which facilitates the endoproteolytic cleavage and maturation of prelamin A and modifies B-type lamins and G-proteins; and isopentenylpyrophosphate, which is involved in a nucleoside modification of selenocysteinyl-tRNA and thus indirectly related to the synthesis of all selenoproteins (estimated at 35). The nature of statin neuromyotoxicity remains unresolved; however, investigating the cellular corollaries of deranged isoprenoid metabolism may uncover clues that lead to a more complete understanding of the elusive pathophysiology.</p>","PeriodicalId":87159,"journal":{"name":"Timely topics in medicine. Cardiovascular diseases","volume":"9 ","pages":"E26"},"PeriodicalIF":0.0,"publicationDate":"2005-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25630730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
News in hypertension management: a report from the 15th European Meeting on Hypertension. 高血压管理新闻:来自第15届欧洲高血压会议的报告。
Xavier Rabasseda
{"title":"News in hypertension management: a report from the 15th European Meeting on Hypertension.","authors":"Xavier Rabasseda","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":87159,"journal":{"name":"Timely topics in medicine. Cardiovascular diseases","volume":"9 ","pages":"E22"},"PeriodicalIF":0.0,"publicationDate":"2005-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25286454","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Newsbites on diabetes and diabetes therapy: a report from the 65th Scientific Sessions of the American Diabetes Association. 关于糖尿病和糖尿病治疗的新闻报道:来自第65届美国糖尿病协会科学会议的报告。
Xavier Rabasseda
{"title":"Newsbites on diabetes and diabetes therapy: a report from the 65th Scientific Sessions of the American Diabetes Association.","authors":"Xavier Rabasseda","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":87159,"journal":{"name":"Timely topics in medicine. Cardiovascular diseases","volume":"9 ","pages":"E21"},"PeriodicalIF":0.0,"publicationDate":"2005-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25286453","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Thrombosis and angiogenesis. 血栓形成和血管生成。
Akira Matsumori
{"title":"Thrombosis and angiogenesis.","authors":"Akira Matsumori","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":87159,"journal":{"name":"Timely topics in medicine. Cardiovascular diseases","volume":"9 ","pages":"E18"},"PeriodicalIF":0.0,"publicationDate":"2005-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25265555","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Advances in the understanding of cardiovascular disease in diabetes mellitus: highlights from the Annual Professional Conference of Diabetes UK. 对糖尿病心血管疾病认识的进展:来自英国糖尿病年度专业会议的亮点。
Prabirkumar Bandyopadhyay
{"title":"Advances in the understanding of cardiovascular disease in diabetes mellitus: highlights from the Annual Professional Conference of Diabetes UK.","authors":"Prabirkumar Bandyopadhyay","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>April 20-22, 2005, Diabetes UK held its annual conference in Glasgow, United Kingdom. The meeting brought together investigators, clinicians, professionals and policy makers interested in the field of diabetes. This report will examine the advances in understanding the risk factors, epidemiology, risk reduction and management of cardiovascular disease and lipid abnormalities in diabetic patients.</p>","PeriodicalId":87159,"journal":{"name":"Timely topics in medicine. Cardiovascular diseases","volume":"9 ","pages":"E17"},"PeriodicalIF":0.0,"publicationDate":"2005-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25265263","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Modern therapy for hypertension and related disorders: a report from the 20th Annual Scientific Meeting of the American Society of Hypertension. May 14-18, 2005. San Francisco, California, USA. 高血压及相关疾病的现代治疗:美国高血压学会第20届年度科学会议报告2005年5月14日至18日。美国加州旧金山。
Xavier Rabasseda
{"title":"Modern therapy for hypertension and related disorders: a report from the 20th Annual Scientific Meeting of the American Society of Hypertension. May 14-18, 2005. San Francisco, California, USA.","authors":"Xavier Rabasseda","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":87159,"journal":{"name":"Timely topics in medicine. Cardiovascular diseases","volume":"9 ","pages":"E19"},"PeriodicalIF":0.0,"publicationDate":"2005-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25265264","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Adrenomedullin as a potent antioxidative and antiatherosclerotic substance. 肾上腺髓质素是一种有效的抗氧化和抗动脉粥样硬化物质。
Tatsuo Shimosawa, Toshiro Fujita
{"title":"Adrenomedullin as a potent antioxidative and antiatherosclerotic substance.","authors":"Tatsuo Shimosawa,&nbsp;Toshiro Fujita","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Adrenomedullin was originally discovered as a vasodilative peptide, but recent studies have revealed its pleiotropic effects. Among these studies, the antioxidative properties of adrenomedullin were observed in adrenomedullin knockout mice. Through its antioxidative effect, adrenomedullin can protect organs from damage induced by high blood pressure, ischemia and aging. This indicates that antioxidants that can inhibit reactive oxygen species production but do not have a scavenging effect could be a new effective therapeutic target for organ protection in hypertension as well as metabolic syndrome, in which higher oxidative stress plays a pivotal role.</p>","PeriodicalId":87159,"journal":{"name":"Timely topics in medicine. Cardiovascular diseases","volume":"9 ","pages":"E15"},"PeriodicalIF":0.0,"publicationDate":"2005-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25299736","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Inflammatory biomarkers and statins. 炎症生物标志物和他汀类药物。
Luis Miguel Blanco-Colio, José Tuñón, José Luis Martín-Ventura, Jesús Egido
{"title":"Inflammatory biomarkers and statins.","authors":"Luis Miguel Blanco-Colio,&nbsp;José Tuñón,&nbsp;José Luis Martín-Ventura,&nbsp;Jesús Egido","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The concept of atherosclerosis as an inflammatory disorder has led to the exploration of new pathogeneses of this disease. In this regard, the levels of several inflammatory molecules are frequently increased in subjects at high risk of developing an acute coronary event. With a simple analysis we can characterize the circulating levels of a marker and its therapeutic modulation with various drugs. In this review we have analyzed different inflammatory markers currently used, such as C-reactive protein (CRP), CD40 ligand, adhesion molecules and chemokines, and their possible modulation by therapeutic intervention with 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors. Moreover, in the future, new technologies will allow us to discover new markers, or sets of them, that could indicate the direction to be taken in the prevention and treatment of cardiovascular diseases.</p>","PeriodicalId":87159,"journal":{"name":"Timely topics in medicine. Cardiovascular diseases","volume":"9 ","pages":"E16"},"PeriodicalIF":0.0,"publicationDate":"2005-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25299737","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Advances in atherosclerosis: new treatments, new targets. A report from the 75th European Atherosclerosis Society Annual Meeting. 动脉粥样硬化的进展:新的治疗方法,新的靶点。一份来自第75届欧洲动脉粥样硬化学会年会的报告。
Xavier Rabasseda
{"title":"Advances in atherosclerosis: new treatments, new targets. A report from the 75th European Atherosclerosis Society Annual Meeting.","authors":"Xavier Rabasseda","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":87159,"journal":{"name":"Timely topics in medicine. Cardiovascular diseases","volume":"9 ","pages":"E14"},"PeriodicalIF":0.0,"publicationDate":"2005-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25299735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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